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Q8VIM5

- MYCD_MOUSE

UniProt

Q8VIM5 - MYCD_MOUSE

Protein

Myocardin

Gene

Myocd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.5 Publications

    GO - Molecular functioni

    1. histone acetyltransferase binding Source: MGI
    2. histone deacetylase binding Source: MGI
    3. nucleic acid binding Source: InterPro
    4. protein binding Source: UniProtKB
    5. RNA polymerase II transcription factor binding transcription factor activity Source: BHF-UCL
    6. R-SMAD binding Source: BHF-UCL
    7. transcription coactivator activity Source: MGI

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: BHF-UCL
    2. cardiac ventricle development Source: MGI
    3. cell growth involved in cardiac muscle cell development Source: Ensembl
    4. cellular component maintenance Source: MGI
    5. cellular response to growth factor stimulus Source: Ensembl
    6. cellular response to hypoxia Source: Ensembl
    7. digestive tract development Source: MGI
    8. ductus arteriosus closure Source: MGI
    9. heart development Source: MGI
    10. hepatic stellate cell activation Source: Ensembl
    11. lung alveolus development Source: MGI
    12. muscle cell differentiation Source: MGI
    13. negative regulation of cardiac muscle cell apoptotic process Source: MGI
    14. negative regulation of myotube differentiation Source: MGI
    15. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    16. positive regulation of cardiac muscle cell differentiation Source: InterPro
    17. positive regulation of cardiac vascular smooth muscle cell differentiation Source: Ensembl
    18. positive regulation of cell proliferation Source: MGI
    19. positive regulation of DNA binding Source: MGI
    20. positive regulation of transcription, DNA-templated Source: MGI
    21. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    22. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
    23. positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
    24. regulation of cell growth by extracellular stimulus Source: MGI
    25. regulation of histone acetylation Source: UniProtKB
    26. regulation of myoblast differentiation Source: MGI
    27. regulation of transcription from RNA polymerase II promoter Source: MGI
    28. smooth muscle cell differentiation Source: MGI
    29. transcription from RNA polymerase II promoter Source: GOC
    30. urinary bladder development Source: MGI
    31. uterus development Source: MGI
    32. vasculogenesis Source: MGI
    33. ventricular cardiac muscle cell differentiation Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myocardin
    Alternative name(s):
    Basic SAP coiled-coil transcription activator 2
    SRF cofactor protein
    Gene namesi
    Name:Myocd
    Synonyms:Bsac2, Mycd, Srfcp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2137495. Myocd.

    Subcellular locationi

    Nucleus speckle 2 Publications
    Note: Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB
    3. SRF-myogenin-E12 complex Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi387 – 3893ELR → PSF: Activation of ANF promoter abolished, no effect on SM22 promoter. 1 Publication
    Mutagenesisi408 – 4103DRL → PGH: Activation of ANF promoter abolished, no effect on SM22 promoter. 1 Publication
    Mutagenesisi812 – 8121S → A: No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-859; A-866 and A-893. 2 Publications
    Mutagenesisi812 – 8121S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-859; D-866 and D-893. 2 Publications
    Mutagenesisi859 – 8591S → A: No effect on SRF activation; No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812, A-866 and A-893. 2 Publications
    Mutagenesisi859 – 8591S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-866 and D-893. 2 Publications
    Mutagenesisi866 – 8661S → A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812; A-859 and A-893. 2 Publications
    Mutagenesisi866 – 8661S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-893. 2 Publications
    Mutagenesisi893 – 8931T → A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-specific genes trancription; when associated with A-812; A-859 and A-866. 2 Publications
    Mutagenesisi893 – 8931T → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-866. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 935935MyocardinPRO_0000126632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei454 – 4541Phosphoserine; by GSK3-beta1 Publication
    Modified residuei458 – 4581Phosphoserine; by GSK3-beta1 Publication
    Modified residuei462 – 4621Phosphoserine; by GSK3-beta1 Publication
    Modified residuei466 – 4661Phosphoserine; by GSK3-beta1 Publication
    Modified residuei624 – 6241Phosphoserine; by GSK3-beta1 Publication
    Modified residuei628 – 6281Phosphoserine; by GSK3-beta1 Publication
    Modified residuei632 – 6321Phosphoserine; by GSK3-beta1 Publication
    Modified residuei636 – 6361Phosphoserine; by GSK3-beta1 Publication
    Modified residuei812 – 8121Phosphoserine; by MAPK1 AND MAPK31 Publication
    Modified residuei859 – 8591Phosphoserine; by MAPK1 and MAPK31 Publication
    Modified residuei866 – 8661Phosphoserine; by MAPK1 and MAPK31 Publication
    Modified residuei893 – 8931Phosphothreonine; by MAPK1 and MAPK31 Publication

