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Q8VIG1

- REST_MOUSE

UniProt

Q8VIG1 - REST_MOUSE

Protein

RE1-silencing transcription factor

Gene

Rest

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri154 – 17623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri211 – 23525C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri243 – 26523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri327 – 35024C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40724C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1036 – 105823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. core promoter binding Source: UniProtKB
    3. core promoter sequence-specific DNA binding Source: Ensembl
    4. DNA binding Source: MGI
    5. metal ion binding Source: UniProtKB-KW
    6. outward rectifier potassium channel activity Source: UniProtKB
    7. protein binding Source: UniProtKB
    8. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    9. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    10. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cardiac muscle cell myoblast differentiation Source: UniProtKB
    2. cellular response to drug Source: UniProtKB
    3. cellular response to electrical stimulus Source: UniProtKB
    4. cellular response to glucocorticoid stimulus Source: UniProtKB
    5. hematopoietic progenitor cell differentiation Source: MGI
    6. histone H4 deacetylation Source: UniProtKB
    7. negative regulation by host of viral transcription Source: UniProtKB
    8. negative regulation of aldosterone biosynthetic process Source: UniProtKB
    9. negative regulation of amniotic stem cell differentiation Source: UniProtKB
    10. negative regulation of calcium ion-dependent exocytosis Source: UniProtKB
    11. negative regulation of cell proliferation Source: UniProtKB
    12. negative regulation of cortisol biosynthetic process Source: UniProtKB
    13. negative regulation of dense core granule biogenesis Source: UniProtKB
    14. negative regulation of gene expression Source: UniProtKB
    15. negative regulation of insulin secretion Source: UniProtKB
    16. negative regulation of neurogenesis Source: MGI
    17. negative regulation of neuron differentiation Source: UniProtKB
    18. negative regulation of transcription, DNA-templated Source: UniProtKB
    19. positive regulation of apoptotic process Source: UniProtKB
    20. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    21. positive regulation of transcription, DNA-templated Source: Ensembl
    22. potassium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RE1-silencing transcription factor
    Alternative name(s):
    Neural-restrictive silencer factor
    Gene namesi
    Name:Rest
    Synonyms:Nrsf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:104897. Rest.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10821082RE1-silencing transcription factorPRO_0000269548Add
    BLAST

    Proteomic databases

    PRIDEiQ8VIG1.

    PTM databases

    PhosphoSiteiQ8VIG1.

    Expressioni

    Tissue specificityi

    Expressed in many non-neuronal tissues including the heart and liver.1 Publication

    Developmental stagei

    During embryogenesis, expressed at high levels in non-neuronal and differentiated peripheral nervous tissues, but is not expressed in differentiating neurons in the CNS.2 Publications

    Gene expression databases

    BgeeiQ8VIG1.
    CleanExiMM_REST.
    GenevestigatoriQ8VIG1.

