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Protein

Fibroblast growth factor 23

Gene

Fgf23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.By similarity2 Publications

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_280054. FGFR1c ligand binding and activation.
REACT_284342. FGFR4 ligand binding and activation.
REACT_291658. PI3K Cascade.
REACT_299102. PIP3 activates AKT signaling.
REACT_311191. FGFR3c ligand binding and activation.
REACT_312503. FGFR2c ligand binding and activation.
REACT_341391. FGFR1c and Klotho ligand binding and activation.
REACT_357272. Phospholipase C-mediated cascade: FGFR1.
REACT_357338. Phospholipase C-mediated cascade, FGFR4.
REACT_357361. PI-3K cascade:FGFR4.
REACT_357712. SHC-mediated cascade:FGFR2.
REACT_358624. Negative regulation of FGFR4 signaling.
REACT_358869. Phospholipase C-mediated cascade, FGFR3.
REACT_359240. FRS2-mediated FGFR4 signaling.
REACT_359268. Negative regulation of FGFR2 signaling.
REACT_359276. Negative regulation of FGFR1 signaling.
REACT_359641. PI-3K cascade:FGFR1.
REACT_359767. SHC-mediated cascade:FGFR3.
REACT_360014. FRS-mediated FGFR3 signaling.
REACT_360543. FRS-mediated FGFR2 signaling.
REACT_360800. Negative regulation of FGFR3 signaling.
REACT_360842. PI-3K cascade:FGFR2.
REACT_360887. FRS-mediated FGFR1 signaling.
REACT_360936. Phospholipase C-mediated cascade, FGFR2.
REACT_361671. SHC-mediated cascade:FGFR1.
REACT_362207. SHC-mediated cascade:FGFR4.
REACT_362510. PI-3K cascade:FGFR3.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 23
Short name:
FGF-23
Gene namesi
Name:Fgf23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unassembled WGS sequence

Organism-specific databases

RGDi620178. Fgf23.

Subcellular locationi

  • Secreted By similarity

  • Note: Secretion is dependent on O-glycosylation.By similarity

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 251227Fibroblast growth factor 23PRO_0000009000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 113By similarity
Glycosylationi178 – 1781O-linked (GalNAc)By similarity

Post-translational modificationi

Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases (By similarity).By similarity
O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8VI82.

Expressioni

Tissue specificityi

Expressed in the parathyroid.1 Publication

Gene expression databases

GenevisibleiQ8VI82. RN.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026888.

Structurei

3D structure databases

ProteinModelPortaliQ8VI82.
SMRiQ8VI82. Positions 29-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG270405.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112573.
HOVERGENiHBG051613.
InParanoidiQ8VI82.
KOiK04358.
OMAiNIFGSHH.
OrthoDBiEOG71K63W.
PhylomeDBiQ8VI82.
TreeFamiTF335872.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028304. FGF23.
IPR002209. Fibroblast_GF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF69. PTHR11486:SF69. 1 hit.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VI82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGACLRLLV GALCTVCSLG TARAYSDTSP LLGSNWGSLT HLYTATARNS
60 70 80 90 100
YHLQIHRDGH VDGTPHQTIY SALMITSEDA GSVVIIGAMT RRFLCMDLRG
110 120 130 140 150
NIFGSYHFSP ENCRFRQWTL ENGYDVYLSP KHHYLVSLGR SKRIFQPGTN
160 170 180 190 200
PPPFSQFLAR RNEVPLLHFY TARPRRHTRS AEDPPERDPL NVLKPRPRAT
210 220 230 240 250
PIPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARRGAGG TDRCRPFPRF

V
Length:251
Mass (Da):27,912
Last modified:March 1, 2002 - v1
Checksum:i35A229E1B3900593
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078777 mRNA. Translation: BAB84108.1.
RefSeqiNP_570110.1. NM_130754.1.
UniGeneiRn.154421.

Genome annotation databases

EnsembliENSRNOT00000078299; ENSRNOP00000075536; ENSRNOG00000052205.
GeneIDi170583.
KEGGirno:170583.
UCSCiRGD:620178. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078777 mRNA. Translation: BAB84108.1.
RefSeqiNP_570110.1. NM_130754.1.
UniGeneiRn.154421.

3D structure databases

ProteinModelPortaliQ8VI82.
SMRiQ8VI82. Positions 29-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026888.

Proteomic databases

PRIDEiQ8VI82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000078299; ENSRNOP00000075536; ENSRNOG00000052205.
GeneIDi170583.
KEGGirno:170583.
UCSCiRGD:620178. rat.

Organism-specific databases

CTDi8074.
RGDi620178. Fgf23.

Phylogenomic databases

eggNOGiNOG270405.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112573.
HOVERGENiHBG051613.
InParanoidiQ8VI82.
KOiK04358.
OMAiNIFGSHH.
OrthoDBiEOG71K63W.
PhylomeDBiQ8VI82.
TreeFamiTF335872.

Enzyme and pathway databases

ReactomeiREACT_280054. FGFR1c ligand binding and activation.
REACT_284342. FGFR4 ligand binding and activation.
REACT_291658. PI3K Cascade.
REACT_299102. PIP3 activates AKT signaling.
REACT_311191. FGFR3c ligand binding and activation.
REACT_312503. FGFR2c ligand binding and activation.
REACT_341391. FGFR1c and Klotho ligand binding and activation.
REACT_357272. Phospholipase C-mediated cascade: FGFR1.
REACT_357338. Phospholipase C-mediated cascade, FGFR4.
REACT_357361. PI-3K cascade:FGFR4.
REACT_357712. SHC-mediated cascade:FGFR2.
REACT_358624. Negative regulation of FGFR4 signaling.
REACT_358869. Phospholipase C-mediated cascade, FGFR3.
REACT_359240. FRS2-mediated FGFR4 signaling.
REACT_359268. Negative regulation of FGFR2 signaling.
REACT_359276. Negative regulation of FGFR1 signaling.
REACT_359641. PI-3K cascade:FGFR1.
REACT_359767. SHC-mediated cascade:FGFR3.
REACT_360014. FRS-mediated FGFR3 signaling.
REACT_360543. FRS-mediated FGFR2 signaling.
REACT_360800. Negative regulation of FGFR3 signaling.
REACT_360842. PI-3K cascade:FGFR2.
REACT_360887. FRS-mediated FGFR1 signaling.
REACT_360936. Phospholipase C-mediated cascade, FGFR2.
REACT_361671. SHC-mediated cascade:FGFR1.
REACT_362207. SHC-mediated cascade:FGFR4.
REACT_362510. PI-3K cascade:FGFR3.

Miscellaneous databases

NextBioi621084.
PROiQ8VI82.

Gene expression databases

GenevisibleiQ8VI82. RN.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028304. FGF23.
IPR002209. Fibroblast_GF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF69. PTHR11486:SF69. 1 hit.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rattus norvegicus fgf23."
    Itoh N.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Klotho converts canonical FGF receptor into a specific receptor for FGF23."
    Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., Fujita T., Fukumoto S., Yamashita T.
    Nature 444:770-774(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFGF23_RAT
AccessioniPrimary (citable) accession number: Q8VI82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.