ID   CCG6_RAT                Reviewed;         260 AA.
AC   Q8VHW7; Q8VHW6;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   24-JAN-2024, entry version 120.
DE   RecName: Full=Voltage-dependent calcium channel gamma-6 subunit;
DE   AltName: Full=Neuronal voltage-gated calcium channel gamma-6 subunit;
GN   Name=Cacng6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA   Chu P.-J., Robertson H.M., Best P.M.;
RT   "Calcium channel gamma subunits provide insights into the evolution of this
RT   gene family.";
RL   Gene 280:37-48(2001).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=21127204; DOI=10.1096/fj.10-172353;
RA   Yang L., Katchman A., Morrow J.P., Doshi D., Marx S.O.;
RT   "Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.";
RL   FASEB J. 25:928-936(2011).
CC   -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC       contain CACNA1C as pore-forming subunit.
CC       {ECO:0000250|UniProtKB:Q9BXT2}.
CC   -!- SUBUNIT: Interacts with CACNA1C. Identified in a complex with the L-
CC       type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or
CC       CACNB2. {ECO:0000250|UniProtKB:Q9BXT2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXT2};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXT2}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=Q8VHW7-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=Q8VHW7-2; Sequence=VSP_005074;
CC   -!- TISSUE SPECIFICITY: Detected in heart atrium and ventricle, aorta and
CC       skeletal muscle (PubMed:11738816). Detected in heart left ventricle
CC       (PubMed:21127204). {ECO:0000269|PubMed:11738816,
CC       ECO:0000269|PubMed:21127204}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF361343; AAL50038.1; -; mRNA.
DR   EMBL; AF361344; AAL50039.1; -; mRNA.
DR   RefSeq; NP_542425.1; NM_080694.1. [Q8VHW7-1]
DR   RefSeq; XP_008756971.1; XM_008758749.1. [Q8VHW7-2]
DR   AlphaFoldDB; Q8VHW7; -.
DR   SMR; Q8VHW7; -.
DR   STRING; 10116.ENSRNOP00000074853; -.
DR   PhosphoSitePlus; Q8VHW7; -.
DR   PaxDb; 10116-ENSRNOP00000019211; -.
DR   Ensembl; ENSRNOT00000106854.1; ENSRNOP00000092698.1; ENSRNOG00000063051.1. [Q8VHW7-2]
DR   Ensembl; ENSRNOT00000111328.1; ENSRNOP00000095459.1; ENSRNOG00000063051.1. [Q8VHW7-1]
DR   Ensembl; ENSRNOT00055053767; ENSRNOP00055044486; ENSRNOG00055030984. [Q8VHW7-1]
DR   Ensembl; ENSRNOT00060043327; ENSRNOP00060035883; ENSRNOG00060025031. [Q8VHW7-1]
DR   Ensembl; ENSRNOT00065052675; ENSRNOP00065043301; ENSRNOG00065030558. [Q8VHW7-1]
DR   GeneID; 140727; -.
DR   KEGG; rno:140727; -.
DR   UCSC; RGD:628806; rat. [Q8VHW7-1]
DR   AGR; RGD:628806; -.
DR   CTD; 59285; -.
DR   RGD; 628806; Cacng6.
DR   eggNOG; ENOG502QUPR; Eukaryota.
DR   GeneTree; ENSGT00390000007786; -.
DR   HOGENOM; CLU_093876_0_0_1; -.
DR   InParanoid; Q8VHW7; -.
DR   OMA; PWQRCLP; -.
DR   OrthoDB; 4230292at2759; -.
DR   PhylomeDB; Q8VHW7; -.
DR   TreeFam; TF331651; -.
DR   Reactome; R-RNO-5576892; Phase 0 - rapid depolarisation.
DR   Reactome; R-RNO-5576893; Phase 2 - plateau phase.
DR   PRO; PR:Q8VHW7; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000057852; Expressed in skeletal muscle tissue and 8 other cell types or tissues.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:1902514; P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; IBA:GO_Central.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR008370; VDCC_g6su.
DR   InterPro; IPR008368; VDCC_gsu.
DR   PANTHER; PTHR15025; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED; 1.
DR   PANTHER; PTHR15025:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT; 1.
DR   Pfam; PF13903; Claudin_2; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01794; VDCCGAMMA6.
DR   Genevisible; Q8VHW7; RN.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Calcium; Calcium channel; Calcium transport;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..260
FT                   /note="Voltage-dependent calcium channel gamma-6 subunit"
FT                   /id="PRO_0000164686"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         136..181
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000303|PubMed:11738816"
FT                   /id="VSP_005074"
SQ   SEQUENCE   260 AA;  28255 MW;  DBE75E0F21C2BFC5 CRC64;
     MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA TLAVLAVGTE
     FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR ETCGPAELPG EANCTYFKFF
     TTGENAHIFQ RTTKKEVNLA AAVIAVLGLT AMALGCLCVI MVLSKGAEFL LRLGAVCFGL
     SGLLLFVSLE VFRHSVRALL QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL
     LTLPSWPWRS LCPKRGGPTA
//