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Protein

Fibroblast growth factor 23

Gene

Fgf23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-RNO-109704 PI3K Cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-190322 FGFR4 ligand binding and activation
R-RNO-190372 FGFR3c ligand binding and activation
R-RNO-190373 FGFR1c ligand binding and activation
R-RNO-190374 FGFR1c and Klotho ligand binding and activation
R-RNO-190375 FGFR2c ligand binding and activation
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1
R-RNO-5654221 Phospholipase C-mediated cascade, FGFR2
R-RNO-5654227 Phospholipase C-mediated cascade, FGFR3
R-RNO-5654228 Phospholipase C-mediated cascade, FGFR4
R-RNO-5654687 Downstream signaling of activated FGFR1
R-RNO-5654688 SHC-mediated cascade:FGFR1
R-RNO-5654689 PI-3K cascade:FGFR1
R-RNO-5654693 FRS-mediated FGFR1 signaling
R-RNO-5654695 PI-3K cascade:FGFR2
R-RNO-5654699 SHC-mediated cascade:FGFR2
R-RNO-5654700 FRS-mediated FGFR2 signaling
R-RNO-5654704 SHC-mediated cascade:FGFR3
R-RNO-5654706 FRS-mediated FGFR3 signaling
R-RNO-5654710 PI-3K cascade:FGFR3
R-RNO-5654712 FRS-mediated FGFR4 signaling
R-RNO-5654719 SHC-mediated cascade:FGFR4
R-RNO-5654720 PI-3K cascade:FGFR4
R-RNO-5654726 Negative regulation of FGFR1 signaling
R-RNO-5654727 Negative regulation of FGFR2 signaling
R-RNO-5654732 Negative regulation of FGFR3 signaling
R-RNO-5654733 Negative regulation of FGFR4 signaling
R-RNO-5658623 FGFRL1 modulation of FGFR1 signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 23
Short name:
FGF-23
Gene namesi
Name:Fgf23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620178 Fgf23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000900025 – 251Fibroblast growth factor 23Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 113By similarity
Glycosylationi178O-linked (GalNAc) threonineBy similarity1

Post-translational modificationi

Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases (By similarity).By similarity
O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VI82
PRIDEiQ8VI82

Expressioni

Tissue specificityi

Expressed in the parathyroid.1 Publication

Gene expression databases

BgeeiENSRNOG00000052205
GenevisibleiQ8VI82 RN

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026888

Structurei

3D structure databases

ProteinModelPortaliQ8VI82
SMRiQ8VI82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112573
HOVERGENiHBG051613
InParanoidiQ8VI82
KOiK22428
OMAiQIHKDGH
OrthoDBiEOG091G0NAY
PhylomeDBiQ8VI82
TreeFamiTF335872

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028304 FGF23
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF69 PTHR11486:SF69, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VI82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGACLRLLV GALCTVCSLG TARAYSDTSP LLGSNWGSLT HLYTATARNS
60 70 80 90 100
YHLQIHRDGH VDGTPHQTIY SALMITSEDA GSVVIIGAMT RRFLCMDLRG
110 120 130 140 150
NIFGSYHFSP ENCRFRQWTL ENGYDVYLSP KHHYLVSLGR SKRIFQPGTN
160 170 180 190 200
PPPFSQFLAR RNEVPLLHFY TARPRRHTRS AEDPPERDPL NVLKPRPRAT
210 220 230 240 250
PIPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARRGAGG TDRCRPFPRF

V
Length:251
Mass (Da):27,912
Last modified:March 1, 2002 - v1
Checksum:i35A229E1B3900593
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078777 mRNA Translation: BAB84108.1
RefSeqiNP_570110.1, NM_130754.1
UniGeneiRn.154421

Genome annotation databases

EnsembliENSRNOT00000078299; ENSRNOP00000075536; ENSRNOG00000052205
GeneIDi170583
KEGGirno:170583
UCSCiRGD:620178 rat

Similar proteinsi

Entry informationi

Entry nameiFGF23_RAT
AccessioniPrimary (citable) accession number: Q8VI82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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