ID   TIMD3_MOUSE             Reviewed;         281 AA.
AC   Q8VIM0;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-NOV-2009, entry version 61.
DE   RecName: Full=Hepatitis A virus cellular receptor 2 homolog;
DE            Short=HAVcr-2;
DE   AltName: Full=T-cell immunoglobulin and mucin domain-containing protein 3;
DE            Short=TIMD-3;
DE   AltName: Full=T-cell membrane protein 3;
DE   AltName: Full=TIM-3;
DE   Flags: Precursor;
GN   Name=Havcr2; Synonyms=Tim3, Timd3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=DBA/2; TISSUE=Spleen;
RX   MEDLINE=21582130; PubMed=11725301; DOI=10.1038/ni739;
RA   McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K.,
RA   Barsh G.S., Freeman G.J., Umetsu D.T., DeKruyff R.H.;
RT   "Identification of Tapr (an airway hyperreactivity regulatory locus)
RT   and the linked Tim gene family.";
RL   Nat. Immunol. 2:1109-1116(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=11823861; DOI=10.1038/415536a;
RA   Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T.,
RA   Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J.,
RA   Kuchroo V.K.;
RT   "Th1-specific cell surface protein Tim-3 regulates macrophage
RT   activation and severity of an autoimmune disease.";
RL   Nature 415:536-541(2002).
CC   -!- FUNCTION: Regulates macrophage activation. Inhibits T-helper type
CC       1 lymphocyte (Th1)-mediated auto- and alloimmune responses and
CC       promotes immunological tolerance. May be also involved in T-cell
CC       homing. Receptor for LGALS9 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed in T-helper type 1 lymphocytes. Not
CC       expressed by naive T-cells but up-regulated as they differentiate
CC       into T-helper-1 cells. Also expressed by differentiated type 1
CC       CD8+ cytotoxic T-cells.
CC   -!- MISCELLANEOUS: Belongs to the T-cell and airway phenotype
CC       regulator (Tapr) locus, a single chromosomal region that confers
CC       reduced T-helper type 2 responsiveness and protects against airway
CC       hyperactivity (AHR), the hallmark of human asthma.
CC   -!- MISCELLANEOUS: In vivo administration of antibody to HAVCR2
CC       enhances the clinical and pathological severity of experimental
CC       autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune
CC       disease and increases the number and activation level of
CC       macrophages.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. TIM family.
CC   -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like)
CC       domain.
CC   -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC       Note=TIMD-3;
CC       URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_other_382";
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DR   EMBL; AF399831; AAL35776.1; -; mRNA.
DR   EMBL; AL669948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IPI; IPI00270293; -.
DR   RefSeq; NP_599011.2; -.
DR   UniGene; Mm.72168; -.
DR   SMR; Q8VIM0; 24-131.
DR   STRING; Q8VIM0; -.
DR   PhosphoSite; Q8VIM0; -.
DR   PRIDE; Q8VIM0; -.
DR   Ensembl; ENSMUST00000020668; ENSMUSP00000020668; ENSMUSG00000020399; Mus musculus.
DR   GeneID; 171285; -.
DR   KEGG; mmu:171285; -.
DR   UCSC; uc007ion.1; mouse.
DR   CTD; 171285; -.
DR   MGI; MGI:2159682; Havcr2.
DR   HOGENOM; Q8VIM0; -.
DR   HOVERGEN; Q8VIM0; -.
DR   OMA; PRMLTTK; -.
DR   NextBio; 370963; -.
DR   ArrayExpress; Q8VIM0; -.
DR   Bgee; Q8VIM0; -.
DR   CleanEx; MM_HAVCR2; -.
DR   Genevestigator; Q8VIM0; -.
DR   GermOnline; ENSMUSG00000020399; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Signal;
KW   Transmembrane.
FT   SIGNAL        1     19       Potential.
FT   CHAIN        20    281       Hepatitis A virus cellular receptor 2
FT                                homolog.
FT                                /FTId=PRO_0000042102.
FT   TOPO_DOM     20    193       Extracellular (Potential).
FT   TRANSMEM    194    214       Potential.
FT   TOPO_DOM    215    281       Cytoplasmic (Potential).
FT   DOMAIN       20    125       Ig-like V-type.
FT   COMPBIAS    221    224       Poly-Lys.
FT   CARBOHYD     74     74       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    100    100       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    172    172       N-linked (GlcNAc...) (Potential).
FT   DISULFID     38    111       By similarity.
FT   DISULFID     52     63       By similarity.
FT   DISULFID     58    110       By similarity.
SQ   SEQUENCE   281 AA;  30934 MW;  C0349E4BD0E5761D CRC64;
     MFSGLTLNCV LLLLQLLLAR SLENAYVFEV GKNAYLPCSY TLSTPGALVP MCWGKGFCPW
     SQCTNELLRT DERNVTYQKS SRYQLKGDLN KGDVSLIIKN VTLDDHGTYC CRIQFPGLMN
     DKKLELKLDI KAAKVTPAQT AHGDSTTASP RTLTTERNGS ETQTLVTLHN NNGTKISTWA
     DEIKDSGETI RTAIHIGVGV SAGLTLALII GVLILKWYSC KKKKLSSLSL ITLANLPPGG
     LANAGAVRIR SEENIYTIEE NVYEVENSNE YYCYVNSQQP S
//