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Protein

Voltage-dependent calcium channel gamma-6 subunit

Gene

Cacng6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5576893. Phase 2 - plateau phase.
R-RNO-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-6 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-6 subunit
Gene namesi
Name:Cacng6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628806. Cacng6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646861 – 260Voltage-dependent calcium channel gamma-6 subunitAdd BLAST260

Proteomic databases

PaxDbiQ8VHW7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014326.
GenevisibleiQ8VHW7. RN.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019211.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWHM. Eukaryota.
ENOG4111I1Z. LUCA.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ8VHW7.
KOiK04871.
OMAiGEANCTY.
OrthoDBiEOG091G0HUO.
PhylomeDBiQ8VHW7.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q8VHW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA
60 70 80 90 100
TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR
110 120 130 140 150
ETCGPAELPG EANCTYFKFF TTGENAHIFQ RTTKKEVNLA AAVIAVLGLT
160 170 180 190 200
AMALGCLCVI MVLSKGAEFL LRLGAVCFGL SGLLLFVSLE VFRHSVRALL
210 220 230 240 250
QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS
260
LCPKRGGPTA
Length:260
Mass (Da):28,255
Last modified:March 1, 2002 - v1
Checksum:iDBE75E0F21C2BFC5
GO
Isoform Short (identifier: Q8VHW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-181: Missing.

Show »
Length:214
Mass (Da):23,651
Checksum:i9D6D2761D17067BD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005074136 – 181Missing in isoform Short. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361343 mRNA. Translation: AAL50038.1.
AF361344 mRNA. Translation: AAL50039.1.
RefSeqiNP_542425.1. NM_080694.1. [Q8VHW7-1]
XP_008756971.1. XM_008758749.1. [Q8VHW7-2]
UniGeneiRn.91033.

Genome annotation databases

EnsembliENSRNOT00000081837; ENSRNOP00000074853; ENSRNOG00000057852. [Q8VHW7-1]
GeneIDi140727.
KEGGirno:140727.
UCSCiRGD:628806. rat. [Q8VHW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361343 mRNA. Translation: AAL50038.1.
AF361344 mRNA. Translation: AAL50039.1.
RefSeqiNP_542425.1. NM_080694.1. [Q8VHW7-1]
XP_008756971.1. XM_008758749.1. [Q8VHW7-2]
UniGeneiRn.91033.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019211.

Proteomic databases

PaxDbiQ8VHW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081837; ENSRNOP00000074853; ENSRNOG00000057852. [Q8VHW7-1]
GeneIDi140727.
KEGGirno:140727.
UCSCiRGD:628806. rat. [Q8VHW7-1]

Organism-specific databases

CTDi59285.
RGDi628806. Cacng6.

Phylogenomic databases

eggNOGiENOG410IWHM. Eukaryota.
ENOG4111I1Z. LUCA.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ8VHW7.
KOiK04871.
OMAiGEANCTY.
OrthoDBiEOG091G0HUO.
PhylomeDBiQ8VHW7.
TreeFamiTF331651.

Enzyme and pathway databases

ReactomeiR-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5576893. Phase 2 - plateau phase.
R-RNO-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

PROiQ8VHW7.

Gene expression databases

BgeeiENSRNOG00000014326.
GenevisibleiQ8VHW7. RN.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.
ProtoNetiSearch...

Entry informationi

Entry nameiCCG6_RAT
AccessioniPrimary (citable) accession number: Q8VHW7
Secondary accession number(s): Q8VHW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.