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Q8VI23

- S12A8_MOUSE

UniProt

Q8VI23 - S12A8_MOUSE

Protein

Solute carrier family 12 member 8

Gene

Slc12a8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. potassium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Potassium transport, Symport, Transport

    Keywords - Ligandi

    Chloride, Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 12 member 8
    Alternative name(s):
    Cation-chloride cotransporter 9
    Gene namesi
    Name:Slc12a8
    Synonyms:Ccc9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2443672. Slc12a8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 705705Solute carrier family 12 member 8PRO_0000305288Add
    BLAST

    Proteomic databases

    PRIDEiQ8VI23.

    PTM databases

    PhosphoSiteiQ8VI23.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VI23.
    BgeeiQ8VI23.
    GenevestigatoriQ8VI23.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VI23.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei587 – 60721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei612 – 63221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC12A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00560000076892.
    HOGENOMiHOG000045198.
    HOVERGENiHBG108430.
    InParanoidiQ8VI23.
    KOiK14428.
    OMAiGRGPNKV.
    OrthoDBiEOG7VB2DV.
    PhylomeDBiQ8VI23.
    TreeFamiTF313191.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    [Graphical view]
    PfamiPF00324. AA_permease. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VI23-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQRSPQELF HEAAQQGILA QPQPWWKIQL FMWEPVLFGT WDGVFTSCMI    50
    NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV VLVALITVLS GIGVAEHGGI 100
    SSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYITGF AESISDLLGL 150
    GDIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLLLLA VSTLDFVVGS 200
    FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF 250
    NMGGDLRDPA DSVPLGSLAA VGVSWFLYII FAFLLGAVCT REALRSDFLI 300
    AEKVSLVGFL FLLGLYISSL ASCMGGLYGA PRILQCIAQD KVIPALAFLA 350
    NGKGPNKTPV AAICLTSLVT MAFVLVGQVN VLAPVVTINF MLTYIMVDYS 400
    YFALSMAHCG LAPSPEPVPR QGPDTLHCSE HLLQDRAPSY GSDVPARSLS 450
    EGTLLEFTKD MDQFLQPIEE LESRQLGSRE GNNPKNQKRK GKKGAKQTLQ 500
    DSFLLDPGSP LSFPTRTSER LSVAFCGEQE SYQKQQTSRS ESHDHLVPDL 550
    RNQPRVNRED FFLKCRLQEQ EIQRRPSVFY ACMCNPWVSL LGALASLLIM 600
    FVIQWLYTLA SMGVAALVYF YIGQASPGLY LGSASNFSFF QWMKSFLVPS 650
    CRSLRSAQEQ IILAPSPAKV DMAMTQLTQD NADFATRDRY HHSSFLSREQ 700
    LMPPY 705
    Length:705
    Mass (Da):77,020
    Last modified:October 2, 2007 - v2
    Checksum:i0AF9193CB067D315
    GO
    Isoform 2 (identifier: Q8VI23-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAQRSP → MSQV

    Show »
    Length:703
    Mass (Da):76,794
    Checksum:i90FCDF8BF7ADF11E
    GO
    Isoform 3 (identifier: Q8VI23-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-31: Missing.
         304-352: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:625
    Mass (Da):68,291
    Checksum:iD0C2AED2F5DEBE7B
    GO
    Isoform 4 (identifier: Q8VI23-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-246: Missing.
         304-352: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:410
    Mass (Da):45,717
    Checksum:iCF8D2962EAAC808F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1831L → P in AAL37178. 1 PublicationCurated
    Sequence conflicti236 – 2361F → L in AAL37178. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 246246Missing in isoform 4. 1 PublicationVSP_028333Add
    BLAST
    Alternative sequencei1 – 3131Missing in isoform 3. 1 PublicationVSP_028334Add
    BLAST
    Alternative sequencei1 – 66MAQRSP → MSQV in isoform 2. 1 PublicationVSP_028335
    Alternative sequencei304 – 35249Missing in isoform 3 and isoform 4. 2 PublicationsVSP_028336Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319951 mRNA. Translation: AAL37178.1.
    AK165080 mRNA. Translation: BAE38029.1.
    AC121570 Genomic DNA. No translation available.
    AC127412 Genomic DNA. No translation available.
    BC030926 mRNA. Translation: AAH30926.1.
    CCDSiCCDS37317.1. [Q8VI23-3]
    CCDS49834.1. [Q8VI23-1]
    RefSeqiNP_001077371.1. NM_001083902.1. [Q8VI23-3]
    NP_599012.2. NM_134251.2. [Q8VI23-1]
    XP_006521883.1. XM_006521820.1. [Q8VI23-1]
    UniGeneiMm.35253.

