Q8VIL0 (Q8VIL0_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Retinoic acid hydroxylase EMBL AAL32056.2

Gene names

Name:	Cyp26a1 RGD 620161
Synonyms:	CYP26A1 EMBL AAL32056.2

Organism

Rattus norvegicus (Rat) EMBL AAL32056.2

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Heme group By similarity. SAAS SAAS002403
Sequence similarities	Belongs to the cytochrome P450 family. RuleBase RU000461

Ontologies

Keywords
Ligand	Heme RuleBase RU000461 SAAS SAAS002403 Iron Metal-binding
Molecular function	Monooxygenase RuleBase RU000461 Oxidoreductase
Gene Ontology (GO)
Biological_process	retinoic acid metabolic process Inferred from expression pattern PubMed 19700416. Source: RGD
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro retinoic acid 4-hydroxylase activity Inferred by curator PubMed 19700416. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8VIL0 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 242A6441F0E399EC	FASTA	497	56,174
	10 20 30 40 50 60 MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG FPFFGETLQM 70 80 90 100 110 120 VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL 130 140 150 160 170 180 GAGCLSNLHD SSHKQRKKVI MQAFNREALQ CYVPVIAEEV SGCLEQWLSC GERGLLVYPE 190 200 210 220 230 240 VKRLMFRIAM RILLGCEPGP AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR 250 260 270 280 290 300 NLIHARIEEN IRAKIRRLQA AEPDAGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 310 320 330 340 350 360 GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSH HEDKLDMETL EQLKYIGCVI 370 380 390 400 410 420 KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVADSFTN KEEFNPDRFT 430 440 450 460 470 480 SLHPEDTSRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RRCDWQLLNG PPTMKTSPPV 490 YPVDNLPARF THFQGDI

References

[1]	"Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo." Wang Y., Zolfaghari R., Ross A.C. Arch. Biochem. Biophys. 401:235-243(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAL32056.2.
[2]	Zolfaghari R., Ross A.C. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAL32056.2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF439720 mRNA. Translation: AAL32056.2.
IPI	IPI00208204.
RefSeq	NP_569092.2. NM_130408.2.
UniGene	Rn.81072.
3D structure databases
ProteinModelPortal	Q8VIL0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	154985.
KEGG	rno:154985.
UCSC	RGD:620161. rat.
Organism-specific databases
CTD	1592.
RGD	620161. Cyp26a1.
Phylogenomic databases
HOVERGEN	HBG051099.
InParanoid	Q8VIL0.
KO	K07437.
Gene expression databases
Genevestigator	Q8VIL0.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002403. Cyt_P450_E_grp-IV. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00465. EP450IV. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	620872.

Entry information

Entry name

Q8VIL0_RAT

Accession

Primary (citable) accession number: Q8VIL0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)