VPS10 domain-containing receptor SorCS3 precursor - Mus musculus (Mouse)

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Q8VI51 (SORC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 76. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
VPS10 domain-containing receptor SorCS3

Gene names

Name:

Sorcs3

Organism

Mus musculus (Mouse)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the VPS10-related sortilin family. SORCS subfamily.

Contains 6 BNR repeats.

Contains 1 PKD domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

33

Potential

Chain

1186

VPS10 domain-containing receptor SorCS3

PRO_0000033175

Regions

Topological domain

1089

Lumenal Potential

Transmembrane

21

Helical; Potential

Topological domain

76

Cytoplasmic Potential

Repeat

12

BNR 1

Repeat

12

BNR 2

Repeat

12

BNR 3

Repeat

12

BNR 4

Repeat

12

BNR 5

Repeat

12

BNR 6

Domain

91

PKD

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q8VI51 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: ABB3278A2EFEC7C4
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1,219

135,985

        10         20         30         40         50         60 
MEAAGTERPA GWPGAPLART GLLLLSTWVL AGAEITWGAT GGPGRLVSPA SRPPVLPPLL 

        70         80         90        100        110        120 
PRAAENRWPE ELASARRAAA PRRRSRLEPL SQASRGEIRT EAAGMSPEGA RWVPGIPSPS 

       130        140        150        160        170        180 
QAGSARRTRR AQPPSPLERG DSWATALADG AKGSRPHTKG SREEVRATRT GGASTEELRL 

       190        200        210        220        230        240 
PSTSFALTGD SAHNQAMVHW SGHNSSVILI LTKLYDFNLG SVTESSLWRS VDYGATYEKL 

       250        260        270        280        290        300 
NDKVGLKTVL SYLYVNPTNK RKIMLLSDPE MESSVLISSD EGATYQKYRL TFYIQSLLFH 

       310        320        330        340        350        360 
PKQEDWVLAY SLDQKLYSSM DFGRRWQLMH ERITPNRFYW SVSGLDKEAD LVHMEVRTAD 

       370        380        390        400        410        420 
GYAHYLTCRI QECAETTRSG PFARSIDISS LVVQDEYIFI QVTIGGRASY YVSYRREAFA 

       430        440        450        460        470        480 
QIKLPKYSLP KDMHIISTDE NQVFAAVQEW NQNDTYNLYI SDTRGIYFTL AMENIKSSRG 

       490        500        510        520        530        540 
LMGNIIIELY EVAGIKGIFL ANKKVDDQVK TYITYNKGRD WRLLQAPDVD LRGSPVHCLL 

       550        560        570        580        590        600 
PFCSLHLHLQ LSENPYSSGR ISSKDTAPGL VVATGNIGSE LSYTDIGVFI SSDGGNTWRQ 

       610        620        630        640        650        660 
IFDEEYNVWF LDWGGALVAM KHTPLPVRHL WVSFDEGHSW DKYGFTLLPL FVDGALVEAG 

       670        680        690        700        710        720 
VETHIMTVFG HFSLRSEWQL VKVDYKSIFS RRCTKEDFET WHLLNQGEPC VMGERKIFKK 

       730        740        750        760        770        780 
RKPGAQCALG REYSGSVVSE PCVCADWDFE CDYGYERHGE SQCVPAFWYN PASPSKDCSL 

       790        800        810        820        830        840 
GQSYLNSTGY RRIVSNNCTD GLRDKYSAKT QLCPGKAPRG LHVVTTDGRL VAEQGHNATF 

       850        860        870        880        890        900 
IILMEEGDLQ RTNIQLDFGD GVAVSYANFS PIEDGIRHVY KSAGIFQVTA YAENNLGSDT 

       910        920        930        940        950        960 
AFLFLHVVCP VEHVHLRVPF VAIRNKDVNI SAVVWPSQLG TLTYFWWFGN STKPLITLDS 

       970        980        990       1000       1010       1020 
SISFTFLAEG TNTITVQVAA GNALIQDTKE IAVHEYFQSQ LLSFSPNLDY HNPDIPEWRQ 

      1030       1040       1050       1060       1070       1080 
DIGNVIKRAL IKVTSVPEDQ ILVAVFPGLP TSAELFILPP KNLTERRKGH EGDLEQIVET 

      1090       1100       1110       1120       1130       1140 
LFNALNQNLV QFELKPGVQV IVYVTQLTLA PLVDSSAGHS SSAMLMLLSV VFVGLAVFLI 

      1150       1160       1170       1180       1190       1200 
YKFKRKIPWI NIYAQVQHDK EQEMIGSVSQ SENAPKITLS DFTEPEELLD KELDTRVIGS 

      1210 
IATIASSEST KEIPNCTSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel vps10 domain receptor." Hermey G., Rezgaoui M., Hermans-Borgmeyer I. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[2]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 244-261, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1191-1219. Strain: C57BL/6J. Tissue: Hypothalamus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF276314 mRNA. Translation: AAL36983.1. AK020713 mRNA. No translation available.
IPI	IPI00128776.
RefSeq	NP_079972.1. NM_025696.3.
UniGene	Mm.70980.
3D structure databases
ProteinModelPortal	Q8VI51.
SMR	Q8VI51. Positions 292-334, 566-642, 795-912.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VI51.
PTM databases
PhosphoSite	Q8VI51.
Proteomic databases
PRIDE	Q8VI51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000078880; ENSMUSP00000077919; ENSMUSG00000063434.
GeneID	66673.
KEGG	mmu:66673.
Organism-specific databases
CTD	22986.
MGI	MGI:1913923. Sorcs3.
Phylogenomic databases
GeneTree	ENSGT00510000046443.
HOGENOM	HBG445080.
HOVERGEN	HBG059252.
InParanoid	Q8VI51.
OMA	FSRRCTK.
OrthoDB	EOG46HG8Z.
PhylomeDB	Q8VI51.
Gene expression databases
ArrayExpress	Q8VI51.
Bgee	Q8VI51.
Genevestigator	Q8VI51.
GermOnline	ENSMUSG00000063434. Mus musculus.
Family and domain databases
InterPro	IPR000601. PKD_dom. IPR006581. VPS10. [Graphical view]
Gene3D	G3DSA:2.60.40.670. PKD. 1 hit.
SMART	SM00602. VPS10. 1 hit. [Graphical view]
SUPFAM	SSF49299. PKD. 2 hits.
PROSITE	PS50093. PKD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	322337.
SOURCE	Search...

Entry information

Entry name

SORC3_MOUSE

Accession

Primary (citable) accession number: Q8VI51
Secondary accession number(s): Q9CTR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	March 1, 2002
Last modified:	September 21, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents