Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VI23

- S12A8_MOUSE

UniProt

Q8VI23 - S12A8_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Solute carrier family 12 member 8

Gene

Slc12a8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.By similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. potassium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Symport, Transport

Keywords - Ligandi

Chloride, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 8
Alternative name(s):
Cation-chloride cotransporter 9
Gene namesi
Name:Slc12a8
Synonyms:Ccc9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2443672. Slc12a8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Solute carrier family 12 member 8PRO_0000305288Add
BLAST

Proteomic databases

PRIDEiQ8VI23.

PTM databases

PhosphoSiteiQ8VI23.

Expressioni

Gene expression databases

BgeeiQ8VI23.
ExpressionAtlasiQ8VI23. baseline and differential.
GenevestigatoriQ8VI23.

Structurei

3D structure databases

ProteinModelPortaliQ8VI23.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence AnalysisAdd
BLAST
Transmembranei587 – 60721HelicalSequence AnalysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000045198.
HOVERGENiHBG108430.
InParanoidiQ8VI23.
KOiK14428.
OMAiGRGPNKV.
OrthoDBiEOG7VB2DV.
PhylomeDBiQ8VI23.
TreeFamiTF313191.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VI23-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRSPQELF HEAAQQGILA QPQPWWKIQL FMWEPVLFGT WDGVFTSCMI
60 70 80 90 100
NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV VLVALITVLS GIGVAEHGGI
110 120 130 140 150
SSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYITGF AESISDLLGL
160 170 180 190 200
GDIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLLLLA VSTLDFVVGS
210 220 230 240 250
FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF
260 270 280 290 300
NMGGDLRDPA DSVPLGSLAA VGVSWFLYII FAFLLGAVCT REALRSDFLI
310 320 330 340 350
AEKVSLVGFL FLLGLYISSL ASCMGGLYGA PRILQCIAQD KVIPALAFLA
360 370 380 390 400
NGKGPNKTPV AAICLTSLVT MAFVLVGQVN VLAPVVTINF MLTYIMVDYS
410 420 430 440 450
YFALSMAHCG LAPSPEPVPR QGPDTLHCSE HLLQDRAPSY GSDVPARSLS
460 470 480 490 500
EGTLLEFTKD MDQFLQPIEE LESRQLGSRE GNNPKNQKRK GKKGAKQTLQ
510 520 530 540 550
DSFLLDPGSP LSFPTRTSER LSVAFCGEQE SYQKQQTSRS ESHDHLVPDL
560 570 580 590 600
RNQPRVNRED FFLKCRLQEQ EIQRRPSVFY ACMCNPWVSL LGALASLLIM
610 620 630 640 650
FVIQWLYTLA SMGVAALVYF YIGQASPGLY LGSASNFSFF QWMKSFLVPS
660 670 680 690 700
CRSLRSAQEQ IILAPSPAKV DMAMTQLTQD NADFATRDRY HHSSFLSREQ

LMPPY
Length:705
Mass (Da):77,020
Last modified:October 2, 2007 - v2
Checksum:i0AF9193CB067D315
GO
Isoform 2 (identifier: Q8VI23-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAQRSP → MSQV

Show »
Length:703
Mass (Da):76,794
Checksum:i90FCDF8BF7ADF11E
GO
Isoform 3 (identifier: Q8VI23-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     304-352: Missing.

Note: No experimental confirmation available.

Show »
Length:625
Mass (Da):68,291
Checksum:iD0C2AED2F5DEBE7B
GO
Isoform 4 (identifier: Q8VI23-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.
     304-352: Missing.

Note: No experimental confirmation available.

Show »
Length:410
Mass (Da):45,717
Checksum:iCF8D2962EAAC808F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831L → P in AAL37178. 1 PublicationCurated
Sequence conflicti236 – 2361F → L in AAL37178. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 246246Missing in isoform 4. 1 PublicationVSP_028333Add
BLAST
Alternative sequencei1 – 3131Missing in isoform 3. 1 PublicationVSP_028334Add
BLAST
Alternative sequencei1 – 66MAQRSP → MSQV in isoform 2. 1 PublicationVSP_028335
Alternative sequencei304 – 35249Missing in isoform 3 and isoform 4. 2 PublicationsVSP_028336Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319951 mRNA. Translation: AAL37178.1.
AK165080 mRNA. Translation: BAE38029.1.
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
BC030926 mRNA. Translation: AAH30926.1.
CCDSiCCDS37317.1. [Q8VI23-3]
CCDS49834.1. [Q8VI23-1]
RefSeqiNP_001077371.1. NM_001083902.1. [Q8VI23-3]
NP_599012.2. NM_134251.2. [Q8VI23-1]
XP_006521883.1. XM_006521820.1. [Q8VI23-1]
UniGeneiMm.35253.

Genome annotation databases

EnsembliENSMUST00000059056; ENSMUSP00000062337; ENSMUSG00000035506. [Q8VI23-1]
ENSMUST00000119173; ENSMUSP00000113633; ENSMUSG00000035506. [Q8VI23-3]
ENSMUST00000121925; ENSMUSP00000112439; ENSMUSG00000035506. [Q8VI23-1]
GeneIDi171286.
KEGGimmu:171286.
UCSCiuc007zad.1. mouse. [Q8VI23-1]
uc007zae.1. mouse. [Q8VI23-3]
uc007zag.1. mouse. [Q8VI23-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319951 mRNA. Translation: AAL37178.1 .
AK165080 mRNA. Translation: BAE38029.1 .
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
BC030926 mRNA. Translation: AAH30926.1 .
CCDSi CCDS37317.1. [Q8VI23-3 ]
CCDS49834.1. [Q8VI23-1 ]
RefSeqi NP_001077371.1. NM_001083902.1. [Q8VI23-3 ]
NP_599012.2. NM_134251.2. [Q8VI23-1 ]
XP_006521883.1. XM_006521820.1. [Q8VI23-1 ]
UniGenei Mm.35253.

3D structure databases

ProteinModelPortali Q8VI23.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VI23.

Proteomic databases

PRIDEi Q8VI23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059056 ; ENSMUSP00000062337 ; ENSMUSG00000035506 . [Q8VI23-1 ]
ENSMUST00000119173 ; ENSMUSP00000113633 ; ENSMUSG00000035506 . [Q8VI23-3 ]
ENSMUST00000121925 ; ENSMUSP00000112439 ; ENSMUSG00000035506 . [Q8VI23-1 ]
GeneIDi 171286.
KEGGi mmu:171286.
UCSCi uc007zad.1. mouse. [Q8VI23-1 ]
uc007zae.1. mouse. [Q8VI23-3 ]
uc007zag.1. mouse. [Q8VI23-4 ]

Organism-specific databases

CTDi 84561.
MGIi MGI:2443672. Slc12a8.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119053.
HOGENOMi HOG000045198.
HOVERGENi HBG108430.
InParanoidi Q8VI23.
KOi K14428.
OMAi GRGPNKV.
OrthoDBi EOG7VB2DV.
PhylomeDBi Q8VI23.
TreeFami TF313191.

Miscellaneous databases

NextBioi 370967.
PROi Q8VI23.
SOURCEi Search...

Gene expression databases

Bgeei Q8VI23.
ExpressionAtlasi Q8VI23. baseline and differential.
Genevestigatori Q8VI23.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of mouse CCC9 (SLC12A9), a new member of the cation-chloride cotransporter gene family."
    Mount D.B.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Ovary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiS12A8_MOUSE
AccessioniPrimary (citable) accession number: Q8VI23
Secondary accession number(s): Q3TNQ9, Q8K0M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3