Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8VHW7

- CCG6_RAT

UniProt

Q8VHW7 - CCG6_RAT

Protein

Voltage-dependent calcium channel gamma-6 subunit

Gene

Cacng6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Thought to stabilize the calcium channel in an inactivated (closed) state.By similarity

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-6 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-6 subunit
    Gene namesi
    Name:Cacng6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi628806. Cacng6.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Voltage-dependent calcium channel gamma-6 subunitPRO_0000164686Add
    BLAST

    Proteomic databases

    PaxDbiQ8VHW7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8VHW7.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45843.
    GeneTreeiENSGT00390000007786.
    HOGENOMiHOG000293219.
    HOVERGENiHBG003868.
    InParanoidiQ8VHW7.
    KOiK04871.
    OMAiVCDAAHL.
    OrthoDBiEOG7WQ7TF.
    PhylomeDBiQ8VHW7.
    TreeFamiTF331651.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR008370. VDCC_g6su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF13903. Claudin_2. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01794. VDCCGAMMA6.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q8VHW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA    50
    TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR 100
    ETCGPAELPG EANCTYFKFF TTGENAHIFQ RTTKKEVNLA AAVIAVLGLT 150
    AMALGCLCVI MVLSKGAEFL LRLGAVCFGL SGLLLFVSLE VFRHSVRALL 200
    QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS 250
    LCPKRGGPTA 260
    Length:260
    Mass (Da):28,255
    Last modified:March 1, 2002 - v1
    Checksum:iDBE75E0F21C2BFC5
    GO
    Isoform Short (identifier: Q8VHW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         136-181: Missing.

    Show »
    Length:214
    Mass (Da):23,651
    Checksum:i9D6D2761D17067BD
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei136 – 18146Missing in isoform Short. 1 PublicationVSP_005074Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361343 mRNA. Translation: AAL50038.1.
    AF361344 mRNA. Translation: AAL50039.1.
    RefSeqiNP_542425.1. NM_080694.1. [Q8VHW7-1]
    UniGeneiRn.91033.

    Genome annotation databases

    EnsembliENSRNOT00000019191; ENSRNOP00000019191; ENSRNOG00000014326. [Q8VHW7-2]
    ENSRNOT00000019211; ENSRNOP00000019211; ENSRNOG00000014326. [Q8VHW7-1]
    GeneIDi140727.
    KEGGirno:140727.
    UCSCiRGD:628806. rat. [Q8VHW7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361343 mRNA. Translation: AAL50038.1 .
    AF361344 mRNA. Translation: AAL50039.1 .
    RefSeqi NP_542425.1. NM_080694.1. [Q8VHW7-1 ]
    UniGenei Rn.91033.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8VHW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019191 ; ENSRNOP00000019191 ; ENSRNOG00000014326 . [Q8VHW7-2 ]
    ENSRNOT00000019211 ; ENSRNOP00000019211 ; ENSRNOG00000014326 . [Q8VHW7-1 ]
    GeneIDi 140727.
    KEGGi rno:140727.
    UCSCi RGD:628806. rat. [Q8VHW7-1 ]

    Organism-specific databases

    CTDi 59285.
    RGDi 628806. Cacng6.

    Phylogenomic databases

    eggNOGi NOG45843.
    GeneTreei ENSGT00390000007786.
    HOGENOMi HOG000293219.
    HOVERGENi HBG003868.
    InParanoidi Q8VHW7.
    KOi K04871.
    OMAi VCDAAHL.
    OrthoDBi EOG7WQ7TF.
    PhylomeDBi Q8VHW7.
    TreeFami TF331651.

    Miscellaneous databases

    NextBioi 620705.
    PROi Q8VHW7.

    Gene expression databases

    Genevestigatori Q8VHW7.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR008370. VDCC_g6su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF13903. Claudin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01794. VDCCGAMMA6.
    ProtoNeti Search...

    Publicationsi

    1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
      Chu P.-J., Robertson H.M., Best P.M.
      Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiCCG6_RAT
    AccessioniPrimary (citable) accession number: Q8VHW7
    Secondary accession number(s): Q8VHW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3