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Q8VHY0

- CSPG4_MOUSE

UniProt

Q8VHY0 - CSPG4_MOUSE

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Protein

Chondroitin sulfate proteoglycan 4

Gene
Cspg4, An2, Kiaa4232, Ng2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. angiogenesis Source: UniProtKB-KW
  3. cell proliferation Source: MGI
  4. glial cell migration Source: MGI
  5. intracellular signal transduction Source: Ensembl
  6. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  7. tissue remodeling Source: UniProtKB-KW
  8. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Transducer

Keywords - Biological processi

Angiogenesis, Differentiation, Tissue remodeling

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_198981. CS/DS degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 4
Alternative name(s):
Chondroitin sulfate proteoglycan NG2
Proteoglycan AN2
Gene namesi
Name:Cspg4
Synonyms:An2, Kiaa4232, Ng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2153093. Cspg4.

Subcellular locationi

Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projectionlamellipodium membrane; Single-pass type I membrane protein; Extracellular side
Note: Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. A fraction may undergo cell surface proteolysis and secretion By similarity. Localizes to the plasma membrane of oligodendrocytes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 22292200Extracellular Reviewed predictionAdd
BLAST
Transmembranei2230 – 225021Helical; Reviewed predictionAdd
BLAST
Topological domaini2251 – 232777Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. lamellipodium membrane Source: UniProtKB-SubCell
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are unresponsive to PDGF-AA through PDGF-alpha receptor.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2324 – 23241Q → G: No effect on interaction with GRIP1 and GRIP2. 1 Publication
Mutagenesisi2325 – 23251Y → F: No effect on interaction with GRIP1 and GRIP2. 1 Publication
Mutagenesisi2325 – 23251Y → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication
Mutagenesisi2326 – 23261W → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication
Mutagenesisi2327 – 23271V → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 23272298Chondroitin sulfate proteoglycan 4PRO_0000041963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...)1 Publication
Disulfide bondi170 ↔ 193 By similarity
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi355 ↔ 381 By similarity
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi686 – 6861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi773 – 7731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1000 – 10001O-linked (Xyl...) (chondroitin sulfate) By similarity
Glycosylationi1136 – 11361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1207 – 12071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1369 – 13691N-linked (GlcNAc...)1 Publication
Glycosylationi1454 – 14541N-linked (GlcNAc...)1 Publication
Glycosylationi1650 – 16501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1914 – 19141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2021 – 20211N-linked (GlcNAc...)1 Publication
Glycosylationi2039 – 20391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2045 – 20451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2080 – 20801N-linked (GlcNAc...)1 Publication
Modified residuei2257 – 22571Phosphothreonine; by PKC/PRKCA By similarity

Post-translational modificationi

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation. Involved in interaction with MMP16 and ITGA4 By similarity.
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ8VHY0.
PRIDEiQ8VHY0.

PTM databases

PhosphoSiteiQ8VHY0.

Expressioni

Tissue specificityi

Expressed in microcascular pericytes and not endothelial cells.1 Publication

Gene expression databases

ArrayExpressiQ8VHY0.
CleanExiMM_CSPG4.
GenevestigatoriQ8VHY0.

Interactioni

Subunit structurei

Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16. Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA By similarity. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gria2P238192EBI-8327479,EBI-77538
Grip1Q925T67EBI-8327479,EBI-537752
Grip2Q9WTW12EBI-8327479,EBI-936045From a different organism.

Protein-protein interaction databases

IntActiQ8VHY0. 5 interactions.
MINTiMINT-1787512.

Structurei

3D structure databases

ProteinModelPortaliQ8VHY0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 193164Laminin G-like 1Add
BLAST
Domaini203 – 381179Laminin G-like 2Add
BLAST
Repeati431 – 52494CSPG 1Add
BLAST
Repeati557 – 64488CSPG 2Add
BLAST
Repeati666 – 765100CSPG 3Add
BLAST
Repeati793 – 88391CSPG 4Add
BLAST
Repeati905 – 99490CSPG 5Add
BLAST
Repeati1025 – 111389CSPG 6Add
BLAST
Repeati1133 – 122189CSPG 7Add
BLAST
Repeati1246 – 134297CSPG 8Add
BLAST
Repeati1365 – 145490CSPG 9Add
BLAST
Repeati1481 – 156686CSPG 10Add
BLAST
Repeati1588 – 168497CSPG 11Add
BLAST
Repeati1712 – 180897CSPG 12Add
BLAST
Repeati1840 – 192788CSPG 13Add
BLAST
Repeati1949 – 203486CSPG 14Add
BLAST
Repeati2053 – 2152100CSPG 15Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 640611Globular or compact configuration stabilized by disulfide bondsAdd
BLAST
Regioni30 – 640611Neurite growth inhibition By similarityAdd
BLAST
Regioni575 – 1045471Interaction with COL6A2 By similarityAdd
BLAST
Regioni632 – 1451820Interaction with COL5A1 By similarityAdd
BLAST
Regioni1591 – 2226636Neurite growth inhibition By similarityAdd
BLAST
Regioni1592 – 2226635Cysteine-containingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2325 – 23273PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi640 – 1591952Gly/Ser-rich (glycosaminoglycan attachment domain)Add
BLAST

Sequence similaritiesi

Contains 15 CSPG (NG2) repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG261397.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000170195.
HOVERGENiHBG081360.
InParanoidiQ8VHY0.
KOiK08115.
OMAiRPIYRFT.
OrthoDBiEOG77DJ56.
TreeFamiTF316876.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VHY0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLGPGHPLS APALALALTL ALLVRSTAPA SFFGENHLEV PVPSALTRVD     50
LLLQFSTSQP EALLLLAAGQ DDHLLLQLHS GCLQVRLALG QKELKLQTPA 100
DTVLSDSAPH TVVLTVSDSW AVLSVDGVLN TSAPIPRASH LKATYGLFVG 150
SSGSLDLPYL KGISRPLRGC LHSAILNGRN LLRPLTSDVH EGCAEEFSAG 200
DEVGLGFSGP HSLAAFPAWS TREEGTLEFT LTTRSQQAPL AFQAGDKRGN 250
FIYVDIFEGH LRAVVEKGQG TMLLRNSVPV ADGQPHEVSV HIDVHRLEIS 300
VDQYPTRTFN RGVLSYLEPR GSLLLGGLDT EASRHLQEHR LGLAPGAANI 350
SLVGCIEDFS VNGRRQGLRD AWLTRDMSAG CRPEEDEYEE EVYGPYETFS 400
TLAPEAWPAM ELPEPCIPEP GLPAVFANFT QLLTISPLVV AEGGTAWLEW 450
RHVQPTLDLT EAELRKSQVL FSVSQSARHG DLELDILGAQ TRKMFTLLDV 500
VNRKARFVHD GSEDTSDQLM LEVSVTARAP VPSCLRRGQI YILPIQVNPV 550
NDPPRIIFPH GSLMVILEHT QKPLGPEIFQ AYDPDSACEG LTFQLLGVSS 600
GVPVEHRDQP GEPATEFSCR ELEVGDIVYV HRGGPAQDLT FRVSDGMQAS 650
APATLKVVAV RPAIQILHNT GLHLAQGSAA AILPANLSVE TNAVGQDVSV 700
LFRVTGTLQF GELQKQGAGG VEGTEWWDTL AFHQRDVEQG RVRYLSTDPQ 750
HHTQDTVEDL ILEVQVGQET LSNLSFPVTI QRATVWMLRL EPLHTQNPHQ 800
ETLTPAHLEA SLEEEEEEGS PQPHTFHYEL VQAPRRGNLL LQGTRLSDGE 850
SFSQSDLQAG RVTYRATMRT SEAADDSFRF RVTSPPHFSP LYTFPIHIGG 900
DPNAPVLTNV LLMVPEGGEG VLSADHLFVK SLNSASYLYE VMEQPHHGKL 950
AWRDPKGKST PVTSFTNEDL LHGRLVYQHD DSETIEDDIP FVATRQGEGS 1000
GDMAWEEVRG VFRVAIQPVN DHAPVQTISR VFHVARGGQR LLTTDDVAFS 1050
DADSGFSDAQ LVLTRKDLLF GSIVAMEEPT RPIYRFTQED LRKKQVLFVH 1100
SGADHGWLQL QVSDGQHQAT AMLEVQASEP YLHVANSSSL VVPQGGQGTI 1150
DTAVLQLDTN LDIRSGNEVH YHVTAGPQWG QLLRDGQSVT SFSQRDLLDG 1200
AILYSHNGSL SPQDTLAFSV AAGPVHTNTF LQVTIALEGP LAPLQLVQHK 1250
KIYVFQGEAA EIRRDQLEVV QEAVLPADIM FSLRSPPNAG YLVMVSHGAS 1300
AEEPPSLDPV QSFSQEAVNS GRVLYLHSRP GAWSDSFSLD VASGLGDPLE 1350
GISVELEVLP TVIPLDVQNF SVPEGGTRTL APPLVQITGP YFPTLPGLVL 1400
QVLEPPQHGA LQKEDHSQDG SLSTFSWREV EEQLIRYVHD GSETQTDAFV 1450
LLANASEMDR QSQPVAFTIT ILPVNDQPPV LTTNTGLQIW EGAIVPIPPE 1500
ALRGTDNDSG PEDLVYTIEQ PSNGRIALRV APDTEVHRFT QAQLDSGLVL 1550
FSHRGALEGG FHFDLSDGAH TSPGHFFRVV AQKQALLSLE GTRKLTVCPE 1600
SVQPLSSQSL SASSSTGADP RHLLYRVVRG PQLGRLLHAQ QGSAEEVLVN 1650
FTQAEVNAGN ILYEHEMSSE PFWEAHDTIG LLLSSPPARD LAATLAVMVS 1700
FDAACPQRPS RLWKNKGLWV PEGQRAKITV AALDAANLLA SVPASQRSRH 1750
DVLFQVTQFP TRGQLLVSEE PLHARRPYFL QSELAAGQLV YAHGGGGTQQ 1800
DGFRFRAHLQ GPTGTSVAGP QTSEAFVITV RDVNERPPQP QASIPLRVTR 1850
GSRAPVSRAQ LSVVDPDSAP GEIEYEVQRA PHNGFLSLAG DNTGPVTHFT 1900
QADVDAGRLA FVANGSSVAG VFQLSMSDGA SPPIPMSLAV DVLPSTIEVQ 1950
LRAPLEVPQA LGRTSLSRQQ LQVISDREEP DVAYRLTQGP LYGQLLVGGQ 2000
PASAFSQLQV DQGDVVFVFT NFSSSQDHFK VVALARGVNA SATVNVTVQA 2050
LLHVWAGGPW PQGTTLRLDP TVLDASELAN RTGSMPHFRL LAGPRYGRVV 2100
RVSQGRTESR SNQLVEHFTQ RDLEEGQLGL EVGKPEGRST GPAGDRLTLE 2150
LWAKGVPPAV ALLDFATEPY HAAKSYSVAL LSVPEAVRTE TEKPGRSVPT 2200
GQPGQAASSP VPTAAKGGFL GFLEANMFSI IIPVCLILLL LALILPLLFY 2250
LRKRNKTGKH DVQVLTAKPR NGLAGDTETF RKVEPGQAIP LITVPGQGPP 2300
PGGQPDPELL QFCRTPNPAL RNGQYWV 2327
Length:2,327
Mass (Da):252,309
Last modified:October 3, 2012 - v3
Checksum:iC101DF60FCE3A7BC
GO
Isoform 2 (identifier: Q8VHY0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1666: Missing.

Note: No experimental confirmation available.

Show »
Length:661
Mass (Da):70,843
Checksum:iDA679F6CCF894532
GO
Isoform 3 (identifier: Q8VHY0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1657-1694: NAGNILYEHE...SPPARDLAAT → RASLLSHHTD...ASLDPVPAQG
     1695-2327: Missing.

Note: No experimental confirmation available.

Show »
Length:1,694
Mass (Da):184,393
Checksum:i52625A76C5070FBB
GO

Sequence cautioni

The sequence BAC26150.1 differs from that shown. Reason: Frameshift at position 1889.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 16661666Missing in isoform 2. VSP_015656Add
BLAST
Alternative sequencei1657 – 169438NAGNI…DLAAT → RASLLSHHTDPNLTSGGCQL EHPPHWQLASLDPVPAQG in isoform 3. VSP_015657Add
BLAST
Alternative sequencei1695 – 2327633Missing in isoform 3. VSP_015658Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1058 – 10581D → V in AAL37505. 1 Publication
Sequence conflicti1113 – 11131S → P in BAD90326. 1 Publication
Sequence conflicti1427 – 14271W → R in AAL37505. 1 Publication
Sequence conflicti1520 – 15201Q → E in AAL37505. 1 Publication
Sequence conflicti1546 – 15461S → G in AAL37505. 1 Publication
Sequence conflicti1929 – 19291G → E in AAL37505. 1 Publication
Sequence conflicti2000 – 20001Q → R in AAL37505. 1 Publication
Sequence conflicti2011 – 20111D → H in BAC26150. 1 Publication
Sequence conflicti2093 – 20931G → E in AAL37505. 1 Publication
Sequence conflicti2248 – 22481L → H in AAL37505. 1 Publication
Sequence conflicti2300 – 23001P → S in AAL37505. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352400 mRNA. Translation: AAL37505.1.
AK028844 mRNA. Translation: BAC26150.1. Sequence problems.
AK075625 mRNA. Translation: BAC35866.1.
AC126257 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25876.1.
AK220559 mRNA. Translation: BAD90326.1.
CCDSiCCDS23211.1. [Q8VHY0-1]
RefSeqiNP_620570.2. NM_139001.2. [Q8VHY0-1]
UniGeneiMm.41329.

Genome annotation databases

EnsembliENSMUST00000035661; ENSMUSP00000038909; ENSMUSG00000032911. [Q8VHY0-1]
GeneIDi121021.
KEGGimmu:121021.
UCSCiuc009ptl.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352400 mRNA. Translation: AAL37505.1 .
AK028844 mRNA. Translation: BAC26150.1 . Sequence problems.
AK075625 mRNA. Translation: BAC35866.1 .
AC126257 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25876.1 .
AK220559 mRNA. Translation: BAD90326.1 .
CCDSi CCDS23211.1. [Q8VHY0-1 ]
RefSeqi NP_620570.2. NM_139001.2. [Q8VHY0-1 ]
UniGenei Mm.41329.

3D structure databases

ProteinModelPortali Q8VHY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VHY0. 5 interactions.
MINTi MINT-1787512.

PTM databases

PhosphoSitei Q8VHY0.

Proteomic databases

PaxDbi Q8VHY0.
PRIDEi Q8VHY0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035661 ; ENSMUSP00000038909 ; ENSMUSG00000032911 . [Q8VHY0-1 ]
GeneIDi 121021.
KEGGi mmu:121021.
UCSCi uc009ptl.1. mouse.

Organism-specific databases

CTDi 1464.
MGIi MGI:2153093. Cspg4.
Rougei Search...

Phylogenomic databases

eggNOGi NOG261397.
GeneTreei ENSGT00550000074429.
HOGENOMi HOG000170195.
HOVERGENi HBG081360.
InParanoidi Q8VHY0.
KOi K08115.
OMAi RPIYRFT.
OrthoDBi EOG77DJ56.
TreeFami TF316876.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_198981. CS/DS degradation.

Miscellaneous databases

NextBioi 369752.
PROi Q8VHY0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VHY0.
CleanExi MM_CSPG4.
Genevestigatori Q8VHY0.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
SMARTi SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling."
    Stegmueller J., Werner H., Nave K.-A., Trotter J.
    J. Biol. Chem. 278:3590-3598(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH GRIP1; GRIP2 AND GRIA2, MUTAGENESIS OF GLN-2324; TYR-2325; TRP-2326 AND VAL-2327, DOMAIN, SUBCELLULAR LOCATION.
    Tissue: Oligodendrocyte.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 999-2327 (ISOFORM 3).
    Tissue: Fetal brain.
  6. "PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse."
    Grako K.A., Ochiya T., Barritt D., Nishiyama A., Stallcup W.B.
    J. Cell Sci. 112:905-915(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
    Fukushi J., Makagiansar I.T., Stallcup W.B.
    Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  8. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130; ASN-1369; ASN-1454; ASN-2021 AND ASN-2080.
    Tissue: Myoblast.

Entry informationi

Entry nameiCSPG4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHY0
Secondary accession number(s): G5E892
, Q5DTG1, Q8BPI8, Q8CE79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Valuable marker for several incompletely differentiated precursor cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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