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Protein

Solute carrier family 12 member 8

Gene

Slc12a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Symport, Transport

Keywords - Ligandi

Chloride, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 8
Alternative name(s):
Cation-chloride cotransporter 9
Gene namesi
Name:Slc12a8
Synonyms:Ccc9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443672. Slc12a8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052881 – 705Solute carrier family 12 member 8Add BLAST705

Proteomic databases

PaxDbiQ8VI23.
PRIDEiQ8VI23.

PTM databases

iPTMnetiQ8VI23.
PhosphoSitePlusiQ8VI23.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035506.
ExpressionAtlasiQ8VI23. baseline and differential.
GenevisibleiQ8VI23. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062337.

Structurei

3D structure databases

ProteinModelPortaliQ8VI23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000045198.
HOVERGENiHBG108430.
InParanoidiQ8VI23.
KOiK14428.
OMAiTKNWYSG.
OrthoDBiEOG091G02VO.
PhylomeDBiQ8VI23.
TreeFamiTF313191.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VI23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRSPQELF HEAAQQGILA QPQPWWKIQL FMWEPVLFGT WDGVFTSCMI
60 70 80 90 100
NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV VLVALITVLS GIGVAEHGGI
110 120 130 140 150
SSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYITGF AESISDLLGL
160 170 180 190 200
GDIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLLLLA VSTLDFVVGS
210 220 230 240 250
FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF
260 270 280 290 300
NMGGDLRDPA DSVPLGSLAA VGVSWFLYII FAFLLGAVCT REALRSDFLI
310 320 330 340 350
AEKVSLVGFL FLLGLYISSL ASCMGGLYGA PRILQCIAQD KVIPALAFLA
360 370 380 390 400
NGKGPNKTPV AAICLTSLVT MAFVLVGQVN VLAPVVTINF MLTYIMVDYS
410 420 430 440 450
YFALSMAHCG LAPSPEPVPR QGPDTLHCSE HLLQDRAPSY GSDVPARSLS
460 470 480 490 500
EGTLLEFTKD MDQFLQPIEE LESRQLGSRE GNNPKNQKRK GKKGAKQTLQ
510 520 530 540 550
DSFLLDPGSP LSFPTRTSER LSVAFCGEQE SYQKQQTSRS ESHDHLVPDL
560 570 580 590 600
RNQPRVNRED FFLKCRLQEQ EIQRRPSVFY ACMCNPWVSL LGALASLLIM
610 620 630 640 650
FVIQWLYTLA SMGVAALVYF YIGQASPGLY LGSASNFSFF QWMKSFLVPS
660 670 680 690 700
CRSLRSAQEQ IILAPSPAKV DMAMTQLTQD NADFATRDRY HHSSFLSREQ

LMPPY
Length:705
Mass (Da):77,020
Last modified:October 2, 2007 - v2
Checksum:i0AF9193CB067D315
GO
Isoform 2 (identifier: Q8VI23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAQRSP → MSQV

Show »
Length:703
Mass (Da):76,794
Checksum:i90FCDF8BF7ADF11E
GO
Isoform 3 (identifier: Q8VI23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     304-352: Missing.

Note: No experimental confirmation available.
Show »
Length:625
Mass (Da):68,291
Checksum:iD0C2AED2F5DEBE7B
GO
Isoform 4 (identifier: Q8VI23-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.
     304-352: Missing.

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):45,717
Checksum:iCF8D2962EAAC808F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183L → P in AAL37178 (Ref. 1) Curated1
Sequence conflicti236F → L in AAL37178 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0283331 – 246Missing in isoform 4. 1 PublicationAdd BLAST246
Alternative sequenceiVSP_0283341 – 31Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0283351 – 6MAQRSP → MSQV in isoform 2. 1 Publication6
Alternative sequenceiVSP_028336304 – 352Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319951 mRNA. Translation: AAL37178.1.
AK165080 mRNA. Translation: BAE38029.1.
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
BC030926 mRNA. Translation: AAH30926.1.
CCDSiCCDS37317.1. [Q8VI23-3]
CCDS49834.1. [Q8VI23-1]
RefSeqiNP_001077371.1. NM_001083902.1. [Q8VI23-3]
NP_599012.2. NM_134251.2. [Q8VI23-1]
XP_006521883.1. XM_006521820.2. [Q8VI23-1]
UniGeneiMm.35253.

Genome annotation databases

EnsembliENSMUST00000059056; ENSMUSP00000062337; ENSMUSG00000035506. [Q8VI23-1]
ENSMUST00000119173; ENSMUSP00000113633; ENSMUSG00000035506. [Q8VI23-3]
ENSMUST00000121925; ENSMUSP00000112439; ENSMUSG00000035506. [Q8VI23-1]
GeneIDi171286.
KEGGimmu:171286.
UCSCiuc007zad.1. mouse. [Q8VI23-1]
uc007zae.1. mouse. [Q8VI23-3]
uc007zag.1. mouse. [Q8VI23-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319951 mRNA. Translation: AAL37178.1.
AK165080 mRNA. Translation: BAE38029.1.
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
BC030926 mRNA. Translation: AAH30926.1.
CCDSiCCDS37317.1. [Q8VI23-3]
CCDS49834.1. [Q8VI23-1]
RefSeqiNP_001077371.1. NM_001083902.1. [Q8VI23-3]
NP_599012.2. NM_134251.2. [Q8VI23-1]
XP_006521883.1. XM_006521820.2. [Q8VI23-1]
UniGeneiMm.35253.

3D structure databases

ProteinModelPortaliQ8VI23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062337.

PTM databases

iPTMnetiQ8VI23.
PhosphoSitePlusiQ8VI23.

Proteomic databases

PaxDbiQ8VI23.
PRIDEiQ8VI23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059056; ENSMUSP00000062337; ENSMUSG00000035506. [Q8VI23-1]
ENSMUST00000119173; ENSMUSP00000113633; ENSMUSG00000035506. [Q8VI23-3]
ENSMUST00000121925; ENSMUSP00000112439; ENSMUSG00000035506. [Q8VI23-1]
GeneIDi171286.
KEGGimmu:171286.
UCSCiuc007zad.1. mouse. [Q8VI23-1]
uc007zae.1. mouse. [Q8VI23-3]
uc007zag.1. mouse. [Q8VI23-4]

Organism-specific databases

CTDi84561.
MGIiMGI:2443672. Slc12a8.

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000045198.
HOVERGENiHBG108430.
InParanoidiQ8VI23.
KOiK14428.
OMAiTKNWYSG.
OrthoDBiEOG091G02VO.
PhylomeDBiQ8VI23.
TreeFamiTF313191.

Miscellaneous databases

PROiQ8VI23.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035506.
ExpressionAtlasiQ8VI23. baseline and differential.
GenevisibleiQ8VI23. MM.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS12A8_MOUSE
AccessioniPrimary (citable) accession number: Q8VI23
Secondary accession number(s): Q3TNQ9, Q8K0M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.