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Protein

Filamin-C

Gene

Flnc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • ankyrin binding Source: MGI
  • cytoskeletal protein binding Source: MGI

GO - Biological processi

  • actin filament-based process Source: MGI
  • muscle fiber development Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-446353. Cell-extracellular matrix interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-C
Short name:
FLN-C
Alternative name(s):
ABP-280-like protein
ABP-L
Actin-binding-like protein
Filamin-2
Gamma-filamin
Gene namesi
Name:Flnc
Synonyms:Abpl, Fln2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95557. Flnc.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity
  • Cytoplasmcytoskeleton By similarity
  • CytoplasmmyofibrilsarcomereZ line By similarity

  • Note: A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme (By similarity). Targeting to developing and mature Z lines is mediated by the intradomain insert (By similarity).By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: MGI
  • focal adhesion Source: MGI
  • plasma membrane Source: MGI
  • sarcolemma Source: MGI
  • sarcoplasm Source: Ensembl
  • Z disc Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873021 – 2726Filamin-CAdd BLAST2726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei1003Omega-N-methylarginineCombined sources1
Modified residuei1162PhosphoserineBy similarity1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei2043PhosphoserineBy similarity1
Modified residuei2234PhosphoserineCombined sources1
Modified residuei2237PhosphoserineBy similarity1
Modified residuei2239PhosphothreonineBy similarity1
Modified residuei2587PhosphoserineBy similarity1
Modified residuei2618PhosphoserineBy similarity1
Modified residuei2621PhosphoserineBy similarity1
Modified residuei2633PhosphoserineBy similarity1
Modified residuei2715PhosphoserineBy similarity1
Modified residuei2719PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by FBXL22, leading to proteasomal degradation.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8VHX6.
PeptideAtlasiQ8VHX6.
PRIDEiQ8VHX6.

PTM databases

iPTMnetiQ8VHX6.
PhosphoSitePlusiQ8VHX6.

Expressioni

Developmental stagei

During myogenesis, isoform 1 is expressed the first day, then is replaced by isoform 2.1 Publication

Gene expression databases

BgeeiENSMUSG00000068699.
CleanExiMM_FLNC.
ExpressionAtlasiQ8VHX6. baseline and differential.
GenevisibleiQ8VHX6. MM.

Interactioni

Subunit structurei

Homodimer; the filamin repeat 24 and the second hinge domain are important for dimer formation (By similarity). Interacts with FLNB, INPPL1, ITGB1A, KCND2, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only). Interacts with FBLIM1 (By similarity). Interacts with XIRP1; this interaction is mediated by filamin 20 repeat (By similarity). Interacts with KY. Interacts with IGFN1. Interacts with MICALL2. Interacts with ANK3 (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • ankyrin binding Source: MGI
  • cytoskeletal protein binding Source: MGI

Protein-protein interaction databases

BioGridi213053. 7 interactors.
IntActiQ8VHX6. 9 interactors.
MINTiMINT-1520143.
STRINGi10090.ENSMUSP00000087960.

Structurei

3D structure databases

ProteinModelPortaliQ8VHX6.
SMRiQ8VHX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 260Actin-bindingAdd BLAST260
Domaini37 – 143CH 1PROSITE-ProRule annotationAdd BLAST107
Domaini160 – 260CH 2PROSITE-ProRule annotationAdd BLAST101
Repeati271 – 369Filamin 1Add BLAST99
Repeati371 – 469Filamin 2Add BLAST99
Repeati470 – 566Filamin 3Add BLAST97
Repeati567 – 659Filamin 4Add BLAST93
Repeati663 – 759Filamin 5Add BLAST97
Repeati760 – 862Filamin 6Add BLAST103
Repeati863 – 961Filamin 7Add BLAST99
Repeati962 – 1057Filamin 8Add BLAST96
Repeati1058 – 1150Filamin 9Add BLAST93
Repeati1151 – 1245Filamin 10Add BLAST95
Repeati1246 – 1345Filamin 11Add BLAST100
Repeati1346 – 1438Filamin 12Add BLAST93
Repeati1439 – 1534Filamin 13Add BLAST96
Repeati1535 – 1631Filamin 14Add BLAST97
Repeati1636 – 1735Filamin 15Add BLAST100
Repeati1760 – 1855Filamin 16Add BLAST96
Repeati1856 – 1947Filamin 17Add BLAST92
Repeati1948 – 2034Filamin 18Add BLAST87
Repeati2037 – 2129Filamin 19Add BLAST93
Repeati2212 – 2307Filamin 20; mediates interaction with XIRP1PROSITE-ProRule annotationAdd BLAST96
Repeati2310 – 2402Filamin 21Add BLAST93
Repeati2404 – 2497Filamin 22Add BLAST94
Repeati2501 – 2593Filamin 23Add BLAST93
Repeati2631 – 2725Filamin 24Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1736 – 1759Hinge 1Add BLAST24
Regioni2163 – 2244Intradomain insert; mediate targeting to Z linesBy similarityAdd BLAST82
Regioni2404 – 2725Interaction with INPPL1By similarityAdd BLAST322
Regioni2594 – 2726Self-association site, tailBy similarityAdd BLAST133
Regioni2594 – 2630Hinge 2Add BLAST37

