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Protein

BarH-like 2 homeobox protein

Gene

Barhl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cell fate commitment Source: MGI
  • cell fate determination Source: MGI
  • neuron differentiation Source: MGI
  • neuron migration Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of translation Source: MGI
  • regulation of axon extension Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 2 homeobox protein
Alternative name(s):
Bar-class homeodomain protein MBH1
Homeobox protein B-H1
Gene namesi
Name:Barhl2
Synonyms:Barh1, Mbh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1859314. Barhl2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488301 – 384BarH-like 2 homeobox proteinAdd BLAST384

Proteomic databases

PaxDbiQ8VIB5.
PRIDEiQ8VIB5.

PTM databases

iPTMnetiQ8VIB5.
PhosphoSitePlusiQ8VIB5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034384.
CleanExiMM_BARHL2.
GenevisibleiQ8VIB5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084005.

Structurei

3D structure databases

ProteinModelPortaliQ8VIB5.
SMRiQ8VIB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 118Pro-richAdd BLAST56
Compositional biasi85 – 91His-rich7
Compositional biasi128 – 131Ala-rich4
Compositional biasi327 – 333Poly-Ala7

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00880000137844.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiQ8VIB5.
KOiK09360.
OMAiMEPPEPH.
OrthoDBiEOG091G13SM.
PhylomeDBiQ8VIB5.
TreeFamiTF316128.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VIB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP
60 70 80 90 100
SPCSEIDTVG TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HSQQPPPPSA
110 120 130 140 150
VPAQSLQPSP QQQPPPQPQS AAQQLGSAAA APRTSTSSFL IKDILGDSKP
160 170 180 190 200
LAACAPYSTS VSSPHHTPKQ ESNAAHESFR PKLEQEDGKT KLDKREDPQS
210 220 230 240 250
DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ LNQLERSFER
260 270 280 290 300
QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN
310 320 330 340 350
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ
360 370 380
RPLVPRVLIH GLGPGGQPAL NPLSNPIPGT PHPR
Length:384
Mass (Da):41,459
Last modified:August 2, 2005 - v2
Checksum:i0ECD1F92E8C22B7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078444 mRNA. Translation: AAH78444.1.
AB063281 Genomic DNA. Translation: BAB79292.1.
CCDSiCCDS19497.1.
RefSeqiNP_001005477.1. NM_001005477.1.
UniGeneiMm.271593.

Genome annotation databases

EnsembliENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384.
GeneIDi104382.
KEGGimmu:104382.
UCSCiuc008ylm.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBARH2_MOUSE
AccessioniPrimary (citable) accession number: Q8VIB5
Secondary accession number(s): Q66L43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 2, 2005
Last modified: June 7, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families