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Protein
Submitted name:

Retinoic acid hydroxylase

Gene

Cyp26a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. retinoic acid 4-hydroxylase activity Source: RGD

GO - Biological processi

  1. retinoic acid metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Retinoic acid hydroxylaseImported
Gene namesi
Name:Cyp26a1Imported
Synonyms:CYP26A1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620161. Cyp26a1.

Expressioni

Gene expression databases

GenevestigatoriQ8VIL0.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG051099.
KOiK07437.
PhylomeDBiQ8VIL0.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VIL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG
60 70 80 90 100
FPFFGETLQM VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI
110 120 130 140 150
LLGEHRLVSV HWPASVRTIL GAGCLSNLHD SSHKQRKKVI MQAFNREALQ
160 170 180 190 200
CYVPVIAEEV SGCLEQWLSC GERGLLVYPE VKRLMFRIAM RILLGCEPGP
210 220 230 240 250
AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR NLIHARIEEN
260 270 280 290 300
IRAKIRRLQA AEPDAGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG
310 320 330 340 350
GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSH HEDKLDMETL
360 370 380 390 400
EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD
410 420 430 440 450
THDVADSFTN KEEFNPDRFT SLHPEDTSRF SFIPFGGGLR SCVGKEFAKI
460 470 480 490
LLKIFTVELA RRCDWQLLNG PPTMKTSPPV YPVDNLPARF THFQGDI
Length:497
Mass (Da):56,174
Last modified:December 6, 2005 - v2
Checksum:i242A6441F0E399EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439720 mRNA. Translation: AAL32056.2.
RefSeqiNP_569092.2. NM_130408.2.
UniGeneiRn.81072.

Genome annotation databases

GeneIDi154985.
KEGGirno:154985.
UCSCiRGD:620161. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439720 mRNA. Translation: AAL32056.2.
RefSeqiNP_569092.2. NM_130408.2.
UniGeneiRn.81072.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi154985.
KEGGirno:154985.
UCSCiRGD:620161. rat.

Organism-specific databases

CTDi1592.
RGDi620161. Cyp26a1.

Phylogenomic databases

HOVERGENiHBG051099.
KOiK07437.
PhylomeDBiQ8VIL0.

Miscellaneous databases

NextBioi620872.

Gene expression databases

GenevestigatoriQ8VIL0.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo."
    Wang Y., Zolfaghari R., Ross A.C.
    Arch. Biochem. Biophys. 401:235-243(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. Zolfaghari R., Ross A.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ8VIL0_RAT
AccessioniPrimary (citable) accession number: Q8VIL0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: December 6, 2005
Last modified: April 1, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.