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Protein

Nucleolar complex protein 3 homolog

Gene

Noc3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be required for adipogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • fat cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 3 homolog
Short name:
NOC3 protein homolog
Alternative name(s):
Factor for adipocyte differentiation 24
NOC3-like protein
Nucleolar complex-associated protein 3-like protein
Gene namesi
Name:Noc3l
Synonyms:Ad24, Fad24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1932610. Noc3l.

Subcellular locationi

GO - Cellular componenti

  • nuclear speck Source: MGI
  • nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734751 – 807Nucleolar complex protein 3 homologAdd BLAST807

Proteomic databases

EPDiQ8VI84.
MaxQBiQ8VI84.
PaxDbiQ8VI84.
PeptideAtlasiQ8VI84.
PRIDEiQ8VI84.

PTM databases

iPTMnetiQ8VI84.
PhosphoSitePlusiQ8VI84.

Expressioni

Inductioni

Induced between 1 and 12 hours following adipogenic stimulus.1 Publication

Gene expression databases

BgeeiENSMUSG00000024999.
GenevisibleiQ8VI84. MM.

Interactioni

Protein-protein interaction databases

BioGridi208315. 1 interactor.
IntActiQ8VI84. 3 interactors.
MINTiMINT-4120266.
STRINGi10090.ENSMUSP00000025963.

Structurei

3D structure databases

ProteinModelPortaliQ8VI84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili449 – 489Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2153. Eukaryota.
COG5117. LUCA.
GeneTreeiENSGT00390000008540.
HOGENOMiHOG000293323.
HOVERGENiHBG082040.
InParanoidiQ8VI84.
KOiK14834.
OMAiIFSQKAR.
OrthoDBiEOG091G087E.
TreeFamiTF318817.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. Noc3_N.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8VI84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKARRNKKQV PSFRKLIKTS KVKLENKLKN KQFKQQSTIK KYRKEQRKLR
60 70 80 90 100
QAVKDAVSKK PIPLEDPKSK RPVKRMEREE DEEEEALPLD MMDEDDLQLM
110 120 130 140 150
KDLGQKASFL TRDLSSSEPV HIKKRKHESV IEKYEKVPRT LQTAPEKELI
160 170 180 190 200
HLLPIKDKSG IIPQAREKPV TDVQQEEEAE EELEDEEEVI EDPRKELTIE
210 220 230 240 250
EHVIERKKKL QDKKIQIAAL ASAILSDPES HIKKLKELRS MLMEQDPDVA
260 270 280 290 300
VTVRKLVIIS LMELFKDITP SYKIRPLTEA EKSTKIRKET QKLREFEEGL
310 320 330 340 350
VSQYKFYLEN LEQIVKDWKQ RKLKKSNVVS LKAYKGLAEV AVKSLCELLV
360 370 380 390 400
ALPHFNFHNN IIVLIVPLMN DGSKPVSEMC CEAVKKLFKQ DKLGQASLGV
410 420 430 440 450
IKVISGFVKG RNYEVRPEML KTFLCLRIKE VEVKKDTEDI NKPKRFMTFK
460 470 480 490 500
EKRKTLSRMQ RKWKKAEEKL ERELREAEAS ESTEKKLKLH TETLNIVFVT
510 520 530 540 550
YFRILKKAQK SPLLPAVLEG LAKFAHLINV EFFDDLLVVL HTLIESGELS
560 570 580 590 600
YQESLHCVQT AFHILSGQGD VLNIDPMKFY THLYKTLFTL HAGATNDGIE
610 620 630 640 650
IVLHCLDVML SKRRKQVSHQ RALAFIKRLC TLALQVLPNS SIGLLATTRI
660 670 680 690 700
LMHTFPRTDL LLDNESQGSG VFLPELEEPE YCNAQNTALW ELHTLRRHYH
710 720 730 740 750
PIVRRFAAHL LAGAPSEGSE ALKPELSRRS AVELFETYSM AAMTFNPPVE
760 770 780 790 800
SSHSKRKDKF LPGDSFLNED LNQLIKRYCN EAAPETPLDF AKCLESSSRQ

YRVNGLS
Length:807
Mass (Da):93,211
Last modified:July 27, 2011 - v2
Checksum:i497734D35EF7707C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173V → L in BAB84193 (PubMed:15564382).Curated1
Sequence conflicti173V → L in AAH31132 (PubMed:15489334).Curated1
Sequence conflicti744T → S in AAF40207 (PubMed:11146508).Curated1
Sequence conflicti751S → C in AAF40207 (PubMed:11146508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077991 mRNA. Translation: BAB84193.1.
AC101775 Genomic DNA. No translation available.
AC111023 Genomic DNA. No translation available.
AC158131 Genomic DNA. No translation available.
BC031132 mRNA. Translation: AAH31132.1.
AF233884 mRNA. Translation: AAF40207.1.
CCDSiCCDS37974.1.
RefSeqiNP_067290.2. NM_021315.2.
UniGeneiMm.86482.

Genome annotation databases

EnsembliENSMUST00000025963; ENSMUSP00000025963; ENSMUSG00000024999.
GeneIDi57753.
KEGGimmu:57753.
UCSCiuc008hjr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077991 mRNA. Translation: BAB84193.1.
AC101775 Genomic DNA. No translation available.
AC111023 Genomic DNA. No translation available.
AC158131 Genomic DNA. No translation available.
BC031132 mRNA. Translation: AAH31132.1.
AF233884 mRNA. Translation: AAF40207.1.
CCDSiCCDS37974.1.
RefSeqiNP_067290.2. NM_021315.2.
UniGeneiMm.86482.

3D structure databases

ProteinModelPortaliQ8VI84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208315. 1 interactor.
IntActiQ8VI84. 3 interactors.
MINTiMINT-4120266.
STRINGi10090.ENSMUSP00000025963.

PTM databases

iPTMnetiQ8VI84.
PhosphoSitePlusiQ8VI84.

Proteomic databases

EPDiQ8VI84.
MaxQBiQ8VI84.
PaxDbiQ8VI84.
PeptideAtlasiQ8VI84.
PRIDEiQ8VI84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025963; ENSMUSP00000025963; ENSMUSG00000024999.
GeneIDi57753.
KEGGimmu:57753.
UCSCiuc008hjr.2. mouse.

Organism-specific databases

CTDi64318.
MGIiMGI:1932610. Noc3l.

Phylogenomic databases

eggNOGiKOG2153. Eukaryota.
COG5117. LUCA.
GeneTreeiENSGT00390000008540.
HOGENOMiHOG000293323.
HOVERGENiHBG082040.
InParanoidiQ8VI84.
KOiK14834.
OMAiIFSQKAR.
OrthoDBiEOG091G087E.
TreeFamiTF318817.

Miscellaneous databases

PROiQ8VI84.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024999.
GenevisibleiQ8VI84. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. Noc3_N.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNOC3L_MOUSE
AccessioniPrimary (citable) accession number: Q8VI84
Secondary accession number(s): E9QQ46, Q9JKM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.