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Q8VHW7

- CCG6_RAT

UniProt

Q8VHW7 - CCG6_RAT

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Protein

Voltage-dependent calcium channel gamma-6 subunit

Gene

Cacng6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state.By similarity

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-6 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-6 subunit
Gene namesi
Name:Cacng6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi628806. Cacng6.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Voltage-dependent calcium channel gamma-6 subunitPRO_0000164686Add
BLAST

Proteomic databases

PaxDbiQ8VHW7.

Expressioni

Gene expression databases

GenevestigatoriQ8VHW7.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45843.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ8VHW7.
KOiK04871.
OMAiVCDAAHL.
OrthoDBiEOG7WQ7TF.
PhylomeDBiQ8VHW7.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q8VHW7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA
60 70 80 90 100
TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR
110 120 130 140 150
ETCGPAELPG EANCTYFKFF TTGENAHIFQ RTTKKEVNLA AAVIAVLGLT
160 170 180 190 200
AMALGCLCVI MVLSKGAEFL LRLGAVCFGL SGLLLFVSLE VFRHSVRALL
210 220 230 240 250
QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS
260
LCPKRGGPTA
Length:260
Mass (Da):28,255
Last modified:March 1, 2002 - v1
Checksum:iDBE75E0F21C2BFC5
GO
Isoform Short (identifier: Q8VHW7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-181: Missing.

Show »
Length:214
Mass (Da):23,651
Checksum:i9D6D2761D17067BD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 18146Missing in isoform Short. 1 PublicationVSP_005074Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361343 mRNA. Translation: AAL50038.1.
AF361344 mRNA. Translation: AAL50039.1.
RefSeqiNP_542425.1. NM_080694.1. [Q8VHW7-1]
UniGeneiRn.91033.

Genome annotation databases

EnsembliENSRNOT00000019191; ENSRNOP00000019191; ENSRNOG00000014326. [Q8VHW7-2]
ENSRNOT00000019211; ENSRNOP00000019211; ENSRNOG00000014326. [Q8VHW7-1]
GeneIDi140727.
KEGGirno:140727.
UCSCiRGD:628806. rat. [Q8VHW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361343 mRNA. Translation: AAL50038.1 .
AF361344 mRNA. Translation: AAL50039.1 .
RefSeqi NP_542425.1. NM_080694.1. [Q8VHW7-1 ]
UniGenei Rn.91033.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8VHW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019191 ; ENSRNOP00000019191 ; ENSRNOG00000014326 . [Q8VHW7-2 ]
ENSRNOT00000019211 ; ENSRNOP00000019211 ; ENSRNOG00000014326 . [Q8VHW7-1 ]
GeneIDi 140727.
KEGGi rno:140727.
UCSCi RGD:628806. rat. [Q8VHW7-1 ]

Organism-specific databases

CTDi 59285.
RGDi 628806. Cacng6.

Phylogenomic databases

eggNOGi NOG45843.
GeneTreei ENSGT00390000007786.
HOGENOMi HOG000293219.
HOVERGENi HBG003868.
InParanoidi Q8VHW7.
KOi K04871.
OMAi VCDAAHL.
OrthoDBi EOG7WQ7TF.
PhylomeDBi Q8VHW7.
TreeFami TF331651.

Miscellaneous databases

NextBioi 620705.
PROi Q8VHW7.

Gene expression databases

Genevestigatori Q8VHW7.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF13903. Claudin_2. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.
ProtoNeti Search...

Publicationsi

  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCCG6_RAT
AccessioniPrimary (citable) accession number: Q8VHW7
Secondary accession number(s): Q8VHW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3