    Post-translational modificationi

    Phosphorylation regulates negatively transcriptional activity.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8VIM5.
    PRIDEiQ8VIM5.

    PTM databases

    PhosphoSiteiQ8VIM5.

    Expressioni

    Tissue specificityi

    Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus. Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues. Isoform 3 is the most abundant isoform in the heart from embryo to adult.5 Publications

    Developmental stagei

    Detected in the cardiac crescent at 7.75 dpc and in the linear heart tube at 8.0 dpc and the developing atrial and aortic ventricular chambers until birth. Also detected in a subset of vascular and visceral smooth muscle cells: aortic arch arteries at 9.5 dpc; walls of the esophagus, dorsal aorta, pulmonary outflow tract, lung, gut, stomach, small intestine, bladder, and the head mesenchyme at 13.5 dpc until birth. Not detected in skeletal muscle cells.2 Publications

    Gene expression databases

    ArrayExpressiQ8VIM5.
    BgeeiQ8VIM5.
    CleanExiMM_MYOCD.
    GenevestigatoriQ8VIM5.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with MLLT7/FOXO4 By similarity. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts (via C-terminal) with EP300 (via CREB-binding domain). Interacts with HDAC4 and HDAC5. Interacts with MEF2C.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi229522. 15 interactions.
    DIPiDIP-29754N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VIM5.
    SMRiQ8VIM5. Positions 17-129, 372-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati18 – 4326RPEL 1Add
    BLAST
    Repeati62 – 8726RPEL 2Add
    BLAST
    Repeati106 – 13126RPEL 3Add
    BLAST
    Domaini380 – 41435SAPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni153 – 20149HDAC5-bindingAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili287 – 32236Sequence AnalysisAdd
    BLAST
    Coiled coili519 – 56345Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 2716MEF2C-bindingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi287 – 32034Gln-richAdd
    BLAST
    Compositional biasi300 – 32021Poly-GlnAdd
    BLAST

    Domaini

    The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation.

    Sequence similaritiesi

    Contains 3 RPEL repeats.PROSITE-ProRule annotation
    Contains 1 SAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG79803.
    GeneTreeiENSGT00530000063195.
    HOGENOMiHOG000038001.
    HOVERGENiHBG036493.
    InParanoidiQ6W8X1.
    OMAiSFTESPW.
    OrthoDBiEOG7VMP4N.
    TreeFamiTF326024.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    InterProiIPR028721. MYOCD.
    IPR004018. RPEL_repeat.
    IPR003034. SAP_dom.
    [Graphical view]
    PANTHERiPTHR22793:SF11. PTHR22793:SF11. 1 hit.
    PfamiPF02755. RPEL. 1 hit.
    PF02037. SAP. 1 hit.
    [Graphical view]
    SMARTiSM00707. RPEL. 3 hits.
    SM00513. SAP. 1 hit.
    [Graphical view]
    PROSITEiPS51073. RPEL. 3 hits.
    PS50800. SAP. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VIM5-1) [UniParc]FASTAAdd to Basket

