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Protein

VPS10 domain-containing receptor SorCS3

Gene

Sorcs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • learning Source: MGI
  • memory Source: MGI
  • regulation of long term synaptic depression Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS3
Gene namesi
Name:Sorcs3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1913923. Sorcs3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 11221089LumenalSequence analysisAdd
BLAST
Transmembranei1123 – 114321HelicalSequence analysisAdd
BLAST
Topological domaini1144 – 121976CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • neuronal postsynaptic density Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 12191186VPS10 domain-containing receptor SorCS3PRO_0000033175Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence analysis
Glycosylationi786 – 7861N-linked (GlcNAc...)Sequence analysis
Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence analysis
Glycosylationi837 – 8371N-linked (GlcNAc...)Sequence analysis
Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence analysis
Glycosylationi950 – 9501N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8VI51.
PaxDbiQ8VI51.
PRIDEiQ8VI51.

PTM databases

PhosphoSiteiQ8VI51.

Expressioni

Gene expression databases

BgeeiQ8VI51.
ExpressionAtlasiQ8VI51. baseline and differential.
GenevisibleiQ8VI51. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077919.

Structurei

3D structure databases

ProteinModelPortaliQ8VI51.
SMRiQ8VI51. Positions 190-801, 804-910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati228 – 23912BNR 1Add
BLAST
Repeati276 – 28712BNR 2Add
BLAST
Repeati317 – 32812BNR 3Add
BLAST
Repeati512 – 52312BNR 4Add
BLAST
Repeati589 – 60012BNR 5Add
BLAST
Repeati631 – 64212BNR 6Add
BLAST
Domaini824 – 91491PKDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 BNR repeats.Curated
Contains 1 PKD domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISX9. Eukaryota.
ENOG410XNN6. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ8VI51.
OMAiLDQKLYS.
OrthoDBiEOG7GJ6C3.
PhylomeDBiQ8VI51.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR000601. PKD_dom.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
PF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 2 hits.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VI51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAGTERPA GWPGAPLART GLLLLSTWVL AGAEITWGAT GGPGRLVSPA
60 70 80 90 100
SRPPVLPPLL PRAAENRWPE ELASARRAAA PRRRSRLEPL SQASRGEIRT
110 120 130 140 150
EAAGMSPEGA RWVPGIPSPS QAGSARRTRR AQPPSPLERG DSWATALADG
160 170 180 190 200
AKGSRPHTKG SREEVRATRT GGASTEELRL PSTSFALTGD SAHNQAMVHW
210 220 230 240 250
SGHNSSVILI LTKLYDFNLG SVTESSLWRS VDYGATYEKL NDKVGLKTVL
260 270 280 290 300
SYLYVNPTNK RKIMLLSDPE MESSVLISSD EGATYQKYRL TFYIQSLLFH
310 320 330 340 350
PKQEDWVLAY SLDQKLYSSM DFGRRWQLMH ERITPNRFYW SVSGLDKEAD
360 370 380 390 400
LVHMEVRTAD GYAHYLTCRI QECAETTRSG PFARSIDISS LVVQDEYIFI
410 420 430 440 450
QVTIGGRASY YVSYRREAFA QIKLPKYSLP KDMHIISTDE NQVFAAVQEW
460 470 480 490 500
NQNDTYNLYI SDTRGIYFTL AMENIKSSRG LMGNIIIELY EVAGIKGIFL
510 520 530 540 550
ANKKVDDQVK TYITYNKGRD WRLLQAPDVD LRGSPVHCLL PFCSLHLHLQ
560 570 580 590 600
LSENPYSSGR ISSKDTAPGL VVATGNIGSE LSYTDIGVFI SSDGGNTWRQ
610 620 630 640 650
IFDEEYNVWF LDWGGALVAM KHTPLPVRHL WVSFDEGHSW DKYGFTLLPL
660 670 680 690 700
FVDGALVEAG VETHIMTVFG HFSLRSEWQL VKVDYKSIFS RRCTKEDFET
710 720 730 740 750
WHLLNQGEPC VMGERKIFKK RKPGAQCALG REYSGSVVSE PCVCADWDFE
760 770 780 790 800
CDYGYERHGE SQCVPAFWYN PASPSKDCSL GQSYLNSTGY RRIVSNNCTD
810 820 830 840 850
GLRDKYSAKT QLCPGKAPRG LHVVTTDGRL VAEQGHNATF IILMEEGDLQ
860 870 880 890 900
RTNIQLDFGD GVAVSYANFS PIEDGIRHVY KSAGIFQVTA YAENNLGSDT
910 920 930 940 950
AFLFLHVVCP VEHVHLRVPF VAIRNKDVNI SAVVWPSQLG TLTYFWWFGN
960 970 980 990 1000
STKPLITLDS SISFTFLAEG TNTITVQVAA GNALIQDTKE IAVHEYFQSQ
1010 1020 1030 1040 1050
LLSFSPNLDY HNPDIPEWRQ DIGNVIKRAL IKVTSVPEDQ ILVAVFPGLP
1060 1070 1080 1090 1100
TSAELFILPP KNLTERRKGH EGDLEQIVET LFNALNQNLV QFELKPGVQV
1110 1120 1130 1140 1150
IVYVTQLTLA PLVDSSAGHS SSAMLMLLSV VFVGLAVFLI YKFKRKIPWI
1160 1170 1180 1190 1200
NIYAQVQHDK EQEMIGSVSQ SENAPKITLS DFTEPEELLD KELDTRVIGS
1210
IATIASSEST KEIPNCTSV
Length:1,219
Mass (Da):135,985
Last modified:March 1, 2002 - v1
Checksum:iABB3278A2EFEC7C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276314 mRNA. Translation: AAL36983.1.
AK020713 mRNA. No translation available.
CCDSiCCDS38020.1.
RefSeqiNP_079972.1. NM_025696.3.
UniGeneiMm.70980.

