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Protein

Stereocilin

Gene

Strc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential to the formation of horizontal top connectors between outer hair cell stereocilia.1 Publication

GO - Biological processi

  • auditory receptor cell stereocilium organization Source: UniProtKB
  • cell-matrix adhesion Source: GO_Central
  • detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Stereocilin
Gene namesi
Name:Strc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2153816. Strc.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: GO_Central
  • kinocilium Source: UniProtKB
  • stereocilium tip Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 18091787StereocilinPRO_0000022427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence analysis
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence analysis
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence analysis
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence analysis
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence analysis
Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence analysis
Glycosylationi952 – 9521N-linked (GlcNAc...)Sequence analysis
Glycosylationi1000 – 10001N-linked (GlcNAc...)Sequence analysis
Glycosylationi1213 – 12131N-linked (GlcNAc...)Sequence analysis
Glycosylationi1308 – 13081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VIM6.
PRIDEiQ8VIM6.

PTM databases

iPTMnetiQ8VIM6.
PhosphoSiteiQ8VIM6.

Expressioni

Tissue specificityi

Strongly expressed in the inner ear, detected in the testis, and barely detected in the eye. Detected in the six sensory areas of the inner ear by immunofluorescence. Expressed only in the sensory hair cells and associated with the stereocilia, the stiff microvilli forming the structure for mechanoreception of sound stimulation.2 Publications

Gene expression databases

BgeeiENSMUSG00000033498.
CleanExiMM_STRC.
ExpressionAtlasiQ8VIM6. baseline and differential.
GenevisibleiQ8VIM6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039378.

Structurei

3D structure databases

ProteinModelPortaliQ8VIM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi378 – 42548Pro/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the stereocilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIWF. Eukaryota.
ENOG410ZQVX. LUCA.
GeneTreeiENSGT00530000063809.
HOGENOMiHOG000231838.
HOVERGENiHBG079223.
InParanoidiQ8VIM6.
OMAiCIPGQPI.
OrthoDBiEOG091G00ZK.
TreeFamiTF330914.

Family and domain databases

InterProiIPR026061. Stereocilin.
IPR026664. Stereocilin-rel.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 2 hits.
PTHR23412:SF14. PTHR23412:SF14. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VIM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLQPQLL LLLSLLPQEV TSAPTGPQSL DAGLSLLKSF VATLDQAPQR
60 70 80 90 100
SLSQSRFSAF LANISSSFQL GRMGEGPVGE PPPLQPPALR LHDFLVTLRG
110 120 130 140 150
SPDWEPMLGL LGDVLALLGQ EQTPRDFLVH QAGVLGGLVE ALLGALVPGG
160 170 180 190 200
PPAPTRPPCT RDGPSDCVLA ADWLPSLMLL LEGTRWQALV QLQPSVDPTN
210 220 230 240 250
ATGLDGREPA PHFLQGLLGL LTPAGELGSE EALWGGLLRT VGAPLYAAFQ
260 270 280 290 300
EGLLRVTHSL QDEVFSIMGQ PEPDASGQCQ GGNLQQLLLW GMRNNLSWDA
310 320 330 340 350
RALGFLSGSP PPPPALLHCL SRGVPLPRAS QPAAHISPRQ RRAISVEALC
360 370 380 390 400
ENHSGPEPPY SISNFSIYLL CQHIKPATPR PPPTTPRPPP TTPQPPPTTT
410 420 430 440 450
QPIPDTTQPP PVTPRPPPTT PQPPPSTAVI CQTAVWYAVS WAPGARGWLQ
460 470 480 490 500
ACHDQFPDQF LDMICGNLSF SALSGPSRPL VKQLCAGLLP PPTSCPPGLI
510 520 530 540 550
PVPLTPEIFW GCFLENETLW AERLCVEDSL QAVPPRNQAW VQHVCRGPTL
560 570 580 590 600
DATDFPPCRV GPCGERCPDG GSFLLMVCAN DTLYEALVPF WAWLAGQCRI
610 620 630 640 650
SRGGNDTCFL EGMLGPLLPS LPPLGPSPLC LAPGPFLLGM LSQLPRCQSS
660 670 680 690 700
VPALAHPTRL HYLLRLLTFL LGPGTGGAET QGMLGQALLL SSLPDNCSFW
710 720 730 740 750
DAFRPEGRRS VLRTVGEYLQ REEPTPPGLD SSLSLGSGMS KMELLSCFSP
760 770 780 790 800
VLWDLLQREK SVWALRTLVK AYLRMPPEDL QQLVLSAEME AAQGFLTLML
810 820 830 840 850
RSWAKLKVQP SEEQAMGRLT ALLLQRYPRL TSQLFIDMSP LIPFLAVPDL
860 870 880 890 900
MRFPPSLLAN DSVLAAIRDH SSGMKPEQKE ALAKRLLAPE LFGEVPDWPQ
910 920 930 940 950
ELLWAALPLL PHLPLESFLQ LSPHQIQALE DSWPVADLGP GHARHVLRSL
960 970 980 990 1000
VNQSMEDGEE QVLRLGSLAC FLSPEELQSL VPLSDPMGPV EQGLLECAAN
1010 1020 1030 1040 1050
GTLSPEGRVA YELLGVLRSS GGTVLSPREL RVWAPLFPQL GLRFLQELSE
1060 1070 1080 1090 1100
TQLRAMLPAL QGASVTPAQA VLLFGRLLPK HDLSLEELCS LHPLLPGLSP
1110 1120 1130 1140 1150
QTLQAIPKRV LVGACSCLGP ELSRLSACQI AALLQTFRVK DGVKNMGAAG
1160 1170 1180 1190 1200
AGSAVCIPGQ PTTWPDCLLP LLPLKLLQLD AAALLANRRL YRQLPWSEQQ
1210 1220 1230 1240 1250
AQFLWKKMQV PTNLSLRNLQ ALGNLAGGMT CEFLQQISSM VDFLDVVHML
1260 1270 1280 1290 1300
YQLPTGVRES LRACIWTELQ RRMTMPEPEL TTLGPELSEL DTKLLLDLPI
1310 1320 1330 1340 1350
QLMDRLSNDS IMLVVEMVQG APEQLLALTP LHQTALAERA LKNLAPKETP
1360 1370 1380 1390 1400
ISKEVLETLG PLVGFLGIES TRRIPLPILL SHLSQLQGFC LGETFATELG
1410 1420 1430 1440 1450
WLLLQEPVLG KPELWSQDEI EQAGRLVFTL SAEAISSIPR EALGPETLER
1460 1470 1480 1490 1500
LLGKHQSWEQ SRVGHLCGES QLAHKKAALV AGIVHPAAEG LQEPVPNCAD
1510 1520 1530 1540 1550
IRGTFPAAWS ATQISEMELS DFEDCLSLFA GDPGLGPEEL RAAMGKAKQL
1560 1570 1580 1590 1600
WGPPRGFRPE QILQLGRLLI GLGERELQEL TLVDWGVLSS LGQIDGWSSM
1610 1620 1630 1640 1650
QLRAVVSSFL RQSGRHVSHL DFIYLTALGY TVCGLRPEEL QHISSWEFSQ
1660 1670 1680 1690 1700
AALFLGSLHL PCSEEQLEVL AYLLVLPGGF GPVSNWGPEI FTEIGTIAAG
1710 1720 1730 1740 1750
IPDLALSALL RGQIQGLTPL AISVIPAPKF AVVFNPIQLS SLTRGQAVAV
1760 1770 1780 1790 1800
TPEQLAYLSP EQRRAVAWAQ HEGKEIPEQL GRNSAWGLYD WFQASWALAL

PVSIFGHLL
Length:1,809
Mass (Da):196,347
Last modified:July 27, 2011 - v2
Checksum:iFEDE974426C44F6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti477 – 4793SRP → NRR in AAL35321 (PubMed:11687802).Curated
Sequence conflicti622 – 6221P → L in AAL35321 (PubMed:11687802).Curated
Sequence conflicti937 – 9371D → G in AAL35321 (PubMed:11687802).Curated
Sequence conflicti1632 – 16321V → L in AAL35321 (PubMed:11687802).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF375593 mRNA. Translation: AAL35321.1.
AL845466 Genomic DNA. Translation: CAM24226.1.
CCDSiCCDS16641.1.
RefSeqiNP_536707.2. NM_080459.2.
XP_006498797.1. XM_006498734.1.
UniGeneiMm.467475.

Genome annotation databases

EnsembliENSMUST00000038389; ENSMUSP00000039378; ENSMUSG00000033498.
GeneIDi140476.
KEGGimmu:140476.
UCSCiuc008lyw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF375593 mRNA. Translation: AAL35321.1.
AL845466 Genomic DNA. Translation: CAM24226.1.
CCDSiCCDS16641.1.
RefSeqiNP_536707.2. NM_080459.2.
XP_006498797.1. XM_006498734.1.
UniGeneiMm.467475.

3D structure databases

ProteinModelPortaliQ8VIM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039378.

PTM databases

iPTMnetiQ8VIM6.
PhosphoSiteiQ8VIM6.

Proteomic databases

PaxDbiQ8VIM6.
PRIDEiQ8VIM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038389; ENSMUSP00000039378; ENSMUSG00000033498.
GeneIDi140476.
KEGGimmu:140476.
UCSCiuc008lyw.1. mouse.

Organism-specific databases

CTDi161497.
MGIiMGI:2153816. Strc.

Phylogenomic databases

eggNOGiENOG410IIWF. Eukaryota.
ENOG410ZQVX. LUCA.
GeneTreeiENSGT00530000063809.
HOGENOMiHOG000231838.
HOVERGENiHBG079223.
InParanoidiQ8VIM6.
OMAiCIPGQPI.
OrthoDBiEOG091G00ZK.
TreeFamiTF330914.

Miscellaneous databases

PROiQ8VIM6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033498.
CleanExiMM_STRC.
ExpressionAtlasiQ8VIM6. baseline and differential.
GenevisibleiQ8VIM6. MM.

Family and domain databases

InterProiIPR026061. Stereocilin.
IPR026664. Stereocilin-rel.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 2 hits.
PTHR23412:SF14. PTHR23412:SF14. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSTRC_MOUSE
AccessioniPrimary (citable) accession number: Q8VIM6
Secondary accession number(s): A2ARP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.