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Q8VI47

- MRP2_MOUSE

UniProt

Q8VI47 - MRP2_MOUSE

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Protein

Canalicular multispecific organic anion transporter 1

Gene

Abcc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi669 – 6768ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1332 – 13398ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular chloride ion homeostasis Source: Ensembl
  2. drug transmembrane transport Source: Ensembl
  3. prostaglandin transport Source: Ensembl
  4. response to arsenic-containing substance Source: Ensembl
  5. response to estrogen Source: Ensembl
  6. response to heat Source: Ensembl
  7. response to methotrexate Source: Ensembl
  8. response to oxidative stress Source: Ensembl
  9. thyroid hormone transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Gene namesi
Name:Abcc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1352447. Abcc2.

Subcellular locationi

Apical cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. integral component of plasma membrane Source: MGI
  3. intercellular canaliculus Source: MGI
  4. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15431543Canalicular multispecific organic anion transporter 1PRO_0000093357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Modified residuei281 – 2811PhosphoserineBy similarity
Modified residuei876 – 8761PhosphoserineBy similarity
Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VI47.
PaxDbiQ8VI47.
PRIDEiQ8VI47.

PTM databases

PhosphoSiteiQ8VI47.

Expressioni

Gene expression databases

BgeeiQ8VI47.
ExpressionAtlasiQ8VI47. baseline and differential.
GenevestigatoriQ8VI47.

Structurei

3D structure databases

ProteinModelPortaliQ8VI47.
SMRiQ8VI47. Positions 634-860.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularBy similarityAdd
BLAST
Topological domaini48 – 6720CytoplasmicBy similarityAdd
BLAST
Topological domaini89 – 924ExtracellularBy similarity
Topological domaini114 – 12512CytoplasmicBy similarityAdd
BLAST
Topological domaini147 – 16418ExtracellularBy similarityAdd
BLAST
Topological domaini186 – 311126CytoplasmicBy similarityAdd
BLAST
Topological domaini333 – 35826ExtracellularBy similarityAdd
BLAST
Topological domaini380 – 43556CytoplasmicBy similarityAdd
BLAST
Topological domaini457 – 4593ExtracellularBy similarity
Topological domaini481 – 54262CytoplasmicBy similarityAdd
BLAST
Topological domaini564 – 58522ExtracellularBy similarityAdd
BLAST
Topological domaini607 – 969363CytoplasmicBy similarityAdd
BLAST
Topological domaini991 – 103141ExtracellularBy similarityAdd
BLAST
Topological domaini1053 – 109543CytoplasmicBy similarityAdd
BLAST
Topological domaini1117 – 11171ExtracellularBy similarity
Topological domaini1139 – 120971CytoplasmicBy similarityAdd
BLAST
Topological domaini1231 – 12322ExtracellularBy similarity
Topological domaini1254 – 1543290CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Transmembranei68 – 8821Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Transmembranei93 – 11321Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Transmembranei126 – 14621Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Transmembranei165 – 18521Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Transmembranei312 – 33221Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Transmembranei359 – 37921Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Transmembranei436 – 45621Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Transmembranei460 – 48021Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Transmembranei543 – 56321Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Transmembranei586 – 60621Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Transmembranei970 – 99021Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Transmembranei1032 – 105221Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Transmembranei1096 – 111621Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Transmembranei1118 – 113821Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Transmembranei1210 – 123021Helical; Name=16PROSITE-ProRule annotationAdd
BLAST
Transmembranei1233 – 125321Helical; Name=17PROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini320 – 603284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini635 – 859225ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini977 – 1262286ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1298 – 1532235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00760000119056.
HOVERGENiHBG108314.
InParanoidiQ8VI47.
KOiK05666.
OMAiMISFASD.
OrthoDBiEOG7MWGW0.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VI47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEFCNSTFW NLSLLKSPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYRI
60 70 80 90 100
YRSRTKRFAI TKFYLAKQVF VVCLLILAAI DLSLALTEDT GQATIPPVKY
110 120 130 140 150
TNPILYLCTW LLVLVIQHCR QCCIQKNSWF LSMFWILSLL CGIFQFQTLI
160 170 180 190 200
RALLQDSKSN MTYSCLFFVS YGFQIVILIL SAFSESSDST HAPSATASFL
210 220 230 240 250
SSVTFSWYDS TVLKGYKHPL TIEDVWDIEE NLKAKSLTSK FKTIMTKDLQ
260 270 280 290 300
KARQALQRRL KKSQQSPEGT SHGLTKKQSQ SQDVLVLEDS KKKKKKSEAT
310 320 330 340 350
KDFPKSWLVK ALFKTFYVVI LKSFILKLAH DILLFLNPQL LKFLIGFVKD
360 370 380 390 400
PDSYPWVGYI YAILMFSVTL IQSFFLQCYF QFCFVLGMTV RTTIIASVYK
410 420 430 440 450
KALTLSNLAR RQYTIGETVN LMSVDSQKLM DVTNYIHLLW SSVLQIALSI
460 470 480 490 500
FFLWRELGPS ILAGVGLMVL LVPVNGVLAT KIRKIQVQNM KNKDKRLKIM
510 520 530 540 550
NEILSGIKIL KYFAWEPSFK EQVNSIRKKE LRNLLRFSQL QTILIFILHL
560 570 580 590 600
TPTLVSVITF SVYVLVDSQN VLNAEKAFTS ITLFNILRFP LAMLPMVISS
610 620 630 640 650
VIQASVSVDR LEQYLGSDDL DLSAIRHVCH FDKAVQFSEA SFTWDRDLEA
660 670 680 690 700
TIQDVNLDIK PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA
710 720 730 740 750
YVPQQAWIQN GTIKDNILFG SEYDEKKYQR VIEACALLPD LEMLPGGDMA
760 770 780 790 800
EIGEKGINLS GGQKHRVSLA RATYQDADIY ILDDPLSAVD THVGKHIFNK
810 820 830 840 850
VVGPNGLLSG KTRILVTHGI HFLPQVDEIV VLGKGTILEK GSYSDLMDKK
860 870 880 890 900
GVFAKNWKTF MKHSGPEGEA TVDNDSEEED GDCGLIPTVE EIPDDAASLT
910 920 930 940 950
MRRENSLRRT LSRSSRSGSR RGKSLKSSLK IKSVNALNKK EEVVKGQKLI
960 970 980 990 1000
KKEFVETGKV KFSIYLKYLQ AVGWWSLLFI VIFYVLNYVA FIGTNLWLSA
1010 1020 1030 1040 1050
WTSDSEKQNG TDNSPSQRDM RIGVFGALGI AQGIFLLSSS LWSIYACRNA
1060 1070 1080 1090 1100
SKTLHRQLLT NILRAPMSFF DTTPTGRIVN RFAGDISTVD DTLPQTLRSW
1110 1120 1130 1140 1150
LLCFFGIVST LVMICMATPI FIIIIIPLSI LYVSVQVFYV ATSRQLRRLD
1160 1170 1180 1190 1200
SVTKSPIYSH FSETVSGLPV IRAFEHQQRF LANSEKQIDT NQKCVFSWIT
1210 1220 1230 1240 1250
SNRWLAIRLE LVGNLIVFCS ALLLVIYKNS LTGDTVGFVL SNALNITQTL
1260 1270 1280 1290 1300
NWLVRMTSEV ETNIVAVERI NEYINVDNEA PWVTDKKPPA DWPKKGEIQF
1310 1320 1330 1340 1350
NNYQVRYRPE LDLVLKGITC NIKSTEKVGV VGRTGAGKSS LTNCLFRILE
1360 1370 1380 1390 1400
SAGGQIIIDG IDIASIGLHD LRGRLTIIPQ DPILFSGNLR MNLDPFNKYS
1410 1420 1430 1440 1450
DEEIWRALEL AHLKSFVAGL QLGLLHEVTE GGDNLSIGQR QLLCLGRAVL
1460 1470 1480 1490 1500
RKSKILVLDE ATAAVDLETD SLIQTTIRNE FSQCTVITIA HRLHTIMDSD
1510 1520 1530 1540
KIMVLDSGKI VEYGSPEELL SNMGPFYLMA KEAGIESVNH TEL
Length:1,543
Mass (Da):173,671
Last modified:June 28, 2011 - v2
Checksum:i2D73F2881511FEC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti613 – 6131Q → R in AAL36985. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282772 mRNA. Translation: AAL36985.1.
AF282773 mRNA. Translation: AAL36986.1.
CCDSiCCDS29838.1.
RefSeqiNP_038834.2. NM_013806.2.
UniGeneiMm.39054.

