Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8VIM0 (HAVR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatitis A virus cellular receptor 2 homolog

Short name=HAVcr-2
Alternative name(s):
T-cell immunoglobulin and mucin domain-containing protein 3
Short name=TIMD-3
T-cell immunoglobulin mucin receptor 3
Short name=TIM-3
T-cell membrane protein 3
Gene names
Name:Havcr2
Synonyms:Tim3, Timd3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9 By similarity. Ref.3

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed in T-helper type 1 lymphocytes. Not expressed by naive T-cells but up-regulated as they differentiate into T-helper-1 cells. Also expressed by differentiated type 1 CD8+ cytotoxic T-cells. Ref.3

Miscellaneous

Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.

In vivo administration of antibody to HAVCR2 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease and increases the number and activation level of macrophages.

Sequence similarities

Belongs to the immunoglobulin superfamily. TIM family.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Hmgb1P631584EBI-6665112,EBI-6665811

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 281262Hepatitis A virus cellular receptor 2 homolog
PRO_0000042102

Regions

Topological domain20 – 193174Extracellular Potential
Transmembrane194 – 21421Helical; Potential
Topological domain215 – 28167Cytoplasmic Potential
Domain20 – 125106Ig-like V-type
Compositional bias221 – 2244Poly-Lys

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Disulfide bond38 ↔ 111 By similarity
Disulfide bond52 ↔ 63 By similarity
Disulfide bond58 ↔ 110 By similarity

Secondary structure

......................... 281
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8VIM0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: C0349E4BD0E5761D

FASTA28130,934
        10         20         30         40         50         60 
MFSGLTLNCV LLLLQLLLAR SLENAYVFEV GKNAYLPCSY TLSTPGALVP MCWGKGFCPW 

        70         80         90        100        110        120 
SQCTNELLRT DERNVTYQKS SRYQLKGDLN KGDVSLIIKN VTLDDHGTYC CRIQFPGLMN 

       130        140        150        160        170        180 
DKKLELKLDI KAAKVTPAQT AHGDSTTASP RTLTTERNGS ETQTLVTLHN NNGTKISTWA 

       190        200        210        220        230        240 
DEIKDSGETI RTAIHIGVGV SAGLTLALII GVLILKWYSC KKKKLSSLSL ITLANLPPGG 

       250        260        270        280 
LANAGAVRIR SEENIYTIEE NVYEVENSNE YYCYVNSQQP S 

« Hide

References

« Hide 'large scale' references
[1]"Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family."
McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K., Barsh G.S., Freeman G.J., Umetsu D.T., DeKruyff R.H.
Nat. Immunol. 2:1109-1116(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DBA/2.
Tissue: Spleen.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."
Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K.
Nature 415:536-541(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF399831 mRNA. Translation: AAL35776.1.
AL669948 Genomic DNA. No translation available.
CCDSCCDS36135.1.
RefSeqNP_599011.2. NM_134250.2.
UniGeneMm.72168.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3KAAX-ray3.00A/B29-133[»]
ProteinModelPortalQ8VIM0.
SMRQ8VIM0. Positions 25-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid228588. 1 interaction.
IntActQ8VIM0. 1 interaction.

PTM databases

PhosphoSiteQ8VIM0.

Proteomic databases

PRIDEQ8VIM0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020668; ENSMUSP00000020668; ENSMUSG00000020399.
GeneID171285.
KEGGmmu:171285.
UCSCuc011xtp.1. mouse.

Organism-specific databases

CTD84868.
MGIMGI:2159682. Havcr2.

Phylogenomic databases

eggNOGNOG41841.
GeneTreeENSGT00440000039800.
HOVERGENHBG098563.
InParanoidQ8VIM0.
OMAPRMLTTR.
OrthoDBEOG74XS6M.
PhylomeDBQ8VIM0.
TreeFamTF336163.

Gene expression databases

ArrayExpressQ8VIM0.
BgeeQ8VIM0.
CleanExMM_HAVCR2.
GenevestigatorQ8VIM0.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHAVCR2. mouse.
EvolutionaryTraceQ8VIM0.
NextBio370963.
PROQ8VIM0.
SOURCESearch...

Entry information

Entry nameHAVR2_MOUSE
AccessionPrimary (citable) accession number: Q8VIM0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot