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Q8VI82

- FGF23_RAT

UniProt

Q8VI82 - FGF23_RAT

Protein

Fibroblast growth factor 23

Gene

Fgf23

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Regulator of phosphate homeostasis By similarity. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels By similarity. Regulator of vitamin-D metabolism By similarity. Negatively regulates osteoblasts differentiation and matrix mineralization By similarity. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.By similarity2 Publications

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: RGD

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cellular phosphate ion homeostasis Source: Ensembl
    3. negative regulation of bone mineralization Source: Ensembl
    4. negative regulation of hormone secretion Source: UniProtKB
    5. negative regulation of osteoblast differentiation Source: Ensembl
    6. phosphate-containing compound metabolic process Source: RGD
    7. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    8. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
    9. positive regulation of transcription, DNA-templated Source: Ensembl
    10. positive regulation of vitamin D 24-hydroxylase activity Source: Ensembl
    11. regulation of phosphate transport Source: Ensembl
    12. vitamin D catabolic process Source: Ensembl
    13. vitamin D metabolic process Source: RGD

    Keywords - Molecular functioni

    Growth factor

    Keywords - Biological processi

    Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_198665. Signaling by FGFR mutants.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198798. Signaling by activated point mutants of FGFR3.
    REACT_198804. Signaling by FGFR3 mutants.
    REACT_198810. Signaling by activated point mutants of FGFR1.
    REACT_198813. Activated point mutants of FGFR2.
    REACT_198995. Negative regulation of FGFR signaling.
    REACT_202034. Phospholipase C-mediated cascade.
    REACT_79133. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 23
    Short name:
    FGF-23
    Gene namesi
    Name:Fgf23
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi620178. Fgf23.

    Subcellular locationi

    Secreted By similarity
    Note: Secretion is dependent on O-glycosylation.By similarity

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 251227Fibroblast growth factor 23PRO_0000009000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi95 ↔ 113By similarity
    Glycosylationi178 – 1781O-linked (GalNAc)By similarity

    Post-translational modificationi

    Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases By similarity.By similarity
    O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8VI82.

    Expressioni

    Tissue specificityi

    Expressed in the parathyroid.1 Publication

    Gene expression databases

    GenevestigatoriQ8VI82.

    Interactioni

    Subunit structurei

    Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VI82.
    SMRiQ8VI82. Positions 29-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG270405.
    GeneTreeiENSGT00530000063469.
    HOGENOMiHOG000112573.
    HOVERGENiHBG051613.
    InParanoidiQ8VI82.
    KOiK04358.
    OMAiDVYHSPQ.
    OrthoDBiEOG71K63W.
    PhylomeDBiQ8VI82.
    TreeFamiTF335872.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028304. FGF23.
    IPR002209. Fibroblast_GF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF69. PTHR11486:SF69. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VI82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGACLRLLV GALCTVCSLG TARAYSDTSP LLGSNWGSLT HLYTATARNS    50
    YHLQIHRDGH VDGTPHQTIY SALMITSEDA GSVVIIGAMT RRFLCMDLRG 100
    NIFGSYHFSP ENCRFRQWTL ENGYDVYLSP KHHYLVSLGR SKRIFQPGTN 150
    PPPFSQFLAR RNEVPLLHFY TARPRRHTRS AEDPPERDPL NVLKPRPRAT 200
    PIPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARRGAGG TDRCRPFPRF 250
    V 251
    Length:251
    Mass (Da):27,912
    Last modified:March 1, 2002 - v1
    Checksum:i35A229E1B3900593
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078777 mRNA. Translation: BAB84108.1.
    RefSeqiNP_570110.1. NM_130754.1.
    UniGeneiRn.154421.

    Genome annotation databases

    EnsembliENSRNOT00000026888; ENSRNOP00000026888; ENSRNOG00000019855.
    GeneIDi170583.
    KEGGirno:170583.
    UCSCiRGD:620178. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078777 mRNA. Translation: BAB84108.1 .
    RefSeqi NP_570110.1. NM_130754.1.
    UniGenei Rn.154421.

    3D structure databases

    ProteinModelPortali Q8VI82.
    SMRi Q8VI82. Positions 29-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026888.

    Proteomic databases

    PRIDEi Q8VI82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026888 ; ENSRNOP00000026888 ; ENSRNOG00000019855 .
    GeneIDi 170583.
    KEGGi rno:170583.
    UCSCi RGD:620178. rat.

    Organism-specific databases

    CTDi 8074.
    RGDi 620178. Fgf23.

    Phylogenomic databases

    eggNOGi NOG270405.
    GeneTreei ENSGT00530000063469.
    HOGENOMi HOG000112573.
    HOVERGENi HBG051613.
    InParanoidi Q8VI82.
    KOi K04358.
    OMAi DVYHSPQ.
    OrthoDBi EOG71K63W.
    PhylomeDBi Q8VI82.
    TreeFami TF335872.

    Enzyme and pathway databases

    Reactomei REACT_198665. Signaling by FGFR mutants.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198798. Signaling by activated point mutants of FGFR3.
    REACT_198804. Signaling by FGFR3 mutants.
    REACT_198810. Signaling by activated point mutants of FGFR1.
    REACT_198813. Activated point mutants of FGFR2.
    REACT_198995. Negative regulation of FGFR signaling.
    REACT_202034. Phospholipase C-mediated cascade.
    REACT_79133. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 621084.
    PROi Q8VI82.

    Gene expression databases

    Genevestigatori Q8VI82.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028304. FGF23.
    IPR002209. Fibroblast_GF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF69. PTHR11486:SF69. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rattus norvegicus fgf23."
      Itoh N.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Klotho converts canonical FGF receptor into a specific receptor for FGF23."
      Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., Fujita T., Fukumoto S., Yamashita T.
      Nature 444:770-774(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFGF23_RAT
    AccessioniPrimary (citable) accession number: Q8VI82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3