Genome annotation databases

EnsembliENSMUST00000078880; ENSMUSP00000077919; ENSMUSG00000063434.
GeneIDi66673.
KEGGimmu:66673.
UCSCiuc008hvx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276314 mRNA. Translation: AAL36983.1.
AK020713 mRNA. No translation available.
CCDSiCCDS38020.1.
RefSeqiNP_079972.1. NM_025696.3.
UniGeneiMm.70980.

3D structure databases

ProteinModelPortaliQ8VI51.
SMRiQ8VI51. Positions 190-801, 804-910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077919.

PTM databases

PhosphoSiteiQ8VI51.

Proteomic databases

MaxQBiQ8VI51.
PaxDbiQ8VI51.
PRIDEiQ8VI51.

Protocols and materials databases

DNASUi66673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078880; ENSMUSP00000077919; ENSMUSG00000063434.
GeneIDi66673.
KEGGimmu:66673.
UCSCiuc008hvx.1. mouse.

Organism-specific databases

CTDi22986.
MGIiMGI:1913923. Sorcs3.

Phylogenomic databases

eggNOGiENOG410ISX9. Eukaryota.
ENOG410XNN6. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ8VI51.
OMAiLDQKLYS.
OrthoDBiEOG7GJ6C3.
PhylomeDBiQ8VI51.
TreeFamiTF324918.

Miscellaneous databases

ChiTaRSiSorcs3. mouse.
NextBioi322337.
PROiQ8VI51.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VI51.
ExpressionAtlasiQ8VI51. baseline and differential.
GenevisibleiQ8VI51. MM.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR000601. PKD_dom.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
PF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 2 hits.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel vps10 domain receptor."
    Hermey G., Rezgaoui M., Hermans-Borgmeyer I.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 244-261, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1191-1219.
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSORC3_MOUSE
AccessioniPrimary (citable) accession number: Q8VI51
Secondary accession number(s): Q9CTR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: March 1, 2002
Last modified: December 9, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.