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Q8VI56

- LRP4_MOUSE

UniProt

Q8VI56 - LRP4_MOUSE

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Protein

Low-density lipoprotein receptor-related protein 4

Gene
Lrp4, Kiaa0816
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.2 Publications

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: IntAct
  3. protein homodimerization activity Source: UniProtKB
  4. receptor tyrosine kinase binding Source: UniProtKB
  5. scaffold protein binding Source: UniProt

GO - Biological processi

  1. anatomical structure development Source: MGI
  2. dendrite morphogenesis Source: UniProt
  3. dorsal/ventral pattern formation Source: MGI
  4. embryonic digit morphogenesis Source: MGI
  5. embryonic limb morphogenesis Source: MGI
  6. endocytosis Source: UniProtKB-KW
  7. hair follicle development Source: MGI
  8. kidney development Source: MGI
  9. negative regulation of axonogenesis Source: UniProt
  10. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  11. negative regulation of ossification Source: Ensembl
  12. negative regulation of Wnt signaling pathway Source: MGI
  13. odontogenesis of dentin-containing tooth Source: MGI
  14. positive regulation of presynaptic membrane organization Source: UniProt
  15. postsynaptic membrane assembly Source: UniProt
  16. presynaptic membrane assembly Source: UniProt
  17. protein heterotetramerization Source: UniProt
  18. protein localization Source: MGI
  19. proximal/distal pattern formation Source: MGI
  20. receptor clustering Source: MGI
  21. regulation of protein phosphorylation Source: UniProtKB
  22. skeletal muscle acetylcholine-gated channel clustering Source: UniProt
  23. synapse organization Source: UniProt
  24. synaptic growth at neuromuscular junction Source: UniProt
  25. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Endocytosis, Wnt signaling pathway

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 4
Short name:
LRP-4
Alternative name(s):
LDLR dan
Gene namesi
Name:Lrp4
Synonyms:Kiaa0816
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2442252. Lrp4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 17251705Extracellular Reviewed predictionAdd
BLAST
Transmembranei1726 – 174621Helical; Reviewed predictionAdd
BLAST
Topological domaini1747 – 1905159Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. dendrite Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. neuromuscular junction Source: UniProt
  5. neuronal cell body Source: UniProt
  6. plasma membrane Source: MGI
  7. postsynaptic density Source: UniProt
  8. synaptic membrane Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 19051885Low-density lipoprotein receptor-related protein 4PRO_0000017326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 44 By similarity
Disulfide bondi34 ↔ 57 By similarity
Disulfide bondi51 ↔ 66 By similarity
Disulfide bondi71 ↔ 83 By similarity
Disulfide bondi78 ↔ 96 By similarity
Disulfide bondi90 ↔ 105 By similarity
Disulfide bondi110 ↔ 122 By similarity
Disulfide bondi117 ↔ 135 By similarity
Disulfide bondi129 ↔ 143 By similarity
Disulfide bondi148 ↔ 160 By similarity
Disulfide bondi155 ↔ 173 By similarity
Disulfide bondi167 ↔ 182 By similarity
Disulfide bondi191 ↔ 203 By similarity
Disulfide bondi198 ↔ 216 By similarity
Disulfide bondi210 ↔ 225 By similarity
Disulfide bondi231 ↔ 243 By similarity
Disulfide bondi238 ↔ 256 By similarity
Disulfide bondi250 ↔ 265 By similarity
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi270 ↔ 282 By similarity
Disulfide bondi277 ↔ 295 By similarity
Disulfide bondi289 ↔ 304 By similarity
Disulfide bondi312 ↔ 324 By similarity
Disulfide bondi319 ↔ 337 By similarity
Disulfide bondi331 ↔ 349 By similarity
Disulfide bondi358 ↔ 369 By similarity
Disulfide bondi365 ↔ 378 By similarity
Disulfide bondi380 ↔ 393 By similarity
Disulfide bondi399 ↔ 409 By similarity
Disulfide bondi405 ↔ 418 By similarity
Disulfide bondi420 ↔ 433 By similarity
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi702 ↔ 713 By similarity
Disulfide bondi709 ↔ 722 By similarity
Glycosylationi719 – 7191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi724 ↔ 736 By similarity
Glycosylationi901 – 9011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1077 – 10771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1415 – 14151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1467 – 14671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VI56.
PRIDEiQ8VI56.

PTM databases

PhosphoSiteiQ8VI56.

Expressioni

Gene expression databases

BgeeiQ8VI56.
GenevestigatoriQ8VI56.

