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Protein

Voltage-dependent calcium channel gamma-5 subunit

Gene

Cacng5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. According to PubMed:18817736, shows only specificity for GRIA2 and specifically to the form of GRIA2 for which a single amino acid in the pore region has been edited from a glutamine to an arginine residue. Thought to stabilize the calcium channel in an inactivated (closed) state.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5576893. Phase 2 - plateau phase.
R-RNO-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-5 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name:
TARP gamma-5
Gene namesi
Name:Cacng5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi628805. Cacng5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • AMPA glutamate receptor complex Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646831 – 275Voltage-dependent calcium channel gamma-5 subunitAdd BLAST275

Proteomic databases

PaxDbiQ8VHW8.
PRIDEiQ8VHW8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003288.
GenevisibleiQ8VHW8. RN.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4.3 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004578.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiQ8VHW8.
KOiK04870.
OMAiLKCPEYE.
OrthoDBiEOG091G0F73.
PhylomeDBiQ8VHW8.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.

Sequencei

Sequence statusi: Complete.

Q8VHW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTCGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGI ILPQNQSTEV
60 70 80 90 100
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNSQMTSEST VNVLKMIRSA
110 120 130 140 150
TPFPLVSLFF MFIGFILSNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF
210 220 230 240 250
MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWIRG RSPSDISSDA
260 270
SLQMNSNYPA LLKCPDYDQM SSSPC
Length:275
Mass (Da):30,924
Last modified:March 1, 2002 - v1
Checksum:i31177F24A99A34CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361342 mRNA. Translation: AAL50037.1.
RefSeqiNP_542424.1. NM_080693.1.
XP_017452463.1. XM_017596974.1.
UniGeneiRn.81219.

Genome annotation databases

EnsembliENSRNOT00000004578; ENSRNOP00000004578; ENSRNOG00000003288.
GeneIDi140726.
KEGGirno:140726.
UCSCiRGD:628805. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361342 mRNA. Translation: AAL50037.1.
RefSeqiNP_542424.1. NM_080693.1.
XP_017452463.1. XM_017596974.1.
UniGeneiRn.81219.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004578.

Proteomic databases

PaxDbiQ8VHW8.
PRIDEiQ8VHW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004578; ENSRNOP00000004578; ENSRNOG00000003288.
GeneIDi140726.
KEGGirno:140726.
UCSCiRGD:628805. rat.

Organism-specific databases

CTDi27091.
RGDi628805. Cacng5.

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiQ8VHW8.
KOiK04870.
OMAiLKCPEYE.
OrthoDBiEOG091G0F73.
PhylomeDBiQ8VHW8.

Enzyme and pathway databases

ReactomeiR-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5576893. Phase 2 - plateau phase.
R-RNO-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

PROiQ8VHW8.

Gene expression databases

BgeeiENSRNOG00000003288.
GenevisibleiQ8VHW8. RN.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.
ProtoNetiSearch...

Entry informationi

Entry nameiCCG5_RAT
AccessioniPrimary (citable) accession number: Q8VHW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.