SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VI23

- S12A8_MOUSE

UniProt

Q8VI23 - S12A8_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Solute carrier family 12 member 8
Gene
Slc12a8, Ccc9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation By similarity.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. potassium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Symport, Transport

Keywords - Ligandi

Chloride, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 8
Alternative name(s):
Cation-chloride cotransporter 9
Gene namesi
Name:Slc12a8
Synonyms:Ccc9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2443672. Slc12a8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821Helical; Reviewed prediction
Add
BLAST
Transmembranei69 – 8921Helical; Reviewed prediction
Add
BLAST
Transmembranei92 – 11221Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei181 – 20121Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei306 – 32621Helical; Reviewed prediction
Add
BLAST
Transmembranei368 – 38821Helical; Reviewed prediction
Add
BLAST
Transmembranei390 – 41021Helical; Reviewed prediction
Add
BLAST
Transmembranei587 – 60721Helical; Reviewed prediction
Add
BLAST
Transmembranei612 – 63221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Solute carrier family 12 member 8
PRO_0000305288Add
BLAST

Proteomic databases

PRIDEiQ8VI23.

PTM databases

PhosphoSiteiQ8VI23.

Expressioni

Gene expression databases

ArrayExpressiQ8VI23.
BgeeiQ8VI23.
GenevestigatoriQ8VI23.

Structurei

3D structure databases

ProteinModelPortaliQ8VI23.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00560000076892.
HOGENOMiHOG000045198.
HOVERGENiHBG108430.
InParanoidiQ8VI23.
KOiK14428.
OMAiGRGPNKV.
OrthoDBiEOG7VB2DV.
PhylomeDBiQ8VI23.
TreeFamiTF313191.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VI23-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQRSPQELF HEAAQQGILA QPQPWWKIQL FMWEPVLFGT WDGVFTSCMI    50
NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV VLVALITVLS GIGVAEHGGI 100
SSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYITGF AESISDLLGL 150
GDIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLLLLA VSTLDFVVGS 200
FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF 250
NMGGDLRDPA DSVPLGSLAA VGVSWFLYII FAFLLGAVCT REALRSDFLI 300
AEKVSLVGFL FLLGLYISSL ASCMGGLYGA PRILQCIAQD KVIPALAFLA 350
NGKGPNKTPV AAICLTSLVT MAFVLVGQVN VLAPVVTINF MLTYIMVDYS 400
YFALSMAHCG LAPSPEPVPR QGPDTLHCSE HLLQDRAPSY GSDVPARSLS 450
EGTLLEFTKD MDQFLQPIEE LESRQLGSRE GNNPKNQKRK GKKGAKQTLQ 500
DSFLLDPGSP LSFPTRTSER LSVAFCGEQE SYQKQQTSRS ESHDHLVPDL 550
RNQPRVNRED FFLKCRLQEQ EIQRRPSVFY ACMCNPWVSL LGALASLLIM 600
FVIQWLYTLA SMGVAALVYF YIGQASPGLY LGSASNFSFF QWMKSFLVPS 650
CRSLRSAQEQ IILAPSPAKV DMAMTQLTQD NADFATRDRY HHSSFLSREQ 700
LMPPY 705
Length:705
Mass (Da):77,020
Last modified:October 2, 2007 - v2
Checksum:i0AF9193CB067D315
GO
Isoform 2 (identifier: Q8VI23-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAQRSP → MSQV

Show »
Length:703
Mass (Da):76,794
Checksum:i90FCDF8BF7ADF11E
GO
Isoform 3 (identifier: Q8VI23-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     304-352: Missing.

Note: No experimental confirmation available.

Show »
Length:625
Mass (Da):68,291
Checksum:iD0C2AED2F5DEBE7B
GO
Isoform 4 (identifier: Q8VI23-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.
     304-352: Missing.

Note: No experimental confirmation available.

Show »
Length:410
Mass (Da):45,717
Checksum:iCF8D2962EAAC808F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 246246Missing in isoform 4.
VSP_028333Add
BLAST
Alternative sequencei1 – 3131Missing in isoform 3.
VSP_028334Add
BLAST
Alternative sequencei1 – 66MAQRSP → MSQV in isoform 2.
VSP_028335
Alternative sequencei304 – 35249Missing in isoform 3 and isoform 4.
VSP_028336Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831L → P in AAL37178. 1 Publication
Sequence conflicti236 – 2361F → L in AAL37178. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319951 mRNA. Translation: AAL37178.1.
AK165080 mRNA. Translation: BAE38029.1.
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
BC030926 mRNA. Translation: AAH30926.1.
CCDSiCCDS37317.1. [Q8VI23-3]
CCDS49834.1. [Q8VI23-1]
RefSeqiNP_001077371.1. NM_001083902.1. [Q8VI23-3]
NP_599012.2. NM_134251.2. [Q8VI23-1]
XP_006521883.1. XM_006521820.1. [Q8VI23-1]
UniGeneiMm.35253.

Genome annotation databases

EnsembliENSMUST00000059056; ENSMUSP00000062337; ENSMUSG00000035506. [Q8VI23-1]
ENSMUST00000119173; ENSMUSP00000113633; ENSMUSG00000035506. [Q8VI23-3]
ENSMUST00000121925; ENSMUSP00000112439; ENSMUSG00000035506. [Q8VI23-1]
GeneIDi171286.
KEGGimmu:171286.
UCSCiuc007zad.1. mouse. [Q8VI23-1]
uc007zae.1. mouse. [Q8VI23-3]
uc007zag.1. mouse. [Q8VI23-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319951 mRNA. Translation: AAL37178.1 .
AK165080 mRNA. Translation: BAE38029.1 .
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
BC030926 mRNA. Translation: AAH30926.1 .
CCDSi CCDS37317.1. [Q8VI23-3 ]
CCDS49834.1. [Q8VI23-1 ]
RefSeqi NP_001077371.1. NM_001083902.1. [Q8VI23-3 ]
NP_599012.2. NM_134251.2. [Q8VI23-1 ]
XP_006521883.1. XM_006521820.1. [Q8VI23-1 ]
UniGenei Mm.35253.

3D structure databases

ProteinModelPortali Q8VI23.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VI23.

Proteomic databases

PRIDEi Q8VI23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059056 ; ENSMUSP00000062337 ; ENSMUSG00000035506 . [Q8VI23-1 ]
ENSMUST00000119173 ; ENSMUSP00000113633 ; ENSMUSG00000035506 . [Q8VI23-3 ]
ENSMUST00000121925 ; ENSMUSP00000112439 ; ENSMUSG00000035506 . [Q8VI23-1 ]
GeneIDi 171286.
KEGGi mmu:171286.
UCSCi uc007zad.1. mouse. [Q8VI23-1 ]
uc007zae.1. mouse. [Q8VI23-3 ]
uc007zag.1. mouse. [Q8VI23-4 ]

Organism-specific databases

CTDi 84561.
MGIi MGI:2443672. Slc12a8.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00560000076892.
HOGENOMi HOG000045198.
HOVERGENi HBG108430.
InParanoidi Q8VI23.
KOi K14428.
OMAi GRGPNKV.
OrthoDBi EOG7VB2DV.
PhylomeDBi Q8VI23.
TreeFami TF313191.

Miscellaneous databases

NextBioi 370967.
PROi Q8VI23.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VI23.
Bgeei Q8VI23.
Genevestigatori Q8VI23.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of mouse CCC9 (SLC12A9), a new member of the cation-chloride cotransporter gene family."
    Mount D.B.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Ovary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiS12A8_MOUSE
AccessioniPrimary (citable) accession number: Q8VI23
Secondary accession number(s): Q3TNQ9, Q8K0M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi