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Protein

U3 small nucleolar ribonucleoprotein protein IMP4

Gene

Imp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name:
U3 snoRNP protein IMP4
Gene namesi
Name:Imp4
Synonyms:D1Wsu40e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:106572. Imp4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291U3 small nucleolar ribonucleoprotein protein IMP4PRO_0000120237Add
BLAST

Proteomic databases

EPDiQ8VHZ7.
MaxQBiQ8VHZ7.
PaxDbiQ8VHZ7.
PeptideAtlasiQ8VHZ7.
PRIDEiQ8VHZ7.

PTM databases

PhosphoSiteiQ8VHZ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026127.
ExpressionAtlasiQ8VHZ7. baseline and differential.
GenevisibleiQ8VHZ7. MM.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205703. 2 interactions.
IntActiQ8VHZ7. 1 interaction.
STRINGi10090.ENSMUSP00000027303.

Structurei

3D structure databases

ProteinModelPortaliQ8VHZ7.
SMRiQ8VHZ7. Positions 84-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 264182BrixPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 4846Arg/Glu/Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2781. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
HOVERGENiHBG056795.
InParanoidiQ8VHZ7.
KOiK14561.
OMAiRFEMKPY.
OrthoDBiEOG091G0GP1.
PhylomeDBiQ8VHZ7.
TreeFamiTF300016.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRREARLRR EYLYRKAREE AQRSVQEKKE RVKRALEENQ LIPTELRREA
60 70 80 90 100
LALQGSLEFD DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF
110 120 130 140 150
AKELKLVFPG AQRMNRGRHE VGALVRACKA NGVTDLLVVH EHRGTPVGLI
160 170 180 190 200
VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS EAKPHLITHG FSSRLGKRVS
210 220 230 240 250
DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR NVELTEVGPR
260 270 280 290
FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLSA E
Length:291
Mass (Da):33,656
Last modified:March 1, 2002 - v1
Checksum:i5AFF74AA16E0C7BC
GO

Sequence cautioni

The sequence BAB26989 differs from that shown. Reason: Frameshift at position 249. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 232QR → HG in BAB28797 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334609 mRNA. Translation: AAL73190.1.
AK010504 mRNA. Translation: BAB26989.1. Frameshift.
AK013334 mRNA. Translation: BAB28797.1.
AK084933 mRNA. Translation: BAC39313.1.
AK151176 mRNA. Translation: BAE30178.1.
AK152214 mRNA. Translation: BAE31042.1.
AK166903 mRNA. Translation: BAE39105.1.
BC037602 mRNA. Translation: AAH37602.1.
BC069930 mRNA. Translation: AAH69930.1.
CCDSiCCDS35536.1.
RefSeqiNP_848716.2. NM_178601.3.
UniGeneiMm.289667.

Genome annotation databases

EnsembliENSMUST00000027303; ENSMUSP00000027303; ENSMUSG00000026127.
GeneIDi27993.
KEGGimmu:27993.
UCSCiuc007aor.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334609 mRNA. Translation: AAL73190.1.
AK010504 mRNA. Translation: BAB26989.1. Frameshift.
AK013334 mRNA. Translation: BAB28797.1.
AK084933 mRNA. Translation: BAC39313.1.
AK151176 mRNA. Translation: BAE30178.1.
AK152214 mRNA. Translation: BAE31042.1.
AK166903 mRNA. Translation: BAE39105.1.
BC037602 mRNA. Translation: AAH37602.1.
BC069930 mRNA. Translation: AAH69930.1.
CCDSiCCDS35536.1.
RefSeqiNP_848716.2. NM_178601.3.
UniGeneiMm.289667.

3D structure databases

ProteinModelPortaliQ8VHZ7.
SMRiQ8VHZ7. Positions 84-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205703. 2 interactions.
IntActiQ8VHZ7. 1 interaction.
STRINGi10090.ENSMUSP00000027303.

PTM databases

PhosphoSiteiQ8VHZ7.

Proteomic databases

EPDiQ8VHZ7.
MaxQBiQ8VHZ7.
PaxDbiQ8VHZ7.
PeptideAtlasiQ8VHZ7.
PRIDEiQ8VHZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027303; ENSMUSP00000027303; ENSMUSG00000026127.
GeneIDi27993.
KEGGimmu:27993.
UCSCiuc007aor.2. mouse.

Organism-specific databases

CTDi92856.
MGIiMGI:106572. Imp4.

Phylogenomic databases

eggNOGiKOG2781. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
HOVERGENiHBG056795.
InParanoidiQ8VHZ7.
KOiK14561.
OMAiRFEMKPY.
OrthoDBiEOG091G0GP1.
PhylomeDBiQ8VHZ7.
TreeFamiTF300016.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ8VHZ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026127.
ExpressionAtlasiQ8VHZ7. baseline and differential.
GenevisibleiQ8VHZ7. MM.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMP4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHZ7
Secondary accession number(s): Q3U8H6
, Q8CI42, Q9CWN6, Q9CYT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.