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Protein

Chondroitin sulfate proteoglycan 4

Gene

Cspg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.2 Publications

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • angiogenesis Source: UniProtKB-KW
  • cell proliferation Source: MGI
  • glial cell migration Source: MGI
  • intracellular signal transduction Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • tissue remodeling Source: UniProtKB-KW
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Transducer

Keywords - Biological processi

Angiogenesis, Differentiation, Tissue remodeling

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022870. Chondroitin sulfate biosynthesis.
R-MMU-2022923. Dermatan sulfate biosynthesis.
R-MMU-2024101. CS/DS degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 4
Alternative name(s):
Chondroitin sulfate proteoglycan NG2
Proteoglycan AN2
Gene namesi
Name:Cspg4
Synonyms:An2, Kiaa4232, Ng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2153093. Cspg4.

Subcellular locationi

  • Cell membrane 1 Publication; Single-pass type I membrane protein By similarity; Extracellular side By similarity
  • Apical cell membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity
  • Cell projectionlamellipodium membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity
  • Cell surface By similarity

  • Note: Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. A fraction may undergo cell surface proteolysis and secretion (By similarity). Localizes to the plasma membrane of oligodendrocytes (PubMed:12458226).By similarity1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 2229ExtracellularBy similarityAdd BLAST2200
Transmembranei2230 – 2250HelicalSequence analysisAdd BLAST21
Topological domaini2251 – 2327CytoplasmicBy similarityAdd BLAST77

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are unresponsive to PDGF-AA through PDGF-alpha receptor.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2324Q → G: No effect on interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2325Y → F: No effect on interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2325Y → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2326W → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2327V → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004196330 – 2327Chondroitin sulfate proteoglycan 4Add BLAST2298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...)1 Publication1
Disulfide bondi170 ↔ 193PROSITE-ProRule annotation
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi355 ↔ 381PROSITE-ProRule annotation
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
Glycosylationi686N-linked (GlcNAc...)Sequence analysis1
Glycosylationi773N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1000O-linked (Xyl...) (chondroitin sulfate)By similarity1
Glycosylationi1136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1369N-linked (GlcNAc...)1 Publication1
Glycosylationi1454N-linked (GlcNAc...)1 Publication1
Glycosylationi1650N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1914N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2021N-linked (GlcNAc...)1 Publication1
Glycosylationi2039N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2045N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2080N-linked (GlcNAc...)1 Publication1
Modified residuei2257Phosphothreonine; by PKC/PRKCABy similarity1

Post-translational modificationi

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation. Involved in interaction with MMP16 and ITGA4 (By similarity).By similarity
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ8VHY0.
PeptideAtlasiQ8VHY0.
PRIDEiQ8VHY0.

PTM databases

iPTMnetiQ8VHY0.
PhosphoSitePlusiQ8VHY0.

Expressioni

Tissue specificityi

Expressed in microcascular pericytes and not endothelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000032911.
CleanExiMM_CSPG4.
GenevisibleiQ8VHY0. MM.

Interactioni

Subunit structurei

Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16. Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA (By similarity). Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gria2P238192EBI-8327479,EBI-77538
Grip1Q925T67EBI-8327479,EBI-537752
Grip2Q9WTW12EBI-8327479,EBI-936045From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VHY0. 5 interactors.
MINTiMINT-1787512.
STRINGi10090.ENSMUSP00000038909.

Structurei

3D structure databases

ProteinModelPortaliQ8VHY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 193Laminin G-like 1PROSITE-ProRule annotationAdd BLAST164
Domaini203 – 381Laminin G-like 2PROSITE-ProRule annotationAdd BLAST179
Repeati431 – 524CSPG 1Add BLAST94
Repeati557 – 644CSPG 2Add BLAST88
Repeati666 – 765CSPG 3Add BLAST100
Repeati793 – 883CSPG 4Add BLAST91
Repeati905 – 994CSPG 5Add BLAST90
Repeati1025 – 1113CSPG 6Add BLAST89
Repeati1133 – 1221CSPG 7Add BLAST89
Repeati1246 – 1342CSPG 8Add BLAST97
Repeati1365 – 1454CSPG 9Add BLAST90
Repeati1481 – 1566CSPG 10Add BLAST86
Repeati1588 – 1684CSPG 11Add BLAST97
Repeati1712 – 1808CSPG 12Add BLAST97
Repeati1840 – 1927CSPG 13Add BLAST88
Repeati1949 – 2034CSPG 14Add BLAST86
Repeati2053 – 2152CSPG 15Add BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 640Globular or compact configuration stabilized by disulfide bondsAdd BLAST611
Regioni30 – 640Neurite growth inhibitionBy similarityAdd BLAST611
Regioni575 – 1045Interaction with COL6A2By similarityAdd BLAST471
Regioni632 – 1451Interaction with COL5A1By similarityAdd BLAST820
Regioni1591 – 2226Neurite growth inhibitionBy similarityAdd BLAST636
Regioni1592 – 2226Cysteine-containingAdd BLAST635

