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Protein

Urotensin-2 receptor

Gene

Uts2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2 receptor
Short name:
UR-2-R
Alternative name(s):
G-protein coupled receptor 14
Urotensin II receptor
Short name:
UR-II-R
Gene namesi
Name:Uts2r
Synonyms:Gpr14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2183450. Uts2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353ExtracellularSequence analysisAdd
BLAST
Transmembranei54 – 7623Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini77 – 8610CytoplasmicSequence analysis
Transmembranei87 – 11226Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini113 – 12311ExtracellularSequence analysisAdd
BLAST
Transmembranei124 – 14522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini146 – 16621CytoplasmicSequence analysisAdd
BLAST
Transmembranei167 – 18519Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini186 – 20823ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 23123Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 25726CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 28326Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini284 – 29815ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 32022Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini321 – 38565CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2346494.
GuidetoPHARMACOLOGYi365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Urotensin-2 receptorPRO_0000070195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi122 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VIH9.
PRIDEiQ8VIH9.

PTM databases

iPTMnetiQ8VIH9.
PhosphoSiteiQ8VIH9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039321.
CleanExiMM_UTS2R.
ExpressionAtlasiQ8VIH9. baseline and differential.
GenevisibleiQ8VIH9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046920.

Chemistry

BindingDBiQ8VIH9.

Structurei

3D structure databases

ProteinModelPortaliQ8VIH9.
SMRiQ8VIH9. Positions 30-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00670000098072.
HOGENOMiHOG000060074.
HOVERGENiHBG098595.
InParanoidiQ8VIH9.
KOiK04241.
OMAiTVMSSER.
OrthoDBiEOG091G0DD6.
PhylomeDBiQ8VIH9.
TreeFamiTF334200.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000670. Urot_II_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00647. UROTENSIN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VIH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLESTSF PMLAVSRSTA SELPGGFNVS HNSSWTGPTD PSSLQDLVAT
60 70 80 90 100
GVIGAVLSTM GVVGVVGNVY TLVVMCRFLR ASASMYVYVV NLALADLLYL
110 120 130 140 150
LSIPFIVATY VTKDWHFGDV GCRVLFSLDF LTMHASIFTL TIMSSERYAA
160 170 180 190 200
VLRPLDTVQR SKGYRKLLAL GTWLLALLLT LPMMLAIRLV RRGSKSLCLP
210 220 230 240 250
AWGPRAHRTY LTLLFGTSIV GPGLVIGLLY IRLARAYWLS QQASFKQTRR
260 270 280 290 300
LPNPRVLYLI LGIVLLFWAC FLPFWLWQLL AQYHQAMPLT PETARIINYL
310 320 330 340 350
TACLTYGNSC INPFLYTLLT KNYREYLRGR QRSLGSSCRG PGSAGSFLSS
360 370 380
RVHLQQDSGR SLSSNSQQAT ETLVLSPVPP NGAFV
Length:385
Mass (Da):42,523
Last modified:March 1, 2002 - v1
Checksum:i64F853C07014B5F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441863 mRNA. Translation: AAL34551.1.
AY065981 mRNA. Translation: AAL55427.1.
CCDSiCCDS25769.1.
RefSeqiNP_663415.1. NM_145440.1.
UniGeneiMm.20122.

Genome annotation databases

EnsembliENSMUST00000039044; ENSMUSP00000046920; ENSMUSG00000039321.
GeneIDi217369.
KEGGimmu:217369.
UCSCiuc007mvj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441863 mRNA. Translation: AAL34551.1.
AY065981 mRNA. Translation: AAL55427.1.
CCDSiCCDS25769.1.
RefSeqiNP_663415.1. NM_145440.1.
UniGeneiMm.20122.

3D structure databases

ProteinModelPortaliQ8VIH9.
SMRiQ8VIH9. Positions 30-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046920.

Chemistry

BindingDBiQ8VIH9.
ChEMBLiCHEMBL2346494.
GuidetoPHARMACOLOGYi365.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8VIH9.
PhosphoSiteiQ8VIH9.

Proteomic databases

PaxDbiQ8VIH9.
PRIDEiQ8VIH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039044; ENSMUSP00000046920; ENSMUSG00000039321.
GeneIDi217369.
KEGGimmu:217369.
UCSCiuc007mvj.1. mouse.

Organism-specific databases

CTDi2837.
MGIiMGI:2183450. Uts2r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00670000098072.
HOGENOMiHOG000060074.
HOVERGENiHBG098595.
InParanoidiQ8VIH9.
KOiK04241.
OMAiTVMSSER.
OrthoDBiEOG091G0DD6.
PhylomeDBiQ8VIH9.
TreeFamiTF334200.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ8VIH9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039321.
CleanExiMM_UTS2R.
ExpressionAtlasiQ8VIH9. baseline and differential.
GenevisibleiQ8VIH9. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000670. Urot_II_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00647. UROTENSIN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUR2R_MOUSE
AccessioniPrimary (citable) accession number: Q8VIH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.