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Q8VI56

- LRP4_MOUSE

UniProt

Q8VI56 - LRP4_MOUSE

Protein

Low-density lipoprotein receptor-related protein 4

Gene

Lrp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.2 Publications

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct
    3. protein homodimerization activity Source: UniProtKB
    4. receptor tyrosine kinase binding Source: UniProtKB
    5. scaffold protein binding Source: UniProt

    GO - Biological processi

    1. anatomical structure development Source: MGI
    2. dendrite morphogenesis Source: UniProt
    3. dorsal/ventral pattern formation Source: MGI
    4. embryonic digit morphogenesis Source: MGI
    5. embryonic limb morphogenesis Source: MGI
    6. endocytosis Source: UniProtKB-KW
    7. hair follicle development Source: MGI
    8. kidney development Source: MGI
    9. negative regulation of axonogenesis Source: UniProt
    10. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    11. negative regulation of ossification Source: Ensembl
    12. negative regulation of Wnt signaling pathway Source: MGI
    13. odontogenesis of dentin-containing tooth Source: MGI
    14. positive regulation of presynaptic membrane organization Source: UniProt
    15. postsynaptic membrane assembly Source: UniProt
    16. presynaptic membrane assembly Source: UniProt
    17. protein heterotetramerization Source: UniProt
    18. protein localization Source: MGI
    19. proximal/distal pattern formation Source: MGI
    20. receptor clustering Source: MGI
    21. regulation of protein phosphorylation Source: UniProtKB
    22. skeletal muscle acetylcholine-gated channel clustering Source: UniProt
    23. synapse organization Source: UniProt
    24. synaptic growth at neuromuscular junction Source: UniProt
    25. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Differentiation, Endocytosis, Wnt signaling pathway

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low-density lipoprotein receptor-related protein 4
    Short name:
    LRP-4
    Alternative name(s):
    LDLR dan
    Gene namesi
    Name:Lrp4
    Synonyms:Kiaa0816
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2442252. Lrp4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. dendrite Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. neuromuscular junction Source: UniProt
    5. neuronal cell body Source: UniProt
    6. plasma membrane Source: MGI
    7. postsynaptic density Source: UniProt
    8. synaptic membrane Source: UniProt

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 19051885Low-density lipoprotein receptor-related protein 4PRO_0000017326Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 44PROSITE-ProRule annotation
    Disulfide bondi34 ↔ 57PROSITE-ProRule annotation
    Disulfide bondi51 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 83PROSITE-ProRule annotation
    Disulfide bondi78 ↔ 96PROSITE-ProRule annotation
    Disulfide bondi90 ↔ 105PROSITE-ProRule annotation
    Disulfide bondi110 ↔ 122PROSITE-ProRule annotation
    Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
    Disulfide bondi129 ↔ 143PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 160PROSITE-ProRule annotation
    Disulfide bondi155 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi167 ↔ 182PROSITE-ProRule annotation
    Disulfide bondi191 ↔ 203PROSITE-ProRule annotation
    Disulfide bondi198 ↔ 216PROSITE-ProRule annotation
    Disulfide bondi210 ↔ 225PROSITE-ProRule annotation
    Disulfide bondi231 ↔ 243PROSITE-ProRule annotation
    Disulfide bondi238 ↔ 256PROSITE-ProRule annotation
    Disulfide bondi250 ↔ 265PROSITE-ProRule annotation
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi270 ↔ 282PROSITE-ProRule annotation
    Disulfide bondi277 ↔ 295PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 304PROSITE-ProRule annotation
    Disulfide bondi312 ↔ 324PROSITE-ProRule annotation
    Disulfide bondi319 ↔ 337PROSITE-ProRule annotation
    Disulfide bondi331 ↔ 349PROSITE-ProRule annotation
    Disulfide bondi358 ↔ 369PROSITE-ProRule annotation
    Disulfide bondi365 ↔ 378PROSITE-ProRule annotation
    Disulfide bondi380 ↔ 393PROSITE-ProRule annotation
    Disulfide bondi399 ↔ 409PROSITE-ProRule annotation
    Disulfide bondi405 ↔ 418PROSITE-ProRule annotation
    Disulfide bondi420 ↔ 433PROSITE-ProRule annotation
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi702 ↔ 713PROSITE-ProRule annotation
    Disulfide bondi709 ↔ 722PROSITE-ProRule annotation
    Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi724 ↔ 736PROSITE-ProRule annotation
    Glycosylationi901 – 9011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1077 – 10771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1415 – 14151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1467 – 14671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8VI56.
    PRIDEiQ8VI56.

    PTM databases

    PhosphoSiteiQ8VI56.