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2325 – 2327PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi640 – 1591Gly/Ser-rich (glycosaminoglycan attachment domain)Add BLAST952

Sequence similaritiesi

Contains 15 CSPG (NG2) repeats.Curated
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3597. Eukaryota.
ENOG410XQ29. LUCA.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000170195.
HOVERGENiHBG081360.
InParanoidiQ8VHY0.
KOiK08115.
OMAiRPIYRFT.
OrthoDBiEOG091G00BN.
TreeFamiTF316876.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLGPGHPLS APALALALTL ALLVRSTAPA SFFGENHLEV PVPSALTRVD
60 70 80 90 100
LLLQFSTSQP EALLLLAAGQ DDHLLLQLHS GCLQVRLALG QKELKLQTPA
110 120 130 140 150
DTVLSDSAPH TVVLTVSDSW AVLSVDGVLN TSAPIPRASH LKATYGLFVG
160 170 180 190 200
SSGSLDLPYL KGISRPLRGC LHSAILNGRN LLRPLTSDVH EGCAEEFSAG
210 220 230 240 250
DEVGLGFSGP HSLAAFPAWS TREEGTLEFT LTTRSQQAPL AFQAGDKRGN
260 270 280 290 300
FIYVDIFEGH LRAVVEKGQG TMLLRNSVPV ADGQPHEVSV HIDVHRLEIS
310 320 330 340 350
VDQYPTRTFN RGVLSYLEPR GSLLLGGLDT EASRHLQEHR LGLAPGAANI
360 370 380 390 400
SLVGCIEDFS VNGRRQGLRD AWLTRDMSAG CRPEEDEYEE EVYGPYETFS
410 420 430 440 450
TLAPEAWPAM ELPEPCIPEP GLPAVFANFT QLLTISPLVV AEGGTAWLEW
460 470 480 490 500
RHVQPTLDLT EAELRKSQVL FSVSQSARHG DLELDILGAQ TRKMFTLLDV
510 520 530 540 550
VNRKARFVHD GSEDTSDQLM LEVSVTARAP VPSCLRRGQI YILPIQVNPV
560 570 580 590 600
NDPPRIIFPH GSLMVILEHT QKPLGPEIFQ AYDPDSACEG LTFQLLGVSS
610 620 630 640 650
GVPVEHRDQP GEPATEFSCR ELEVGDIVYV HRGGPAQDLT FRVSDGMQAS
660 670 680 690 700
APATLKVVAV RPAIQILHNT GLHLAQGSAA AILPANLSVE TNAVGQDVSV
710 720 730 740 750
LFRVTGTLQF GELQKQGAGG VEGTEWWDTL AFHQRDVEQG RVRYLSTDPQ
760 770 780 790 800
HHTQDTVEDL ILEVQVGQET LSNLSFPVTI QRATVWMLRL EPLHTQNPHQ
810 820 830 840 850
ETLTPAHLEA SLEEEEEEGS PQPHTFHYEL VQAPRRGNLL LQGTRLSDGE
860 870 880 890 900
SFSQSDLQAG RVTYRATMRT SEAADDSFRF RVTSPPHFSP LYTFPIHIGG
910 920 930 940 950
DPNAPVLTNV LLMVPEGGEG VLSADHLFVK SLNSASYLYE VMEQPHHGKL
960 970 980 990 1000
AWRDPKGKST PVTSFTNEDL LHGRLVYQHD DSETIEDDIP FVATRQGEGS
1010 1020 1030 1040 1050
GDMAWEEVRG VFRVAIQPVN DHAPVQTISR VFHVARGGQR LLTTDDVAFS
1060 1070 1080 1090 1100
DADSGFSDAQ LVLTRKDLLF GSIVAMEEPT RPIYRFTQED LRKKQVLFVH
