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Q8VIM5

- MYCD_MOUSE

UniProt

Q8VIM5 - MYCD_MOUSE

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Protein

Myocardin

Gene

Myocd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.5 Publications

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: Ensembl
  2. histone acetyltransferase binding Source: MGI
  3. histone deacetylase binding Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. RNA polymerase II transcription factor binding transcription factor activity Source: BHF-UCL
  6. R-SMAD binding Source: BHF-UCL
  7. transcription coactivator activity Source: MGI

GO - Biological processi

  1. cardiac muscle cell differentiation Source: BHF-UCL
  2. cardiac ventricle development Source: MGI
  3. cell growth involved in cardiac muscle cell development Source: Ensembl
  4. cellular component maintenance Source: MGI
  5. cellular response to growth factor stimulus Source: Ensembl
  6. cellular response to hypoxia Source: Ensembl
  7. digestive tract development Source: MGI
  8. ductus arteriosus closure Source: MGI
  9. heart development Source: MGI
  10. hepatic stellate cell activation Source: Ensembl
  11. lung alveolus development Source: MGI
  12. muscle cell differentiation Source: MGI
  13. negative regulation of beta-amyloid clearance Source: Ensembl
  14. negative regulation of cardiac muscle cell apoptotic process Source: MGI
  15. negative regulation of cell proliferation Source: Ensembl
  16. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  17. negative regulation of myotube differentiation Source: MGI
  18. negative regulation of skeletal muscle cell differentiation Source: Ensembl
  19. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  20. positive regulation of cardiac muscle cell differentiation Source: Ensembl
  21. positive regulation of cardiac vascular smooth muscle cell differentiation Source: Ensembl
  22. positive regulation of cell proliferation Source: MGI
  23. positive regulation of DNA binding Source: MGI
  24. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  25. positive regulation of smooth muscle contraction Source: Ensembl
  26. positive regulation of transcription, DNA-templated Source: MGI
  27. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  28. positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: Ensembl
  29. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
  30. positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  31. regulation of cell growth by extracellular stimulus Source: MGI
  32. regulation of histone acetylation Source: UniProtKB
  33. regulation of myoblast differentiation Source: MGI
  34. regulation of transcription from RNA polymerase II promoter Source: MGI
  35. smooth muscle cell differentiation Source: MGI
  36. transcription from RNA polymerase II promoter Source: GOC
  37. urinary bladder development Source: MGI
  38. uterus development Source: MGI
  39. vasculogenesis Source: MGI
  40. ventricular cardiac muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Myocardin
Alternative name(s):
Basic SAP coiled-coil transcription activator 2
SRF cofactor protein
Gene namesi
Name:Myocd
Synonyms:Bsac2, Mycd, Srfcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2137495. Myocd.

Subcellular locationi

Nucleus speckle 2 Publications
Note: Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. SRF-myogenin-E12 complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi387 – 3893ELR → PSF: Activation of ANF promoter abolished, no effect on SM22 promoter. 1 Publication
Mutagenesisi408 – 4103DRL → PGH: Activation of ANF promoter abolished, no effect on SM22 promoter. 1 Publication
Mutagenesisi812 – 8121S → A: No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-859; A-866 and A-893. 1 Publication
Mutagenesisi812 – 8121S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-859; D-866 and D-893. 1 Publication
Mutagenesisi859 – 8591S → A: No effect on SRF activation; No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812, A-866 and A-893. 1 Publication
Mutagenesisi859 – 8591S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-866 and D-893. 1 Publication
Mutagenesisi866 – 8661S → A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812; A-859 and A-893. 1 Publication
Mutagenesisi866 – 8661S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-893. 1 Publication
Mutagenesisi893 – 8931T → A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-specific genes trancription; when associated with A-812; A-859 and A-866. 1 Publication
Mutagenesisi893 – 8931T → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-866. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 935935MyocardinPRO_0000126632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei454 – 4541Phosphoserine; by GSK3-beta1 Publication
Modified residuei458 – 4581Phosphoserine; by GSK3-beta1 Publication
Modified residuei462 – 4621Phosphoserine; by GSK3-beta1 Publication
Modified residuei466 – 4661Phosphoserine; by GSK3-beta1 Publication
Modified residuei624 – 6241Phosphoserine; by GSK3-beta1 Publication
Modified residuei628 – 6281Phosphoserine; by GSK3-beta1 Publication
Modified residuei632 – 6321Phosphoserine; by GSK3-beta1 Publication
Modified residuei636 – 6361Phosphoserine; by GSK3-beta1 Publication
Modified residuei812 – 8121Phosphoserine; by MAPK1 AND MAPK31 Publication
Modified residuei859 – 8591Phosphoserine; by MAPK1 and MAPK31 Publication
Modified residuei866 – 8661Phosphoserine; by MAPK1 and MAPK31 Publication
Modified residuei893 – 8931Phosphothreonine; by MAPK1 and MAPK31 Publication

