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Protein

ZW10 interactor

Gene

Zwint

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.
R-RNO-5663220. RHO GTPases Activate Formins.
R-RNO-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
ZW10 interactor
Alternative name(s):
SNAP25-interacting protein 30
Scoilin
ZW10-interacting protein 1
Short name:
Zwint-1
Gene namesi
Name:Zwint
Synonyms:Sip30
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi628671. Zwint.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266ZW10 interactorPRO_0000066596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321PhosphoserineCombined sources
Modified residuei265 – 2651PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VIL3.
PRIDEiQ8VIL3.

PTM databases

iPTMnetiQ8VIL3.
PhosphoSiteiQ8VIL3.

Expressioni

Tissue specificityi

Expressed abundantly in brain and at lower levels in testis and kidney.

Gene expression databases

BgeeiENSRNOG00000048682.
GenevisibleiQ8VIL3. RN.

Interactioni

Subunit structurei

Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1 (By similarity). Interacts with SNAP25.By similarity1 Publication

Protein-protein interaction databases

BioGridi251696. 1 interaction.
STRINGi10116.ENSRNOP00000067414.

Structurei

3D structure databases

ProteinModelPortaliQ8VIL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 16176Interaction with NDC80 and ZW10By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili136 – 237102Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ58. Eukaryota.
ENOG4111831. LUCA.
GeneTreeiENSGT00390000017639.
HOVERGENiHBG079391.
InParanoidiQ8VIL3.
KOiK19943.
OMAiIAAKEQW.
OrthoDBiEOG091G0GKM.
PhylomeDBiQ8VIL3.

Family and domain databases

InterProiIPR029092. Zwint-1.
[Graphical view]
PANTHERiPTHR31504. PTHR31504. 1 hit.
PfamiPF15556. Zwint. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VIL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAEKNAVA EKNAVAEENA VAEENAVADK NATKEVLAEA ASVLEPVGLP
60 70 80 90 100
EEAELPAKIM EEFMRNSRKK DKLLCSQLQV VNFLQTFLAQ EDNTDQNPDA
110 120 130 140 150
LASEDTSRQK ATETKEQWKE LKATYMDHVD VIKCALSEAL PQVKEAHRKY
160 170 180 190 200
TELQKAFEQL EAKKRVLEEK LQLAQKQWVL QQKRLQNLTK ISAEVKRRRK
210 220 230 240 250
RALEKLDGSH QELETLKQQA GQEQEKLQRN QSYLQLLCSL QNKLVISESK
260
ADDKDVKGPA LPPKSP
Length:266
Mass (Da):30,142
Last modified:March 1, 2002 - v1
Checksum:i869E69510E35CC6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439397 mRNA. Translation: AAL35221.1.
AF532776 mRNA. Translation: AAM95974.1.
BC063144 mRNA. Translation: AAH63144.1.
RefSeqiNP_671479.1. NM_147138.2.
UniGeneiRn.163272.

Genome annotation databases

EnsembliENSRNOT00000074404; ENSRNOP00000067414; ENSRNOG00000048682.
GeneIDi257644.
KEGGirno:257644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439397 mRNA. Translation: AAL35221.1.
AF532776 mRNA. Translation: AAM95974.1.
BC063144 mRNA. Translation: AAH63144.1.
RefSeqiNP_671479.1. NM_147138.2.
UniGeneiRn.163272.

3D structure databases

ProteinModelPortaliQ8VIL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251696. 1 interaction.
STRINGi10116.ENSRNOP00000067414.

PTM databases

iPTMnetiQ8VIL3.
PhosphoSiteiQ8VIL3.

Proteomic databases

PaxDbiQ8VIL3.
PRIDEiQ8VIL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074404; ENSRNOP00000067414; ENSRNOG00000048682.
GeneIDi257644.
KEGGirno:257644.

Organism-specific databases

CTDi11130.
RGDi628671. Zwint.

Phylogenomic databases

eggNOGiENOG410IJ58. Eukaryota.
ENOG4111831. LUCA.
GeneTreeiENSGT00390000017639.
HOVERGENiHBG079391.
InParanoidiQ8VIL3.
KOiK19943.
OMAiIAAKEQW.
OrthoDBiEOG091G0GKM.
PhylomeDBiQ8VIL3.

Enzyme and pathway databases

ReactomeiR-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.
R-RNO-5663220. RHO GTPases Activate Formins.
R-RNO-68877. Mitotic Prometaphase.

Miscellaneous databases

PROiQ8VIL3.

Gene expression databases

BgeeiENSRNOG00000048682.
GenevisibleiQ8VIL3. RN.

Family and domain databases

InterProiIPR029092. Zwint-1.
[Graphical view]
PANTHERiPTHR31504. PTHR31504. 1 hit.
PfamiPF15556. Zwint. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZWINT_RAT
AccessioniPrimary (citable) accession number: Q8VIL3
Secondary accession number(s): Q546Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.