true2002-05-102024-01-24129CCG6_MOUSECalcium channel gamma subunits provide insights into the evolution of this gene family.Chu P.-J.Robertson H.M.Best P.M.doi:10.1016/s0378-1119(01)00738-72001Gene28037-48NUCLEOTIDE SEQUENCE [MRNA]BALB/cJCardiac L-type calcium channel (Cav1.2) associates with gamma subunits.Yang L.Katchman A.Morrow J.P.Doshi D.Marx S.O.doi:10.1096/fj.10-1723532011FASEB J.25928-936IDENTIFICATION IN A COMPLEX WITH CACNA1CSUBUNITTISSUE SPECIFICITY130 antibodies from 19 providersmouseCacng6EukaryotaPhase 0 - rapid depolarisationPhase 2 - plateau phase3 hits in 76 CRISPR screensProteinExpressed in quadriceps femoris and 42 other cell types or tissuesbaseline and differentialPMP22/EMP/MP20/ClaudinVDCC_g6suVDCC_gsuVOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATEDVOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNITClaudin_2VDCCGAMMAVDCCGAMMA6MMVoltage-dependent calcium channel gamma-6 subunitNeuronal voltage-gated calcium channel gamma-6 subunitCacng6Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.Interacts with CACNA1C (PubMed:21127204). Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity).Detected in brain and heart (at protein level).Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Voltage-dependent calcium channel gamma-6 subunit281451260Helical4363Helical143163Helical169189Helical2212412002-03-01128145ce61bbc3e37922542cd06366ce024cc7MMWSNFFMQEEDRRRTAVGRRRAQEQQNLGLTPEREGKIKLGLLVAIVGATLAVLAVGTEFWVELNTYKTNGSAVCEAAHLGLWKVCIKRLWQADVPAGRETCGPAELPGEANCTYFKFFTTGENARIFQRTTKKEVNLAAAVIAVLGLTAMALGCLCVIMVLSKGAESLLRLGAVCFGLSGLLLFVSLEVFRHSVGALLQGVNPETPPAPRLAYEYSWSLGCGVGAGLILLLGGVCFLLLTLPSWPWRSLCPKWGGPTAtruetruetruetruetruetrue