1110 1120 1130 1140 1150
SGADHGWLQL QVSDGQHQAT AMLEVQASEP YLHVANSSSL VVPQGGQGTI
1160 1170 1180 1190 1200
DTAVLQLDTN LDIRSGNEVH YHVTAGPQWG QLLRDGQSVT SFSQRDLLDG
1210 1220 1230 1240 1250
AILYSHNGSL SPQDTLAFSV AAGPVHTNTF LQVTIALEGP LAPLQLVQHK
1260 1270 1280 1290 1300
KIYVFQGEAA EIRRDQLEVV QEAVLPADIM FSLRSPPNAG YLVMVSHGAS
1310 1320 1330 1340 1350
AEEPPSLDPV QSFSQEAVNS GRVLYLHSRP GAWSDSFSLD VASGLGDPLE
1360 1370 1380 1390 1400
GISVELEVLP TVIPLDVQNF SVPEGGTRTL APPLVQITGP YFPTLPGLVL
1410 1420 1430 1440 1450
QVLEPPQHGA LQKEDHSQDG SLSTFSWREV EEQLIRYVHD GSETQTDAFV
1460 1470 1480 1490 1500
LLANASEMDR QSQPVAFTIT ILPVNDQPPV LTTNTGLQIW EGAIVPIPPE
1510 1520 1530 1540 1550
ALRGTDNDSG PEDLVYTIEQ PSNGRIALRV APDTEVHRFT QAQLDSGLVL
1560 1570 1580 1590 1600
FSHRGALEGG FHFDLSDGAH TSPGHFFRVV AQKQALLSLE GTRKLTVCPE
1610 1620 1630 1640 1650
SVQPLSSQSL SASSSTGADP RHLLYRVVRG PQLGRLLHAQ QGSAEEVLVN
1660 1670 1680 1690 1700
FTQAEVNAGN ILYEHEMSSE PFWEAHDTIG LLLSSPPARD LAATLAVMVS
1710 1720 1730 1740 1750
FDAACPQRPS RLWKNKGLWV PEGQRAKITV AALDAANLLA SVPASQRSRH
1760 1770 1780 1790 1800
DVLFQVTQFP TRGQLLVSEE PLHARRPYFL QSELAAGQLV YAHGGGGTQQ
1810 1820 1830 1840 1850
DGFRFRAHLQ GPTGTSVAGP QTSEAFVITV RDVNERPPQP QASIPLRVTR
1860 1870 1880 1890 1900
GSRAPVSRAQ LSVVDPDSAP GEIEYEVQRA PHNGFLSLAG DNTGPVTHFT
1910 1920 1930 1940 1950
QADVDAGRLA FVANGSSVAG VFQLSMSDGA SPPIPMSLAV DVLPSTIEVQ
1960 1970 1980 1990 2000
LRAPLEVPQA LGRTSLSRQQ LQVISDREEP DVAYRLTQGP LYGQLLVGGQ
2010 2020 2030 2040 2050
PASAFSQLQV DQGDVVFVFT NFSSSQDHFK VVALARGVNA SATVNVTVQA
2060 2070 2080 2090 2100
LLHVWAGGPW PQGTTLRLDP TVLDASELAN RTGSMPHFRL LAGPRYGRVV
2110 2120 2130 2140 2150
RVSQGRTESR SNQLVEHFTQ RDLEEGQLGL EVGKPEGRST GPAGDRLTLE
2160 2170 2180 2190 2200
LWAKGVPPAV ALLDFATEPY HAAKSYSVAL LSVPEAVRTE TEKPGRSVPT
2210 2220 2230 2240 2250
GQPGQAASSP VPTAAKGGFL GFLEANMFSI IIPVCLILLL LALILPLLFY
2260 2270 2280 2290 2300
LRKRNKTGKH DVQVLTAKPR NGLAGDTETF RKVEPGQAIP LITVPGQGPP
2310 2320
PGGQPDPELL QFCRTPNPAL RNGQYWV
Length:2,327
Mass (Da):252,309
Last modified:October 3, 2012 - v3
Checksum:iC101DF60FCE3A7BC
GO
Isoform 2 (identifier: Q8VHY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1666: Missing.

