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Protein

Solute carrier family 28 member 3

Gene

Slc28a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • retina homeostasis Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 28 member 3
Alternative name(s):
Concentrative Na(+)-nucleoside cotransporter 3
Short name:
CNT 3
Short name:
rCNT3
Gene namesi
Name:Slc28a3
Synonyms:Cnt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621224. Slc28a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 121121CytoplasmicSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Topological domaini143 – 1442ExtracellularSequence analysis
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Topological domaini166 – 18722CytoplasmicSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 2179ExtracellularSequence analysis
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Topological domaini239 – 2402CytoplasmicSequence analysis
Transmembranei241 – 26121HelicalSequence analysisAdd
BLAST
Topological domaini262 – 30443ExtracellularSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Topological domaini326 – 3316CytoplasmicSequence analysis
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Topological domaini353 – 37927ExtracellularSequence analysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Topological domaini401 – 4055CytoplasmicSequence analysis
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Topological domaini427 – 46034ExtracellularSequence analysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence analysisAdd
BLAST
Topological domaini482 – 49514CytoplasmicSequence analysisAdd
BLAST
Transmembranei496 – 51621HelicalSequence analysisAdd
BLAST
Topological domaini517 – 57559ExtracellularSequence analysisAdd
BLAST
Transmembranei576 – 59621HelicalSequence analysisAdd
BLAST
Topological domaini597 – 61014CytoplasmicSequence analysisAdd
BLAST
Transmembranei611 – 63121HelicalSequence analysisAdd
BLAST
Topological domaini632 – 70574ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Solute carrier family 28 member 3PRO_0000324148Add
BLAST

Proteomic databases

PaxDbiQ8VIH3.
PRIDEiQ8VIH3.

Expressioni

Tissue specificityi

Expressed in kidney; in the proximal tubule, glomerulus and cortical collecting duct.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025745.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3747. Eukaryota.
COG1972. LUCA.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiQ8VIH3.
KOiK11536.
PhylomeDBiQ8VIH3.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030211. CNT3.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Gate_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF18. PTHR10590:SF18. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VIH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSDPDPGK NSEPSKSKMS LELRPTAPSD QGRLNEAFQD EDLEEQNAPG
60 70 80 90 100
NSTVRSRVVQ SGEQGRAKQD DRQITIEQEP LGPKEGTEEE SEDERQKGFL
110 120 130 140 150
ERKYDTVCEF CRKHRVILQH TIWAVLLTGF LALVIAACAL NFHRALPLFV
160 170 180 190 200
ITLVTIFFVV WDRLMAKYEQ RIDDVLSPGK RLLERHWFWL KWVVWCSLIL
210 220 230 240 250
AVILWLALDT ARLGQQQLIS FGGLVMYIVL LFLFSKHPTR VYWRPVFWGI
260 270 280 290 300
GLQFLLGLLI LRTRPGFVAF DWMGKQVQTF LGYTDAGAQF VFGEKYTDHF
310 320 330 340 350
FAFKILPIVV FFSTVMSMLY YLGLMQWIIR KVGWLMLVTM GSSPIESVVA
360 370 380 390 400
AGNIFVGQTE SPLLVQPYLP HVTKSELHTI MTAGFATIAG SVLGAYISFG
410 420 430 440 450
VSSTHLLTAS VMSAPAALAV AKLFWPETEK PKITLKNAMK MENGDSRNLL
460 470 480 490 500
EAATQGASSS IPLVANIAAN LIAFLALLSF VNSALSWFGS MFDYPQLSFE
510 520 530 540 550
LICSYIFMPF SFMMGVDWQD RFMVAKLIGY KTFFNEFVAY EHLSKFINLR
560 570 580 590 600
KAAGPKFVNG VQQYMSIRSE TIATYALCGF ANFGSLGIVI GGLTSIAPSR
610 620 630 640 650
KRDIASGAMR ALIAGTIACF MTACIAGMLS DTPVAINCHH VLESSKVLSN
660 670 680 690 700
TTEVASCCQG LFNSTVARGP NDVLPGGNFS LYTLKSCCNL LKPPTLNCGW

IPNIP
Length:705
Mass (Da):78,374
Last modified:March 1, 2002 - v1
Checksum:i5DF4B4AC3C416BE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059414 mRNA. Translation: AAL27091.1.
RefSeqiNP_543184.1. NM_080908.1.
UniGeneiRn.81200.

Genome annotation databases

GeneIDi140944.
KEGGirno:140944.
UCSCiRGD:621224. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059414 mRNA. Translation: AAL27091.1.
RefSeqiNP_543184.1. NM_080908.1.
UniGeneiRn.81200.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025745.

Proteomic databases

PaxDbiQ8VIH3.
PRIDEiQ8VIH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140944.
KEGGirno:140944.
UCSCiRGD:621224. rat.

Organism-specific databases

CTDi64078.
RGDi621224. Slc28a3.

Phylogenomic databases

eggNOGiKOG3747. Eukaryota.
COG1972. LUCA.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiQ8VIH3.
KOiK11536.
PhylomeDBiQ8VIH3.

Miscellaneous databases

NextBioi620850.
PROiQ8VIH3.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030211. CNT3.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Gate_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF18. PTHR10590:SF18. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A rat concentrative Na+-nucleoside cotransporter protein (Cnt3) broadly selective for purine and pyrimidine nucleosides (system cib)."
    Yao S.Y.M., Ng A.M.L., Loewen S.K., Cass C.E., Baldwin S.A., Young J.D.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pancreas.
  2. "Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes."
    Rodriguez-Mulero S., Errasti-Murugarren E., Ballarin J., Felipe A., Doucet A., Casado F.J., Pastor-Anglada M.
    Kidney Int. 68:665-672(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiS28A3_RAT
AccessioniPrimary (citable) accession number: Q8VIH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.