    Expressioni

    Gene expression databases

    BgeeiQ8VI56.
    GenevestigatoriQ8VI56.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with MUSK; the heterodimer forms an AGRIN receptor complex that binds AGRIN resulting in activation of MUSK. Interacts (via the extracellular domain) with SOST; the interaction facilitates the inhibition of Wnt signaling By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AgrnP253043EBI-2106160,EBI-2106099From a different organism.
    Mesdc2Q9ERE72EBI-2106160,EBI-6662606

    Protein-protein interaction databases

    IntActiQ8VI56. 13 interactions.
    MINTiMINT-6801185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VI56.
    SMRiQ8VI56. Positions 27-1640.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 17251705ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1747 – 1905159CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1726 – 174621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 6742LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini70 – 10637LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini109 – 14436LDL-receptor class A 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini147 – 18337LDL-receptor class A 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini190 – 22637LDL-receptor class A 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 26637LDL-receptor class A 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini269 – 30537LDL-receptor class A 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini311 – 35040LDL-receptor class A 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini354 – 39441EGF-like 1; atypicalAdd
    BLAST
    Domaini395 – 43440EGF-like 2; calcium-bindingAdd
    BLAST
    Repeati480 – 52243LDL-receptor class B 1Add
    BLAST
    Repeati523 – 56543LDL-receptor class B 2Add
    BLAST
    Repeati566 – 60944LDL-receptor class B 3Add
    BLAST
    Repeati610 – 65243LDL-receptor class B 4Add
    BLAST
    Repeati653 – 69341LDL-receptor class B 5Add
    BLAST
    Domaini698 – 73740EGF-like 3Add
    BLAST
    Repeati785 – 82743LDL-receptor class B 6Add
    BLAST
    Repeati828 – 87043LDL-receptor class B 7Add
    BLAST
    Repeati871 – 91444LDL-receptor class B 8Add
    BLAST
    Repeati915 – 95642LDL-receptor class B 9Add
    BLAST
    Repeati957 – 99842LDL-receptor class B 10Add
    BLAST
    Repeati1093 – 113543LDL-receptor class B 11Add
    BLAST
    Repeati1136 – 117843LDL-receptor class B 12Add
    BLAST
    Repeati1179 – 122244LDL-receptor class B 13Add
    BLAST
    Repeati1223 – 126341LDL-receptor class B 14Add
    BLAST
    Repeati1264 – 130643LDL-receptor class B 15Add
    BLAST
    Repeati1397 – 143943LDL-receptor class B 16Add
    BLAST
    Repeati1440 – 148243LDL-receptor class B 17Add
    BLAST
    Repeati1483 – 152644LDL-receptor class B 18Add
    BLAST
    Repeati1527 – 156842LDL-receptor class B 19Add
    BLAST
    Repeati1569 – 161042LDL-receptor class B 20Add
    BLAST

    Sequence similaritiesi

    Belongs to the LDLR family.Curated
    Contains 3 EGF-like domains.Curated
    Contains 8 LDL-receptor class A domains.PROSITE-ProRule annotation
    Contains 20 LDL-receptor class B repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235850.
    GeneTreeiENSGT00750000117273.
    HOGENOMiHOG000047507.
    HOVERGENiHBG049163.
    InParanoidiA2AGT4.
    OMAiPAPPCNL.
    OrthoDBiEOG75XGK3.
    PhylomeDBiQ8VI56.
    TreeFamiTF315253.

