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Protein

Outer dense fiber protein 4

Gene

Odf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 4
Alternative name(s):
Outer dense fiber of sperm tails protein 4
Testis-specific protein oppo 1
Gene namesi
Name:Odf4
Synonyms:Oppo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2182079. Odf4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • motile cilium Source: MGI
  • outer dense fiber Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Outer dense fiber protein 4PRO_0000304723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VI88.
PRIDEiQ8VI88.

PTM databases

PhosphoSiteiQ8VI88.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Developmental stagei

Expressed from late pachytene stage and expression persists during embryonic development.1 Publication

Gene expression databases

BgeeiQ8VI88.
CleanExiMM_ODF4.
ExpressionAtlasiQ8VI88. baseline.
GenevisibleiQ8VI88. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040050.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 604Poly-Leu

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZV4. Eukaryota.
ENOG4111BHV. LUCA.
GeneTreeiENSGT00390000003542.
HOGENOMiHOG000115258.
HOVERGENiHBG097511.
InParanoidiQ8VI88.
OMAiSVPIGWS.
OrthoDBiEOG7M0NS9.
PhylomeDBiQ8VI88.
TreeFamiTF338228.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VI88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPDLNEEES ERIRTSRNRR SLEHRRNSLL PFQWKATNNS RWMAQVVASE
60 70 80 90 100
FSLVAFLLLL VMVFSKKWLY PSKSRFHQRY PQNVTKRVYT SIHSMSTGLL
110 120 130 140 150
YICVSKSCPS SDNGEDNFKM WTIHPVFGVA KISFTLAIGL GFVLTTWLHL
160 170 180 190 200
PYLPCLQRMP FFGLIGIILS FCEVTLIFLT LLLFPVNLWI YELRKNISVP
210 220 230 240 250
IGWSYFIGWL VLILYFTCGI LCYLNHKNYW SLIMSSTTIN TACSSLGPES
260 270 280 290
LVSPSQTPSS QENSQESPKD DQKPSSPDKV VSPPQPDTTG
Length:290
Mass (Da):33,177
Last modified:March 1, 2002 - v1
Checksum:iBB59B7FBFF83D520
GO
Isoform 2 (identifier: Q8VI88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-178: VTLIF → GAPQL
     179-290: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,593
Checksum:iE40383104594FC08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161Missing in AAH60992 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei174 – 1785VTLIF → GAPQL in isoform 2. 1 PublicationVSP_028117
Alternative sequencei179 – 290112Missing in isoform 2. 1 PublicationVSP_028118Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074438 mRNA. Translation: BAB83865.1.
AL603662 Genomic DNA. Translation: CAI25532.1.
BC060992 mRNA. Translation: AAH60992.1.
CCDSiCCDS24872.1. [Q8VI88-1]
RefSeqiNP_665689.1. NM_145746.2. [Q8VI88-1]
UniGeneiMm.76826.

Genome annotation databases

EnsembliENSMUST00000038932; ENSMUSP00000040050; ENSMUSG00000032921. [Q8VI88-1]
ENSMUST00000130271; ENSMUSP00000134383; ENSMUSG00000032921. [Q8VI88-2]
GeneIDi252868.
KEGGimmu:252868.
UCSCiuc007joj.2. mouse. [Q8VI88-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074438 mRNA. Translation: BAB83865.1.
AL603662 Genomic DNA. Translation: CAI25532.1.
BC060992 mRNA. Translation: AAH60992.1.
CCDSiCCDS24872.1. [Q8VI88-1]
RefSeqiNP_665689.1. NM_145746.2. [Q8VI88-1]
UniGeneiMm.76826.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040050.

PTM databases

PhosphoSiteiQ8VI88.

Proteomic databases

PaxDbiQ8VI88.
PRIDEiQ8VI88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038932; ENSMUSP00000040050; ENSMUSG00000032921. [Q8VI88-1]
ENSMUST00000130271; ENSMUSP00000134383; ENSMUSG00000032921. [Q8VI88-2]
GeneIDi252868.
KEGGimmu:252868.
UCSCiuc007joj.2. mouse. [Q8VI88-1]

Organism-specific databases

CTDi146852.
MGIiMGI:2182079. Odf4.

Phylogenomic databases

eggNOGiENOG410IZV4. Eukaryota.
ENOG4111BHV. LUCA.
GeneTreeiENSGT00390000003542.
HOGENOMiHOG000115258.
HOVERGENiHBG097511.
InParanoidiQ8VI88.
OMAiSVPIGWS.
OrthoDBiEOG7M0NS9.
PhylomeDBiQ8VI88.
TreeFamiTF338228.

Miscellaneous databases

NextBioi387359.
PROiQ8VI88.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VI88.
CleanExiMM_ODF4.
ExpressionAtlasiQ8VI88. baseline.
GenevisibleiQ8VI88. MM.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of Oppo 1: a haploid germ cell-specific complementary DNA encoding sperm tail protein."
    Nakamura Y., Tanaka H., Koga M., Miyagawa Y., Iguchi N., Egydio de Carvalho C., Yomogida K., Nozaki M., Nojima H., Matsumiya K., Okuyama A., Nishimune Y.
    Biol. Reprod. 67:1-7(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiODFP4_MOUSE
AccessioniPrimary (citable) accession number: Q8VI88
Secondary accession number(s): Q6P8Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.