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Q8VI24

- SATB2_MOUSE

UniProt

Q8VI24 - SATB2_MOUSE

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Protein

DNA-binding protein SATB2

Gene

Satb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi350 – 43788CUT 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi473 – 56088CUT 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi615 – 67460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. cartilage development Source: MGI
  2. cellular response to organic substance Source: MGI
  3. chromatin remodeling Source: MGI
  4. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  5. embryonic pattern specification Source: MGI
  6. embryonic skeletal system morphogenesis Source: MGI
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. neuron migration Source: MGI
  9. osteoblast development Source: MGI
  10. palate development Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. regulation of gene expression Source: MGI
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein SATB2
Alternative name(s):
Special AT-rich sequence-binding protein 2
Gene namesi
Name:Satb2
Synonyms:Kiaa1034
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2679336. Satb2.

Subcellular locationi

Nucleus matrix PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. histone deacetylase complex Source: MGI
  3. nuclear chromatin Source: MGI
  4. nucleus Source: MGI
  5. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Malformations in 2 of the major axonal tracts interconnecting the cortical hemispheres: the corpus callosum (c.c) and the anterior commissure (a.c). Misrouted afferent and efferent cortical axon connections. Impaired migration of upper-layer neurons. Ectopic expression of Ctip2. Craniofacial abnormalities and defects in osteoblast differentiation and function.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733DNA-binding protein SATB2PRO_0000202401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki233 – 233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki350 – 350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8VI24.
PaxDbiQ8VI24.
PRIDEiQ8VI24.

PTM databases

PhosphoSiteiQ8VI24.

Expressioni

Tissue specificityi

Expressed in cortical neurons that extend axons across the corpus callosum. Also expressed in branchial arches and in cells of the osteoblast lineage, but not in chondrocytes and osteoclasts.2 Publications

Developmental stagei

Expression first detected at 10.5 dpc in the maxillary component of the first pharyngeal arch and the lateral aspect of the frontonasal process in the regions that will subsequently fuse to form the primary palate. At 11 - 11.5 dpc, the expression pattern demarcates the region of the medial aspect of the maxillary process within the primitive oral cavity, which will form the palate shelf. By 12.5 dpc, symmetrical expression is seen in the medial edges of the developing palate shelves and this continues until 13.5 dpc when the strongest expression is in the mesenchyme underlying the medial edge epithelia. By the time of palatal shelf fusion at 14.5 dpc the expression is dramatically down-regulated. No expression detected elsewhere in the embryo at any stage examined.1 Publication

Gene expression databases

BgeeiQ8VI24.
CleanExiMM_SATB2.
ExpressionAtlasiQ8VI24. baseline and differential.
GenevestigatoriQ8VI24.

Interactioni

Subunit structurei

Interacts with PIAS1 (By similarity). Interacts with ATF4 and RUNX2; resulting in enhanced DNA binding and transactivation by these transcription factors.By similarity1 Publication

Protein-protein interaction databases

BioGridi229351. 6 interactions.
DIPiDIP-60021N.
IntActiQ8VI24. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8VI24.
SMRiQ8VI24. Positions 57-157, 165-231, 350-437, 473-560, 615-674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 2 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG313826.
GeneTreeiENSGT00390000008096.
HOGENOMiHOG000004805.
HOVERGENiHBG054240.
InParanoidiQ8VI24.
OMAiPPAEDSC.
OrthoDBiEOG7FBRH5.
PhylomeDBiQ8VI24.
TreeFamiTF332714.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 2 hits.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 2 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 2 hits.
PROSITEiPS51042. CUT. 2 hits.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VI24-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA
60 70 80 90 100
VAKAVGGLMI PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA
110 120 130 140 150
LLALGYSHSS AAQAQGIIKL GRWNPLPLSY VTDAPDATVA DMLQDVYHVV
160 170 180 190 200
TLKIQLQSCS KLEDLPAEQW NHATVRNALK ELLKEMNQST LAKECPLSQS
210 220 230 240 250
MISSIVNSTY YANVSATKCQ EFGRWYKKYK KIKVERVERE NLSDYCVLGQ
260 270 280 290 300
RPMHLPNMNQ LASLGKTNEQ SPHSQIHHST PIRNQVPALQ PIMSPGLLSP
310 320 330 340 350
QLSPQLVRQQ IAMAHLINQQ IAVSRLLAHQ HPQAINQQFL NHPPIPRAVK
360 370 380 390 400
PEPTNSSVEV SPDIYQQVRD ELKRASVSQA VFARVAFNRT QGLLSEILRK
410 420 430 440 450
EEDPRTASQS LLVNLRAMQN FLNLPEVERD RIYQDERERS MNPNVSMVSS
460 470 480 490 500
ASSSPSSSRT PQAKTSTPTT DLPIKVDGAN VNITAAIYDE IQQEMKRAKV
510 520 530 540 550
SQALFAKVAA NKSQGWLCEL LRWKENPSPE NRTLWENLCT IRRFLNLPQH
560 570 580 590 600
ERDVIYEEES RHHHSERMQH VVQLPPEPVQ VLHRQQSQPT KESSPPREEA
610 620 630 640 650
PPPPPPTEDS CAKKPRSRTK ISLEALGILQ SFIHDVGLYP DQEAIHTLSA
660 670 680 690 700
QLDLPKHTII KFFQNQRYHV KHHGKLKEHL GSAVDVAEYK DEELLTESEE
710 720 730
NDSEEGSEEM YKVEAEEENA DKSKAAPAET DQR
Length:733
Mass (Da):82,559
Last modified:March 1, 2002 - v1
Checksum:i153CFD1CC3491F25
GO
Isoform 2 (identifier: Q8VI24-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-116: Missing.

Note: No experimental confirmation available.

Show »
Length:674
Mass (Da):76,039
Checksum:i199D04A796B2FB77
GO

Sequence cautioni

The sequence BAC98080.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 11659Missing in isoform 2. 1 PublicationVSP_008967Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319623 mRNA. Translation: AAL37172.1.
AK129270 mRNA. Translation: BAC98080.1. Different initiation.
CCDSiCCDS14965.1. [Q8VI24-1]
RefSeqiNP_631885.1. NM_139146.2. [Q8VI24-1]
UniGeneiMm.145599.

Genome annotation databases

EnsembliENSMUST00000042857; ENSMUSP00000046067; ENSMUSG00000038331. [Q8VI24-2]
ENSMUST00000114415; ENSMUSP00000110057; ENSMUSG00000038331. [Q8VI24-1]
GeneIDi212712.
KEGGimmu:212712.
UCSCiuc007bas.1. mouse. [Q8VI24-1]
uc011wlc.1. mouse. [Q8VI24-2]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319623 mRNA. Translation: AAL37172.1 .
AK129270 mRNA. Translation: BAC98080.1 . Different initiation.
CCDSi CCDS14965.1. [Q8VI24-1 ]
RefSeqi NP_631885.1. NM_139146.2. [Q8VI24-1 ]
UniGenei Mm.145599.

3D structure databases

ProteinModelPortali Q8VI24.
SMRi Q8VI24. Positions 57-157, 165-231, 350-437, 473-560, 615-674.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229351. 6 interactions.
DIPi DIP-60021N.
IntActi Q8VI24. 1 interaction.

PTM databases

PhosphoSitei Q8VI24.

Proteomic databases

MaxQBi Q8VI24.
PaxDbi Q8VI24.
PRIDEi Q8VI24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042857 ; ENSMUSP00000046067 ; ENSMUSG00000038331 . [Q8VI24-2 ]
ENSMUST00000114415 ; ENSMUSP00000110057 ; ENSMUSG00000038331 . [Q8VI24-1 ]
GeneIDi 212712.
KEGGi mmu:212712.
UCSCi uc007bas.1. mouse. [Q8VI24-1 ]
uc011wlc.1. mouse. [Q8VI24-2 ]

Organism-specific databases

CTDi 23314.
MGIi MGI:2679336. Satb2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG313826.
GeneTreei ENSGT00390000008096.
HOGENOMi HOG000004805.
HOVERGENi HBG054240.
InParanoidi Q8VI24.
OMAi PPAEDSC.
OrthoDBi EOG7FBRH5.
PhylomeDBi Q8VI24.
TreeFami TF332714.

Miscellaneous databases

ChiTaRSi Satb2. mouse.
NextBioi 373676.
PROi Q8VI24.
SOURCEi Search...

Gene expression databases

Bgeei Q8VI24.
CleanExi MM_SATB2.
ExpressionAtlasi Q8VI24. baseline and differential.
Genevestigatori Q8VI24.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 2 hits.
InterProi IPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 2 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 2 hits.
PROSITEi PS51042. CUT. 2 hits.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryonic tail.
  3. "SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation."
    Dobreva G., Chahrour M., Dautzenberg M., Chirivella L., Kanzler B., Farinas I., Karsenty G., Grosschedl R.
    Cell 125:971-986(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH ATF4 AND RUNX2, TISSUE SPECIFICITY.
  4. "Satb2 regulates callosal projection neuron identity in the developing cerebral cortex."
    Alcamo E.A., Chirivella L., Dautzenberg M., Dobreva G., Farinas I., Grosschedl R., McConnell S.K.
    Neuron 57:364-377(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  5. "Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex."
    Britanova O., de Juan Romero C., Cheung A., Kwan K.Y., Schwark M., Gyorgy A., Vogel T., Akopov S., Mitkovski M., Agoston D., Sestan N., Molnar Z., Tarabykin V.
    Neuron 57:378-392(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSATB2_MOUSE
AccessioniPrimary (citable) accession number: Q8VI24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3