ID   CCG6_MOUSE              Reviewed;         260 AA.
AC   Q8VHW3;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Voltage-dependent calcium channel gamma-6 subunit;
DE   AltName: Full=Neuronal voltage-gated calcium channel gamma-6 subunit;
GN   Name=Cacng6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ;
RX   PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA   Chu P.-J., Robertson H.M., Best P.M.;
RT   "Calcium channel gamma subunits provide insights into the evolution of this
RT   gene family.";
RL   Gene 280:37-48(2001).
RN   [2]
RP   IDENTIFICATION IN A COMPLEX WITH CACNA1C, SUBUNIT, AND TISSUE SPECIFICITY.
RX   PubMed=21127204; DOI=10.1096/fj.10-172353;
RA   Yang L., Katchman A., Morrow J.P., Doshi D., Marx S.O.;
RT   "Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.";
RL   FASEB J. 25:928-936(2011).
CC   -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC       contain CACNA1C as pore-forming subunit.
CC       {ECO:0000250|UniProtKB:Q9BXT2}.
CC   -!- SUBUNIT: Interacts with CACNA1C (PubMed:21127204). Identified in a
CC       complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and
CC       either CACNB1 or CACNB2 (By similarity). {ECO:0000250|UniProtKB:Q9BXT2,
CC       ECO:0000269|PubMed:21127204}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXT2};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXT2}.
CC   -!- TISSUE SPECIFICITY: Detected in brain and heart (at protein level).
CC       {ECO:0000269|PubMed:21127204}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF361348; AAL50043.1; -; mRNA.
DR   CCDS; CCDS39726.1; -.
DR   RefSeq; NP_573446.1; NM_133183.2.
DR   AlphaFoldDB; Q8VHW3; -.
DR   SMR; Q8VHW3; -.
DR   STRING; 10090.ENSMUSP00000138622; -.
DR   PhosphoSitePlus; Q8VHW3; -.
DR   PaxDb; 10090-ENSMUSP00000138622; -.
DR   ProteomicsDB; 281422; -.
DR   Antibodypedia; 32772; 130 antibodies from 19 providers.
DR   DNASU; 54378; -.
DR   Ensembl; ENSMUST00000183200.8; ENSMUSP00000138622.2; ENSMUSG00000078815.9.
DR   GeneID; 54378; -.
DR   KEGG; mmu:54378; -.
DR   UCSC; uc009euy.1; mouse.
DR   AGR; MGI:1859168; -.
DR   CTD; 59285; -.
DR   MGI; MGI:1859168; Cacng6.
DR   VEuPathDB; HostDB:ENSMUSG00000078815; -.
DR   eggNOG; ENOG502QUPR; Eukaryota.
DR   GeneTree; ENSGT00390000007786; -.
DR   InParanoid; Q8VHW3; -.
DR   OMA; PWQRCLP; -.
DR   OrthoDB; 4230292at2759; -.
DR   PhylomeDB; Q8VHW3; -.
DR   TreeFam; TF331651; -.
DR   Reactome; R-MMU-5576892; Phase 0 - rapid depolarisation.
DR   Reactome; R-MMU-5576893; Phase 2 - plateau phase.
DR   BioGRID-ORCS; 54378; 3 hits in 76 CRISPR screens.
DR   PRO; PR:Q8VHW3; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8VHW3; Protein.
DR   Bgee; ENSMUSG00000078815; Expressed in quadriceps femoris and 42 other cell types or tissues.
DR   ExpressionAtlas; Q8VHW3; baseline and differential.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:1902514; P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; IBA:GO_Central.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR008370; VDCC_g6su.
DR   InterPro; IPR008368; VDCC_gsu.
DR   PANTHER; PTHR15025; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED; 1.
DR   PANTHER; PTHR15025:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT; 1.
DR   Pfam; PF13903; Claudin_2; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01794; VDCCGAMMA6.
DR   Genevisible; Q8VHW3; MM.
PE   1: Evidence at protein level;
KW   Calcium; Calcium channel; Calcium transport; Cell membrane; Ion channel;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..260
FT                   /note="Voltage-dependent calcium channel gamma-6 subunit"
FT                   /id="PRO_0000164685"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  28145 MW;  583C326BE6D88C80 CRC64;
     MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA TLAVLAVGTE
     FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR ETCGPAELPG EANCTYFKFF
     TTGENARIFQ RTTKKEVNLA AAVIAVLGLT AMALGCLCVI MVLSKGAESL LRLGAVCFGL
     SGLLLFVSLE VFRHSVGALL QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL
     LTLPSWPWRS LCPKWGGPTA
//