Post-translational modificationi

Phosphorylation regulates negatively transcriptional activity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VIM5.
PRIDEiQ8VIM5.

PTM databases

PhosphoSiteiQ8VIM5.

Expressioni

Tissue specificityi

Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus. Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues. Isoform 3 is the most abundant isoform in the heart from embryo to adult.5 Publications

Developmental stagei

Detected in the cardiac crescent at 7.75 dpc and in the linear heart tube at 8.0 dpc and the developing atrial and aortic ventricular chambers until birth. Also detected in a subset of vascular and visceral smooth muscle cells: aortic arch arteries at 9.5 dpc; walls of the esophagus, dorsal aorta, pulmonary outflow tract, lung, gut, stomach, small intestine, bladder, and the head mesenchyme at 13.5 dpc until birth. Not detected in skeletal muscle cells.2 Publications

Gene expression databases

BgeeiQ8VIM5.
CleanExiMM_MYOCD.
ExpressionAtlasiQ8VIM5. baseline and differential.
GenevestigatoriQ8VIM5.

Interactioni

Subunit structurei

Homodimer. Interacts with MLLT7/FOXO4 (By similarity). Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts (via C-terminal) with EP300 (via CREB-binding domain). Interacts with HDAC4 and HDAC5. Interacts with MEF2C.By similarity4 Publications

Protein-protein interaction databases

BioGridi229522. 15 interactions.
DIPiDIP-29754N.

Structurei

3D structure databases

ProteinModelPortaliQ8VIM5.
SMRiQ8VIM5. Positions 17-129, 372-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 4326RPEL 1Add
BLAST
Repeati62 – 8726RPEL 2Add
BLAST
Repeati106 – 13126RPEL 3Add
BLAST
Domaini380 – 41435SAPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni153 – 20149HDAC5-bindingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili287 – 32236Sequence AnalysisAdd
BLAST
Coiled coili519 – 56345Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 2716MEF2C-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi287 – 32034Gln-richAdd
BLAST
Compositional biasi300 – 32021Poly-GlnAdd
BLAST

Domaini

The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation.

Sequence similaritiesi

Contains 3 RPEL repeats.PROSITE-ProRule annotation
Contains 1 SAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG79803.
GeneTreeiENSGT00530000063195.
HOGENOMiHOG000038001.
HOVERGENiHBG036493.
InParanoidiQ8VIM5.
OMAiSFTESPW.
OrthoDBiEOG7VMP4N.
TreeFamiTF326024.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR028721. MYOCD.
IPR004018. RPEL_repeat.
IPR003034. SAP_dom.
[Graphical view]
PANTHERiPTHR22793:SF11. PTHR22793:SF11. 1 hit.
PfamiPF02755. RPEL. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00707. RPEL. 3 hits.
SM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS51073. RPEL. 3 hits.
PS50800. SAP. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VIM5-1) [UniParc]FASTAAdd to Basket

Also known as: MYOCD-v2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLLGSEHSL LIRRKFRSVL QLRLQQRRTQ EQLANQGLIP PLKGPTEFHD
60 70 80 90 100
PRKQLDSAKT EDSLRRKGRN RSDRASLVTM HILQASTAER SIPTAQMKLK
110 120 130 140 150
RARLADDLNE KIALRPGPLE LVEKNILPMD SSVKEAIKGT EVSLSKAADA
160 170 180 190 200
FAFEDDSSRD GLSPDQARSE DPQGSTGSTP DIKSTEAPLD TIQDLTPGSE
210 220 230 240 250
SDKNDAASQP GNQSDPGKQV LGPLSTPIPV HTAVKSKSLG DSKNRHKKPK
260 270 280 290 300
DPKPKVKKLK YHQYIPPDQK AEKSPPPMDS AYARLLQQQQ LFLQLQILSQ
310 320 330 340 350
QQQQQQQQQQ QQQQQQQQQQ RFSYPGMHQT HLKEPNEQMA RNPNPSSTPL
360 370 380 390 400
SNTPLSPVKN SISGQTGVSS LKPGPLPPNL DDLKVSELRQ QLRIRGLPVS
410 420 430 440 450
GTKTALVDRL RPFQDCAGNP VPNFGDITTV TFPVTPNTLP SYQSSPTGFY
460 470 480 490 500
HFGSTSSSPP ISPASSDLSA AGSLPDTFTD ASPGFGLHAS PVPACTDESL
510 520 530 540 550
LSSLNGGSGP SEPDGLDSEK DKMLVEKQKV INQLTWKLRQ EQRQVEELRM
560 570 580 590 600
QLQKQKSSCS DQKPLPFLAT TIKQEDVSSC PFAPQQASGK GQGHSSDSPP
610 620 630 640 650
PACETAQLLP HCVESSGQTH VLSSTFLSPQ CSPQHSPLGG LKSPQHISLP
660 670 680 690 700
PSPNNHYFLA SSSGAQRENH GVSSPSSSQG CAQMTGLQSS DKVGPTFSIP
710 720 730 740 750
SPTFSKSSSA VSDITQPPSY EDAVKQQMTR SQQMDELLDV LIESGEMPAD
760 770 780 790 800
AREDHSCLQK IPKIPGSSCS PTAIPPKPSA SFEQASSGGQ MAFDHYANDS
810 820 830 840 850
DEHLEVLLNS HSPIGKVSDV TLLKIGSEEP PFDSIMDGFP GKAAEDLFSA
860 870 880 890 900
HELLPGPLSP MHAQLSPPSV DSSGLQLSFT ESPWETMEWL DLTPPSSTPG
910 920 930
FSNLTSSGPS IFNIDFLDVT DLNLNSPMDL HLQQW
Length:935
Mass (Da):101,400
Last modified:July 27, 2011 - v2
Checksum:iA8FCFC68A923A5CB
GO
Isoform 2 (identifier: Q8VIM5-2) [UniParc]FASTAAdd to Basket

Also known as: BSAC2A, Myocardin A, MYOCD-v5

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

Note: No experimental confirmation available.

Show »
Length:855
Mass (Da):91,592
Checksum:i73C3AAB62E61DB33
GO
Isoform 3 (identifier: Q8VIM5-3) [UniParc]FASTAAdd to Basket

Also known as: =Myocardin A, MYOCD-v1

The sequence of this isoform differs from the canonical sequence as follows:
     683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

Show »
Length:983
Mass (Da):106,223
Checksum:i7640D2863F9DB517
GO
Isoform 4 (identifier: Q8VIM5-4) [UniParc]FASTAAdd to Basket

Also known as: MYOCD-v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

Show »
Length:904
Mass (Da):97,066
Checksum:i535A0D43433EEDD7
GO
Isoform 5 (identifier: Q8VIM5-5) [UniParc]FASTAAdd to Basket

Also known as: MYOCD-v4

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:856
Mass (Da):92,243
Checksum:iD2243E5464F1297D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161P → Q in AAK71683. (PubMed:11439182)Curated
Sequence conflicti794 – 7941D → G in AAK71683. (PubMed:11439182)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 128128Missing in isoform 2. 1 PublicationVSP_007662Add
BLAST
Alternative sequencei1 – 7979Missing in isoform 4 and isoform 5. CuratedVSP_041684Add
BLAST
Alternative sequencei683 – 6831Q → QNSGAHEGHSSSFSSPASSL HQPFSGTQADSSHSAGLNPC PKSPSIHPK in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_007663

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF384055 mRNA. Translation: AAK71683.2.
AY303755 mRNA. Translation: AAQ63841.1.
AF437877 mRNA. Translation: AAL30892.1.
AK084700 mRNA. Translation: BAC39258.1.
AK142216 mRNA. Translation: BAE24980.1.
AL669846 Genomic DNA. Translation: CAI25017.1.
CCDSiCCDS24843.1. [Q8VIM5-1]
CCDS48819.1. [Q8VIM5-3]
RefSeqiNP_660118.3. NM_145136.4. [Q8VIM5-3]
NP_666498.2. NM_146386.3. [Q8VIM5-1]
XP_006532880.1. XM_006532817.1. [Q8VIM5-4]
UniGeneiMm.32257.

Genome annotation databases

EnsembliENSMUST00000101042; ENSMUSP00000098603; ENSMUSG00000020542. [Q8VIM5-2]
ENSMUST00000102635; ENSMUSP00000099695; ENSMUSG00000020542. [Q8VIM5-1]
ENSMUST00000108695; ENSMUSP00000104335; ENSMUSG00000020542. [Q8VIM5-3]
GeneIDi214384.
KEGGimmu:214384.
UCSCiuc007jky.2. mouse. [Q8VIM5-3]
uc007jkz.2. mouse. [Q8VIM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF384055 mRNA. Translation: AAK71683.2 .
AY303755 mRNA. Translation: AAQ63841.1 .
AF437877 mRNA. Translation: AAL30892.1 .
AK084700 mRNA. Translation: BAC39258.1 .
AK142216 mRNA. Translation: BAE24980.1 .
AL669846 Genomic DNA. Translation: CAI25017.1 .
CCDSi CCDS24843.1. [Q8VIM5-1 ]
CCDS48819.1. [Q8VIM5-3 ]
RefSeqi NP_660118.3. NM_145136.4. [Q8VIM5-3 ]
NP_666498.2. NM_146386.3. [Q8VIM5-1 ]
XP_006532880.1. XM_006532817.1. [Q8VIM5-4 ]
UniGenei Mm.32257.

3D structure databases

ProteinModelPortali Q8VIM5.
SMRi Q8VIM5. Positions 17-129, 372-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229522. 15 interactions.
DIPi DIP-29754N.

PTM databases

PhosphoSitei Q8VIM5.

Proteomic databases

PaxDbi Q8VIM5.
PRIDEi Q8VIM5.

Protocols and materials databases

DNASUi 214384.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101042 ; ENSMUSP00000098603 ; ENSMUSG00000020542 . [Q8VIM5-2 ]
ENSMUST00000102635 ; ENSMUSP00000099695 ; ENSMUSG00000020542 . [Q8VIM5-1 ]
ENSMUST00000108695 ; ENSMUSP00000104335 ; ENSMUSG00000020542 . [Q8VIM5-3 ]
GeneIDi 214384.
KEGGi mmu:214384.
UCSCi uc007jky.2. mouse. [Q8VIM5-3 ]
uc007jkz.2. mouse. [Q8VIM5-1 ]

Organism-specific databases

CTDi 93649.
MGIi MGI:2137495. Myocd.

Phylogenomic databases

eggNOGi NOG79803.
GeneTreei ENSGT00530000063195.
HOGENOMi HOG000038001.
HOVERGENi HBG036493.
InParanoidi Q8VIM5.
OMAi SFTESPW.
OrthoDBi EOG7VMP4N.
TreeFami TF326024.

Miscellaneous databases

NextBioi 374288.
PROi Q8VIM5.
SOURCEi Search...

Gene expression databases

Bgeei Q8VIM5.
CleanExi MM_MYOCD.
ExpressionAtlasi Q8VIM5. baseline and differential.
Genevestigatori Q8VIM5.

Family and domain databases

Gene3Di 1.10.720.30. 1 hit.
InterProi IPR028721. MYOCD.
IPR004018. RPEL_repeat.
IPR003034. SAP_dom.
[Graphical view ]
PANTHERi PTHR22793:SF11. PTHR22793:SF11. 1 hit.
Pfami PF02755. RPEL. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view ]
SMARTi SM00707. RPEL. 3 hits.
SM00513. SAP. 1 hit.
[Graphical view ]
PROSITEi PS51073. RPEL. 3 hits.
PS50800. SAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor."
    Wang D.-Z., Chang P.S., Wang Z., Sutherland L., Richardson J.A., Small E., Krieg P.A., Olson E.N.
    Cell 105:851-862(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, INTERACTION WITH SRF, MUTAGENESIS OF 387-GLU--ARG-389 AND 408-ASP--LEU-410.
    Tissue: Heart.
  2. "Potentiation of serum response factor activity by a family of myocardin-related transcription factors."
    Wang D.-Z., Li S., Hockemeyer D., Sutherland L., Wang Z., Schratt G., Richardson J.A., Nordheim A., Olson E.N.
    Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SEQUENCE REVISION TO 1-128.
  3. "Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis."
    Ueyama T., Kasahara H., Ishiwata T., Nie Q., Izumo S.
    Mol. Cell. Biol. 23:9222-9232(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Strain: NIH Swiss.
  4. "An alternative splicing form of myocardin (BSAC2), myocardin A (BSAC2A)."
    Sawada T., Okazaki T., Nakano H.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Heart.
  5. "Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation."
    Du K.L., Ip H.S., Li J., Chen M., Dandre F., Yu W., Lu M.M., Owens G.K., Parmacek M.S.
    Mol. Cell. Biol. 23:2425-2437(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic heart.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  8. "Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes."
    Yoshida T., Sinha S., Dandre F., Wamhoff B.R., Hoofnagle M.H., Kremer B.E., Wang D.-Z., Olson E.N., Owens G.K.
    Circ. Res. 92:856-864(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH SRF.
  9. "Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation."
    Badorff C., Seeger F.H., Zeiher A.M., Dimmeler S.
    Circ. Res. 97:645-654(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-454; SER-458; SER-462; SER-466; SER-624; SER-628; SER-632 AND SER-636.
  10. "Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin."
    Cao D., Wang Z., Zhang C.L., Oh J., Xing W., Li S., Richardson J.A., Wang D.Z., Olson E.N.
    Mol. Cell. Biol. 25:364-376(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH EP300; HDAC4 AND HDAC5.
  11. "Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR."
    Creemers E.E., Sutherland L.B., Oh J., Barbosa A.C., Olson E.N.
    Mol. Cell 23:83-96(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 4), INTERACTION WITH MEF2C, FUNCTION.
  12. "Phosphorylation of myocardin by extracellular signal-regulated kinase."
    Taurin S., Sandbo N., Yau D.M., Sethakorn N., Kach J., Dulin N.O.
    J. Biol. Chem. 284:33789-33794(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-812; SER-859; SER-866 AND THR-893, MUTAGENESIS OF SER-812; SER-859; SER-866 AND THR-893.
  13. "Expression and functional activity of four myocardin isoforms."
    Imamura M., Long X., Nanda V., Miano J.M.
    Gene 464:1-10(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4 AND 5), TISSUE SPECIFICITY OF ISOFORMS, FUNCTION.

Entry informationi

Entry nameiMYCD_MOUSE
AccessioniPrimary (citable) accession number: Q8VIM5
Secondary accession number(s): Q5SS65
, Q6W8X1, Q8C3W6, Q8VIL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3