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Protein

Canalicular multispecific organic anion transporter 1

Gene

Abcc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi669 – 676ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1332 – 1339ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Gene namesi
Name:Abcc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1352447. Abcc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularBy similarityAdd BLAST26
Transmembranei27 – 47Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini48 – 67CytoplasmicBy similarityAdd BLAST20
Transmembranei68 – 88Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini89 – 92ExtracellularBy similarity4
Transmembranei93 – 113Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini114 – 125CytoplasmicBy similarityAdd BLAST12
Transmembranei126 – 146Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini147 – 164ExtracellularBy similarityAdd BLAST18
Transmembranei165 – 185Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini186 – 311CytoplasmicBy similarityAdd BLAST126
Transmembranei312 – 332Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini333 – 358ExtracellularBy similarityAdd BLAST26
Transmembranei359 – 379Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini380 – 435CytoplasmicBy similarityAdd BLAST56
Transmembranei436 – 456Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini457 – 459ExtracellularBy similarity3
Transmembranei460 – 480Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini481 – 542CytoplasmicBy similarityAdd BLAST62
Transmembranei543 – 563Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini564 – 585ExtracellularBy similarityAdd BLAST22
Transmembranei586 – 606Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini607 – 969CytoplasmicBy similarityAdd BLAST363
Transmembranei970 – 990Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini991 – 1031ExtracellularBy similarityAdd BLAST41
Transmembranei1032 – 1052Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1053 – 1095CytoplasmicBy similarityAdd BLAST43
Transmembranei1096 – 1116Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1117ExtracellularBy similarity1
Transmembranei1118 – 1138Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1139 – 1209CytoplasmicBy similarityAdd BLAST71
Transmembranei1210 – 1230Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1231 – 1232ExtracellularBy similarity2
Transmembranei1233 – 1253Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1254 – 1543CytoplasmicBy similarityAdd BLAST290

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • cell surface Source: MGI
  • integral component of plasma membrane Source: MGI
  • intercellular canaliculus Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933571 – 1543Canalicular multispecific organic anion transporter 1Add BLAST1543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi160N-linked (GlcNAc...)Sequence analysis1
Modified residuei279PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1
Modified residuei876PhosphoserineCombined sources1
Modified residuei924PhosphoserineBy similarity1
Modified residuei928PhosphoserineBy similarity1
Glycosylationi1009N-linked (GlcNAc...)Sequence analysis1
Modified residuei1436PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VI47.
PaxDbiQ8VI47.
PeptideAtlasiQ8VI47.
PRIDEiQ8VI47.

PTM databases

iPTMnetiQ8VI47.
PhosphoSitePlusiQ8VI47.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025194.
ExpressionAtlasiQ8VI47. baseline and differential.
GenevisibleiQ8VI47. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026208.