    Also known as: MYOCD-v2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLLGSEHSL LIRRKFRSVL QLRLQQRRTQ EQLANQGLIP PLKGPTEFHD    50
    PRKQLDSAKT EDSLRRKGRN RSDRASLVTM HILQASTAER SIPTAQMKLK 100
    RARLADDLNE KIALRPGPLE LVEKNILPMD SSVKEAIKGT EVSLSKAADA 150
    FAFEDDSSRD GLSPDQARSE DPQGSTGSTP DIKSTEAPLD TIQDLTPGSE 200
    SDKNDAASQP GNQSDPGKQV LGPLSTPIPV HTAVKSKSLG DSKNRHKKPK 250
    DPKPKVKKLK YHQYIPPDQK AEKSPPPMDS AYARLLQQQQ LFLQLQILSQ 300
    QQQQQQQQQQ QQQQQQQQQQ RFSYPGMHQT HLKEPNEQMA RNPNPSSTPL 350
    SNTPLSPVKN SISGQTGVSS LKPGPLPPNL DDLKVSELRQ QLRIRGLPVS 400
    GTKTALVDRL RPFQDCAGNP VPNFGDITTV TFPVTPNTLP SYQSSPTGFY 450
    HFGSTSSSPP ISPASSDLSA AGSLPDTFTD ASPGFGLHAS PVPACTDESL 500
    LSSLNGGSGP SEPDGLDSEK DKMLVEKQKV INQLTWKLRQ EQRQVEELRM 550
    QLQKQKSSCS DQKPLPFLAT TIKQEDVSSC PFAPQQASGK GQGHSSDSPP 600
    PACETAQLLP HCVESSGQTH VLSSTFLSPQ CSPQHSPLGG LKSPQHISLP 650
    PSPNNHYFLA SSSGAQRENH GVSSPSSSQG CAQMTGLQSS DKVGPTFSIP 700
    SPTFSKSSSA VSDITQPPSY EDAVKQQMTR SQQMDELLDV LIESGEMPAD 750
    AREDHSCLQK IPKIPGSSCS PTAIPPKPSA SFEQASSGGQ MAFDHYANDS 800
    DEHLEVLLNS HSPIGKVSDV TLLKIGSEEP PFDSIMDGFP GKAAEDLFSA 850
    HELLPGPLSP MHAQLSPPSV DSSGLQLSFT ESPWETMEWL DLTPPSSTPG 900
    FSNLTSSGPS IFNIDFLDVT DLNLNSPMDL HLQQW 935
    Length:935
    Mass (Da):101,400
    Last modified:July 27, 2011 - v2
    Checksum:iA8FCFC68A923A5CB
    GO
    Isoform 2 (identifier: Q8VIM5-2) [UniParc]FASTAAdd to Basket

    Also known as: BSAC2A, Myocardin A, MYOCD-v5

    The sequence of this isoform differs from the canonical sequence as follows:
         1-128: Missing.
         683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

    Note: No experimental confirmation available.

    Show »
    Length:855
    Mass (Da):91,592
    Checksum:i73C3AAB62E61DB33
    GO
    Isoform 3 (identifier: Q8VIM5-3) [UniParc]FASTAAdd to Basket

    Also known as: =Myocardin A, MYOCD-v1

    The sequence of this isoform differs from the canonical sequence as follows:
         683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

    Show »
    Length:983
    Mass (Da):106,223
    Checksum:i7640D2863F9DB517
    GO
    Isoform 4 (identifier: Q8VIM5-4) [UniParc]FASTAAdd to Basket

    Also known as: MYOCD-v3

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.
         683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

    Show »
    Length:904
    Mass (Da):97,066
    Checksum:i535A0D43433EEDD7
    GO
    Isoform 5 (identifier: Q8VIM5-5) [UniParc]FASTAAdd to Basket

    Also known as: MYOCD-v4

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.