    Family and domain databases

    Gene3Di2.120.10.30. 4 hits.
    4.10.400.10. 7 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view]
    PfamiPF07645. EGF_CA. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF00058. Ldl_recept_b. 16 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00181. EGF. 4 hits.
    SM00179. EGF_CA. 1 hit.
    SM00192. LDLa. 8 hits.
    SM00135. LY. 20 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    SSF57424. SSF57424. 8 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS01187. EGF_CA. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 8 hits.
    PS51120. LDLRB. 20 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VI56-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRWWGALLL GALLCAHGIA SSLECACGRS HFTCAVSALG ECTCIPAQWQ     50
    CDGDNDCGDH SDEDGCTLPT CSPLDFHCDN GKCIRRSWVC DGDNDCEDDS 100
    DEQDCPPREC EEDEFPCQNG YCIRSLWHCD GDNDCGDNSD EQCDMRKCSD 150
    KEFRCSDGSC IAEHWYCDGD TDCKDGSDEE SCPSAVPSPP CNLEEFQCAY 200
    GRCILDIYHC DGDDDCGDWS DESDCSSHQP CRSGEFMCDS GLCINSGWRC 250
    DGDADCDDQS DERNCTTSMC TAEQFRCRSG RCVRLSWRCD GEDDCADNSD 300
    EENCENTGSP QCASDQFLCW NGRCIGQRKL CNGINDCGDS SDESPQQNCR 350
    PRTGEENCNV NNGGCAQKCQ MVRGAVQCTC HTGYRLTEDG RTCQDVNECA 400
    EEGYCSQGCT NTEGAFQCWC EAGYELRPDR RSCKALGPEP VLLFANRIDI 450
    RQVLPHRSEY TLLLNNLENA IALDFHHRRE LVFWSDVTLD RILRANLNGS 500
    NVEEVVSTGL ESPGGLAVDW VHDKLYWTDS GTSRIEVANL DGAHRKVLLW 550
    QSLEKPRAIA LHPMEGTIYW TDWGNTPRIE ASSMDGSGRR IIADTHLFWP 600
    NGLTIDYAGR RMYWVDAKHH VIERANLDGS HRKAVISQGL PHPFAITVFE 650
    DSLYWTDWHT KSINSANKFT GKNQEIIRNK LHFPMDIHTL HPQRQPAGKN 700
    RCGDNNGGCT HLCLPSGQNY TCACPTGFRK INSHACAQSL DKFLLFARRM 750
    DIRRISFDTE DLSDDVIPLA DVRSAVALDW DSRDDHVYWT DVSTDTISRA 800
    KWDGTGQEVV VDTSLESPAG LAIDWVTNKL YWTDAGTDRI EVANTDGSMR 850
    TVLIWENLDR PRDIVVEPMG GYMYWTDWGA SPKIERAGMD ASSRQVIISS 900
    NLTWPNGLAI DYGSQRLYWA DAGMKTIEFA GLDGSKRKVL IGSQLPHPFG 950
    LTLYGQRIYW TDWQTKSIQS ADRLTGLDRE TLQENLENLM DIHVFHRQRP 1000
    PVTTLCAVEN GGCSHLCLRS PNPSGFSCTC PTGINLLRDG KTCSPGMNSF 1050
    LIFARRIDVR MVSLDIPYFA DVVVPINMTM KNTIAIGVDP LEGKVYWSDS 1100
    TLHRISRASL DGSQHEDIIT TGLQTTDGLA VDAIGRKVYW TDTGTNRIEV 1150
    GNLDGSMRKV LVWQNLDSPR AIVLYHEMGF MYWTDWGENA KLERSGMDGS 1200
    DRTVLINNNL GWPNGLTVDK TSSQLLWADA HTERIEVADL NGANRHTLVS 1250
    PVQHPYGLTL LDSYIYWTDW QTRSIHRADK STGSNVILVR SNLPGLMDIQ 1300
    AVDRAQPLGF NKCGSRNGGC SHLCLPRPSG FSCACPTGIQ LKGDRKTCDP 1350
    SPETYLLFSS RGSIRRISLD TDDHTDVHVP VPGLNNVISL DYDSVHGKVY 1400
    YTDVFLDVIR RADLNGSNME TVIGHGLKTT DGLAVDWVAR NLYWTDTGRN 1450
    TIEASRLDGS CRKVLINNSL DEPRAIAVFP RKGYLFWTDW GHIAKIERAN 1500
    LDGSERKVLI NTDLGWPNGL TLDYDTRRIY WVDAHLDRIE SADLNGKLRQ 1550
    VLVSHVSHPF ALTQQDRWIY WTDWQTKSIQ RVDKYSGRNK ETVLANVEGL 1600
    MDIIVVSPQR QTGTNACGVN NGGCTHLCFA RASDFVCACP DEPDGHPCSL 1650
    VPGLVPPAPR ATSMNEKSPV LPNTLPTTLH SSTTKTRTSL EGAGGRCSER 1700
    DAQLGLCAHS NEAVPAAPGE GLHVSYAIGG LLSILLILLV IAALMLYRHR 1750
    KSKFTDPGMG NLTYSNPSYR TSTQEVKLEA APKPAVYNQL CYKKEGGPDH 1800
    SYTKEKIKIV EGIRLLAGDD AEWGDLKQLR SSRGGLLRDH VCMKTDTVSI 1850
    QASSGSLDDT ETEQLLQEEQ SECSSVHTAA TPERRGSLPD TGWKHERKLS 1900
    SESQV 1905
    Length:1,905
    Mass (Da):211,954
    Last modified:June 16, 2009 - v3
    Checksum:i282CA859B76D9BAD
    GO
    Isoform 2 (identifier: Q8VI56-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1564-1620: Missing.

