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Protein

Voltage-dependent calcium channel gamma-5 subunit

Gene

Cacng5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.

Protein family/group databases

TCDBi8.A.16.2.4. the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-5 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name:
TARP gamma-5
Gene namesi
Name:Cacng5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2157946. Cacng5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646821 – 275Voltage-dependent calcium channel gamma-5 subunitAdd BLAST275

Proteomic databases

PaxDbiQ8VHW4.
PRIDEiQ8VHW4.

PTM databases

iPTMnetiQ8VHW4.
PhosphoSitePlusiQ8VHW4.

Expressioni

Tissue specificityi

Brain. Enriched in Bergman glia, as well as a variety of neuronal populations including locus coeruleus, olfactory bulb, lateral septal nucleus, interpeduncular nucleus,and the CA2 and rostral/medial CA1 regions of hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000040373.
ExpressionAtlasiQ8VHW4. baseline and differential.
GenevisibleiQ8VHW4. MM.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047888.

Structurei

3D structure databases

ProteinModelPortaliQ8VHW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiQ8VHW4.
KOiK04870.
OMAiLKCPEYE.
OrthoDBiEOG091G0F73.
PhylomeDBiQ8VHW4.
TreeFamiTF327980.

Family and domain databases

InterProiView protein in InterPro
IPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
PANTHERiPTHR12107:SF21. PTHR12107:SF21. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.

Sequencei

Sequence statusi: Complete.

Q8VHW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGI ILPQNQSTEV
60 70 80 90 100
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNSQMTSEST VNVLKMIRSA
110 120 130 140 150
TPFPLVSLFF MFIGFILSNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF
210 220 230 240 250
MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWIRG RSPSDISSDA
260 270
SLQMNSNYPA LLKCPDYDQM SSSPC
Length:275
Mass (Da):30,894
Last modified:March 1, 2002 - v1
Checksum:i37A01454A6CAC1CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361347 mRNA. Translation: AAL50042.1.
CCDSiCCDS25572.1.
RefSeqiNP_001186230.1. NM_001199301.1.
NP_542375.1. NM_080644.3.
UniGeneiMm.87663.

Genome annotation databases

EnsembliENSMUST00000039071; ENSMUSP00000047888; ENSMUSG00000040373.
ENSMUST00000106742; ENSMUSP00000102353; ENSMUSG00000040373.
GeneIDi140723.
KEGGimmu:140723.
UCSCiuc007mbb.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCCG5_MOUSE
AccessioniPrimary (citable) accession number: Q8VHW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: May 10, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families