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Q8VI47 (MRP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Gene names
Name:Abcc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1543 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter By similarity.

Subcellular location

Apical cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular chloride ion homeostasis

Inferred from electronic annotation. Source: Ensembl

drug transmembrane transport

Inferred from electronic annotation. Source: Ensembl

prostaglandin transport

Inferred from electronic annotation. Source: Ensembl

response to arsenic-containing substance

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to methotrexate

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

thyroid hormone transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from direct assay PubMed 12951053. Source: MGI

integral component of plasma membrane

Inferred from direct assay PubMed 12951053. Source: MGI

intercellular canaliculus

Inferred from direct assay PubMed 12068294. Source: MGI

membrane

Inferred from direct assay PubMed 11279518. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity, coupled to transmembrane movement of substances

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15431543Canalicular multispecific organic anion transporter 1
PRO_0000093357

Regions

Topological domain1 – 2626Extracellular By similarity
Transmembrane27 – 4721Helical; Name=1; By similarity
Topological domain48 – 6720Cytoplasmic By similarity
Transmembrane68 – 8821Helical; Name=2; By similarity
Topological domain89 – 924Extracellular By similarity
Transmembrane93 – 11321Helical; Name=3; By similarity
Topological domain114 – 12512Cytoplasmic By similarity
Transmembrane126 – 14621Helical; Name=4; By similarity
Topological domain147 – 16418Extracellular By similarity
Transmembrane165 – 18521Helical; Name=5; By similarity
Topological domain186 – 311126Cytoplasmic By similarity
Transmembrane312 – 33221Helical; Name=6; By similarity
Topological domain333 – 35826Extracellular By similarity
Transmembrane359 – 37921Helical; Name=7; By similarity
Topological domain380 – 43556Cytoplasmic By similarity
Transmembrane436 – 45621Helical; Name=8; By similarity
Topological domain457 – 4593Extracellular By similarity
Transmembrane460 – 48021Helical; Name=9; By similarity
Topological domain481 – 54262Cytoplasmic By similarity
Transmembrane543 – 56321Helical; Name=10; By similarity
Topological domain564 – 58522Extracellular By similarity
Transmembrane586 – 60621Helical; Name=11; By similarity
Topological domain607 – 969363Cytoplasmic By similarity
Transmembrane970 – 99021Helical; Name=12; By similarity
Topological domain991 – 103141Extracellular By similarity
Transmembrane1032 – 105221Helical; Name=13; By similarity
Topological domain1053 – 109543Cytoplasmic By similarity
Transmembrane1096 – 111621Helical; Name=14; By similarity
Topological domain11171Extracellular By similarity
Transmembrane1118 – 113821Helical; Name=15; By similarity
Topological domain1139 – 120971Cytoplasmic By similarity
Transmembrane1210 – 123021Helical; Name=16; By similarity
Topological domain1231 – 12322Extracellular By similarity
Transmembrane1233 – 125321Helical; Name=17; By similarity
Topological domain1254 – 1543290Cytoplasmic By similarity
Domain320 – 603284ABC transmembrane type-1 1
Domain635 – 859225ABC transporter 1
Domain977 – 1262286ABC transmembrane type-1 2
Domain1298 – 1532235ABC transporter 2
Nucleotide binding669 – 6768ATP 1 Potential
Nucleotide binding1332 – 13398ATP 2 Potential

Amino acid modifications

Modified residue2811Phosphoserine By similarity
Modified residue8761Phosphoserine By similarity
Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation10091N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict6131Q → R in AAL36985. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8VI47 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 2D73F2881511FEC0

FASTA1,543173,671
        10         20         30         40         50         60 
MDEFCNSTFW NLSLLKSPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYRI YRSRTKRFAI 

        70         80         90        100        110        120 
TKFYLAKQVF VVCLLILAAI DLSLALTEDT GQATIPPVKY TNPILYLCTW LLVLVIQHCR 

       130        140        150        160        170        180 
QCCIQKNSWF LSMFWILSLL CGIFQFQTLI RALLQDSKSN MTYSCLFFVS YGFQIVILIL 

       190        200        210        220        230        240 
SAFSESSDST HAPSATASFL SSVTFSWYDS TVLKGYKHPL TIEDVWDIEE NLKAKSLTSK 

       250        260        270        280        290        300 
FKTIMTKDLQ KARQALQRRL KKSQQSPEGT SHGLTKKQSQ SQDVLVLEDS KKKKKKSEAT 

       310        320        330        340        350        360 
KDFPKSWLVK ALFKTFYVVI LKSFILKLAH DILLFLNPQL LKFLIGFVKD PDSYPWVGYI 

       370        380        390        400        410        420 
YAILMFSVTL IQSFFLQCYF QFCFVLGMTV RTTIIASVYK KALTLSNLAR RQYTIGETVN 

       430        440        450        460        470        480 
LMSVDSQKLM DVTNYIHLLW SSVLQIALSI FFLWRELGPS ILAGVGLMVL LVPVNGVLAT 

       490        500        510        520        530        540 
KIRKIQVQNM KNKDKRLKIM NEILSGIKIL KYFAWEPSFK EQVNSIRKKE LRNLLRFSQL 

       550        560        570        580        590        600 
QTILIFILHL TPTLVSVITF SVYVLVDSQN VLNAEKAFTS ITLFNILRFP LAMLPMVISS 

       610        620        630        640        650        660 
VIQASVSVDR LEQYLGSDDL DLSAIRHVCH FDKAVQFSEA SFTWDRDLEA TIQDVNLDIK 

       670        680        690        700        710        720 
PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA YVPQQAWIQN GTIKDNILFG 

       730        740        750        760        770        780 
SEYDEKKYQR VIEACALLPD LEMLPGGDMA EIGEKGINLS GGQKHRVSLA RATYQDADIY 

       790        800        810        820        830        840 
ILDDPLSAVD THVGKHIFNK VVGPNGLLSG KTRILVTHGI HFLPQVDEIV VLGKGTILEK 

       850        860        870        880        890        900 
GSYSDLMDKK GVFAKNWKTF MKHSGPEGEA TVDNDSEEED GDCGLIPTVE EIPDDAASLT 

       910        920        930        940        950        960 
MRRENSLRRT LSRSSRSGSR RGKSLKSSLK IKSVNALNKK EEVVKGQKLI KKEFVETGKV 

       970        980        990       1000       1010       1020 
KFSIYLKYLQ AVGWWSLLFI VIFYVLNYVA FIGTNLWLSA WTSDSEKQNG TDNSPSQRDM 

      1030       1040       1050       1060       1070       1080 
RIGVFGALGI AQGIFLLSSS LWSIYACRNA SKTLHRQLLT NILRAPMSFF DTTPTGRIVN 

      1090       1100       1110       1120       1130       1140 
RFAGDISTVD DTLPQTLRSW LLCFFGIVST LVMICMATPI FIIIIIPLSI LYVSVQVFYV 

      1150       1160       1170       1180       1190       1200 
ATSRQLRRLD SVTKSPIYSH FSETVSGLPV IRAFEHQQRF LANSEKQIDT NQKCVFSWIT 

      1210       1220       1230       1240       1250       1260 
SNRWLAIRLE LVGNLIVFCS ALLLVIYKNS LTGDTVGFVL SNALNITQTL NWLVRMTSEV 

      1270       1280       1290       1300       1310       1320 
ETNIVAVERI NEYINVDNEA PWVTDKKPPA DWPKKGEIQF NNYQVRYRPE LDLVLKGITC 

      1330       1340       1350       1360       1370       1380 
NIKSTEKVGV VGRTGAGKSS LTNCLFRILE SAGGQIIIDG IDIASIGLHD LRGRLTIIPQ 

      1390       1400       1410       1420       1430       1440 
DPILFSGNLR MNLDPFNKYS DEEIWRALEL AHLKSFVAGL QLGLLHEVTE GGDNLSIGQR 

      1450       1460       1470       1480       1490       1500 
QLLCLGRAVL RKSKILVLDE ATAAVDLETD SLIQTTIRNE FSQCTVITIA HRLHTIMDSD 

      1510       1520       1530       1540 
KIMVLDSGKI VEYGSPEELL SNMGPFYLMA KEAGIESVNH TEL 

« Hide

References

[1]"Murine cholesterol cholelithiasis is linked to a mutation in the Abcc2 gene."
Bouchard G., Chao H., Lammert F., Carey M.C., Paigen B.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: AKR/J and C57L/J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF282772 mRNA. Translation: AAL36985.1.
AF282773 mRNA. Translation: AAL36986.1.
RefSeqNP_038834.2. NM_013806.2.
UniGeneMm.39054.

3D structure databases

ProteinModelPortalQ8VI47.
SMRQ8VI47. Positions 634-860.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2073681.

PTM databases

PhosphoSiteQ8VI47.

Proteomic databases

PaxDbQ8VI47.
PRIDEQ8VI47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026208; ENSMUSP00000026208; ENSMUSG00000025194.
GeneID12780.
KEGGmmu:12780.
UCSCuc008how.1. mouse.

Organism-specific databases

CTD1244.
MGIMGI:1352447. Abcc2.

Phylogenomic databases

eggNOGCOG1132.
GeneTreeENSGT00750000117309.
HOVERGENHBG108314.
InParanoidQ8VI46.
KOK05666.
OMADRFLKHN.
OrthoDBEOG7MWGW0.
TreeFamTF105199.

Gene expression databases

BgeeQ8VI47.
GenevestigatorQ8VI47.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio282178.
PROQ8VI47.
SOURCESearch...

Entry information

Entry nameMRP2_MOUSE
AccessionPrimary (citable) accession number: Q8VI47
Secondary accession number(s): Q8VI46
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot