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Q8VIM0

- HAVR2_MOUSE

UniProt

Q8VIM0 - HAVR2_MOUSE

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Protein

Hepatitis A virus cellular receptor 2 homolog

Gene

Havcr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9 (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 2 homolog
Short name:
HAVcr-2
Alternative name(s):
T-cell immunoglobulin and mucin domain-containing protein 3
Short name:
TIMD-3
T-cell immunoglobulin mucin receptor 3
Short name:
TIM-3
T-cell membrane protein 3
Gene namesi
Name:Havcr2
Synonyms:Tim3, Timd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2159682. Havcr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 193174ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Topological domaini215 – 28167CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 281262Hepatitis A virus cellular receptor 2 homologPRO_0000042102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 111PROSITE-ProRule annotation
Disulfide bondi52 ↔ 63PROSITE-ProRule annotation
Disulfide bondi58 ↔ 110PROSITE-ProRule annotation
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8VIM0.

PTM databases

PhosphoSiteiQ8VIM0.

Expressioni

Tissue specificityi

Expressed in T-helper type 1 lymphocytes. Not expressed by naive T-cells but up-regulated as they differentiate into T-helper-1 cells. Also expressed by differentiated type 1 CD8+ cytotoxic T-cells.1 Publication

Gene expression databases

BgeeiQ8VIM0.
CleanExiMM_HAVCR2.
ExpressionAtlasiQ8VIM0. baseline and differential.
GenevestigatoriQ8VIM0.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hmgb1P631584EBI-6665112,EBI-6665811

Protein-protein interaction databases

BioGridi228588. 1 interaction.
IntActiQ8VIM0. 1 interaction.

Structurei

Secondary structure

1
281
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 363Combined sources
Beta strandi51 – 577Combined sources
Beta strandi60 – 623Combined sources
Beta strandi66 – 705Combined sources
Beta strandi72 – 776Combined sources
Beta strandi81 – 855Combined sources
Helixi89 – 913Combined sources
Beta strandi96 – 1005Combined sources
Helixi103 – 1053Combined sources
Beta strandi107 – 1137Combined sources
Beta strandi116 – 1194Combined sources
Beta strandi125 – 1306Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KAAX-ray3.00A/B29-133[»]
ProteinModelPortaliQ8VIM0.
SMRiQ8VIM0. Positions 25-131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VIM0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 125106Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 2244Poly-Lys

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41841.
GeneTreeiENSGT00440000039800.
HOVERGENiHBG098563.
InParanoidiQ8VIM0.
OMAiPRMLTTR.
OrthoDBiEOG74XS6M.
PhylomeDBiQ8VIM0.
TreeFamiTF336163.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VIM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSGLTLNCV LLLLQLLLAR SLENAYVFEV GKNAYLPCSY TLSTPGALVP
60 70 80 90 100
MCWGKGFCPW SQCTNELLRT DERNVTYQKS SRYQLKGDLN KGDVSLIIKN
110 120 130 140 150
VTLDDHGTYC CRIQFPGLMN DKKLELKLDI KAAKVTPAQT AHGDSTTASP
160 170 180 190 200
RTLTTERNGS ETQTLVTLHN NNGTKISTWA DEIKDSGETI RTAIHIGVGV
210 220 230 240 250
SAGLTLALII GVLILKWYSC KKKKLSSLSL ITLANLPPGG LANAGAVRIR
260 270 280
SEENIYTIEE NVYEVENSNE YYCYVNSQQP S
Length:281
Mass (Da):30,934
Last modified:March 1, 2002 - v1
Checksum:iC0349E4BD0E5761D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399831 mRNA. Translation: AAL35776.1.
AL669948 Genomic DNA. No translation available.
CCDSiCCDS36135.1.
RefSeqiNP_599011.2. NM_134250.2.
UniGeneiMm.72168.

Genome annotation databases

EnsembliENSMUST00000020668; ENSMUSP00000020668; ENSMUSG00000020399.
GeneIDi171285.
KEGGimmu:171285.
UCSCiuc011xtp.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

TIMD-3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399831 mRNA. Translation: AAL35776.1 .
AL669948 Genomic DNA. No translation available.
CCDSi CCDS36135.1.
RefSeqi NP_599011.2. NM_134250.2.
UniGenei Mm.72168.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KAA X-ray 3.00 A/B 29-133 [» ]
ProteinModelPortali Q8VIM0.
SMRi Q8VIM0. Positions 25-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228588. 1 interaction.
IntActi Q8VIM0. 1 interaction.

PTM databases

PhosphoSitei Q8VIM0.

Proteomic databases

PRIDEi Q8VIM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020668 ; ENSMUSP00000020668 ; ENSMUSG00000020399 .
GeneIDi 171285.
KEGGi mmu:171285.
UCSCi uc011xtp.1. mouse.

Organism-specific databases

CTDi 84868.
MGIi MGI:2159682. Havcr2.

Phylogenomic databases

eggNOGi NOG41841.
GeneTreei ENSGT00440000039800.
HOVERGENi HBG098563.
InParanoidi Q8VIM0.
OMAi PRMLTTR.
OrthoDBi EOG74XS6M.
PhylomeDBi Q8VIM0.
TreeFami TF336163.

Miscellaneous databases

ChiTaRSi Havcr2. mouse.
EvolutionaryTracei Q8VIM0.
NextBioi 370963.
PROi Q8VIM0.
SOURCEi Search...

Gene expression databases

Bgeei Q8VIM0.
CleanExi MM_HAVCR2.
ExpressionAtlasi Q8VIM0. baseline and differential.
Genevestigatori Q8VIM0.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family."
    McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K., Barsh G.S., Freeman G.J., Umetsu D.T., DeKruyff R.H.
    Nat. Immunol. 2:1109-1116(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."
    Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K.
    Nature 415:536-541(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHAVR2_MOUSE
AccessioniPrimary (citable) accession number: Q8VIM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.
In vivo administration of antibody to HAVCR2 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease and increases the number and activation level of macrophages.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3