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Protein

Voltage-dependent calcium channel gamma-8 subunit

Gene

Cacng8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-8 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-8 subunit
Transmembrane AMPAR regulatory protein gamma-8
Short name:
TARP gamma-8
Gene namesi
Name:Cacng8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628808. Cacng8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646921 – 421Voltage-dependent calcium channel gamma-8 subunitAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei251PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VHW5.
PRIDEiQ8VHW5.

PTM databases

iPTMnetiQ8VHW5.
PhosphoSitePlusiQ8VHW5.
SwissPalmiQ8VHW5.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP3CAQ082092EBI-9086576,EBI-352922From a different organism.
Ppp3caP633296EBI-9086576,EBI-7022944

Protein-protein interaction databases

BioGridi250845. 2 interactors.
IntActiQ8VHW5. 8 interactors.
STRINGi10116.ENSRNOP00000019300.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 360Gly-richAdd BLAST116

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVW. Eukaryota.
ENOG4110B1C. LUCA.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8VHW5.
KOiK04873.
PhylomeDBiQ8VHW5.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008372. VDCC_g8su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01796. VDCCGAMMA8.

Sequencei

Sequence statusi: Complete.

Q8VHW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLKRWNEE RGLWCEKGVQ VLLTTIGAFA AFGLMTIAIS TDYWLYTRAL
60 70 80 90 100
ICNTTNLTAG DDGPPHRGGS GSSEKKDPGG LTHSGLWRIC CLEGLKRGVC
110 120 130 140 150
VKINHFPEDT DYDHDSAEYL LRVVRASSIF PILSAILLLL GGVCVAASRV
160 170 180 190 200
YKSKRNIILG AGILFVAAGL SNIIGVIVYI SANAGEPGPK RDEEKKNHYS
210 220 230 240 250
YGWSFYFGGL SFILAEVIGV LAVNIYIERS REAHCQSRSD LLKAGGGAGG
260 270 280 290 300
SGGSGPSAIL RLPSYRFRYR RRSRSSSRGS SEASPSRDAS PGGPGGPGFA
310 320 330 340 350
STDISMYTLS RDPSKGSVAA GLASAGGGGG GAGVGAYGGA AGAAGGGGTG
360 370 380 390 400
SERDRGSSAG FLTLHNAFPK EAASGVTVTV TGPPAAPAPA PPAPAAPAPG
410 420
TLSKEAAASN TNTLNRKTTP V
Length:421
Mass (Da):43,269
Last modified:March 1, 2002 - v1
Checksum:i0FDB1461BDC780A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361346 mRNA. Translation: AAL50041.1.
RefSeqiNP_542427.1. NM_080696.2.
UniGeneiRn.207527.

Genome annotation databases

GeneIDi140729.
KEGGirno:140729.
UCSCiRGD:628808. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361346 mRNA. Translation: AAL50041.1.
RefSeqiNP_542427.1. NM_080696.2.
UniGeneiRn.207527.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250845. 2 interactors.
IntActiQ8VHW5. 8 interactors.
STRINGi10116.ENSRNOP00000019300.

PTM databases

iPTMnetiQ8VHW5.
PhosphoSitePlusiQ8VHW5.
SwissPalmiQ8VHW5.

Proteomic databases

PaxDbiQ8VHW5.
PRIDEiQ8VHW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140729.
KEGGirno:140729.
UCSCiRGD:628808. rat.

Organism-specific databases

CTDi59283.
RGDi628808. Cacng8.

Phylogenomic databases

eggNOGiENOG410IJVW. Eukaryota.
ENOG4110B1C. LUCA.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8VHW5.
KOiK04873.
PhylomeDBiQ8VHW5.

Miscellaneous databases

PROiQ8VHW5.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008372. VDCC_g8su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01796. VDCCGAMMA8.
ProtoNetiSearch...

Entry informationi

Entry nameiCCG8_RAT
AccessioniPrimary (citable) accession number: Q8VHW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.