Q8VJ51 (Y3198_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glutaredoxin Rv3198.1/MT3292
EC=1.-.-.-

Gene names

Ordered Locus Names:	Rv3198.1, MT3292
ORF Names:	Rv3198A

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	84 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 glutaredoxin domain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 84

84

Putative glutaredoxin Rv3198.1/MT3292

PRO_0000363861

Regions

Domain

1 – 84

84

Glutaredoxin

Secondary structure

1

.

.

.

.

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.

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.

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.

.

.

.

.

.

.

84

Helix Strand Turn

Details...

Beta strand

6 – 10

5

Helix

17 – 26

10

Beta strand

32 – 35

4

Turn

36 – 38

3

Helix

40 – 49

10

Beta strand

50 – 54

5

Beta strand

58 – 61

4

Beta strand

66 – 69

4

Helix

72 – 83

12

Sequences

	Sequence		Length	Mass (Da)
	Q8VJ51 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 6E7DD7F00D4CAF3F	FASTA	84	8,963
	10 20 30 40 50 60 MITAALTIYT TSWCGYCLRL KTALTANRIA YDEVDIEHNR AAAEFVGSVN GGNRTVPTVK 70 80 FADGSTLTNP SADEVKAKLV KIAG

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000516 Genomic DNA. Translation: AAK47635.1.
AL123456 Genomic DNA. Translation: CCP46013.1.

RefSeq

NP_337821.1. NC_002755.2.
YP_006516668.1. NC_018143.1.
YP_177941.1. NC_000962.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LQO	NMR	-	A	3-84	[»]
2LQQ	NMR	-	A	3-84	[»]

ProteinModelPortal

Q8VJ51.

SMR

Q8VJ51. Positions 1-84.

ModBase

Search...

Protein-protein interaction databases

STRING

83332.Rv3198A.

Proteomic databases

PRIDE

Q8VJ51.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAK47635; AAK47635; MT3292.

GeneID

13318014.
3205084.
923288.

KEGG

mtc:MT3292.
mtu:Rv3198A.

PATRIC

18128998. VBIMycTub22151_3595.

Organism-specific databases

TubercuList

Rv3198A.

Phylogenomic databases

eggNOG

COG0695.

HOGENOM

HOG000095210.

OMA

GNHVVPT.

ProtClustDB

CLSK799967.

Family and domain databases

Gene3D

3.40.30.10. 1 hit.

InterPro

IPR011915. GlrX_actino.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]

Pfam

PF00462. Glutaredoxin. 1 hit.
[Graphical view]

SUPFAM

SSF52833. Thiordxn-like_fd. 1 hit.

TIGRFAMs

TIGR02200. GlrX_actino. 1 hit.

PROSITE

PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Y3198_MYCTU

Accession

Primary (citable) accession number: Q8VJ51
Secondary accession number(s): L0TC42, Q6MX00

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	March 1, 2002
Last modified:	May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program