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Q8VHW9

- CCG4_RAT

UniProt

Q8VHW9 - CCG4_RAT

Protein

Voltage-dependent calcium channel gamma-4 subunit

Gene

Cacng4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.2 Publications

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: InterPro

    GO - Biological processi

    1. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    2. transmission of nerve impulse Source: Ensembl

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-4 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-4 subunit
    Transmembrane AMPAR regulatory protein gamma-4
    Short name:
    TARP gamma-4
    Gene namesi
    Name:Cacng4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi628804. Cacng4.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. voltage-gated calcium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Voltage-dependent calcium channel gamma-4 subunitPRO_0000164680Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8VHW9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8VHW9.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004383.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 10777ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 1368CytoplasmicSequence Analysis
    Topological domaini158 – 18629ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 327120CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45952.
    GeneTreeiENSGT00550000074547.
    HOGENOMiHOG000233440.
    HOVERGENiHBG003682.
    InParanoidiQ8VHW9.
    KOiK04869.
    OMAiCIGAGRF.
    OrthoDBiEOG7TQV1Q.
    PhylomeDBiQ8VHW9.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR005423. VDCC_g4su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01603. VDCCGAMMA4.

    Sequencei

    Sequence statusi: Complete.

    Q8VHW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD    50
    GPPPRRARGD LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL 100
    LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL 150
    SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV 200
    LAVNIYIEKN KELRFKTKRE FLKASSSSPY SRMPSYRYRR RRSRSSSRST 250
    EASPSRDASP VGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQDAGF 300
    LQMHDFFQQD LKEGFHVSML NRRTTPV 327
    Length:327
    Mass (Da):36,523
    Last modified:March 1, 2002 - v1
    Checksum:i7205476FD8823AD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361341 mRNA. Translation: AAL50036.1.
    RefSeqiNP_542423.1. NM_080692.1.
    UniGeneiRn.162211.

    Genome annotation databases

    EnsembliENSRNOT00000004383; ENSRNOP00000004383; ENSRNOG00000003262.
    GeneIDi140725.
    KEGGirno:140725.
    UCSCiRGD:628804. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361341 mRNA. Translation: AAL50036.1 .
    RefSeqi NP_542423.1. NM_080692.1.
    UniGenei Rn.162211.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004383.

    Proteomic databases

    PaxDbi Q8VHW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004383 ; ENSRNOP00000004383 ; ENSRNOG00000003262 .
    GeneIDi 140725.
    KEGGi rno:140725.
    UCSCi RGD:628804. rat.

    Organism-specific databases

    CTDi 27092.
    RGDi 628804. Cacng4.

    Phylogenomic databases

    eggNOGi NOG45952.
    GeneTreei ENSGT00550000074547.
    HOGENOMi HOG000233440.
    HOVERGENi HBG003682.
    InParanoidi Q8VHW9.
    KOi K04869.
    OMAi CIGAGRF.
    OrthoDBi EOG7TQV1Q.
    PhylomeDBi Q8VHW9.
    TreeFami TF327980.

    Miscellaneous databases

    NextBioi 620697.
    PROi Q8VHW9.

    Gene expression databases

    Genevestigatori Q8VHW9.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR005423. VDCC_g4su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01603. VDCCGAMMA4.
    ProtoNeti Search...

    Publicationsi

    1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
      Chu P.-J., Robertson H.M., Best P.M.
      Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating."
      Milstein A.D., Zhou W., Karimzadegan S., Bredt D.S., Nicoll R.A.
      Neuron 55:905-918(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5."
      Soto D., Coombs I.D., Renzi M., Zonouzi M., Farrant M., Cull-Candy S.G.
      Nat. Neurosci. 12:277-285(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors."
      Schwenk J., Harmel N., Zolles G., Bildl W., Kulik A., Heimrich B., Chisaka O., Jonas P., Schulte U., Fakler B., Kloecker N.
      Science 323:1313-1319(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCCG4_RAT
    AccessioniPrimary (citable) accession number: Q8VHW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3