Reviewed, UniProtKB/Swiss-Prot Q8VIB5 (BARH2_MOUSE)

Names and origin

Protein names

Recommended name:
    BarH-like 2 homeobox protein
Alternative name(s):
    Bar-class homeodomain protein MBH1
    Homeobox protein B-H1

Gene names

Name:	Barhl2
Synonyms:	Barh1, Mbh1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the BAR homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	cell fate determination Inferred from mutant phenotype. Source: MGI neuron differentiation Inferred from direct assay. Source: MGI neuron migration Inferred from mutant phenotype. Source: MGI positive regulation of translation Inferred from mutant phenotype. Source: MGI regulation of axon extension Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	BarH-like 2 homeobox protein		PRO_0000048830
Regions
	DNA binding	229 – 288	60	Homeobox
	Compositional bias	63 – 118	56	Pro-rich
	Compositional bias	85 – 91	7	His-rich
	Compositional bias	128 – 131	4	Ala-rich
	Compositional bias	327 – 333	7	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q8VIB5-1 [UniParc]. Last modified August 2, 2005. Version 2. Checksum: 0ECD1F92E8C22B7B	FASTA	384	41,459
	10 20 30 40 50 60 MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP SPCSEIDTVG 70 80 90 100 110 120 TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HSQQPPPPSA VPAQSLQPSP QQQPPPQPQS 130 140 150 160 170 180 AAQQLGSAAA APRTSTSSFL IKDILGDSKP LAACAPYSTS VSSPHHTPKQ ESNAAHESFR 190 200 210 220 230 240 PKLEQEDGKT KLDKREDPQS DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ 250 260 270 280 290 300 LNQLERSFER QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN 310 320 330 340 350 360 YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ RPLVPRVLIH 370 380 GLGPGGQPAL NPLSNPIPGT PHPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[2]	"Genomic structure, chromosomal localization, and mouse mammalian Barh1 gene." Saba R., Hama T., Nakatsuji N., Saito T. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-205. Strain: 129/SvJ. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC078444 mRNA. Translation: AAH78444.1. AB063281 Genomic DNA. Translation: BAB79292.1.
IPI	IPI00605783.
RefSeq	NP_001005477.1.
UniGene	Mm.271593
3D structure databases
SMR	Q8VIB5. Positions 222-286.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VIB5.
Proteomic databases
PRIDE	Q8VIB5.
Genome annotation databases
Ensembl	ENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384; Mus musculus. [Genome view]
GeneID	104382.
KEGG	mmu:104382.
UCSC	uc008ylm.1. mouse.
Organism-specific databases
CTD	104382.
MGI	MGI:1859314. Barhl2.
Phylogenomic databases
eggNOG	maNOG08957.
HOGENOM	HBG268973.
HOVERGEN	Q8VIB5.
InParanoid	Q8VIB5.
OMA	LHHSQQP.
OrthoDB	EOG93R66C.
PhylomeDB	Q8VIB5.
Gene expression databases
ArrayExpress	Q8VIB5.
Bgee	Q8VIB5.
CleanEx	MM_BARHL2.
Genevestigator	Q8VIB5.
GermOnline	ENSMUSG00000034384. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	357037.
SOURCE	Search...

Entry information

Entry name

BARH2_MOUSE

Accession

Primary (citable) accession number: Q8VIB5
Secondary accession number(s): Q66L43

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	August 2, 2005
Last modified:	January 19, 2010
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)