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Q8VHW3

- CCG6_MOUSE

UniProt

Q8VHW3 - CCG6_MOUSE

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Protein

Voltage-dependent calcium channel gamma-6 subunit

Gene

Cacng6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state.By similarity

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-6 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-6 subunit
Gene namesi
Name:Cacng6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7, UP000000589: Unplaced

Organism-specific databases

MGIiMGI:1859168. Cacng6.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Voltage-dependent calcium channel gamma-6 subunitPRO_0000164685Add
BLAST

Proteomic databases

PRIDEiQ8VHW3.

Expressioni

Tissue specificityi

Highly expressed in muscle.

Gene expression databases

BgeeiQ8VHW3.
ExpressionAtlasiQ8VHW3. baseline and differential.
GenevestigatoriQ8VHW3.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104287.

Structurei

3D structure databases

ProteinModelPortaliQ8VHW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45843.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ8VHW3.
KOiK04871.
OMAiVCDAAHL.
OrthoDBiEOG7WQ7TF.
PhylomeDBiQ8VHW3.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.

Sequencei

Sequence statusi: Complete.

Q8VHW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA
60 70 80 90 100
TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR
110 120 130 140 150
ETCGPAELPG EANCTYFKFF TTGENARIFQ RTTKKEVNLA AAVIAVLGLT
160 170 180 190 200
AMALGCLCVI MVLSKGAESL LRLGAVCFGL SGLLLFVSLE VFRHSVGALL
210 220 230 240 250
QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS
260
LCPKWGGPTA
Length:260
Mass (Da):28,145
Last modified:March 1, 2002 - v1
Checksum:i583C326BE6D88C80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361348 mRNA. Translation: AAL50043.1.
CCDSiCCDS39726.1.
RefSeqiNP_573446.1. NM_133183.1.
UniGeneiMm.424047.
Mm.463590.

Genome annotation databases

EnsembliENSMUST00000182493; ENSMUSP00000138775; ENSMUSG00000097894.
ENSMUST00000183200; ENSMUSP00000138622; ENSMUSG00000078815.
GeneIDi54378.
KEGGimmu:54378.
UCSCiuc009euy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361348 mRNA. Translation: AAL50043.1 .
CCDSi CCDS39726.1.
RefSeqi NP_573446.1. NM_133183.1.
UniGenei Mm.424047.
Mm.463590.

3D structure databases

ProteinModelPortali Q8VHW3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000104287.

Proteomic databases

PRIDEi Q8VHW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000182493 ; ENSMUSP00000138775 ; ENSMUSG00000097894 .
ENSMUST00000183200 ; ENSMUSP00000138622 ; ENSMUSG00000078815 .
GeneIDi 54378.
KEGGi mmu:54378.
UCSCi uc009euy.1. mouse.

Organism-specific databases

CTDi 59285.
MGIi MGI:1859168. Cacng6.

Phylogenomic databases

eggNOGi NOG45843.
GeneTreei ENSGT00390000007786.
HOGENOMi HOG000293219.
HOVERGENi HBG003868.
InParanoidi Q8VHW3.
KOi K04871.
OMAi VCDAAHL.
OrthoDBi EOG7WQ7TF.
PhylomeDBi Q8VHW3.
TreeFami TF331651.

Miscellaneous databases

NextBioi 311196.
PROi Q8VHW3.
SOURCEi Search...

Gene expression databases

Bgeei Q8VHW3.
ExpressionAtlasi Q8VHW3. baseline and differential.
Genevestigatori Q8VHW3.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF13903. Claudin_2. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.
ProtoNeti Search...

Publicationsi

  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.

Entry informationi

Entry nameiCCG6_MOUSE
AccessioniPrimary (citable) accession number: Q8VHW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3