Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2'-5'-oligoadenylate synthase-like protein 1

Gene

Oasl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
2'-5'-oligoadenylate synthase-like protein 1
Alternative name(s):
2',5'-oligoadenylate synthetase-like 9
Gene namesi
Name:Oasl1
Synonyms:oasl9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2180849. Oasl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004186321 – 5112'-5'-oligoadenylate synthase-like protein 1Add BLAST511

Proteomic databases

MaxQBiQ8VI94.
PaxDbiQ8VI94.
PeptideAtlasiQ8VI94.
PRIDEiQ8VI94.

PTM databases

iPTMnetiQ8VI94.
PhosphoSitePlusiQ8VI94.

Expressioni

Inductioni

By type I interferon (IFN) and viruses.1 Publication

Gene expression databases

BgeeiENSMUSG00000041827.
GenevisibleiQ8VI94. MM.

Interactioni

Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi231151. 1 interactor.
STRINGi10090.ENSMUSP00000031540.

Structurei

3D structure databases

ProteinModelPortaliQ8VI94.
SMRiQ8VI94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 429Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST80
Domaini430 – 506Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the 2-5A synthase family.Curated
Contains 2 ubiquitin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00510000046406.
HOGENOMiHOG000022614.
HOVERGENiHBG000994.
InParanoidiQ8VI94.
KOiK14608.
OMAiCFHSFQE.
OrthoDBiEOG091G0160.
PhylomeDBiQ8VI94.
TreeFamiTF329749.

Family and domain databases

Gene3Di1.10.1410.20. 1 hit.
InterProiIPR006117. 2-5-oligoadenylate_synth_CS.
IPR006116. 2-5-oligoadenylate_synth_N.
IPR018952. 2-5-oligoAdlate_synth_1_dom2/C.
IPR026774. 2-5A_synthase.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR11258. PTHR11258. 1 hit.
PfamiPF10421. OAS1_C. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 2 hits.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS00833. 25A_SYNTH_2. 1 hit.
PS50152. 25A_SYNTH_3. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VI94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAQELYGF PASKLDSFVA QWLQPTREWK EEVLETVQTV EQFLRQENFR
60 70 80 90 100
EDRGPARDVR VLKVLKVGCF GNGTVLRSTT DVELVVFLSC FHSFQEEAKH
110 120 130 140 150
HQAVLRLIQK RMYYCQELMD LGLSNLSVTN RVPSSLIFTI QTRETWETIT
160 170 180 190 200
VTVVPAYRAL GPSCPSSEVY ANLIKANGYP GNFSPSFSEL QRNFVKHRPT
210 220 230 240 250
KLKSLLRLVK HWYQQYVRDK CPRANLPPLY ALELLTVYAW EAGTREDANF
260 270 280 290 300
RLDEGLATVM ELLQDHELLC IYWTKHYTLQ HPVIEACVRR QLRGQRPIIL
310 320 330 340 350
DPADPTNNVA EGYRWDIVAQ RANQCLKQDC CYDNRDSPVP SWRVKRAPDI
360 370 380 390 400
QVTVQEWGHS DLTFWVNPYE PIKKLKEKIQ LSQGYLGLQR LSFQEPGGER
410 420 430 440 450
QLIRSHCTLA YYGIFCDTHI CLLDTISPEI QVFVKNPDGR SHAYAIHPLD
460 470 480 490 500
YVLNLKQQIE DRQGLRCQEQ RLEFQGHILE DWFDFKSYGI QDSVTVILSK
510
TTEGAAPFVP S
Length:511
Mass (Da):59,088
Last modified:March 1, 2002 - v1
Checksum:i8E679549424535C1
GO