    Interactioni

    Subunit structurei

    Interacts with SIN3A, SIN3B and RCOR1 By similarity. Interacts with CDYL. Interacts with EHMT1 and EHMT2 only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi202864. 6 interactions.
    IntActiQ8VIG1. 1 interaction.
    MINTiMINT-270819.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VIG1.
    SMRiQ8VIG1. Positions 147-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 11786Interaction with SIN3ABy similarityAdd
    BLAST
    Regioni43 – 5715Interaction with SIN3BBy similarityAdd
    BLAST
    Regioni985 – 106379Interaction with RCOR1By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi395 – 602208Lys-richAdd
    BLAST
    Compositional biasi661 – 792132Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri154 – 17623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri211 – 23525C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri243 – 26523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri327 – 35024C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40724C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1036 – 105823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG271556.
    GeneTreeiENSGT00530000063458.
    HOGENOMiHOG000234631.
    HOVERGENiHBG093893.
    InParanoidiA0JNY8.
    KOiK09222.
    OMAiVQKEPVQ.
    OrthoDBiEOG73FQM4.
    TreeFamiTF332861.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR027757. REST.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF71. PTHR10032:SF71. 1 hit.
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VIG1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATQVMGQSS GGGSLFNNSA NMGMALTNDM YDLHELSKAE LAAPQLIMLA     50
    NVALTGEASG SCCDYLVGEE RQMAELMPVG DNHFSESEGE GLEESADLKG 100
    LENMELGSLE LSAVEPQPVF EASAAPEIYS ANKDPAPETP VAEDKCRSSK 150
    AKPFRCKPCQ YEAESEEQFV HHIRIHSAKK FFVEESAEKQ AKAWESGSSP 200
    AEEGEFSKGP IRCDRCGYNT NRYDHYMAHL KHHLRAGENE RIYKCIICTY 250
    TTVSEYHWRK HLRNHFPRKV YTCSKCNYFS DRKNNYVQHV RTHTGERPYK 300
    CELCPYSSSQ KTHLTRHMRT HSGEKPFKCD QCNYVASNQH EVTRHARQVH 350
    NGPKPLNCPH CDYKTADRSN FKKHVELHVN PRQFNCPVCD YAASKKCNLQ 400
    YHFKSKHPTC PSKTMDVSKV KLKKTKKREA DLLNNAVSNE KMENEQTKTK 450
    GDVSGKKNEK PVKAVGKDAS KEKKPGSSVS VVQVTTRTRK SAVAAETKAA 500
    EVKHTDGQTG NNPEKPCKAK KNKRKKDAEA HPSEEPVNEG PVTKKKKKSE 550
    CKSKIGTNVP KGGGRAEERP GVKKQSASLK KGTKKTPPKT KTSKKGGKLA 600
    PKGMGQTEPS SGALAQVGVS PDPALIQAEV TGSGSSQTEL PSPMDIAKSE 650
    PAQMEVSLTG PPPVEPAQME PSPAKPPQVE APTYPQPPQR GPAPPTGPAP 700
    PTGPAPPTEP APPTGLAEME PSPTEPSQKE PPPSMEPPCP EELPQAEPPP 750
    MEDCQKELPS PVEPAQIEVA QTAPTQVQEE PPPVSEPPRV KPTKRSSLRK 800
    DRAEKELSLL SEMARQEQVL MGVGLVPVRD SKLLKGNKSA QDPPAPPSPS 850
    PKGNSREETP KDQEMVSDGE GTIVFPLKKG GPEEAGESPA ELAALKESAR 900
    VSSSEQNSAM PEGGASHSKC QTGSSGLCDV DTEQKTDTVP MKDSAAEPVS 950
    PPTPTVDRDA GSPAVVASPP ITLAENESQE IDEDEGIHSH DGSDLSDNMS 1000
    EGSDDSGLHG ARPTPPEATS KNGKAGLAGK VTEGEFVCIF CDRSFRKEKD 1050
    YSKHLNRHLV NVYFLEEAAE EQEEQEEREE QE 1082
    Length:1,082
    Mass (Da):117,784
    Last modified:July 27, 2011 - v2
    Checksum:i0D3616BC0820BC2F
    GO
    Isoform 2 (identifier: Q8VIG1-2) [UniParc]FASTAAdd to Basket

    Also known as: N16, REST4

    The sequence of this isoform differs from the canonical sequence as follows:
         323-328: GEKPFK → ECDLAG
         329-1082: Missing.

    Show »
    Length:328
    Mass (Da):36,953
    Checksum:iF47E141348260843
    GO
    Isoform 3 (identifier: Q8VIG1-3) [UniParc]FASTAAdd to Basket

    Also known as: N28

    The sequence of this isoform differs from the canonical sequence as follows:
         324-332: EKPFKCDQC → CDLVGYVFR
         333-1082: Missing.

    Show »
    Length:332
    Mass (Da):37,475
    Checksum:i15B8F53514610413
    GO

    Sequence cautioni

    The sequence AAH96434.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti414 – 4141T → R in BAB82460. 1 PublicationCurated
    Sequence conflicti485 – 4851T → S in BAB82460. 1 PublicationCurated
    Sequence conflicti556 – 5561G → S in BAB82460. 1 PublicationCurated
    Sequence conflicti584 – 5841K → N in BAB82460. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei323 – 3286GEKPFK → ECDLAG in isoform 2. 1 PublicationVSP_022069
    Alternative sequencei324 – 3329EKPFKCDQC → CDLVGYVFR in isoform 3. CuratedVSP_022070
    Alternative sequencei329 – 1082754Missing in isoform 2. 1 PublicationVSP_022071Add
    BLAST
    Alternative sequencei333 – 1082750Missing in isoform 3. CuratedVSP_022072Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024496 mRNA. Translation: BAB82460.1.
    DQ644039 mRNA. Translation: ABG35129.1.
    BC127065 mRNA. Translation: AAI27066.1.
    BC096434 mRNA. Translation: AAH96434.1. Sequence problems.
    AK004945 mRNA. Translation: BAB23689.3.
    AK156514 mRNA. Translation: BAE33741.1.
    CCDSiCCDS19372.1. [Q8VIG1-1]
    RefSeqiNP_035393.2. NM_011263.2. [Q8VIG1-1]
    XP_006534904.1. XM_006534841.1. [Q8VIG1-1]
    XP_006534905.1. XM_006534842.1. [Q8VIG1-1]
    UniGeneiMm.28840.
    Mm.482359.

