SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VI47

- MRP2_MOUSE

UniProt

Q8VI47 - MRP2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Canalicular multispecific organic anion transporter 1

Gene
Abcc2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi669 – 6768ATP 1 Reviewed prediction
Nucleotide bindingi1332 – 13398ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. protein binding Source: MGI

GO - Biological processi

  1. cellular chloride ion homeostasis Source: Ensembl
  2. drug transmembrane transport Source: Ensembl
  3. prostaglandin transport Source: Ensembl
  4. response to arsenic-containing substance Source: Ensembl
  5. response to estrogen Source: Ensembl
  6. response to heat Source: Ensembl
  7. response to methotrexate Source: Ensembl
  8. response to oxidative stress Source: Ensembl
  9. thyroid hormone transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Gene namesi
Name:Abcc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1352447. Abcc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Extracellular By similarityAdd
BLAST
Transmembranei27 – 4721Helical; Name=1; By similarityAdd
BLAST
Topological domaini48 – 6720Cytoplasmic By similarityAdd
BLAST
Transmembranei68 – 8821Helical; Name=2; By similarityAdd
BLAST
Topological domaini89 – 924Extracellular By similarity
Transmembranei93 – 11321Helical; Name=3; By similarityAdd
BLAST
Topological domaini114 – 12512Cytoplasmic By similarityAdd
BLAST
Transmembranei126 – 14621Helical; Name=4; By similarityAdd
BLAST
Topological domaini147 – 16418Extracellular By similarityAdd
BLAST
Transmembranei165 – 18521Helical; Name=5; By similarityAdd
BLAST
Topological domaini186 – 311126Cytoplasmic By similarityAdd
BLAST
Transmembranei312 – 33221Helical; Name=6; By similarityAdd
BLAST
Topological domaini333 – 35826Extracellular By similarityAdd
BLAST
Transmembranei359 – 37921Helical; Name=7; By similarityAdd
BLAST
Topological domaini380 – 43556Cytoplasmic By similarityAdd
BLAST
Transmembranei436 – 45621Helical; Name=8; By similarityAdd
BLAST
Topological domaini457 – 4593Extracellular By similarity
Transmembranei460 – 48021Helical; Name=9; By similarityAdd
BLAST
Topological domaini481 – 54262Cytoplasmic By similarityAdd
BLAST
Transmembranei543 – 56321Helical; Name=10; By similarityAdd
BLAST
Topological domaini564 – 58522Extracellular By similarityAdd
BLAST
Transmembranei586 – 60621Helical; Name=11; By similarityAdd
BLAST
Topological domaini607 – 969363Cytoplasmic By similarityAdd
BLAST
Transmembranei970 – 99021Helical; Name=12; By similarityAdd
BLAST
Topological domaini991 – 103141Extracellular By similarityAdd
BLAST
Transmembranei1032 – 105221Helical; Name=13; By similarityAdd
BLAST
Topological domaini1053 – 109543Cytoplasmic By similarityAdd
BLAST
Transmembranei1096 – 111621Helical; Name=14; By similarityAdd
BLAST
Topological domaini1117 – 11171Extracellular By similarity
Transmembranei1118 – 113821Helical; Name=15; By similarityAdd
BLAST
Topological domaini1139 – 120971Cytoplasmic By similarityAdd
BLAST
Transmembranei1210 – 123021Helical; Name=16; By similarityAdd
BLAST
Topological domaini1231 – 12322Extracellular By similarity
Transmembranei1233 – 125321Helical; Name=17; By similarityAdd
BLAST
Topological domaini1254 – 1543290Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. integral component of plasma membrane Source: MGI
  3. intercellular canaliculus Source: MGI
  4. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15431543Canalicular multispecific organic anion transporter 1PRO_0000093357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Modified residuei281 – 2811Phosphoserine By similarity
Modified residuei876 – 8761Phosphoserine By similarity
Glycosylationi1009 – 10091N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VI47.
PaxDbiQ8VI47.
PRIDEiQ8VI47.

PTM databases

PhosphoSiteiQ8VI47.

Expressioni

Gene expression databases

BgeeiQ8VI47.
GenevestigatoriQ8VI47.

Structurei

3D structure databases

ProteinModelPortaliQ8VI47.
SMRiQ8VI47. Positions 634-860.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini320 – 603284ABC transmembrane type-1 1Add
BLAST
Domaini635 – 859225ABC transporter 1Add
BLAST
Domaini977 – 1262286ABC transmembrane type-1 2Add
BLAST
Domaini1298 – 1532235ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00750000117309.
HOVERGENiHBG108314.
InParanoidiQ8VI46.
KOiK05666.
OMAiMISFASD.
OrthoDBiEOG7MWGW0.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VI47-1 [UniParc]FASTAAdd to Basket