Sequence similaritiesi

Belongs to the filamin family.Curated
Contains 1 actin-binding domain.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 24 filamin repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00660000095431.
HOGENOMiHOG000044235.
HOVERGENiHBG004163.
InParanoidiQ8VHX6.
KOiK04437.
OMAiAEPMESM.
OrthoDBiEOG091G00U5.
PhylomeDBiQ8VHX6.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR032461. FLN_C.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF210. PTHR11915:SF210. 2 hits.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHX6-1) [UniParc]FASTAAdd to basket
Also known as: H1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNNSNYSDA SGLGLVDEAD EMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH
60 70 80 90 100
LKCVGKRLTD LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN
110 120 130 140 150
VSVALEFLER EHIKLVSIDS KAIVDGNLKL ILGLIWTLIL HYSISMPMWE
160 170 180 190 200
DEDDEDARKQ TPKQRLLGWI QNKVPQLPIT NFNRDWQDGK ALGALVDNCA
210 220 230 240 250
PGLCPDWEAW DPNQPVQNAR EAMQQADDWL GVPQVIAPEE IVDPNVDEHS
260 270 280 290 300
VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPQG NTVLQPAHFT
310 320 330 340 350
VQTVDAGVGE VLVYIEDPEG HTEEAKVVPN NDKDRTYAVS YVPKVAGLHK
360 370 380 390 400
VTVLFAGQNI ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD
410 420 430 440 450
IYTAGAGTGD VAVVIVDPQG RRDTVEVALE DKGDNTFRCT YRPVMEGPHT
460 470 480 490 500
VHVAFAGAPI TRSPFPVHVA EACNPNACRA SGRGLQPKGV RVKEVADFKV
510 520 530 540 550
FTKGAGSGEL KVTVKGPKGT EEPVKVREAG DGVFECEYYP VVPGKYVVTI
560 570 580 590 600
TWGGYAIPRS PFEVQVSPEA GAQKVRAWGP GLETGQVGKS ADFVVEAIGT
610 620 630 640 650
EVGTLGFSIE GPSQAKIECD DKGDGSCDVR YWPTEPGEYA VHVICDDEDI
660 670 680 690 700
RDSPFIAHIQ PAPPDCFPDK VKAFGPGLEP TGCIVDRPAE FTIDARAAGK
710 720 730 740 750
GDLKLYAQDA DGCPIDIKVI PNGDGTFRCS YVPTKPIKHT IIVSWGGVNV
760 770 780 790 800
PKSPFRVNVG EGSHPERVKV YGPGVEKTGL KANEPTYFTV DCSEAGQGDV
810 820 830 840 850
SIGIKCAPGV VGPVEADIDF DIIKNDNDTF TVKYTPPGAG HYTIMVLFAN
860 870 880 890 900
QEIPASPFHI KVDPSHDASK VKAEGPGLSR TGVEVGKPTH FTVLTKGAGK
910 920 930 940 950
AKLDVHFAGA AKGEAVRDFE IIDNHDYSYT VKYTAVQQGN MAVTVTYGGD
960 970 980 990 1000
PVPKSPFVVN VAPPLDLSKV KVQGLNSKVA VGQEQAFSVN TRGAGGQGQL
1010 1020 1030 1040 1050
DVRMTSPSRR PIPCKLEPGG GAEAQAVRYM PPEEGPYKVD ITYDGHPVPG
1060 1070 1080 1090 1100
SPFAVEGVLP PDPSKVCAYG PGLKGGLVGT PAPFSIDTKG AGTGGLGLTV
1110 1120 1130 1140 1150
EGPCEAKIEC QDNGDGSCAV SYLPTEPGEY TINILFAEAH IPGSPFKATI
1160 1170 1180 1190 1200
QPVFDPSKVR ASGPGLERGK AGEAATFTVD CSEAGEAELT IEILSDAGVK
1210 1220 1230 1240 1250
AEVLIQNNAD GTYHITYSPA FPGTYTITIK YGGHPIPKFP TRVHVQPAVD
1260 1270 1280 1290 1300
