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Protein

Voltage-dependent calcium channel gamma-6 subunit

Gene

Cacng6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state.By similarity

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-6 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-6 subunit
Gene namesi
Name:Cacng6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7, UP000000589: Unplaced

Organism-specific databases

MGIiMGI:1859168. Cacng6.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Voltage-dependent calcium channel gamma-6 subunitPRO_0000164685Add
BLAST

Proteomic databases

PRIDEiQ8VHW3.

Expressioni

Tissue specificityi

Highly expressed in muscle.

Gene expression databases

BgeeiQ8VHW3.
ExpressionAtlasiQ8VHW3. baseline and differential.
GenevestigatoriQ8VHW3.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104287.

Structurei

3D structure databases

ProteinModelPortaliQ8VHW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45843.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ8VHW3.
KOiK04871.
OMAiGEANCTY.
OrthoDBiEOG7WQ7TF.
PhylomeDBiQ8VHW3.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.

Sequencei

Sequence statusi: Complete.

Q8VHW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA
60 70 80 90 100
TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR
110 120 130 140 150
ETCGPAELPG EANCTYFKFF TTGENARIFQ RTTKKEVNLA AAVIAVLGLT
160 170 180 190 200
AMALGCLCVI MVLSKGAESL LRLGAVCFGL SGLLLFVSLE VFRHSVGALL
210 220 230 240 250
QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS
260
LCPKWGGPTA
Length:260
Mass (Da):28,145
Last modified:March 1, 2002 - v1
Checksum:i583C326BE6D88C80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361348 mRNA. Translation: AAL50043.1.
CCDSiCCDS39726.1.
RefSeqiNP_573446.1. NM_133183.1.
UniGeneiMm.424047.
Mm.463590.

Genome annotation databases

EnsembliENSMUST00000182493; ENSMUSP00000138775; ENSMUSG00000097894.
ENSMUST00000183200; ENSMUSP00000138622; ENSMUSG00000078815.
GeneIDi54378.
KEGGimmu:54378.
UCSCiuc009euy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361348 mRNA. Translation: AAL50043.1.
CCDSiCCDS39726.1.
RefSeqiNP_573446.1. NM_133183.1.
UniGeneiMm.424047.
Mm.463590.

3D structure databases

ProteinModelPortaliQ8VHW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104287.

Proteomic databases

PRIDEiQ8VHW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000182493; ENSMUSP00000138775; ENSMUSG00000097894.
ENSMUST00000183200; ENSMUSP00000138622; ENSMUSG00000078815.
GeneIDi54378.
KEGGimmu:54378.
UCSCiuc009euy.1. mouse.

Organism-specific databases

CTDi59285.
MGIiMGI:1859168. Cacng6.

Phylogenomic databases

eggNOGiNOG45843.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ8VHW3.
KOiK04871.
OMAiGEANCTY.
OrthoDBiEOG7WQ7TF.
PhylomeDBiQ8VHW3.
TreeFamiTF331651.

Miscellaneous databases

NextBioi311196.
PROiQ8VHW3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHW3.
ExpressionAtlasiQ8VHW3. baseline and differential.
GenevestigatoriQ8VHW3.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.
ProtoNetiSearch...

Publicationsi

  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.

Entry informationi

Entry nameiCCG6_MOUSE
AccessioniPrimary (citable) accession number: Q8VHW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.