« Hide

MDEFCNSTFW NLSLLKSPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYRI     50
YRSRTKRFAI TKFYLAKQVF VVCLLILAAI DLSLALTEDT GQATIPPVKY 100
TNPILYLCTW LLVLVIQHCR QCCIQKNSWF LSMFWILSLL CGIFQFQTLI 150
RALLQDSKSN MTYSCLFFVS YGFQIVILIL SAFSESSDST HAPSATASFL 200
SSVTFSWYDS TVLKGYKHPL TIEDVWDIEE NLKAKSLTSK FKTIMTKDLQ 250
KARQALQRRL KKSQQSPEGT SHGLTKKQSQ SQDVLVLEDS KKKKKKSEAT 300
KDFPKSWLVK ALFKTFYVVI LKSFILKLAH DILLFLNPQL LKFLIGFVKD 350
PDSYPWVGYI YAILMFSVTL IQSFFLQCYF QFCFVLGMTV RTTIIASVYK 400
KALTLSNLAR RQYTIGETVN LMSVDSQKLM DVTNYIHLLW SSVLQIALSI 450
FFLWRELGPS ILAGVGLMVL LVPVNGVLAT KIRKIQVQNM KNKDKRLKIM 500
NEILSGIKIL KYFAWEPSFK EQVNSIRKKE LRNLLRFSQL QTILIFILHL 550
TPTLVSVITF SVYVLVDSQN VLNAEKAFTS ITLFNILRFP LAMLPMVISS 600
VIQASVSVDR LEQYLGSDDL DLSAIRHVCH FDKAVQFSEA SFTWDRDLEA 650
TIQDVNLDIK PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA 700
YVPQQAWIQN GTIKDNILFG SEYDEKKYQR VIEACALLPD LEMLPGGDMA 750
EIGEKGINLS GGQKHRVSLA RATYQDADIY ILDDPLSAVD THVGKHIFNK 800
VVGPNGLLSG KTRILVTHGI HFLPQVDEIV VLGKGTILEK GSYSDLMDKK 850
GVFAKNWKTF MKHSGPEGEA TVDNDSEEED GDCGLIPTVE EIPDDAASLT 900
MRRENSLRRT LSRSSRSGSR RGKSLKSSLK IKSVNALNKK EEVVKGQKLI 950
KKEFVETGKV KFSIYLKYLQ AVGWWSLLFI VIFYVLNYVA FIGTNLWLSA 1000
WTSDSEKQNG TDNSPSQRDM RIGVFGALGI AQGIFLLSSS LWSIYACRNA 1050
SKTLHRQLLT NILRAPMSFF DTTPTGRIVN RFAGDISTVD DTLPQTLRSW 1100
LLCFFGIVST LVMICMATPI FIIIIIPLSI LYVSVQVFYV ATSRQLRRLD 1150
SVTKSPIYSH FSETVSGLPV IRAFEHQQRF LANSEKQIDT NQKCVFSWIT 1200
SNRWLAIRLE LVGNLIVFCS ALLLVIYKNS LTGDTVGFVL SNALNITQTL 1250
NWLVRMTSEV ETNIVAVERI NEYINVDNEA PWVTDKKPPA DWPKKGEIQF 1300
NNYQVRYRPE LDLVLKGITC NIKSTEKVGV VGRTGAGKSS LTNCLFRILE 1350
SAGGQIIIDG IDIASIGLHD LRGRLTIIPQ DPILFSGNLR MNLDPFNKYS 1400
DEEIWRALEL AHLKSFVAGL QLGLLHEVTE GGDNLSIGQR QLLCLGRAVL 1450
RKSKILVLDE ATAAVDLETD SLIQTTIRNE FSQCTVITIA HRLHTIMDSD 1500
KIMVLDSGKI VEYGSPEELL SNMGPFYLMA KEAGIESVNH TEL 1543
Length:1,543
Mass (Da):173,671
Last modified:June 28, 2011 - v2
Checksum:i2D73F2881511FEC0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti613 – 6131Q → R in AAL36985. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282772 mRNA. Translation: AAL36985.1.
AF282773 mRNA. Translation: AAL36986.1.
CCDSiCCDS29838.1.
RefSeqiNP_038834.2. NM_013806.2.
UniGeneiMm.39054.

Genome annotation databases

EnsembliENSMUST00000026208; ENSMUSP00000026208; ENSMUSG00000025194.
GeneIDi12780.
KEGGimmu:12780.
UCSCiuc008how.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282772 mRNA. Translation: AAL36985.1 .
AF282773 mRNA. Translation: AAL36986.1 .
CCDSi CCDS29838.1.
RefSeqi NP_038834.2. NM_013806.2.
UniGenei Mm.39054.

3D structure databases

ProteinModelPortali Q8VI47.
SMRi Q8VI47. Positions 634-860.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073681.

PTM databases

PhosphoSitei Q8VI47.

Proteomic databases

MaxQBi Q8VI47.
PaxDbi Q8VI47.
PRIDEi Q8VI47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026208 ; ENSMUSP00000026208 ; ENSMUSG00000025194 .
GeneIDi 12780.
KEGGi mmu:12780.
UCSCi uc008how.1. mouse.

Organism-specific databases

CTDi 1244.
MGIi MGI:1352447. Abcc2.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00750000117309.
HOVERGENi HBG108314.
InParanoidi Q8VI46.
KOi K05666.
OMAi MISFASD.
OrthoDBi EOG7MWGW0.
TreeFami TF105199.

Miscellaneous databases

NextBioi 282178.
PROi Q8VI47.
SOURCEi Search...

Gene expression databases

Bgeei Q8VI47.
Genevestigatori Q8VI47.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Murine cholesterol cholelithiasis is linked to a mutation in the Abcc2 gene."
    Bouchard G., Chao H., Lammert F., Carey M.C., Paigen B.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AKR/J and C57L/J.

Entry informationi

Entry nameiMRP2_MOUSE
AccessioniPrimary (citable) accession number: Q8VI47
Secondary accession number(s): Q8VI46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi