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Protein

Type 2 lactosamine alpha-2,3-sialyltransferase

Gene

St3gal6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.10. 3474.
2.4.99.4. 3474.
ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-4085001. Sialic acid metabolism.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 lactosamine alpha-2,3-sialyltransferase (EC:2.4.99.-)
Alternative name(s):
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
Short name:
ST3GalVI
Sialyltransferase 10
Gene namesi
Name:St3gal6
Synonyms:Siat10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1888707. St3gal6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 329304LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Type 2 lactosamine alpha-2,3-sialyltransferasePRO_0000149306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8VIB3.
PaxDbiQ8VIB3.
PeptideAtlasiQ8VIB3.
PRIDEiQ8VIB3.

PTM databases

PhosphoSiteiQ8VIB3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022747.
ExpressionAtlasiQ8VIB3. baseline and differential.
GenevisibleiQ8VIB3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109997.

Structurei

3D structure databases

ProteinModelPortaliQ8VIB3.
SMRiQ8VIB3. Positions 113-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ8VIB3.
KOiK03792.
OMAiDNVPCKK.
OrthoDBiEOG091G098L.
PhylomeDBiQ8VIB3.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VIB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGYLVAIFL SSIFLYYVLY CILWGTNGYW FPAEEMRTRN NVNNCFKKPA
60 70 80 90 100
FANLLRFPQL YPFLCRADFI KVAAMSGTNN FPLPYGIKTF ETYFSSALSK
110 120 130 140 150
LQSCDLFDEF DRVPCKRCVV VGNGGVLKNK TLGATIDSYD VIIRMNNGPV
160 170 180 190 200
LGHEEEVGTR TTFRLFYPES VFSDSSHYDP NTTAVLVVFK PQDLRWLVEI
210 220 230 240 250
LLGKKINTQG FWKTPALKLI YKQYQIRILD PYITSEAAFQ MLRFPRVFPK
260 270 280 290 300
DQKPKHPTTG IIAITMAFHI CSEVHLAGFK YNFYSPNSPL HYYGNATMSL
310 320
MKQNAYHNLT AEQLFLNDII KKKMVINLT
Length:329
Mass (Da):37,854
Last modified:July 5, 2004 - v3
Checksum:iAD38A825253F6352
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781T → I in BAB79494 (Ref. 1) Curated
Sequence conflicti137 – 1371D → N in AAH52338 (PubMed:15489334).Curated
Sequence conflicti234 – 2341T → I in BAB79494 (Ref. 1) Curated
Sequence conflicti329 – 3291T → TQN in BAB79494 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063326 mRNA. Translation: BAB79494.1.
AF119390 mRNA. Translation: AAD39130.1.
AK033562 mRNA. Translation: BAC28360.1.
AK162619 mRNA. Translation: BAE36994.1.
BC052338 mRNA. Translation: AAH52338.1.
CCDSiCCDS28230.1.
RefSeqiNP_061254.1. NM_018784.2.
XP_006522450.1. XM_006522387.1.
XP_006522451.1. XM_006522388.1.
XP_011244273.1. XM_011245971.1.
XP_011244274.1. XM_011245972.1.
XP_011244275.1. XM_011245973.1.
XP_011244276.1. XM_011245974.1.
UniGeneiMm.212742.

Genome annotation databases

EnsembliENSMUST00000114357; ENSMUSP00000109997; ENSMUSG00000022747.
ENSMUST00000114358; ENSMUSP00000109998; ENSMUSG00000022747.
ENSMUST00000137035; ENSMUSP00000115756; ENSMUSG00000022747.
GeneIDi54613.
KEGGimmu:54613.
UCSCiuc007znt.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal VI

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063326 mRNA. Translation: BAB79494.1.
AF119390 mRNA. Translation: AAD39130.1.
AK033562 mRNA. Translation: BAC28360.1.
AK162619 mRNA. Translation: BAE36994.1.
BC052338 mRNA. Translation: AAH52338.1.
CCDSiCCDS28230.1.
RefSeqiNP_061254.1. NM_018784.2.
XP_006522450.1. XM_006522387.1.
XP_006522451.1. XM_006522388.1.
XP_011244273.1. XM_011245971.1.
XP_011244274.1. XM_011245972.1.
XP_011244275.1. XM_011245973.1.
XP_011244276.1. XM_011245974.1.
UniGeneiMm.212742.

3D structure databases

ProteinModelPortaliQ8VIB3.
SMRiQ8VIB3. Positions 113-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109997.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSiteiQ8VIB3.

Proteomic databases

MaxQBiQ8VIB3.
PaxDbiQ8VIB3.
PeptideAtlasiQ8VIB3.
PRIDEiQ8VIB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114357; ENSMUSP00000109997; ENSMUSG00000022747.
ENSMUST00000114358; ENSMUSP00000109998; ENSMUSG00000022747.
ENSMUST00000137035; ENSMUSP00000115756; ENSMUSG00000022747.
GeneIDi54613.
KEGGimmu:54613.
UCSCiuc007znt.2. mouse.

Organism-specific databases

CTDi10402.
MGIiMGI:1888707. St3gal6.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ8VIB3.
KOiK03792.
OMAiDNVPCKK.
OrthoDBiEOG091G098L.
PhylomeDBiQ8VIB3.
TreeFamiTF354325.

Enzyme and pathway databases

BRENDAi2.4.99.10. 3474.
2.4.99.4. 3474.
ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-4085001. Sialic acid metabolism.

Miscellaneous databases

PROiQ8VIB3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022747.
ExpressionAtlasiQ8VIB3. baseline and differential.
GenevisibleiQ8VIB3. MM.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIA10_MOUSE
AccessioniPrimary (citable) accession number: Q8VIB3
Secondary accession number(s): Q3TRN3, Q80UR7, Q9WVG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.