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Q8VHW7 (CCG6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-6 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-6 subunit
Gene names
Name:Cacng6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionCalcium channel
Ion channel
Voltage-gated channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

voltage-gated ion channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q8VHW7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q8VHW7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     136-181: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Voltage-dependent calcium channel gamma-6 subunit
PRO_0000164686

Regions

Transmembrane43 – 6321Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane221 – 24121Helical; Potential

Natural variations

Alternative sequence136 – 18146Missing in isoform Short.
VSP_005074

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: DBE75E0F21C2BFC5

FASTA26028,255
        10         20         30         40         50         60 
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA TLAVLAVGTE 

        70         80         90        100        110        120 
FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR ETCGPAELPG EANCTYFKFF 

       130        140        150        160        170        180 
TTGENAHIFQ RTTKKEVNLA AAVIAVLGLT AMALGCLCVI MVLSKGAEFL LRLGAVCFGL 

       190        200        210        220        230        240 
SGLLLFVSLE VFRHSVRALL QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL 

       250        260 
LTLPSWPWRS LCPKRGGPTA 

« Hide

Isoform Short [UniParc].

Checksum: 9D6D2761D17067BD
Show »

FASTA21423,651

References

[1]"Calcium channel gamma subunits provide insights into the evolution of this gene family."
Chu P.-J., Robertson H.M., Best P.M.
Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
Strain: Sprague-Dawley.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF361343 mRNA. Translation: AAL50038.1.
AF361344 mRNA. Translation: AAL50039.1.
RefSeqNP_542425.1. NM_080694.1. [Q8VHW7-1]
UniGeneRn.91033.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ8VHW7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000019191; ENSRNOP00000019191; ENSRNOG00000014326. [Q8VHW7-2]
ENSRNOT00000019211; ENSRNOP00000019211; ENSRNOG00000014326. [Q8VHW7-1]
GeneID140727.
KEGGrno:140727.
UCSCRGD:628806. rat. [Q8VHW7-1]

Organism-specific databases

CTD59285.
RGD628806. Cacng6.

Phylogenomic databases

eggNOGNOG45843.
GeneTreeENSGT00390000007786.
HOGENOMHOG000293219.
HOVERGENHBG003868.
InParanoidQ8VHW7.
KOK04871.
OMAVCDAAHL.
OrthoDBEOG7WQ7TF.
PhylomeDBQ8VHW7.
TreeFamTF331651.

Gene expression databases

GenevestigatorQ8VHW7.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.
ProtoNetSearch...

Other

NextBio620705.
PROQ8VHW7.

Entry information

Entry nameCCG6_RAT
AccessionPrimary (citable) accession number: Q8VHW7
Secondary accession number(s): Q8VHW6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families