Interactioni

Subunit structurei

Homooligomer. Interacts with MUSK; the heterodimer forms an AGRIN receptor complex that binds AGRIN resulting in activation of MUSK. Interacts (via the extracellular domain) with SOST; the interaction facilitates the inhibition of Wnt signaling By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AgrnP253043EBI-2106160,EBI-2106099From a different organism.
Mesdc2Q9ERE72EBI-2106160,EBI-6662606

Protein-protein interaction databases

IntActiQ8VI56. 13 interactions.
MINTiMINT-6801185.

Structurei

3D structure databases

ProteinModelPortaliQ8VI56.
SMRiQ8VI56. Positions 27-1640.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6742LDL-receptor class A 1Add
BLAST
Domaini70 – 10637LDL-receptor class A 2Add
BLAST
Domaini109 – 14436LDL-receptor class A 3Add
BLAST
Domaini147 – 18337LDL-receptor class A 4Add
BLAST
Domaini190 – 22637LDL-receptor class A 5Add
BLAST
Domaini230 – 26637LDL-receptor class A 6Add
BLAST
Domaini269 – 30537LDL-receptor class A 7Add
BLAST
Domaini311 – 35040LDL-receptor class A 8Add
BLAST
Domaini354 – 39441EGF-like 1; atypicalAdd
BLAST
Domaini395 – 43440EGF-like 2; calcium-bindingAdd
BLAST
Repeati480 – 52243LDL-receptor class B 1Add
BLAST
Repeati523 – 56543LDL-receptor class B 2Add
BLAST
Repeati566 – 60944LDL-receptor class B 3Add
BLAST
Repeati610 – 65243LDL-receptor class B 4Add
BLAST
Repeati653 – 69341LDL-receptor class B 5Add
BLAST
Domaini698 – 73740EGF-like 3Add
BLAST
Repeati785 – 82743LDL-receptor class B 6Add
BLAST
Repeati828 – 87043LDL-receptor class B 7Add
BLAST
Repeati871 – 91444LDL-receptor class B 8Add
BLAST
Repeati915 – 95642LDL-receptor class B 9Add
BLAST
Repeati957 – 99842LDL-receptor class B 10Add
BLAST
Repeati1093 – 113543LDL-receptor class B 11Add
BLAST
Repeati1136 – 117843LDL-receptor class B 12Add
BLAST
Repeati1179 – 122244LDL-receptor class B 13Add
BLAST
Repeati1223 – 126341LDL-receptor class B 14Add
BLAST
Repeati1264 – 130643LDL-receptor class B 15Add
BLAST
Repeati1397 – 143943LDL-receptor class B 16Add
BLAST
Repeati1440 – 148243LDL-receptor class B 17Add
BLAST
Repeati1483 – 152644LDL-receptor class B 18Add
BLAST
Repeati1527 – 156842LDL-receptor class B 19Add
BLAST
Repeati1569 – 161042LDL-receptor class B 20Add
BLAST

Sequence similaritiesi

Belongs to the LDLR family.
Contains 3 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235850.
GeneTreeiENSGT00750000117273.
HOGENOMiHOG000047507.
HOVERGENiHBG049163.
InParanoidiA2AGT4.
OMAiPAPPCNL.
OrthoDBiEOG75XGK3.
PhylomeDBiQ8VI56.
TreeFamiTF315253.

Family and domain databases

Gene3Di2.120.10.30. 4 hits.
4.10.400.10. 7 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 16 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 1 hit.
SM00192. LDLa. 8 hits.
SM00135. LY. 20 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 8 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 20 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VI56-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRWWGALLL GALLCAHGIA SSLECACGRS HFTCAVSALG ECTCIPAQWQ     50
CDGDNDCGDH SDEDGCTLPT CSPLDFHCDN GKCIRRSWVC DGDNDCEDDS 100
DEQDCPPREC EEDEFPCQNG YCIRSLWHCD GDNDCGDNSD EQCDMRKCSD 150
KEFRCSDGSC IAEHWYCDGD TDCKDGSDEE SCPSAVPSPP CNLEEFQCAY 200
GRCILDIYHC DGDDDCGDWS DESDCSSHQP CRSGEFMCDS GLCINSGWRC 250
DGDADCDDQS DERNCTTSMC TAEQFRCRSG RCVRLSWRCD GEDDCADNSD 300
EENCENTGSP QCASDQFLCW NGRCIGQRKL CNGINDCGDS SDESPQQNCR 350
PRTGEENCNV NNGGCAQKCQ MVRGAVQCTC HTGYRLTEDG RTCQDVNECA 400
EEGYCSQGCT NTEGAFQCWC EAGYELRPDR RSCKALGPEP VLLFANRIDI 450
RQVLPHRSEY TLLLNNLENA IALDFHHRRE LVFWSDVTLD RILRANLNGS 500
NVEEVVSTGL ESPGGLAVDW VHDKLYWTDS GTSRIEVANL DGAHRKVLLW 550
QSLEKPRAIA LHPMEGTIYW TDWGNTPRIE ASSMDGSGRR IIADTHLFWP 600
NGLTIDYAGR RMYWVDAKHH VIERANLDGS HRKAVISQGL PHPFAITVFE 650
DSLYWTDWHT KSINSANKFT GKNQEIIRNK LHFPMDIHTL HPQRQPAGKN 700
RCGDNNGGCT HLCLPSGQNY TCACPTGFRK INSHACAQSL DKFLLFARRM 750
DIRRISFDTE DLSDDVIPLA DVRSAVALDW DSRDDHVYWT DVSTDTISRA 800
KWDGTGQEVV VDTSLESPAG LAIDWVTNKL YWTDAGTDRI EVANTDGSMR 850
TVLIWENLDR PRDIVVEPMG GYMYWTDWGA SPKIERAGMD ASSRQVIISS 900
NLTWPNGLAI DYGSQRLYWA DAGMKTIEFA GLDGSKRKVL IGSQLPHPFG 950
LTLYGQRIYW TDWQTKSIQS ADRLTGLDRE TLQENLENLM DIHVFHRQRP 1000
PVTTLCAVEN GGCSHLCLRS PNPSGFSCTC PTGINLLRDG KTCSPGMNSF 1050
LIFARRIDVR MVSLDIPYFA DVVVPINMTM KNTIAIGVDP LEGKVYWSDS 1100
TLHRISRASL DGSQHEDIIT TGLQTTDGLA VDAIGRKVYW TDTGTNRIEV 1150
GNLDGSMRKV LVWQNLDSPR AIVLYHEMGF MYWTDWGENA KLERSGMDGS 1200
DRTVLINNNL GWPNGLTVDK TSSQLLWADA HTERIEVADL NGANRHTLVS 1250
PVQHPYGLTL LDSYIYWTDW QTRSIHRADK STGSNVILVR SNLPGLMDIQ 1300
AVDRAQPLGF NKCGSRNGGC SHLCLPRPSG FSCACPTGIQ LKGDRKTCDP 1350
SPETYLLFSS RGSIRRISLD TDDHTDVHVP VPGLNNVISL DYDSVHGKVY 1400
YTDVFLDVIR RADLNGSNME TVIGHGLKTT DGLAVDWVAR NLYWTDTGRN 1450
TIEASRLDGS CRKVLINNSL DEPRAIAVFP RKGYLFWTDW GHIAKIERAN 1500
LDGSERKVLI NTDLGWPNGL TLDYDTRRIY WVDAHLDRIE SADLNGKLRQ 1550
VLVSHVSHPF ALTQQDRWIY WTDWQTKSIQ RVDKYSGRNK ETVLANVEGL 1600
MDIIVVSPQR QTGTNACGVN NGGCTHLCFA RASDFVCACP DEPDGHPCSL 1650
VPGLVPPAPR ATSMNEKSPV LPNTLPTTLH SSTTKTRTSL EGAGGRCSER 1700
DAQLGLCAHS NEAVPAAPGE GLHVSYAIGG LLSILLILLV IAALMLYRHR 1750
KSKFTDPGMG NLTYSNPSYR TSTQEVKLEA APKPAVYNQL CYKKEGGPDH 1800
SYTKEKIKIV EGIRLLAGDD AEWGDLKQLR SSRGGLLRDH VCMKTDTVSI 1850
QASSGSLDDT ETEQLLQEEQ SECSSVHTAA TPERRGSLPD TGWKHERKLS 1900
SESQV 1905
Length:1,905
Mass (Da):211,954
Last modified:June 16, 2009 - v3
Checksum:i282CA859B76D9BAD
GO
Isoform 2 (identifier: Q8VI56-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1564-1620: Missing.