    Show »
    Length:1,848
    Mass (Da):205,373
    Checksum:iD494D4B76036B93F
    GO

    Sequence cautioni

    The sequence BAC27835.1 differs from that shown. Reason: Intron retention.
    The sequence BAC29416.1 differs from that shown. Reason: Intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961F → L in BAC27835. (PubMed:16141072)Curated
    Sequence conflicti325 – 3251I → L in BAC29416. (PubMed:16141072)Curated
    Sequence conflicti380 – 3801C → R in AAL36970. 1 PublicationCurated
    Sequence conflicti682 – 6854HFPM → LHTP(PubMed:14621295)Curated
    Sequence conflicti1330 – 13301G → S in AAL36970. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1564 – 162057Missing in isoform 2. 1 PublicationVSP_010034Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF247637 mRNA. Translation: AAL36970.1.
    AL732478, AL691489 Genomic DNA. Translation: CAM24075.1.
    BC132240 mRNA. Translation: AAI32241.1.
    AK032360 mRNA. Translation: BAC27835.1. Different termination.
    AK036406 mRNA. Translation: BAC29416.1. Sequence problems.
    AK129224 Transcribed RNA. Translation: BAC98034.1.
    CCDSiCCDS16432.1. [Q8VI56-1]
    RefSeqiNP_001139329.1. NM_001145857.1.
    NP_766256.3. NM_172668.3. [Q8VI56-1]
    UniGeneiMm.275149.
    Mm.469960.

    Genome annotation databases

    EnsembliENSMUST00000028689; ENSMUSP00000028689; ENSMUSG00000027253. [Q8VI56-1]
    GeneIDi228357.
    KEGGimmu:228357.
    UCSCiuc008kvx.2. mouse. [Q8VI56-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF247637 mRNA. Translation: AAL36970.1 .
    AL732478 , AL691489 Genomic DNA. Translation: CAM24075.1 .
    BC132240 mRNA. Translation: AAI32241.1 .
    AK032360 mRNA. Translation: BAC27835.1 . Different termination.
    AK036406 mRNA. Translation: BAC29416.1 . Sequence problems.
    AK129224 Transcribed RNA. Translation: BAC98034.1 .
    CCDSi CCDS16432.1. [Q8VI56-1 ]
    RefSeqi NP_001139329.1. NM_001145857.1.
    NP_766256.3. NM_172668.3. [Q8VI56-1 ]
    UniGenei Mm.275149.
    Mm.469960.

    3D structure databases

    ProteinModelPortali Q8VI56.
    SMRi Q8VI56. Positions 27-1640.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8VI56. 13 interactions.
    MINTi MINT-6801185.

    PTM databases

    PhosphoSitei Q8VI56.

    Proteomic databases

    PaxDbi Q8VI56.
    PRIDEi Q8VI56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028689 ; ENSMUSP00000028689 ; ENSMUSG00000027253 . [Q8VI56-1 ]
    GeneIDi 228357.
    KEGGi mmu:228357.
    UCSCi uc008kvx.2. mouse. [Q8VI56-1 ]

    Organism-specific databases

    CTDi 4038.
    MGIi MGI:2442252. Lrp4.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG235850.
    GeneTreei ENSGT00750000117273.
    HOGENOMi HOG000047507.
    HOVERGENi HBG049163.
    InParanoidi A2AGT4.
    OMAi PAPPCNL.
    OrthoDBi EOG75XGK3.
    PhylomeDBi Q8VI56.
    TreeFami TF315253.

    Miscellaneous databases

    NextBioi 378964.
    PROi Q8VI56.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VI56.
    Genevestigatori Q8VI56.

    Family and domain databases

    Gene3Di 2.120.10.30. 4 hits.
    4.10.400.10. 7 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF00058. Ldl_recept_b. 16 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 1 hit.
    SM00192. LDLa. 8 hits.
    SM00135. LY. 20 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    SSF57424. SSF57424. 8 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS01187. EGF_CA. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 8 hits.
    PS51120. LDLRB. 20 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of an insertional mutation responsible for abnormal limb development."
      Simon-Chazottes D.C., Tutois S., Bourgade F., Evans M.J., Kuehn M.R., Guenet J.-L.
      (In) Proceedings of the 14th international mouse genome conference, abstract#B10, Narita (2000)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-566 (ISOFORMS 1/2).
      Strain: C57BL/6J.
      Tissue: Bone and Olfactory bulb.
    5. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 682-1905 (ISOFORM 2).
      Tissue: Brain.
    6. Cited for: FUNCTION IN NEUROMUSCULAR JUNCTION DEVELOPMENT, FUNCTION AS RECEPTOR FOR AGRIN, INTERACTION WITH AGRIN AND MUSK.
    7. Cited for: FUNCTION.

    Entry informationi

    Entry nameiLRP4_MOUSE
    AccessioniPrimary (citable) accession number: Q8VI56
    Secondary accession number(s): A2AGT4
    , Q8BPX5, Q8CBB3, Q8CCP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3