TSGIKVSGPG VEPHGVLREV TTEFTVDARS LTATGGNHVT ARVLNPSGAK
1310 1320 1330 1340 1350
TDTYVTDNGD GTYRVQYTAY EEGVHLVEVL YDEVAVPKSP FRVGVTEGCD
1360 1370 1380 1390 1400
PTRVRAFGPG LEGGLVNKAN RFTVETRGAG TGGLGLAIEG PSEAKMSCKD
1410 1420 1430 1440 1450
NKDGSCTVEY IPFTPGDYDV NITFGGQPIP GSPFRVPVKD VVDPGKVKCS
1460 1470 1480 1490 1500
GPGLGTGVRA RVPQTFTVDC SQAGRAPLQV AVLGPTGVAE PVEVRDNGDG
1510 1520 1530 1540 1550
THTVHYTPAT DGPYTVAVKY ADQEVPRSPF KIKVLPSHDA SKVRASGPGL
1560 1570 1580 1590 1600
NASGIPASLP VEFTIDARDA GQGLLTVQIL DPEGKPKKAN IRDNGDGTYT
1610 1620 1630 1640 1650
VSYLPDMSGR YTITIKYGGD EIPYSPFRIH ALPTGDASKC LVTVSIGGHG
1660 1670 1680 1690 1700
LGACLGPRIQ IGEETVITVD AKAAGKGKVT CTVSTPDGAE LDVDVVENHD
1710 1720 1730 1740 1750
GTFDIYYTAP EPGKYVITIR FGGEHIPNSP FHVLACDPLP HVEEPAEMLQ
1760 1770 1780 1790 1800
MRQPYAPLRP GTCPTHWATE EPVVPVEPLE SMLRPFNLVI PFTVQKGELT
1810 1820 1830 1840 1850
GEVRMPSGKT ARPNITDNKD GTITVRYAPT EKGLHQMGIK YDGNHIPGSP
1860 1870 1880 1890 1900
LQFYVDAINS RHVSAYGPGL SHGMVNKPAT FTIVTKDAGE GGLSLAVEGP
1910 1920 1930 1940 1950
SKAEITCKDN KDGTCTVSYL PTAPGDYSII VRFDDKHIPG SPFTAKITGD
1960 1970 1980 1990 2000
DSMRTSQLNV GTSTDVSLKI TEGDLSQLTA SIRAPSGNEE PCLLKRLPNR
2010 2020 2030 2040 2050
HIGISFTPKE VGEHVVSVRK SGKHVTNSPF KILVGPSEIG DASKVRVWGK
2060 2070 2080 2090 2100
GLSEGQTFQV AEFIVDTRNA GYGGLGLSIE GPSKVDINCE DMEDGTCKVT
2110 2120 2130 2140 2150
YCPTEPGTYI INIKFADKHV PGSPFTVKVT GEGRMKESIT RRRQAPSIAT
2160 2170 2180 2190 2200
IGSTCDLNLK IPGNWFQMVS AQERLTRTFT RSSHTYTRTE RTEISKTRGG
2210 2220 2230 2240 2250
ETKREVRVEE STQVGGDPFP AVFGDFLGRE RLGSFGSITR QQEGEASSQD
2260 2270 2280 2290 2300
MTAQVTSPSG KTEAAEIVEG EDSAYSVRFV PQEMGPHTVT VKYRGQHVPG
2310 2320 2330 2340 2350
SPFQFTVGPL GEGGAHKVRA GGTGLERGVA GVPAEFSIWT REAGAGGLSI
2360 2370 2380 2390 2400
AVEGPSKAEI AFEDRKDGSC GVSYVVQEPG DYEVSIKFND EHIPDSPFVV
2410 2420 2430 2440 2450
PVASLSDDAR RLTVTSLQET GLKVNQPASF AVQLNGARGV IDARVHTPSG
2460 2470 2480 2490 2500
AVEECYVSEL DSDKHTIRFI PHENGVHSID VKFNGAHIPG SPFKIRVGEQ
2510 2520 2530 2540 2550
SQAGDPGLVS AYGPGLEGGT TGVSSEFIVN TQNAGSGALS VTIDGPSKVQ
2560 2570 2580 2590 2600
LDCRECPEGH VVTYTPMAPG NYLIAIKYGG PQHIVGSPFK AKVTGPRLSG
2610 2620 2630 2640 2650
GHSLHETSTV LVETVTKSSS SRGASYSSIP KFSSDASKVV TRGPGLSQAF
2660 2670 2680 2690 2700
VGQKNSFTVD CSKAGTNMMM VGVHGPKTPC EEVYVKHMGN RVYNVTYTVK
2710 2720
EKGDYILIVK WGDESVPGSP FKVNVP
Length:2,726
Mass (Da):291,119
Last modified:December 12, 2006 - v3
Checksum:iBFBE03CBFFEE3863
GO
Isoform 2 (identifier: Q8VHX6-2) [UniParc]FASTAAdd to basket
Also known as: Delta-H1

The sequence of this isoform differs from the canonical sequence as follows:
     1735-1767: Missing.