Structurei

3D structure databases

ProteinModelPortaliQ8VI47.
SMRiQ8VI47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini320 – 603ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini635 – 859ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini977 – 1262ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST286
Domaini1298 – 1532ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ8VI47.
KOiK05666.
OMAiGEENANW.
OrthoDBiEOG091G00IN.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR030247. ABCC2.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF176. PTHR24223:SF176. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VI47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEFCNSTFW NLSLLKSPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYRI
60 70 80 90 100
YRSRTKRFAI TKFYLAKQVF VVCLLILAAI DLSLALTEDT GQATIPPVKY
110 120 130 140 150
TNPILYLCTW LLVLVIQHCR QCCIQKNSWF LSMFWILSLL CGIFQFQTLI
160 170 180 190 200
RALLQDSKSN MTYSCLFFVS YGFQIVILIL SAFSESSDST HAPSATASFL
210 220 230 240 250
SSVTFSWYDS TVLKGYKHPL TIEDVWDIEE NLKAKSLTSK FKTIMTKDLQ
260 270 280 290 300
KARQALQRRL KKSQQSPEGT SHGLTKKQSQ SQDVLVLEDS KKKKKKSEAT
310 320 330 340 350
KDFPKSWLVK ALFKTFYVVI LKSFILKLAH DILLFLNPQL LKFLIGFVKD
360 370 380 390 400
PDSYPWVGYI YAILMFSVTL IQSFFLQCYF QFCFVLGMTV RTTIIASVYK
410 420 430 440 450
KALTLSNLAR RQYTIGETVN LMSVDSQKLM DVTNYIHLLW SSVLQIALSI
460 470 480 490 500
FFLWRELGPS ILAGVGLMVL LVPVNGVLAT KIRKIQVQNM KNKDKRLKIM
510 520 530 540 550
NEILSGIKIL KYFAWEPSFK EQVNSIRKKE LRNLLRFSQL QTILIFILHL
560 570 580 590 600
TPTLVSVITF SVYVLVDSQN VLNAEKAFTS ITLFNILRFP LAMLPMVISS
610 620 630 640 650
VIQASVSVDR LEQYLGSDDL DLSAIRHVCH FDKAVQFSEA SFTWDRDLEA
660 670 680 690 700
TIQDVNLDIK PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA
710 720 730 740 750
YVPQQAWIQN GTIKDNILFG SEYDEKKYQR VIEACALLPD LEMLPGGDMA
760 770 780 790 800
EIGEKGINLS GGQKHRVSLA RATYQDADIY ILDDPLSAVD THVGKHIFNK
810 820 830 840 850
VVGPNGLLSG KTRILVTHGI HFLPQVDEIV VLGKGTILEK GSYSDLMDKK
860 870 880 890 900
GVFAKNWKTF MKHSGPEGEA TVDNDSEEED GDCGLIPTVE EIPDDAASLT
910 920 930 940 950
MRRENSLRRT LSRSSRSGSR RGKSLKSSLK IKSVNALNKK EEVVKGQKLI
960 970 980 990 1000
KKEFVETGKV KFSIYLKYLQ AVGWWSLLFI VIFYVLNYVA FIGTNLWLSA
1010 1020 1030 1040 1050
WTSDSEKQNG TDNSPSQRDM RIGVFGALGI AQGIFLLSSS LWSIYACRNA
1060 1070 1080 1090 1100
SKTLHRQLLT NILRAPMSFF DTTPTGRIVN RFAGDISTVD DTLPQTLRSW
1110 1120 1130 1140 1150
LLCFFGIVST LVMICMATPI FIIIIIPLSI LYVSVQVFYV ATSRQLRRLD
1160 1170 1180 1190 1200
SVTKSPIYSH FSETVSGLPV IRAFEHQQRF LANSEKQIDT NQKCVFSWIT
1210 1220 1230 1240 1250
SNRWLAIRLE LVGNLIVFCS ALLLVIYKNS LTGDTVGFVL SNALNITQTL
1260 1270 1280 1290 1300
NWLVRMTSEV ETNIVAVERI NEYINVDNEA PWVTDKKPPA DWPKKGEIQF
1310 1320 1330 1340 1350
NNYQVRYRPE LDLVLKGITC NIKSTEKVGV VGRTGAGKSS LTNCLFRILE
1360 1370 1380 1390 1400
SAGGQIIIDG IDIASIGLHD LRGRLTIIPQ DPILFSGNLR MNLDPFNKYS
1410 1420 1430 1440 1450
DEEIWRALEL AHLKSFVAGL QLGLLHEVTE GGDNLSIGQR QLLCLGRAVL
1460 1470 1480 1490 1500
RKSKILVLDE ATAAVDLETD SLIQTTIRNE FSQCTVITIA HRLHTIMDSD
1510 1520 1530 1540
KIMVLDSGKI VEYGSPEELL SNMGPFYLMA KEAGIESVNH TEL
Length:1,543
Mass (Da):173,671
Last modified:June 28, 2011 - v2
Checksum:i2D73F2881511FEC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti613Q → R in AAL36985 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282772 mRNA. Translation: AAL36985.1.
AF282773 mRNA. Translation: AAL36986.1.
CCDSiCCDS29838.1.
RefSeqiNP_038834.2. NM_013806.2.
UniGeneiMm.39054.

Genome annotation databases

EnsembliENSMUST00000026208; ENSMUSP00000026208; ENSMUSG00000025194.
GeneIDi12780.
KEGGimmu:12780.
UCSCiuc008how.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282772 mRNA. Translation: AAL36985.1.
AF282773 mRNA. Translation: AAL36986.1.
CCDSiCCDS29838.1.
RefSeqiNP_038834.2. NM_013806.2.
UniGeneiMm.39054.

3D structure databases

ProteinModelPortaliQ8VI47.
SMRiQ8VI47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026208.

Chemistry databases

ChEMBLiCHEMBL2073681.

PTM databases

iPTMnetiQ8VI47.
PhosphoSitePlusiQ8VI47.

Proteomic databases

MaxQBiQ8VI47.
PaxDbiQ8VI47.
PeptideAtlasiQ8VI47.
PRIDEiQ8VI47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026208; ENSMUSP00000026208; ENSMUSG00000025194.
GeneIDi12780.
KEGGimmu:12780.
UCSCiuc008how.1. mouse.

Organism-specific databases

CTDi1244.
MGIiMGI:1352447. Abcc2.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ8VI47.
KOiK05666.
OMAiGEENANW.
OrthoDBiEOG091G00IN.
TreeFamiTF105199.

Miscellaneous databases

ChiTaRSiAbcc2. mouse.
PROiQ8VI47.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025194.
ExpressionAtlasiQ8VI47. baseline and differential.
GenevisibleiQ8VI47. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR030247. ABCC2.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF176. PTHR24223:SF176. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP2_MOUSE
AccessioniPrimary (citable) accession number: Q8VI47
Secondary accession number(s): Q8VI46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.