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Protein

Ectodysplasin-A receptor-associated adapter protein

Gene

Edaradd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B (By similarity).By similarity1 Publication

GO - Molecular functioni

  • death receptor binding Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • hair follicle development Source: MGI
  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: MGI
  • trachea gland development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Ectodysplasin-A receptor-associated adapter protein
Alternative name(s):
EDAR-associated death domain protein
Protein crinkled
Gene namesi
Name:Edaradd
Synonyms:Cr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1931001. Edaradd.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi145E → K: Reduces binding to EDAR. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869301 – 208Ectodysplasin-A receptor-associated adapter proteinAdd BLAST208

Proteomic databases

EPDiQ8VHX2.
MaxQBiQ8VHX2.
PaxDbiQ8VHX2.
PRIDEiQ8VHX2.

PTM databases

PhosphoSitePlusiQ8VHX2.

Expressioni

Developmental stagei

Detected in embryonic skin (E12.5 and E14.5) during the formation of hair follicles and at E15.5 in the enamel knot of the developing tooth. Detected in the basal layer of the epidermis and hair follicles of P2 mice.

Interactioni

Subunit structurei

Binds EDAR. Self-associates and binds TRAF1, TRAF2 and TRAF3 (By similarity).By similarity

GO - Molecular functioni

  • death receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136158.

Structurei

3D structure databases

ProteinModelPortaliQ8VHX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 195DeathAdd BLAST80

Sequence similaritiesi

Contains 1 death domain.Curated

Phylogenomic databases

eggNOGiENOG410IK26. Eukaryota.
ENOG410XW8Y. LUCA.
HOGENOMiHOG000013132.
HOVERGENiHBG018567.
InParanoidiQ8VHX2.
PhylomeDBiQ8VHX2.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00531. Death. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VHX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPDDPLRS DHMAKEPVED TDPSTLSFAM SDKYPIQDTG LPKAKECDTV
60 70 80 90 100
NSNCPPNSDD QPQGEENDFP DSTKDPLSGV SRNQPCKDRK GSCSCPSCSP
110 120 130 140 150
RAPTISDLLN DQDLLDTIRI KLDPCHPTVK NWRNFASKWG MPYDELCFLE
160 170 180 190 200
QRPQSPTLEF LFRNSQRTVG QLMELCRLYH RADVEKILRR WVDEEWPHRG

HSDSSMHF
Length:208
Mass (Da):23,753
Last modified:March 1, 2002 - v1
Checksum:iC5BFA0F91E5D5BC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89R → G (PubMed:11882293).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358671 mRNA. Translation: AAL50376.1.
CCDSiCCDS36593.1.
UniGeneiMm.159671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358671 mRNA. Translation: AAL50376.1.
CCDSiCCDS36593.1.
UniGeneiMm.159671.

3D structure databases

ProteinModelPortaliQ8VHX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136158.

PTM databases

PhosphoSitePlusiQ8VHX2.

Proteomic databases

EPDiQ8VHX2.
MaxQBiQ8VHX2.
PaxDbiQ8VHX2.
PRIDEiQ8VHX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1931001. Edaradd.

Phylogenomic databases

eggNOGiENOG410IK26. Eukaryota.
ENOG410XW8Y. LUCA.
HOGENOMiHOG000013132.
HOVERGENiHBG018567.
InParanoidiQ8VHX2.
PhylomeDBiQ8VHX2.

Miscellaneous databases

ChiTaRSiEdaradd. mouse.
PROiQ8VHX2.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00531. Death. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEDAD_MOUSE
AccessioniPrimary (citable) accession number: Q8VHX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.