    Show »
    Length:856
    Mass (Da):92,243
    Checksum:iD2243E5464F1297D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161P → Q in AAK71683. (PubMed:11439182)Curated
    Sequence conflicti794 – 7941D → G in AAK71683. (PubMed:11439182)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 128128Missing in isoform 2. 1 PublicationVSP_007662Add
    BLAST
    Alternative sequencei1 – 7979Missing in isoform 4 and isoform 5. CuratedVSP_041684Add
    BLAST
    Alternative sequencei683 – 6831Q → QNSGAHEGHSSSFSSPASSL HQPFSGTQADSSHSAGLNPC PKSPSIHPK in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_007663

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF384055 mRNA. Translation: AAK71683.2.
    AY303755 mRNA. Translation: AAQ63841.1.
    AF437877 mRNA. Translation: AAL30892.1.
    AK084700 mRNA. Translation: BAC39258.1.
    AK142216 mRNA. Translation: BAE24980.1.
    AL669846 Genomic DNA. Translation: CAI25017.1.
    CCDSiCCDS24843.1. [Q8VIM5-1]
    CCDS48819.1. [Q8VIM5-3]
    RefSeqiNP_660118.3. NM_145136.4. [Q8VIM5-3]
    NP_666498.2. NM_146386.3. [Q8VIM5-1]
    XP_006532880.1. XM_006532817.1. [Q8VIM5-4]
    UniGeneiMm.32257.

    Genome annotation databases

    EnsembliENSMUST00000101042; ENSMUSP00000098603; ENSMUSG00000020542. [Q8VIM5-2]
    ENSMUST00000102635; ENSMUSP00000099695; ENSMUSG00000020542. [Q8VIM5-1]
    ENSMUST00000108695; ENSMUSP00000104335; ENSMUSG00000020542. [Q8VIM5-3]
    GeneIDi214384.
    KEGGimmu:214384.
    UCSCiuc007jky.2. mouse. [Q8VIM5-3]
    uc007jkz.2. mouse. [Q8VIM5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF384055 mRNA. Translation: AAK71683.2 .
    AY303755 mRNA. Translation: AAQ63841.1 .
    AF437877 mRNA. Translation: AAL30892.1 .
    AK084700 mRNA. Translation: BAC39258.1 .
    AK142216 mRNA. Translation: BAE24980.1 .
    AL669846 Genomic DNA. Translation: CAI25017.1 .
    CCDSi CCDS24843.1. [Q8VIM5-1 ]
    CCDS48819.1. [Q8VIM5-3 ]
    RefSeqi NP_660118.3. NM_145136.4. [Q8VIM5-3 ]
    NP_666498.2. NM_146386.3. [Q8VIM5-1 ]
    XP_006532880.1. XM_006532817.1. [Q8VIM5-4 ]
    UniGenei Mm.32257.

    3D structure databases

    ProteinModelPortali Q8VIM5.
    SMRi Q8VIM5. Positions 17-129, 372-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229522. 15 interactions.
    DIPi DIP-29754N.

    PTM databases

    PhosphoSitei Q8VIM5.

    Proteomic databases

    PaxDbi Q8VIM5.
    PRIDEi Q8VIM5.

    Protocols and materials databases

    DNASUi 214384.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101042 ; ENSMUSP00000098603 ; ENSMUSG00000020542 . [Q8VIM5-2 ]
    ENSMUST00000102635 ; ENSMUSP00000099695 ; ENSMUSG00000020542 . [Q8VIM5-1 ]
    ENSMUST00000108695 ; ENSMUSP00000104335 ; ENSMUSG00000020542 . [Q8VIM5-3 ]
    GeneIDi 214384.
    KEGGi mmu:214384.
    UCSCi uc007jky.2. mouse. [Q8VIM5-3 ]
    uc007jkz.2. mouse. [Q8VIM5-1 ]

    Organism-specific databases

    CTDi 93649.
    MGIi MGI:2137495. Myocd.

    Phylogenomic databases

    eggNOGi NOG79803.
    GeneTreei ENSGT00530000063195.
    HOGENOMi HOG000038001.
    HOVERGENi HBG036493.
    InParanoidi Q6W8X1.
    OMAi SFTESPW.
    OrthoDBi EOG7VMP4N.
    TreeFami TF326024.