Genome annotation databases

EnsembliENSMUST00000026208; ENSMUSP00000026208; ENSMUSG00000025194.
GeneIDi12780.
KEGGimmu:12780.
UCSCiuc008how.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282772 mRNA. Translation: AAL36985.1 .
AF282773 mRNA. Translation: AAL36986.1 .
CCDSi CCDS29838.1.
RefSeqi NP_038834.2. NM_013806.2.
UniGenei Mm.39054.

3D structure databases

ProteinModelPortali Q8VI47.
SMRi Q8VI47. Positions 634-860.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073681.

PTM databases

PhosphoSitei Q8VI47.

Proteomic databases

MaxQBi Q8VI47.
PaxDbi Q8VI47.
PRIDEi Q8VI47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026208 ; ENSMUSP00000026208 ; ENSMUSG00000025194 .
GeneIDi 12780.
KEGGi mmu:12780.
UCSCi uc008how.1. mouse.

Organism-specific databases

CTDi 1244.
MGIi MGI:1352447. Abcc2.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00760000119056.
HOVERGENi HBG108314.
InParanoidi Q8VI47.
KOi K05666.
OMAi MISFASD.
OrthoDBi EOG7MWGW0.
TreeFami TF105199.

Miscellaneous databases

NextBioi 282178.
PROi Q8VI47.
SOURCEi Search...

Gene expression databases

Bgeei Q8VI47.
ExpressionAtlasi Q8VI47. baseline and differential.
Genevestigatori Q8VI47.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Murine cholesterol cholelithiasis is linked to a mutation in the Abcc2 gene."
    Bouchard G., Chao H., Lammert F., Carey M.C., Paigen B.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AKR/J and C57L/J.

Entry informationi

Entry nameiMRP2_MOUSE
AccessioniPrimary (citable) accession number: Q8VI47
Secondary accession number(s): Q8VI46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3