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Q8VIM0

- HAVR2_MOUSE

UniProt

Q8VIM0 - HAVR2_MOUSE

Protein

Hepatitis A virus cellular receptor 2 homolog

Gene

Havcr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9 By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatitis A virus cellular receptor 2 homolog
    Short name:
    HAVcr-2
    Alternative name(s):
    T-cell immunoglobulin and mucin domain-containing protein 3
    Short name:
    TIMD-3
    T-cell immunoglobulin mucin receptor 3
    Short name:
    TIM-3
    T-cell membrane protein 3
    Gene namesi
    Name:Havcr2
    Synonyms:Tim3, Timd3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2159682. Havcr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 281262Hepatitis A virus cellular receptor 2 homologPRO_0000042102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 ↔ 111PROSITE-ProRule annotation
    Disulfide bondi52 ↔ 63PROSITE-ProRule annotation
    Disulfide bondi58 ↔ 110PROSITE-ProRule annotation
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8VIM0.

    PTM databases

    PhosphoSiteiQ8VIM0.

    Expressioni

    Tissue specificityi

    Expressed in T-helper type 1 lymphocytes. Not expressed by naive T-cells but up-regulated as they differentiate into T-helper-1 cells. Also expressed by differentiated type 1 CD8+ cytotoxic T-cells.1 Publication

    Gene expression databases

    ArrayExpressiQ8VIM0.
    BgeeiQ8VIM0.
    CleanExiMM_HAVCR2.
    GenevestigatoriQ8VIM0.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hmgb1P631584EBI-6665112,EBI-6665811

    Protein-protein interaction databases

    BioGridi228588. 1 interaction.
    IntActiQ8VIM0. 1 interaction.

    Structurei

    Secondary structure

    1
    281
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 363
    Beta strandi51 – 577
    Beta strandi60 – 623
    Beta strandi66 – 705
    Beta strandi72 – 776
    Beta strandi81 – 855
    Helixi89 – 913
    Beta strandi96 – 1005
    Helixi103 – 1053
    Beta strandi107 – 1137
    Beta strandi116 – 1194
    Beta strandi125 – 1306

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KAAX-ray3.00A/B29-133[»]
    ProteinModelPortaliQ8VIM0.
    SMRiQ8VIM0. Positions 25-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8VIM0.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 193174ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 28167CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 125106Ig-like V-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi221 – 2244Poly-Lys

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. TIM family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41841.
    GeneTreeiENSGT00440000039800.
    HOVERGENiHBG098563.
    InParanoidiQ8VIM0.
    OMAiPRMLTTR.
    OrthoDBiEOG74XS6M.
    PhylomeDBiQ8VIM0.
    TreeFamiTF336163.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VIM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSGLTLNCV LLLLQLLLAR SLENAYVFEV GKNAYLPCSY TLSTPGALVP    50
    MCWGKGFCPW SQCTNELLRT DERNVTYQKS SRYQLKGDLN KGDVSLIIKN 100
    VTLDDHGTYC CRIQFPGLMN DKKLELKLDI KAAKVTPAQT AHGDSTTASP 150
    RTLTTERNGS ETQTLVTLHN NNGTKISTWA DEIKDSGETI RTAIHIGVGV 200
    SAGLTLALII GVLILKWYSC KKKKLSSLSL ITLANLPPGG LANAGAVRIR 250
    SEENIYTIEE NVYEVENSNE YYCYVNSQQP S 281
    Length:281
    Mass (Da):30,934
    Last modified:March 1, 2002 - v1
    Checksum:iC0349E4BD0E5761D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF399831 mRNA. Translation: AAL35776.1.
    AL669948 Genomic DNA. No translation available.
    CCDSiCCDS36135.1.
    RefSeqiNP_599011.2. NM_134250.2.
    UniGeneiMm.72168.

    Genome annotation databases

    EnsembliENSMUST00000020668; ENSMUSP00000020668; ENSMUSG00000020399.
    GeneIDi171285.
    KEGGimmu:171285.
    UCSCiuc011xtp.1. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    TIMD-3

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF399831 mRNA. Translation: AAL35776.1 .
    AL669948 Genomic DNA. No translation available.
    CCDSi CCDS36135.1.
    RefSeqi NP_599011.2. NM_134250.2.
    UniGenei Mm.72168.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KAA X-ray 3.00 A/B 29-133 [» ]
    ProteinModelPortali Q8VIM0.
    SMRi Q8VIM0. Positions 25-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228588. 1 interaction.
    IntActi Q8VIM0. 1 interaction.

    PTM databases

    PhosphoSitei Q8VIM0.

    Proteomic databases

    PRIDEi Q8VIM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020668 ; ENSMUSP00000020668 ; ENSMUSG00000020399 .
    GeneIDi 171285.
    KEGGi mmu:171285.
    UCSCi uc011xtp.1. mouse.

    Organism-specific databases

    CTDi 84868.
    MGIi MGI:2159682. Havcr2.

    Phylogenomic databases

    eggNOGi NOG41841.
    GeneTreei ENSGT00440000039800.
    HOVERGENi HBG098563.
    InParanoidi Q8VIM0.
    OMAi PRMLTTR.
    OrthoDBi EOG74XS6M.
    PhylomeDBi Q8VIM0.
    TreeFami TF336163.

    Miscellaneous databases

    ChiTaRSi HAVCR2. mouse.
    EvolutionaryTracei Q8VIM0.
    NextBioi 370963.
    PROi Q8VIM0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VIM0.
    Bgeei Q8VIM0.
    CleanExi MM_HAVCR2.
    Genevestigatori Q8VIM0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family."
      McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K., Barsh G.S., Freeman G.J., Umetsu D.T., DeKruyff R.H.
      Nat. Immunol. 2:1109-1116(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."
      Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K.
      Nature 415:536-541(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHAVR2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VIM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.
    In vivo administration of antibody to HAVCR2 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease and increases the number and activation level of macrophages.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3