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Q8VI82

- FGF23_RAT

UniProt

Q8VI82 - FGF23_RAT

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Protein

Fibroblast growth factor 23

Gene

Fgf23

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.By similarity2 Publications

GO - Molecular functioni

  1. fibroblast growth factor receptor binding Source: RGD

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. cellular phosphate ion homeostasis Source: Ensembl
  3. negative regulation of bone mineralization Source: Ensembl
  4. negative regulation of hormone secretion Source: UniProtKB
  5. negative regulation of osteoblast differentiation Source: Ensembl
  6. phosphate-containing compound metabolic process Source: RGD
  7. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  8. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
  9. positive regulation of transcription, DNA-templated Source: Ensembl
  10. positive regulation of vitamin D 24-hydroxylase activity Source: Ensembl
  11. regulation of phosphate transport Source: Ensembl
  12. vitamin D catabolic process Source: Ensembl
  13. vitamin D metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_198665. Signaling by FGFR mutants.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198798. Signaling by activated point mutants of FGFR3.
REACT_198804. Signaling by FGFR3 mutants.
REACT_198810. Signaling by activated point mutants of FGFR1.
REACT_198813. Activated point mutants of FGFR2.
REACT_198995. Negative regulation of FGFR signaling.
REACT_202034. Phospholipase C-mediated cascade.
REACT_235451. FGFR4 ligand binding and activation.
REACT_240421. FRS2-mediated cascade.
REACT_244272. FGFR3c ligand binding and activation.
REACT_255209. FGFR1c ligand binding and activation.
REACT_256279. PI3K Cascade.
REACT_256376. PI-3K cascade.
REACT_257653. PIP3 activates AKT signaling.
REACT_259864. FGFR1c and Klotho ligand binding and activation.
REACT_262505. FGFR2c ligand binding and activation.
REACT_79133. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 23
Short name:
FGF-23
Gene namesi
Name:Fgf23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi620178. Fgf23.

Subcellular locationi

Secreted By similarity
Note: Secretion is dependent on O-glycosylation.By similarity

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 251227Fibroblast growth factor 23PRO_0000009000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 113By similarity
Glycosylationi178 – 1781O-linked (GalNAc)By similarity

Post-translational modificationi

Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases (By similarity).By similarity
O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8VI82.

Expressioni

Tissue specificityi

Expressed in the parathyroid.1 Publication

Gene expression databases

GenevestigatoriQ8VI82.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026888.

Structurei

3D structure databases

ProteinModelPortaliQ8VI82.
SMRiQ8VI82. Positions 29-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG270405.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112573.
HOVERGENiHBG051613.
InParanoidiQ8VI82.
KOiK04358.
OMAiDVYHSPQ.
OrthoDBiEOG71K63W.
PhylomeDBiQ8VI82.
TreeFamiTF335872.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028304. FGF23.
IPR002209. Fibroblast_GF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF69. PTHR11486:SF69. 1 hit.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VI82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGACLRLLV GALCTVCSLG TARAYSDTSP LLGSNWGSLT HLYTATARNS
60 70 80 90 100
YHLQIHRDGH VDGTPHQTIY SALMITSEDA GSVVIIGAMT RRFLCMDLRG
110 120 130 140 150
NIFGSYHFSP ENCRFRQWTL ENGYDVYLSP KHHYLVSLGR SKRIFQPGTN
160 170 180 190 200
PPPFSQFLAR RNEVPLLHFY TARPRRHTRS AEDPPERDPL NVLKPRPRAT
210 220 230 240 250
PIPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARRGAGG TDRCRPFPRF

V
Length:251
Mass (Da):27,912
Last modified:March 1, 2002 - v1
Checksum:i35A229E1B3900593
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078777 mRNA. Translation: BAB84108.1.
RefSeqiNP_570110.1. NM_130754.1.
UniGeneiRn.154421.

Genome annotation databases

EnsembliENSRNOT00000026888; ENSRNOP00000026888; ENSRNOG00000019855.
GeneIDi170583.
KEGGirno:170583.
UCSCiRGD:620178. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078777 mRNA. Translation: BAB84108.1 .
RefSeqi NP_570110.1. NM_130754.1.
UniGenei Rn.154421.

3D structure databases

ProteinModelPortali Q8VI82.
SMRi Q8VI82. Positions 29-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026888.

Proteomic databases

PRIDEi Q8VI82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026888 ; ENSRNOP00000026888 ; ENSRNOG00000019855 .
GeneIDi 170583.
KEGGi rno:170583.
UCSCi RGD:620178. rat.

Organism-specific databases

CTDi 8074.
RGDi 620178. Fgf23.

Phylogenomic databases

eggNOGi NOG270405.
GeneTreei ENSGT00530000063469.
HOGENOMi HOG000112573.
HOVERGENi HBG051613.
InParanoidi Q8VI82.
KOi K04358.
OMAi DVYHSPQ.
OrthoDBi EOG71K63W.
PhylomeDBi Q8VI82.
TreeFami TF335872.

Enzyme and pathway databases

Reactomei REACT_198665. Signaling by FGFR mutants.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198798. Signaling by activated point mutants of FGFR3.
REACT_198804. Signaling by FGFR3 mutants.
REACT_198810. Signaling by activated point mutants of FGFR1.
REACT_198813. Activated point mutants of FGFR2.
REACT_198995. Negative regulation of FGFR signaling.
REACT_202034. Phospholipase C-mediated cascade.
REACT_235451. FGFR4 ligand binding and activation.
REACT_240421. FRS2-mediated cascade.
REACT_244272. FGFR3c ligand binding and activation.
REACT_255209. FGFR1c ligand binding and activation.
REACT_256279. PI3K Cascade.
REACT_256376. PI-3K cascade.
REACT_257653. PIP3 activates AKT signaling.
REACT_259864. FGFR1c and Klotho ligand binding and activation.
REACT_262505. FGFR2c ligand binding and activation.
REACT_79133. SHC-mediated cascade.

Miscellaneous databases

NextBioi 621084.
PROi Q8VI82.

Gene expression databases

Genevestigatori Q8VI82.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028304. FGF23.
IPR002209. Fibroblast_GF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF69. PTHR11486:SF69. 1 hit.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rattus norvegicus fgf23."
    Itoh N.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Klotho converts canonical FGF receptor into a specific receptor for FGF23."
    Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., Fujita T., Fukumoto S., Yamashita T.
    Nature 444:770-774(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFGF23_RAT
AccessioniPrimary (citable) accession number: Q8VI82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3