Show »
Length:2,693
Mass (Da):287,365
Checksum:i3CB7C227D50195F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1406C → R in AAI51098 (PubMed:15489334).Curated1
Sequence conflicti2606E → Q in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2609T → S in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2617K → H in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2631K → N in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2663 – 2665KAG → QAR in AAF97411 (PubMed:10679933).Curated3
Sequence conflicti2669M → I in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2695V → F in AAF97411 (PubMed:10679933).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0075801735 – 1767Missing in isoform 2. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC044807 Genomic DNA. No translation available.
BC052186 mRNA. Translation: AAH52186.1.
BC060276 mRNA. Translation: AAH60276.1.
BC151097 mRNA. Translation: AAI51098.1.
BC158128 mRNA. Translation: AAI58129.1.
AF353670 mRNA. Translation: AAL68446.1.
AF119148 mRNA. Translation: AAF97411.1.
CCDSiCCDS39452.1. [Q8VHX6-1]
CCDS80503.1. [Q8VHX6-2]
RefSeqiNP_001074654.1. NM_001081185.1. [Q8VHX6-1]
NP_001298003.1. NM_001311074.1. [Q8VHX6-2]
UniGeneiMm.39046.

Genome annotation databases

EnsembliENSMUST00000065090; ENSMUSP00000064163; ENSMUSG00000068699. [Q8VHX6-1]
ENSMUST00000101617; ENSMUSP00000099139; ENSMUSG00000068699. [Q8VHX6-2]
GeneIDi68794.
KEGGimmu:68794.
UCSCiuc009bdn.1. mouse. [Q8VHX6-1]
uc009bdo.2. mouse. [Q8VHX6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC044807 Genomic DNA. No translation available.
BC052186 mRNA. Translation: AAH52186.1.
BC060276 mRNA. Translation: AAH60276.1.
BC151097 mRNA. Translation: AAI51098.1.
BC158128 mRNA. Translation: AAI58129.1.
AF353670 mRNA. Translation: AAL68446.1.
AF119148 mRNA. Translation: AAF97411.1.
CCDSiCCDS39452.1. [Q8VHX6-1]
CCDS80503.1. [Q8VHX6-2]
RefSeqiNP_001074654.1. NM_001081185.1. [Q8VHX6-1]
NP_001298003.1. NM_001311074.1. [Q8VHX6-2]
UniGeneiMm.39046.

3D structure databases

ProteinModelPortaliQ8VHX6.
SMRiQ8VHX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213053. 7 interactors.
IntActiQ8VHX6. 9 interactors.
MINTiMINT-1520143.
STRINGi10090.ENSMUSP00000087960.

PTM databases

iPTMnetiQ8VHX6.
PhosphoSitePlusiQ8VHX6.

Proteomic databases

PaxDbiQ8VHX6.
PeptideAtlasiQ8VHX6.
PRIDEiQ8VHX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065090; ENSMUSP00000064163; ENSMUSG00000068699. [Q8VHX6-1]
ENSMUST00000101617; ENSMUSP00000099139; ENSMUSG00000068699. [Q8VHX6-2]
GeneIDi68794.
KEGGimmu:68794.
UCSCiuc009bdn.1. mouse. [Q8VHX6-1]
uc009bdo.2. mouse. [Q8VHX6-2]

Organism-specific databases

CTDi2318.
MGIiMGI:95557. Flnc.

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00660000095431.
HOGENOMiHOG000044235.
HOVERGENiHBG004163.
InParanoidiQ8VHX6.
KOiK04437.
OMAiAEPMESM.
OrthoDBiEOG091G00U5.
PhylomeDBiQ8VHX6.

Enzyme and pathway databases

ReactomeiR-MMU-446353. Cell-extracellular matrix interactions.

Miscellaneous databases

PROiQ8VHX6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068699.
CleanExiMM_FLNC.
ExpressionAtlasiQ8VHX6. baseline and differential.
GenevisibleiQ8VHX6. MM.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR032461. FLN_C.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF210. PTHR11915:SF210. 2 hits.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLNC_MOUSE
AccessioniPrimary (citable) accession number: Q8VHX6
Secondary accession number(s): B2RY80
, B9EKT2, Q6PAI6, Q9JJ38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 12, 2006
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.