    Genome annotation databases

    EnsembliENSMUST00000059056; ENSMUSP00000062337; ENSMUSG00000035506. [Q8VI23-1]
    ENSMUST00000119173; ENSMUSP00000113633; ENSMUSG00000035506. [Q8VI23-3]
    ENSMUST00000121925; ENSMUSP00000112439; ENSMUSG00000035506. [Q8VI23-1]
    GeneIDi171286.
    KEGGimmu:171286.
    UCSCiuc007zad.1. mouse. [Q8VI23-1]
    uc007zae.1. mouse. [Q8VI23-3]
    uc007zag.1. mouse. [Q8VI23-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319951 mRNA. Translation: AAL37178.1 .
    AK165080 mRNA. Translation: BAE38029.1 .
    AC121570 Genomic DNA. No translation available.
    AC127412 Genomic DNA. No translation available.
    BC030926 mRNA. Translation: AAH30926.1 .
    CCDSi CCDS37317.1. [Q8VI23-3 ]
    CCDS49834.1. [Q8VI23-1 ]
    RefSeqi NP_001077371.1. NM_001083902.1. [Q8VI23-3 ]
    NP_599012.2. NM_134251.2. [Q8VI23-1 ]
    XP_006521883.1. XM_006521820.1. [Q8VI23-1 ]
    UniGenei Mm.35253.

    3D structure databases

    ProteinModelPortali Q8VI23.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8VI23.

    Proteomic databases

    PRIDEi Q8VI23.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059056 ; ENSMUSP00000062337 ; ENSMUSG00000035506 . [Q8VI23-1 ]
    ENSMUST00000119173 ; ENSMUSP00000113633 ; ENSMUSG00000035506 . [Q8VI23-3 ]
    ENSMUST00000121925 ; ENSMUSP00000112439 ; ENSMUSG00000035506 . [Q8VI23-1 ]
    GeneIDi 171286.
    KEGGi mmu:171286.
    UCSCi uc007zad.1. mouse. [Q8VI23-1 ]
    uc007zae.1. mouse. [Q8VI23-3 ]
    uc007zag.1. mouse. [Q8VI23-4 ]

    Organism-specific databases

    CTDi 84561.
    MGIi MGI:2443672. Slc12a8.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00560000076892.
    HOGENOMi HOG000045198.
    HOVERGENi HBG108430.
    InParanoidi Q8VI23.
    KOi K14428.
    OMAi GRGPNKV.
    OrthoDBi EOG7VB2DV.
    PhylomeDBi Q8VI23.
    TreeFami TF313191.

    Miscellaneous databases

    NextBioi 370967.
    PROi Q8VI23.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VI23.
    Bgeei Q8VI23.
    Genevestigatori Q8VI23.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    [Graphical view ]
    Pfami PF00324. AA_permease. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of mouse CCC9 (SLC12A9), a new member of the cation-chloride cotransporter gene family."
      Mount D.B.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: C57BL/6J.
      Tissue: Ovary.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiS12A8_MOUSE
    AccessioniPrimary (citable) accession number: Q8VI23
    Secondary accession number(s): Q3TNQ9, Q8K0M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3