Note: No experimental confirmation available.
Show »
Length:661
Mass (Da):70,843
Checksum:iDA679F6CCF894532
GO
Isoform 3 (identifier: Q8VHY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1657-1694: NAGNILYEHE...SPPARDLAAT → RASLLSHHTD...ASLDPVPAQG
     1695-2327: Missing.

Note: No experimental confirmation available.
Show »
Length:1,694
Mass (Da):184,393
Checksum:i52625A76C5070FBB
GO

Sequence cautioni

The sequence BAC26150 differs from that shown. Reason: Frameshift at position 1889.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1058D → V in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1113S → P in BAD90326 (Ref. 5) Curated1
Sequence conflicti1427W → R in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1520Q → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1546S → G in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1929G → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2000Q → R in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2011D → H in BAC26150 (PubMed:16141072).Curated1
Sequence conflicti2093G → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2248L → H in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2300P → S in AAL37505 (PubMed:12458226).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156561 – 1666Missing in isoform 2. 1 PublicationAdd BLAST1666
Alternative sequenceiVSP_0156571657 – 1694NAGNI…DLAAT → RASLLSHHTDPNLTSGGCQL EHPPHWQLASLDPVPAQG in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0156581695 – 2327Missing in isoform 3. 1 PublicationAdd BLAST633

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352400 mRNA. Translation: AAL37505.1.
AK028844 mRNA. Translation: BAC26150.1. Sequence problems.
AK075625 mRNA. Translation: BAC35866.1.
AC126257 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25876.1.
AK220559 mRNA. Translation: BAD90326.1.
CCDSiCCDS23211.1. [Q8VHY0-1]
RefSeqiNP_620570.2. NM_139001.2. [Q8VHY0-1]
UniGeneiMm.41329.

Genome annotation databases

EnsembliENSMUST00000035661; ENSMUSP00000038909; ENSMUSG00000032911. [Q8VHY0-1]
GeneIDi121021.
KEGGimmu:121021.
UCSCiuc009ptl.1. mouse. [Q8VHY0-1]
uc009ptn.1. mouse. [Q8VHY0-3]
uc009pto.1. mouse. [Q8VHY0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352400 mRNA. Translation: AAL37505.1.
AK028844 mRNA. Translation: BAC26150.1. Sequence problems.
AK075625 mRNA. Translation: BAC35866.1.
AC126257 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25876.1.
AK220559 mRNA. Translation: BAD90326.1.
CCDSiCCDS23211.1. [Q8VHY0-1]
RefSeqiNP_620570.2. NM_139001.2. [Q8VHY0-1]
UniGeneiMm.41329.

3D structure databases

ProteinModelPortaliQ8VHY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VHY0. 5 interactors.
MINTiMINT-1787512.
STRINGi10090.ENSMUSP00000038909.

PTM databases

iPTMnetiQ8VHY0.
PhosphoSitePlusiQ8VHY0.

Proteomic databases

PaxDbiQ8VHY0.
PeptideAtlasiQ8VHY0.
PRIDEiQ8VHY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035661; ENSMUSP00000038909; ENSMUSG00000032911. [Q8VHY0-1]
GeneIDi121021.
KEGGimmu:121021.
UCSCiuc009ptl.1. mouse. [Q8VHY0-1]
uc009ptn.1. mouse. [Q8VHY0-3]
uc009pto.1. mouse. [Q8VHY0-2]

Organism-specific databases

CTDi1464.
MGIiMGI:2153093. Cspg4.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3597. Eukaryota.
ENOG410XQ29. LUCA.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000170195.
HOVERGENiHBG081360.
InParanoidiQ8VHY0.
KOiK08115.
OMAiRPIYRFT.
OrthoDBiEOG091G00BN.
TreeFamiTF316876.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022870. Chondroitin sulfate biosynthesis.
R-MMU-2022923. Dermatan sulfate biosynthesis.
R-MMU-2024101. CS/DS degradation.

Miscellaneous databases

ChiTaRSiCspg4. mouse.
PROiQ8VHY0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032911.
CleanExiMM_CSPG4.
GenevisibleiQ8VHY0. MM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSPG4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHY0
Secondary accession number(s): G5E892
, Q5DTG1, Q8BPI8, Q8CE79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Valuable marker for several incompletely differentiated precursor cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.