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Protein

Importin-4

Gene

Ipo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. Acts as chaperone for exposed basic domains.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-4
Short name:
Imp4
Alternative name(s):
Importin-4a
Short name:
Imp4a
Ran-binding protein 4
Short name:
RanBP4
Gene namesi
Name:Ipo4
Synonyms:Imp4a, Ranbp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923001. Ipo4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10821082Importin-4PRO_0000120749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VI75.
MaxQBiQ8VI75.
PaxDbiQ8VI75.
PeptideAtlasiQ8VI75.
PRIDEiQ8VI75.

PTM databases

iPTMnetiQ8VI75.
PhosphoSiteiQ8VI75.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002319.
CleanExiMM_IPO4.
ExpressionAtlasiQ8VI75. baseline and differential.
GenevisibleiQ8VI75. MM.

Interactioni

Subunit structurei

Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi217713. 1 interaction.
IntActiQ8VI75. 1 interaction.
MINTiMINT-4098711.
STRINGi10090.ENSMUSP00000036555.

Structurei

3D structure databases

ProteinModelPortaliQ8VI75.
SMRiQ8VI75. Positions 347-711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9067Importin N-terminalPROSITE-ProRule annotationAdd
BLAST
Repeati348 – 38538HEAT 1Add
BLAST
Repeati390 – 42738HEAT 2Add
BLAST
Repeati431 – 47141HEAT 3Add
BLAST
Repeati475 – 51339HEAT 4Add
BLAST
Repeati896 – 93338HEAT 5Add
BLAST
Repeati937 – 97539HEAT 6Add
BLAST

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 6 HEAT repeats.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KD6C. Eukaryota.
ENOG410XP2Z. LUCA.
GeneTreeiENSGT00550000075074.
HOGENOMiHOG000008166.
HOVERGENiHBG049052.
InParanoidiQ8VI75.
KOiK20221.
OMAiFQQETEH.
OrthoDBiEOG091G012W.
PhylomeDBiQ8VI75.
TreeFamiTF323157.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VI75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGLEQIL KELLLPDTER IRRATEQLQT ILRDPAALPA LFDLLATATD
60 70 80 90 100
SQIRQFAAVL TRRRLNNRWR RLAPEQRESL KSLVLTALQK ETVHSVSVSL
110 120 130 140 150
AQLSATIFRK EGLQGWPQFM NLLQHSTHSS HSPEKEVGLL LLSVVVSSQP
160 170 180 190 200
EAFHAHQHEL LQLLNETLSD VSFPGVLFYS LRTLTAIARY VRPDDVSLAR
210 220 230 240 250
MLVPKVVTAL RTLIPLDEVK ACEALEALDE MLETELPIIN PHLSEVLTFC
260 270 280 290 300
LEVAKNVALG EPLRVRVLCC LTFLVKVKSK ALLKNRLVPP LLHALFPLMA
310 320 330 340 350
AEPPMGQLDP EDQDSDDDDL EIGLMGETPK HFAVQVVDML ALHLPPEKLC
360 370 380 390 400
PHVMPMLEEA LRSEDPYQRK AGFLVLAVLS DGAGDHIRQR LLYPLLQIVC
410 420 430 440 450
KGLDDPSQIV RNAALFALGQ FSENLQPHIS SYSEEVMPLL LSYLKSVPMG
460 470 480 490 500
NTHHLAKACY ALENFVENLG PKVQPYLPEL MECMLQPLKN PSKARTKELA
510 520 530 540 550
VSAIGAIATA AQDSLLPYFP TIMDLLREFL LTGHEDFHLV QIQSLETLGV
560 570 580 590 600
LARALGESMK PLAEECCQLG LGLCIHIDDP DVRRCTYSLF AALSGLMGEG
610 620 630 640 650
LGPYLPQITT LMLLSLRSTE GIVPQYDGIS SFLLFDDDSE AEEEEELMDE
660 670 680 690 700
DMEEEGDDSE ISGYSVENAF FDEKEDTCTA LGEISMNTCV AFLPFMDATF
710 720 730 740 750
DEVYKLLECP HMNVRKSAYE ALGQFCCALH KASQRSSSDP SSSPVLQTSL
760 770 780 790 800
ARVMPAYMQA VKVERERPVV MAVLESLTGV LRTCGSLALQ PPGRLSELCN
810 820 830 840 850
VLKAVLQKKT ACQDAEEDDD EDDDQAEYDA MLLEHAGEAI PVLAATAGGH
860 870 880 890 900
AFAPFFATFL PLLLCKTKQS CTVAEKSFAV GTLAESIQGL GTASAQFVSR
910 920 930 940 950
LFPVLLNNAR EADPEVRSNA IFGLGVLAEH GGCPAQDHFP KLLGLLLPLL
960 970 980 990 1000
ARERHDRVRD NICGALARVL MASPVGKTEP QVLATLLRAL PLKEDMEEWL
1010 1020 1030 1040 1050
TIGHLFSFLH QNNPEQVVDV ASELLRICSL ILPDNRIPPD TKAALLLLLT
1060 1070 1080
FLAKQHTDSF HTALGSLPND KAQELQAMMG LT
Length:1,082
Mass (Da):119,275
Last modified:March 1, 2002 - v1
Checksum:iBF78D395A3111FF3
GO

