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Protein

Dehydrogenase/reductase SDR family member 4

Gene

Dhrs4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).By similarity

Catalytic activityi

R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei170 – 1701SubstrateBy similarity
Active sitei183 – 1831Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 6125NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-RNO-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 4 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
Short name:
CR
Short name:
PHCR
NADPH-dependent retinol dehydrogenase/reductase
Short name:
NDRD
Peroxisomal short-chain alcohol dehydrogenase
Short name:
PSCD
Gene namesi
Name:Dhrs4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi708482. Dhrs4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
  • peroxisome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Dehydrogenase/reductase SDR family member 4PRO_0000054652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931N6-acetyllysine; alternateBy similarity
Modified residuei93 – 931N6-succinyllysine; alternateBy similarity
Modified residuei106 – 1061N6-acetyllysineBy similarity
Modified residuei217 – 2171N6-acetyllysine; alternateBy similarity
Modified residuei217 – 2171N6-succinyllysine; alternateBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity
Modified residuei228 – 2281N6-succinyllysineBy similarity
Modified residuei235 – 2351N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8VID1.
PRIDEiQ8VID1.

PTM databases

iPTMnetiQ8VID1.
PhosphoSiteiQ8VID1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018239.
GenevisibleiQ8VID1. RN.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi251774. 1 interaction.
STRINGi10116.ENSRNOP00000024782.

Structurei

3D structure databases

ProteinModelPortaliQ8VID1.
SMRiQ8VID1. Positions 30-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi277 – 2793Microbody targeting signal

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105779.
InParanoidiQ8VID1.
KOiK11147.
OMAiLWMDKAR.
OrthoDBiEOG091G0G3R.
PhylomeDBiQ8VID1.
TreeFamiTF315405.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VID1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKAGLLLRG WTRAWKSVRM ASSGLTRQNP LANKVALVTA STDGIGLAIA
60 70 80 90 100
RRLAEDGAHV VISSRKQQNV DRAVATLQGE GLSVTGVVCH VGKAEDREKL
110 120 130 140 150
VNMALKLHQG IDILVSNAAV NPFFGNLMDV TEEVWNKVLS INVTASAMMI
160 170 180 190 200
KAVVPAMEKR GGGSVVIVSS VAGFVLFPSL GPYNVSKTAL LGLTKNFAAE
210 220 230 240 250
LAPKNIRVNC LAPGLIKTHF SSVLWKEKAR EEMIKETMQI RRLGKPEDCV
260 270
GIVSFLCSED ASYINGETVV VGGGTPSRL
Length:279
Mass (Da):29,822
Last modified:October 5, 2010 - v2
Checksum:iED38F20A7B720FEF
GO

Sequence cautioni

The sequence BAB78529 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474049 Genomic DNA. Translation: EDM14225.1.
BC070961 mRNA. Translation: AAH70961.1.
AB062758 mRNA. Translation: BAB78529.1. Different initiation.
RefSeqiNP_695227.2. NM_153315.2.
UniGeneiRn.12783.

Genome annotation databases

EnsembliENSRNOT00000024782; ENSRNOP00000024782; ENSRNOG00000018239.
GeneIDi266686.
KEGGirno:266686.
UCSCiRGD:708482. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474049 Genomic DNA. Translation: EDM14225.1.
BC070961 mRNA. Translation: AAH70961.1.
AB062758 mRNA. Translation: BAB78529.1. Different initiation.
RefSeqiNP_695227.2. NM_153315.2.
UniGeneiRn.12783.

3D structure databases

ProteinModelPortaliQ8VID1.
SMRiQ8VID1. Positions 30-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251774. 1 interaction.
STRINGi10116.ENSRNOP00000024782.

PTM databases

iPTMnetiQ8VID1.
PhosphoSiteiQ8VID1.

Proteomic databases

PaxDbiQ8VID1.
PRIDEiQ8VID1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024782; ENSRNOP00000024782; ENSRNOG00000018239.
GeneIDi266686.
KEGGirno:266686.
UCSCiRGD:708482. rat.

Organism-specific databases

CTDi10901.
RGDi708482. Dhrs4.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105779.
InParanoidiQ8VID1.
KOiK11147.
OMAiLWMDKAR.
OrthoDBiEOG091G0G3R.
PhylomeDBiQ8VID1.
TreeFamiTF315405.

Enzyme and pathway databases

ReactomeiR-RNO-5365859. RA biosynthesis pathway.

Miscellaneous databases

PROiQ8VID1.

Gene expression databases

BgeeiENSRNOG00000018239.
GenevisibleiQ8VID1. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS4_RAT
AccessioniPrimary (citable) accession number: Q8VID1
Secondary accession number(s): Q6IRD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibited by kaempferol, quercetin, genistein and myristic acid.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.