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Protein

Voltage-dependent calcium channel gamma-4 subunit

Gene

Cacng4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_333015. Trafficking of AMPA receptors.
REACT_336170. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-4 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-4 subunit
Transmembrane AMPAR regulatory protein gamma-4
Short name:
TARP gamma-4
Gene namesi
Name:Cacng4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi628804. Cacng4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 10777ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Topological domaini129 – 1368CytoplasmicSequence Analysis
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 18629ExtracellularSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Topological domaini208 – 327120CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Voltage-dependent calcium channel gamma-4 subunitPRO_0000164680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHW9.

Expressioni

Gene expression databases

GenevestigatoriQ8VHW9.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004383.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45952.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8VHW9.
KOiK04869.
OMAiLYSSAHI.
OrthoDBiEOG7TQV1Q.
PhylomeDBiQ8VHW9.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.

Sequencei

Sequence statusi: Complete.

Q8VHW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD
60 70 80 90 100
GPPPRRARGD LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL
110 120 130 140 150
LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL
160 170 180 190 200
SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV
210 220 230 240 250
LAVNIYIEKN KELRFKTKRE FLKASSSSPY SRMPSYRYRR RRSRSSSRST
260 270 280 290 300
EASPSRDASP VGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQDAGF
310 320
LQMHDFFQQD LKEGFHVSML NRRTTPV
Length:327
Mass (Da):36,523
Last modified:March 1, 2002 - v1
Checksum:i7205476FD8823AD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361341 mRNA. Translation: AAL50036.1.
RefSeqiNP_542423.1. NM_080692.1.
UniGeneiRn.162211.

Genome annotation databases

EnsembliENSRNOT00000004383; ENSRNOP00000004383; ENSRNOG00000003262.
GeneIDi140725.
KEGGirno:140725.
UCSCiRGD:628804. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361341 mRNA. Translation: AAL50036.1.
RefSeqiNP_542423.1. NM_080692.1.
UniGeneiRn.162211.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004383.

Proteomic databases

PaxDbiQ8VHW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004383; ENSRNOP00000004383; ENSRNOG00000003262.
GeneIDi140725.
KEGGirno:140725.
UCSCiRGD:628804. rat.

Organism-specific databases

CTDi27092.
RGDi628804. Cacng4.

Phylogenomic databases

eggNOGiNOG45952.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8VHW9.
KOiK04869.
OMAiLYSSAHI.
OrthoDBiEOG7TQV1Q.
PhylomeDBiQ8VHW9.
TreeFamiTF327980.

Enzyme and pathway databases

ReactomeiREACT_333015. Trafficking of AMPA receptors.
REACT_336170. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Miscellaneous databases

NextBioi620697.
PROiQ8VHW9.

Gene expression databases

GenevestigatoriQ8VHW9.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.
ProtoNetiSearch...

Publicationsi

  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating."
    Milstein A.D., Zhou W., Karimzadegan S., Bredt D.S., Nicoll R.A.
    Neuron 55:905-918(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5."
    Soto D., Coombs I.D., Renzi M., Zonouzi M., Farrant M., Cull-Candy S.G.
    Nat. Neurosci. 12:277-285(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors."
    Schwenk J., Harmel N., Zolles G., Bildl W., Kulik A., Heimrich B., Chisaka O., Jonas P., Schulte U., Fakler B., Kloecker N.
    Science 323:1313-1319(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCCG4_RAT
AccessioniPrimary (citable) accession number: Q8VHW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.