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Protein

Nitrogen permease regulator 3-like protein

Gene

Nprl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • aorta morphogenesis Source: MGI
  • cardiac muscle tissue development Source: MGI
  • cellular response to amino acid starvation Source: MGI
  • negative regulation of TOR signaling Source: MGI
  • palate development Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • ventricular septum development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen permease regulator 3-like protein
Alternative name(s):
Alpha-globin regulatory element-containing gene protein
Gene namesi
Name:Nprl3
Synonyms:Mare
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109258. Nprl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Nitrogen permease regulator 3-like proteinPRO_0000278089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei476 – 4761PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VIJ8.
MaxQBiQ8VIJ8.
PaxDbiQ8VIJ8.
PRIDEiQ8VIJ8.

PTM databases

PhosphoSiteiQ8VIJ8.

Expressioni

Gene expression databases

BgeeiQ8VIJ8.
CleanExiMM_MARE.
ExpressionAtlasiQ8VIJ8. baseline and differential.
GenevisibleiQ8VIJ8. MM.

Interactioni

Subunit structurei

Forms a heterodimer with NPRL2 (By similarity). Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020530.

Structurei

3D structure databases

ProteinModelPortaliQ8VIJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPR3 family.Curated

Phylogenomic databases

eggNOGiKOG3830. Eukaryota.
ENOG410XP4E. LUCA.
GeneTreeiENSGT00390000015916.
HOGENOMiHOG000004787.
HOVERGENiHBG019399.
InParanoidiQ8VIJ8.
OMAiDHADDQD.
OrthoDBiEOG7M0NR3.
PhylomeDBiQ8VIJ8.
TreeFamiTF105965.

Family and domain databases

InterProiIPR008979. Galactose-bd-like.
IPR005365. NPR3.
[Graphical view]
PANTHERiPTHR13153. PTHR13153. 1 hit.
PfamiPF03666. NPR3. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VIJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTN KPRSRYAVNN
60 70 80 90 100
TGEHADDQDG DSRFSDVILA TILATKSEMC GQKFELKIDN VRFVGHPTLL
110 120 130 140 150
QHALGQVSKT DPSPKREAPT MILFNVVFAL RANADPSVIN CLHNLSRRIA
160 170 180 190 200
TVLQHEERRC QYLTREAKLI LALQDEVSAM ADANEGPQSP FQHILPKCKL
210 220 230 240 250
ARDLKEAYDS LCTSGVVRLH INSWLEVSFC LPHKIHYAAS SLIPPEAIER
260 270 280 290 300
SLKAIRPYHA LLLLSDEKSL LSELPIDCSP ALVRVIKTTS AVKNLQQLAQ
310 320 330 340 350
DADLALLQVF QLAAHLVYWG KAVIIYPLCE NNVYVMSPNA SVCLYSPLAE
360 370 380 390 400
QFSRQFPSHD LPSVLAKFSL PVSLSEFRSP LAPPAQETQL IQMVVWMLQR
410 420 430 440 450
RLLIQLHTYV CLMASPSEEE PRLREDDVPF TARVGGRSLS TPNALSFGSP
460 470 480 490 500
TSSDDMTLTS PSMDNSSAEL LPSGDSPLNK RMTENLLASL SEHERAAILN
510 520 530 540 550
VPAAQNPEDL RMFARLLHYF RGRHHLEEIM YNENTRRSQL LMLFDKFRSV
560
LVVTTHEDPV IAVFQALLT
Length:569
Mass (Da):63,618
Last modified:March 1, 2002 - v1
Checksum:iDEB141AB27539E44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY016021 Genomic DNA. Translation: AAL32369.1.
AK036405 mRNA. Translation: BAC29415.1.
AK081902 mRNA. Translation: BAC38366.1.
BC064471 mRNA. Translation: AAH64471.1.
CCDSiCCDS24521.1.
RefSeqiNP_001271288.1. NM_001284359.1.
NP_001271289.1. NM_001284360.1.
NP_853547.1. NM_181569.3.
UniGeneiMm.263161.

Genome annotation databases

EnsembliENSMUST00000020530; ENSMUSP00000020530; ENSMUSG00000020289.
GeneIDi17168.
KEGGimmu:17168.
UCSCiuc007ijc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY016021 Genomic DNA. Translation: AAL32369.1.
AK036405 mRNA. Translation: BAC29415.1.
AK081902 mRNA. Translation: BAC38366.1.
BC064471 mRNA. Translation: AAH64471.1.
CCDSiCCDS24521.1.
RefSeqiNP_001271288.1. NM_001284359.1.
NP_001271289.1. NM_001284360.1.
NP_853547.1. NM_181569.3.
UniGeneiMm.263161.

3D structure databases

ProteinModelPortaliQ8VIJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020530.

PTM databases

PhosphoSiteiQ8VIJ8.

Proteomic databases

EPDiQ8VIJ8.
MaxQBiQ8VIJ8.
PaxDbiQ8VIJ8.
PRIDEiQ8VIJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020530; ENSMUSP00000020530; ENSMUSG00000020289.
GeneIDi17168.
KEGGimmu:17168.
UCSCiuc007ijc.2. mouse.

Organism-specific databases

CTDi8131.
MGIiMGI:109258. Nprl3.

Phylogenomic databases

eggNOGiKOG3830. Eukaryota.
ENOG410XP4E. LUCA.
GeneTreeiENSGT00390000015916.
HOGENOMiHOG000004787.
HOVERGENiHBG019399.
InParanoidiQ8VIJ8.
OMAiDHADDQD.
OrthoDBiEOG7M0NR3.
PhylomeDBiQ8VIJ8.
TreeFamiTF105965.

Miscellaneous databases

NextBioi291454.
PROiQ8VIJ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VIJ8.
CleanExiMM_MARE.
ExpressionAtlasiQ8VIJ8. baseline and differential.
GenevisibleiQ8VIJ8. MM.

Family and domain databases

InterProiIPR008979. Galactose-bd-like.
IPR005365. NPR3.
[Graphical view]
PANTHERiPTHR13153. PTHR13153. 1 hit.
PfamiPF03666. NPR3. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster."
    Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R., Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., Alter B.P., Frischauf A.-M., Higgs D.R.
    Hum. Mol. Genet. 10:371-382(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone and Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiNPRL3_MOUSE
AccessioniPrimary (citable) accession number: Q8VIJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.