Sequence cautioni

The sequence BAE29916 differs from that shown. Reason: Frameshift at position 509.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298I → V in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti298I → V in AAH32152 (PubMed:15489334).Curated1
Sequence conflicti339V → I in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti339V → I in AAH32152 (PubMed:15489334).Curated1
Sequence conflicti352V → L in AAM08092 (PubMed:12222967).Curated1
Sequence conflicti356E → D in AAM08092 (PubMed:12222967).Curated1
Sequence conflicti356E → Q in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti356E → Q in AAH32152 (PubMed:15489334).Curated1
Sequence conflicti360S → P in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti360S → P in AAH32152 (PubMed:15489334).Curated1
Sequence conflicti382S → T in AAM08092 (PubMed:12222967).Curated1
Sequence conflicti383Q → R in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti383Q → R in AAH32152 (PubMed:15489334).Curated1
Sequence conflicti396P → L in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti396P → L in AAH32152 (PubMed:15489334).Curated1
Sequence conflicti485F → L in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti485F → L in AAH32152 (PubMed:15489334).Curated1
Sequence conflicti501T → M in AAN31518 (PubMed:12169584).Curated1
Sequence conflicti501T → M in AAH32152 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426289 mRNA. Translation: AAN31518.1.
AY089728 mRNA. Translation: AAM08092.1.
AY057107 mRNA. Translation: AAL12828.1.
AB067533 mRNA. Translation: BAB84133.1.
AK078690 mRNA. Translation: BAC37360.1.
AK149824 mRNA. Translation: BAE29106.1.
AK150863 mRNA. Translation: BAE29916.1. Frameshift.
AK165578 mRNA. Translation: BAE38269.1.
AC116500 Genomic DNA. No translation available.
BC032152 mRNA. Translation: AAH32152.1.
CCDSiCCDS19575.1.
RefSeqiNP_660210.1. NM_145209.3.
XP_006530357.1. XM_006530294.3.
UniGeneiMm.95479.

Genome annotation databases

EnsembliENSMUST00000031540; ENSMUSP00000031540; ENSMUSG00000041827.
ENSMUST00000112143; ENSMUSP00000107771; ENSMUSG00000041827.
GeneIDi231655.
KEGGimmu:231655.
UCSCiuc008zcv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426289 mRNA. Translation: AAN31518.1.
AY089728 mRNA. Translation: AAM08092.1.
AY057107 mRNA. Translation: AAL12828.1.
AB067533 mRNA. Translation: BAB84133.1.
AK078690 mRNA. Translation: BAC37360.1.
AK149824 mRNA. Translation: BAE29106.1.
AK150863 mRNA. Translation: BAE29916.1. Frameshift.
AK165578 mRNA. Translation: BAE38269.1.
AC116500 Genomic DNA. No translation available.
BC032152 mRNA. Translation: AAH32152.1.
CCDSiCCDS19575.1.
RefSeqiNP_660210.1. NM_145209.3.
XP_006530357.1. XM_006530294.3.
UniGeneiMm.95479.

3D structure databases

ProteinModelPortaliQ8VI94.
SMRiQ8VI94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231151. 1 interactor.
STRINGi10090.ENSMUSP00000031540.

PTM databases

iPTMnetiQ8VI94.
PhosphoSitePlusiQ8VI94.

Proteomic databases

MaxQBiQ8VI94.
PaxDbiQ8VI94.
PeptideAtlasiQ8VI94.
PRIDEiQ8VI94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031540; ENSMUSP00000031540; ENSMUSG00000041827.
ENSMUST00000112143; ENSMUSP00000107771; ENSMUSG00000041827.
GeneIDi231655.
KEGGimmu:231655.
UCSCiuc008zcv.1. mouse.

Organism-specific databases

CTDi231655.
MGIiMGI:2180849. Oasl1.

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00510000046406.
HOGENOMiHOG000022614.
HOVERGENiHBG000994.
InParanoidiQ8VI94.
KOiK14608.
OMAiCFHSFQE.
OrthoDBiEOG091G0160.
PhylomeDBiQ8VI94.
TreeFamiTF329749.

Enzyme and pathway databases

ReactomeiR-MMU-877300. Interferon gamma signaling.

Miscellaneous databases

PROiQ8VI94.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041827.
GenevisibleiQ8VI94. MM.

Family and domain databases

Gene3Di1.10.1410.20. 1 hit.
InterProiIPR006117. 2-5-oligoadenylate_synth_CS.
IPR006116. 2-5-oligoadenylate_synth_N.
IPR018952. 2-5-oligoAdlate_synth_1_dom2/C.
IPR026774. 2-5A_synthase.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR11258. PTHR11258. 1 hit.
PfamiPF10421. OAS1_C. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 2 hits.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS00833. 25A_SYNTH_2. 1 hit.
PS50152. 25A_SYNTH_3. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOASL1_MOUSE
AccessioniPrimary (citable) accession number: Q8VI94
Secondary accession number(s): Q3UBP8, Q8K2A2, Q8QZV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.