Q8VHW3 (CCG6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-6 subunit

Alternative name(s):
Neuronal voltage-gated calcium channel gamma-6 subunit

Gene names

Name:

Cacng6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highly expressed in muscle.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Voltage-dependent calcium channel gamma-6 subunit		PRO_0000164685
Regions
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	169 – 189	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8VHW3 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 583C326BE6D88C80	FASTA	260	28,145
	10 20 30 40 50 60 MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA TLAVLAVGTE 70 80 90 100 110 120 FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR ETCGPAELPG EANCTYFKFF 130 140 150 160 170 180 TTGENARIFQ RTTKKEVNLA AAVIAVLGLT AMALGCLCVI MVLSKGAESL LRLGAVCFGL 190 200 210 220 230 240 SGLLLFVSLE VFRHSVGALL QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL 250 260 LTLPSWPWRS LCPKWGGPTA

References

[1]	"Calcium channel gamma subunits provide insights into the evolution of this gene family." Chu P.-J., Robertson H.M., Best P.M. Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF361348 mRNA. Translation: AAL50043.1.
IPI	IPI00128828.
RefSeq	NP_573446.1. NM_133183.1.
UniGene	Mm.424047. Mm.463590.
3D structure databases
ProteinModelPortal	Q8VHW3.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000104287.
Proteomic databases
PRIDE	Q8VHW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000108647; ENSMUSP00000104287; ENSMUSG00000078815. ENSMUST00000180916; ENSMUSP00000138065; ENSMUSG00000097894.
GeneID	54378.
KEGG	mmu:54378.
Organism-specific databases
CTD	59285.
MGI	MGI:1859168. Cacng6.
Phylogenomic databases
eggNOG	NOG45843.
GeneTree	ENSGT00390000007786.
HOGENOM	HOG000293219.
HOVERGEN	HBG003868.
InParanoid	Q8VHW3.
KO	K04871.
OMA	GEANCTY.
OrthoDB	EOG441QCN.
Gene expression databases
ArrayExpress	Q8VHW3.
Bgee	Q8VHW3.
Genevestigator	Q8VHW3.
Family and domain databases
InterPro	IPR008370. VDCC_g6su. IPR008368. VDCC_gsu. [Graphical view]
PRINTS	PR01792. VDCCGAMMA. PR01794. VDCCGAMMA6.
ProtoNet	Search...
Other
NextBio	311196.
SOURCE	Search...

Entry information

Entry name

CCG6_MOUSE

Accession

Primary (citable) accession number: Q8VHW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program