Reviewed, UniProtKB/Swiss-Prot Q8VIC6 (VN1A1_MOUSE)

Names and origin

Protein names

Recommended name:
    Vomeronasal type-1 receptor A1
      Short name=mV1R1
Alternative name(s):
    Vomeronasal type-1 receptor A8
    Pheromone receptor 1

Gene names

Name:	V1ra1
Synonyms:	Pr1, V1ra8

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ. Ref.1
Disruption phenotype	Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Ref.5
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Vomeronasal type-1 receptor A1		PRO_0000239955
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	1 Potential
	Topological domain	53 – 65	13	Cytoplasmic Potential
	Transmembrane	66 – 86	21	2 Potential
	Topological domain	87 – 109	23	Extracellular Potential
	Transmembrane	110 – 130	21	3 Potential
	Topological domain	131 – 150	20	Cytoplasmic Potential
	Transmembrane	151 – 171	21	4 Potential
	Topological domain	172 – 203	32	Extracellular Potential
	Transmembrane	204 – 224	21	5 Potential
	Topological domain	225 – 254	30	Cytoplasmic Potential
	Transmembrane	255 – 275	21	6 Potential
	Topological domain	276 – 285	10	Extracellular Potential
	Transmembrane	286 – 306	21	7 Potential
	Topological domain	307 – 319	13	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	175	1	N-linked (GlcNAc...) Potential
	Disulfide bond	101 ↔ 188		By similarity
Experimental info
	Sequence conflict	17	1	M → MM in CAA73257. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8VIC6-1 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: 6F42DE9DBCA02261	FASTA	319	36,533
	10 20 30 40 50 60 MNEILFFSPQ PLFSHMMNEN SRVHTHSNLR HIFFSEIGIG ISGNSFLLLF HILKFIHGHR 70 80 90 100 110 120 SRLSDLPIGL LSLIHLLMLL VMAFIATDIF ISWRGWDDII CKFLVYLYRV LRGLSLCTTS 130 140 150 160 170 180 MLSVLQAIIL SPRSSCLAKF KRKSLHHISC AILFLSVLYM LIGSQLLVSI IATPNLTTND 190 200 210 220 230 240 FIYVTQSCSI LPLSYVMQSM FSTLLVIRDV FLISLMVLST WYMVALLCRH RKKTQHLQGI 250 260 270 280 290 300 SLSPKTSPKQ RATQTLLMLM SFFVLMTIYD TIVSCSRTMF LNDPTSYNMQ IFVVHIYATV 310 SPFVFMSTEK HIVNCLRSV

References

[1]	"Isolation of mouse vomeronasal receptor genes and their co-localization with specific G-protein messenger RNAs." Saito H., Mimmack M.L., Keverne E.B., Kishimoto J., Emson P.C. Brain Res. Mol. Brain Res. 60:215-227(1998) [PubMed: 9757043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: BALB/c.
[2]	"Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion." Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J. Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002) [PubMed: 11752409] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Vomeronasal receptor gene diversity in the mammalian genome." Sam M., Matsunami H., Buck L. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." Del Punta K., Rothman A., Rodriguez I., Mombaerts P. Genome Res. 10:1958-1967(2000) [PubMed: 11116090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-319. Strain: 129/SvJ.
[5]	"Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P. Nature 419:70-74(2002) [PubMed: 12214233] [Abstract] Cited for: PUTATIVE FUNCTION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y12725 mRNA. Translation: CAA73257.1. Different initiation. AF129005 Genomic DNA. Translation: AAG43249.1. Different initiation. AB062897 Genomic DNA. Translation: BAB79215.1. Different initiation. AF291481 Genomic DNA. Translation: AAG42075.1.
IPI	IPI00346604.
RefSeq	NP_035813.2.
UniGene	Mm.20471 Mm.415895
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VIC6.
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUST00000072859; ENSMUSP00000072637; ENSMUSG00000062818; Mus musculus. [Genome view]
GeneID	22296.
KEGG	mmu:22296.
UCSC	uc009cwv.1. mouse.
Organism-specific databases
MGI	MGI:1333759. V1ra1.
Phylogenomic databases
HOVERGEN	Q8VIC6.
Gene expression databases
ArrayExpress	Q8VIC6.
Bgee	Q8VIC6.
CleanEx	MM_V1RA1. MM_V1RA8.
Genevestigator	Q8VIC6.
GermOnline	ENSMUSG00000062818. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR004072. Vmron_rcpt_1. [Graphical view]
PANTHER	PTHR11391. Vmron_rcpt_1. 1 hit.
Pfam	PF03402. V1R. 1 hit. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

VN1A1_MOUSE

Accession

Primary (citable) accession number: Q8VIC6
Secondary accession number(s): Q9EPA4, Q9Z195

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	October 13, 2009
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)