    Genome annotation databases

    EnsembliENSMUST00000080359; ENSMUSP00000079231; ENSMUSG00000029249. [Q8VIG1-1]
    ENSMUST00000113449; ENSMUSP00000109076; ENSMUSG00000029249. [Q8VIG1-1]
    GeneIDi19712.
    KEGGimmu:19712.
    UCSCiuc008xvz.2. mouse. [Q8VIG1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024496 mRNA. Translation: BAB82460.1 .
    DQ644039 mRNA. Translation: ABG35129.1 .
    BC127065 mRNA. Translation: AAI27066.1 .
    BC096434 mRNA. Translation: AAH96434.1 . Sequence problems.
    AK004945 mRNA. Translation: BAB23689.3 .
    AK156514 mRNA. Translation: BAE33741.1 .
    CCDSi CCDS19372.1. [Q8VIG1-1 ]
    RefSeqi NP_035393.2. NM_011263.2. [Q8VIG1-1 ]
    XP_006534904.1. XM_006534841.1. [Q8VIG1-1 ]
    XP_006534905.1. XM_006534842.1. [Q8VIG1-1 ]
    UniGenei Mm.28840.
    Mm.482359.

    3D structure databases

    ProteinModelPortali Q8VIG1.
    SMRi Q8VIG1. Positions 147-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202864. 6 interactions.
    IntActi Q8VIG1. 1 interaction.
    MINTi MINT-270819.

    PTM databases

    PhosphoSitei Q8VIG1.

    Proteomic databases

    PRIDEi Q8VIG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080359 ; ENSMUSP00000079231 ; ENSMUSG00000029249 . [Q8VIG1-1 ]
    ENSMUST00000113449 ; ENSMUSP00000109076 ; ENSMUSG00000029249 . [Q8VIG1-1 ]
    GeneIDi 19712.
    KEGGi mmu:19712.
    UCSCi uc008xvz.2. mouse. [Q8VIG1-1 ]

    Organism-specific databases

    CTDi 5978.
    MGIi MGI:104897. Rest.

    Phylogenomic databases

    eggNOGi NOG271556.
    GeneTreei ENSGT00530000063458.
    HOGENOMi HOG000234631.
    HOVERGENi HBG093893.
    InParanoidi A0JNY8.
    KOi K09222.
    OMAi VQKEPVQ.
    OrthoDBi EOG73FQM4.
    TreeFami TF332861.

    Miscellaneous databases

    NextBioi 297094.
    PROi Q8VIG1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VIG1.
    CleanExi MM_REST.
    Genevestigatori Q8VIG1.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR027757. REST.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF71. PTHR10032:SF71. 1 hit.
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative promoter and splicing generate multiple isoforms of the neural-restrictive silencer factor NRSF/REST,a general transcriptional repressor for multiple neuron specific genes."
      Kojima T., Naruse Y., Mori N.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: 129.
    2. "Cloning of the REST4 splice variant of the mouse REST protein."
      Puhl H.L. III, Ikeda S.R.
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Neuroblastoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N-3.
      Tissue: Mammary tumor.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-853 (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Liver and Spleen.
    5. "REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons."
      Chong J.A., Tapia-Ramirez J., Kim S., Toledo-Aral J.J., Zheng Y., Boutros M.C., Altshuller Y.M., Frohman M.A., Kraner S.D., Mandel G.
      Cell 80:949-957(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    6. "The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes."
      Schoenherr C.J., Anderson D.J.
      Science 267:1360-1363(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    7. "Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat."
      Palm K., Metsis M., Timmusk T.
      Brain Res. Mol. Brain Res. 72:30-39(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 3).

    Entry informationi

    Entry nameiREST_MOUSE
    AccessioniPrimary (citable) accession number: Q8VIG1
    Secondary accession number(s): A0JNY8
    , Q155C6, Q3U0W0, Q4VAD6, Q9CW43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3