Show »
Length:1,848
Mass (Da):205,373
Checksum:iD494D4B76036B93F
GO

Sequence cautioni

The sequence BAC27835.1 differs from that shown. Reason: Intron retention.
The sequence BAC29416.1 differs from that shown. Reason: Intron retention.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1564 – 162057Missing in isoform 2. VSP_010034Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961F → L in BAC27835. 1 Publication
Sequence conflicti325 – 3251I → L in BAC29416. 1 Publication
Sequence conflicti380 – 3801C → R in AAL36970. 1 Publication
Sequence conflicti682 – 6854HFPM → LHTP1 Publication
Sequence conflicti1330 – 13301G → S in AAL36970. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF247637 mRNA. Translation: AAL36970.1.
AL732478, AL691489 Genomic DNA. Translation: CAM24075.1.
BC132240 mRNA. Translation: AAI32241.1.
AK032360 mRNA. Translation: BAC27835.1. Different termination.
AK036406 mRNA. Translation: BAC29416.1. Sequence problems.
AK129224 Transcribed RNA. Translation: BAC98034.1.
CCDSiCCDS16432.1. [Q8VI56-1]
RefSeqiNP_001139329.1. NM_001145857.1.
NP_766256.3. NM_172668.3. [Q8VI56-1]
UniGeneiMm.275149.
Mm.469960.

Genome annotation databases

EnsembliENSMUST00000028689; ENSMUSP00000028689; ENSMUSG00000027253. [Q8VI56-1]
GeneIDi228357.
KEGGimmu:228357.
UCSCiuc008kvx.2. mouse. [Q8VI56-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF247637 mRNA. Translation: AAL36970.1 .
AL732478 , AL691489 Genomic DNA. Translation: CAM24075.1 .
BC132240 mRNA. Translation: AAI32241.1 .
AK032360 mRNA. Translation: BAC27835.1 . Different termination.
AK036406 mRNA. Translation: BAC29416.1 . Sequence problems.
AK129224 Transcribed RNA. Translation: BAC98034.1 .
CCDSi CCDS16432.1. [Q8VI56-1 ]
RefSeqi NP_001139329.1. NM_001145857.1.
NP_766256.3. NM_172668.3. [Q8VI56-1 ]
UniGenei Mm.275149.
Mm.469960.

3D structure databases

ProteinModelPortali Q8VI56.
SMRi Q8VI56. Positions 27-1640.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VI56. 13 interactions.
MINTi MINT-6801185.

PTM databases

PhosphoSitei Q8VI56.

Proteomic databases

PaxDbi Q8VI56.
PRIDEi Q8VI56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028689 ; ENSMUSP00000028689 ; ENSMUSG00000027253 . [Q8VI56-1 ]
GeneIDi 228357.
KEGGi mmu:228357.
UCSCi uc008kvx.2. mouse. [Q8VI56-1 ]

Organism-specific databases

CTDi 4038.
MGIi MGI:2442252. Lrp4.
Rougei Search...

Phylogenomic databases

eggNOGi NOG235850.
GeneTreei ENSGT00750000117273.
HOGENOMi HOG000047507.
HOVERGENi HBG049163.
InParanoidi A2AGT4.
OMAi PAPPCNL.
OrthoDBi EOG75XGK3.
PhylomeDBi Q8VI56.
TreeFami TF315253.

Miscellaneous databases

NextBioi 378964.
PROi Q8VI56.
SOURCEi Search...

Gene expression databases

Bgeei Q8VI56.
Genevestigatori Q8VI56.

Family and domain databases

Gene3Di 2.120.10.30. 4 hits.
4.10.400.10. 7 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 16 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 1 hit.
SM00192. LDLa. 8 hits.
SM00135. LY. 20 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 8 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 20 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of an insertional mutation responsible for abnormal limb development."
    Simon-Chazottes D.C., Tutois S., Bourgade F., Evans M.J., Kuehn M.R., Guenet J.-L.
    (In) Proceedings of the 14th international mouse genome conference, abstract#B10, Narita (2000)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-566 (ISOFORMS 1/2).
    Strain: C57BL/6J.
    Tissue: Bone and Olfactory bulb.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 682-1905 (ISOFORM 2).
    Tissue: Brain.
  6. Cited for: FUNCTION IN NEUROMUSCULAR JUNCTION DEVELOPMENT, FUNCTION AS RECEPTOR FOR AGRIN, INTERACTION WITH AGRIN AND MUSK.
  7. Cited for: FUNCTION.

Entry informationi

Entry nameiLRP4_MOUSE
AccessioniPrimary (citable) accession number: Q8VI56
Secondary accession number(s): A2AGT4
, Q8BPX5, Q8CBB3, Q8CCP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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