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Q8VI47

- MRP2_MOUSE

UniProt

Q8VI47 - MRP2_MOUSE

Protein

Canalicular multispecific organic anion transporter 1

Gene

Abcc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi669 – 6768ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1332 – 13398ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: MGI

    GO - Biological processi

    1. cellular chloride ion homeostasis Source: Ensembl
    2. drug transmembrane transport Source: Ensembl
    3. prostaglandin transport Source: Ensembl
    4. response to arsenic-containing substance Source: Ensembl
    5. response to estrogen Source: Ensembl
    6. response to heat Source: Ensembl
    7. response to methotrexate Source: Ensembl
    8. response to oxidative stress Source: Ensembl
    9. thyroid hormone transport Source: Ensembl

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Canalicular multispecific organic anion transporter 1
    Alternative name(s):
    ATP-binding cassette sub-family C member 2
    Gene namesi
    Name:Abcc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1352447. Abcc2.

    Subcellular locationi

    Apical cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. integral component of plasma membrane Source: MGI
    3. intercellular canaliculus Source: MGI
    4. membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15431543Canalicular multispecific organic anion transporter 1PRO_0000093357Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Modified residuei281 – 2811PhosphoserineBy similarity
    Modified residuei876 – 8761PhosphoserineBy similarity
    Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8VI47.
    PaxDbiQ8VI47.
    PRIDEiQ8VI47.

    PTM databases

    PhosphoSiteiQ8VI47.

    Expressioni

    Gene expression databases

    BgeeiQ8VI47.
    GenevestigatoriQ8VI47.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VI47.
    SMRiQ8VI47. Positions 634-860.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularBy similarityAdd
    BLAST
    Topological domaini48 – 6720CytoplasmicBy similarityAdd
    BLAST
    Topological domaini89 – 924ExtracellularBy similarity
    Topological domaini114 – 12512CytoplasmicBy similarityAdd
    BLAST
    Topological domaini147 – 16418ExtracellularBy similarityAdd
    BLAST
    Topological domaini186 – 311126CytoplasmicBy similarityAdd
    BLAST
    Topological domaini333 – 35826ExtracellularBy similarityAdd
    BLAST
    Topological domaini380 – 43556CytoplasmicBy similarityAdd
    BLAST
    Topological domaini457 – 4593ExtracellularBy similarity
    Topological domaini481 – 54262CytoplasmicBy similarityAdd
    BLAST
    Topological domaini564 – 58522ExtracellularBy similarityAdd
    BLAST
    Topological domaini607 – 969363CytoplasmicBy similarityAdd
    BLAST
    Topological domaini991 – 103141ExtracellularBy similarityAdd
    BLAST
    Topological domaini1053 – 109543CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1117 – 11171ExtracellularBy similarity
    Topological domaini1139 – 120971CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1231 – 12322ExtracellularBy similarity
    Topological domaini1254 – 1543290CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei93 – 11321Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei312 – 33221Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei359 – 37921Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei436 – 45621Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei460 – 48021Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei543 – 56321Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei586 – 60621Helical; Name=11PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei970 – 99021Helical; Name=12PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1032 – 105221Helical; Name=13PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1096 – 111621Helical; Name=14PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1118 – 113821Helical; Name=15PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1210 – 123021Helical; Name=16PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1233 – 125321Helical; Name=17PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini320 – 603284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini635 – 859225ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini977 – 1262286ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1298 – 1532235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00750000117309.
    HOVERGENiHBG108314.
    InParanoidiQ8VI46.
    KOiK05666.
    OMAiMISFASD.
    OrthoDBiEOG7MWGW0.
    TreeFamiTF105199.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VI47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEFCNSTFW NLSLLKSPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYRI     50
    YRSRTKRFAI TKFYLAKQVF VVCLLILAAI DLSLALTEDT GQATIPPVKY 100
    TNPILYLCTW LLVLVIQHCR QCCIQKNSWF LSMFWILSLL CGIFQFQTLI 150
    RALLQDSKSN MTYSCLFFVS YGFQIVILIL SAFSESSDST HAPSATASFL 200
    SSVTFSWYDS TVLKGYKHPL TIEDVWDIEE NLKAKSLTSK FKTIMTKDLQ 250
    KARQALQRRL KKSQQSPEGT SHGLTKKQSQ SQDVLVLEDS KKKKKKSEAT 300
    KDFPKSWLVK ALFKTFYVVI LKSFILKLAH DILLFLNPQL LKFLIGFVKD 350
    PDSYPWVGYI YAILMFSVTL IQSFFLQCYF QFCFVLGMTV RTTIIASVYK 400
    KALTLSNLAR RQYTIGETVN LMSVDSQKLM DVTNYIHLLW SSVLQIALSI 450
    FFLWRELGPS ILAGVGLMVL LVPVNGVLAT KIRKIQVQNM KNKDKRLKIM 500
    NEILSGIKIL KYFAWEPSFK EQVNSIRKKE LRNLLRFSQL QTILIFILHL 550
    TPTLVSVITF SVYVLVDSQN VLNAEKAFTS ITLFNILRFP LAMLPMVISS 600
    VIQASVSVDR LEQYLGSDDL DLSAIRHVCH FDKAVQFSEA SFTWDRDLEA 650
    TIQDVNLDIK PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA 700
    YVPQQAWIQN GTIKDNILFG SEYDEKKYQR VIEACALLPD LEMLPGGDMA 750
    EIGEKGINLS GGQKHRVSLA RATYQDADIY ILDDPLSAVD THVGKHIFNK 800
    VVGPNGLLSG KTRILVTHGI HFLPQVDEIV VLGKGTILEK GSYSDLMDKK 850
    GVFAKNWKTF MKHSGPEGEA TVDNDSEEED GDCGLIPTVE EIPDDAASLT 900
    MRRENSLRRT LSRSSRSGSR RGKSLKSSLK IKSVNALNKK EEVVKGQKLI 950
    KKEFVETGKV KFSIYLKYLQ AVGWWSLLFI VIFYVLNYVA FIGTNLWLSA 1000
    WTSDSEKQNG TDNSPSQRDM RIGVFGALGI AQGIFLLSSS LWSIYACRNA 1050
    SKTLHRQLLT NILRAPMSFF DTTPTGRIVN RFAGDISTVD DTLPQTLRSW 1100
    LLCFFGIVST LVMICMATPI FIIIIIPLSI LYVSVQVFYV ATSRQLRRLD 1150
    SVTKSPIYSH FSETVSGLPV IRAFEHQQRF LANSEKQIDT NQKCVFSWIT 1200
    SNRWLAIRLE LVGNLIVFCS ALLLVIYKNS LTGDTVGFVL SNALNITQTL 1250
    NWLVRMTSEV ETNIVAVERI NEYINVDNEA PWVTDKKPPA DWPKKGEIQF 1300
    NNYQVRYRPE LDLVLKGITC NIKSTEKVGV VGRTGAGKSS LTNCLFRILE 1350
    SAGGQIIIDG IDIASIGLHD LRGRLTIIPQ DPILFSGNLR MNLDPFNKYS 1400
    DEEIWRALEL AHLKSFVAGL QLGLLHEVTE GGDNLSIGQR QLLCLGRAVL 1450
    RKSKILVLDE ATAAVDLETD SLIQTTIRNE FSQCTVITIA HRLHTIMDSD 1500
    KIMVLDSGKI VEYGSPEELL SNMGPFYLMA KEAGIESVNH TEL 1543
    Length:1,543
    Mass (Da):173,671
    Last modified:June 28, 2011 - v2
    Checksum:i2D73F2881511FEC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti613 – 6131Q → R in AAL36985. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282772 mRNA. Translation: AAL36985.1.
    AF282773 mRNA. Translation: AAL36986.1.
    CCDSiCCDS29838.1.
    RefSeqiNP_038834.2. NM_013806.2.
    UniGeneiMm.39054.

    Genome annotation databases

    EnsembliENSMUST00000026208; ENSMUSP00000026208; ENSMUSG00000025194.
    GeneIDi12780.
    KEGGimmu:12780.
    UCSCiuc008how.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282772 mRNA. Translation: AAL36985.1 .
    AF282773 mRNA. Translation: AAL36986.1 .
    CCDSi CCDS29838.1.
    RefSeqi NP_038834.2. NM_013806.2.
    UniGenei Mm.39054.

    3D structure databases

    ProteinModelPortali Q8VI47.
    SMRi Q8VI47. Positions 634-860.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2073681.

    PTM databases

    PhosphoSitei Q8VI47.

    Proteomic databases

    MaxQBi Q8VI47.
    PaxDbi Q8VI47.
    PRIDEi Q8VI47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026208 ; ENSMUSP00000026208 ; ENSMUSG00000025194 .
    GeneIDi 12780.
    KEGGi mmu:12780.
    UCSCi uc008how.1. mouse.

    Organism-specific databases

    CTDi 1244.
    MGIi MGI:1352447. Abcc2.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00750000117309.
    HOVERGENi HBG108314.
    InParanoidi Q8VI46.
    KOi K05666.
    OMAi MISFASD.
    OrthoDBi EOG7MWGW0.
    TreeFami TF105199.

    Miscellaneous databases

    NextBioi 282178.
    PROi Q8VI47.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VI47.
    Genevestigatori Q8VI47.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine cholesterol cholelithiasis is linked to a mutation in the Abcc2 gene."
      Bouchard G., Chao H., Lammert F., Carey M.C., Paigen B.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AKR/J and C57L/J.

    Entry informationi

    Entry nameiMRP2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VI47
    Secondary accession number(s): Q8VI46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3