    Miscellaneous databases

    NextBioi 374288.
    PROi Q8VIM5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VIM5.
    Bgeei Q8VIM5.
    CleanExi MM_MYOCD.
    Genevestigatori Q8VIM5.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    InterProi IPR028721. MYOCD.
    IPR004018. RPEL_repeat.
    IPR003034. SAP_dom.
    [Graphical view ]
    PANTHERi PTHR22793:SF11. PTHR22793:SF11. 1 hit.
    Pfami PF02755. RPEL. 1 hit.
    PF02037. SAP. 1 hit.
    [Graphical view ]
    SMARTi SM00707. RPEL. 3 hits.
    SM00513. SAP. 1 hit.
    [Graphical view ]
    PROSITEi PS51073. RPEL. 3 hits.
    PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor."
      Wang D.-Z., Chang P.S., Wang Z., Sutherland L., Richardson J.A., Small E., Krieg P.A., Olson E.N.
      Cell 105:851-862(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, INTERACTION WITH SRF, MUTAGENESIS OF 387-GLU--ARG-389 AND 408-ASP--LEU-410.
      Tissue: Heart.
    2. "Potentiation of serum response factor activity by a family of myocardin-related transcription factors."
      Wang D.-Z., Li S., Hockemeyer D., Sutherland L., Wang Z., Schratt G., Richardson J.A., Nordheim A., Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SEQUENCE REVISION TO 1-128.
    3. "Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis."
      Ueyama T., Kasahara H., Ishiwata T., Nie Q., Izumo S.
      Mol. Cell. Biol. 23:9222-9232(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
      Strain: NIH Swiss.
    4. "An alternative splicing form of myocardin (BSAC2), myocardin A (BSAC2A)."
      Sawada T., Okazaki T., Nakano H.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Heart.
    5. "Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation."
      Du K.L., Ip H.S., Li J., Chen M., Dandre F., Yu W., Lu M.M., Owens G.K., Parmacek M.S.
      Mol. Cell. Biol. 23:2425-2437(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    6. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryonic heart.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    8. "Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes."
      Yoshida T., Sinha S., Dandre F., Wamhoff B.R., Hoofnagle M.H., Kremer B.E., Wang D.-Z., Olson E.N., Owens G.K.
      Circ. Res. 92:856-864(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH SRF.
    9. "Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation."
      Badorff C., Seeger F.H., Zeiher A.M., Dimmeler S.
      Circ. Res. 97:645-654(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-454; SER-458; SER-462; SER-466; SER-624; SER-628; SER-632 AND SER-636.
    10. "Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin."
      Cao D., Wang Z., Zhang C.L., Oh J., Xing W., Li S., Richardson J.A., Wang D.Z., Olson E.N.
      Mol. Cell. Biol. 25:364-376(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH EP300; HDAC4 AND HDAC5.
    11. "Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR."
      Creemers E.E., Sutherland L.B., Oh J., Barbosa A.C., Olson E.N.
      Mol. Cell 23:83-96(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 4), INTERACTION WITH MEF2C, FUNCTION.
    12. "Phosphorylation of myocardin by extracellular signal-regulated kinase."
      Taurin S., Sandbo N., Yau D.M., Sethakorn N., Kach J., Dulin N.O.
      J. Biol. Chem. 284:33789-33794(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-812; SER-859; SER-866 AND THR-893, MUTAGENESIS OF SER-812; SER-859; SER-866 AND THR-893.
    13. "Expression and functional activity of four myocardin isoforms."
      Imamura M., Long X., Nanda V., Miano J.M.
      Gene 464:1-10(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4 AND 5), TISSUE SPECIFICITY OF ISOFORMS, FUNCTION.

    Entry informationi

    Entry nameiMYCD_MOUSE
    AccessioniPrimary (citable) accession number: Q8VIM5
    Secondary accession number(s): Q5SS65
    , Q6W8X1, Q8C3W6, Q8VIL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3