Sequence cautioni

The sequence AAH03469 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC26988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123388 mRNA. Translation: AAL55522.1.
AK030490 mRNA. Translation: BAC26988.1. Different initiation.
AK147086 mRNA. Translation: BAE27666.1.
AK171031 mRNA. Translation: BAE42197.1.
BC003469 mRNA. Translation: AAH03469.1. Different initiation.
CCDSiCCDS27121.1.
RefSeqiNP_077229.4. NM_024267.6.
UniGeneiMm.27546.

Genome annotation databases

EnsembliENSMUST00000047131; ENSMUSP00000036555; ENSMUSG00000002319.
GeneIDi75751.
KEGGimmu:75751.
UCSCiuc007tzp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123388 mRNA. Translation: AAL55522.1.
AK030490 mRNA. Translation: BAC26988.1. Different initiation.
AK147086 mRNA. Translation: BAE27666.1.
AK171031 mRNA. Translation: BAE42197.1.
BC003469 mRNA. Translation: AAH03469.1. Different initiation.
CCDSiCCDS27121.1.
RefSeqiNP_077229.4. NM_024267.6.
UniGeneiMm.27546.

3D structure databases

ProteinModelPortaliQ8VI75.
SMRiQ8VI75. Positions 347-711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217713. 1 interaction.
IntActiQ8VI75. 1 interaction.
MINTiMINT-4098711.
STRINGi10090.ENSMUSP00000036555.

PTM databases

iPTMnetiQ8VI75.
PhosphoSiteiQ8VI75.

Proteomic databases

EPDiQ8VI75.
MaxQBiQ8VI75.
PaxDbiQ8VI75.
PeptideAtlasiQ8VI75.
PRIDEiQ8VI75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047131; ENSMUSP00000036555; ENSMUSG00000002319.
GeneIDi75751.
KEGGimmu:75751.
UCSCiuc007tzp.1. mouse.

Organism-specific databases

CTDi79711.
MGIiMGI:1923001. Ipo4.

Phylogenomic databases

eggNOGiENOG410KD6C. Eukaryota.
ENOG410XP2Z. LUCA.
GeneTreeiENSGT00550000075074.
HOGENOMiHOG000008166.
HOVERGENiHBG049052.
InParanoidiQ8VI75.
KOiK20221.
OMAiFQQETEH.
OrthoDBiEOG091G012W.
PhylomeDBiQ8VI75.
TreeFamiTF323157.

Miscellaneous databases

ChiTaRSiIpo4. mouse.
PROiQ8VI75.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002319.
CleanExiMM_IPO4.
ExpressionAtlasiQ8VI75. baseline and differential.
GenevisibleiQ8VI75. MM.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPO4_MOUSE
AccessioniPrimary (citable) accession number: Q8VI75
Secondary accession number(s): Q3TBW0, Q99J52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.