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Q8VHW3

- CCG6_MOUSE

UniProt

Q8VHW3 - CCG6_MOUSE

Protein

Voltage-dependent calcium channel gamma-6 subunit

Gene

Cacng6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Thought to stabilize the calcium channel in an inactivated (closed) state.By similarity

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-6 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-6 subunit
    Gene namesi
    Name:Cacng6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1859168. Cacng6.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Voltage-dependent calcium channel gamma-6 subunitPRO_0000164685Add
    BLAST

    Proteomic databases

    PRIDEiQ8VHW3.

    Expressioni

    Tissue specificityi

    Highly expressed in muscle.

    Gene expression databases

    BgeeiQ8VHW3.
    GenevestigatoriQ8VHW3.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000104287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45843.
    GeneTreeiENSGT00390000007786.
    HOGENOMiHOG000293219.
    HOVERGENiHBG003868.
    InParanoidiQ8VHW3.
    KOiK04871.
    OMAiVCDAAHL.
    OrthoDBiEOG7WQ7TF.
    PhylomeDBiQ8VHW3.
    TreeFamiTF331651.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR008370. VDCC_g6su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF13903. Claudin_2. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01794. VDCCGAMMA6.

    Sequencei

    Sequence statusi: Complete.

    Q8VHW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA    50
    TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR 100
    ETCGPAELPG EANCTYFKFF TTGENARIFQ RTTKKEVNLA AAVIAVLGLT 150
    AMALGCLCVI MVLSKGAESL LRLGAVCFGL SGLLLFVSLE VFRHSVGALL 200
    QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS 250
    LCPKWGGPTA 260
    Length:260
    Mass (Da):28,145
    Last modified:March 1, 2002 - v1
    Checksum:i583C326BE6D88C80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361348 mRNA. Translation: AAL50043.1.
    CCDSiCCDS39726.1.
    RefSeqiNP_573446.1. NM_133183.1.
    UniGeneiMm.424047.
    Mm.463590.

    Genome annotation databases

    EnsembliENSMUST00000182493; ENSMUSP00000138775; ENSMUSG00000097894.
    ENSMUST00000183200; ENSMUSP00000138622; ENSMUSG00000078815.
    GeneIDi54378.
    KEGGimmu:54378.
    UCSCiuc009euy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361348 mRNA. Translation: AAL50043.1 .
    CCDSi CCDS39726.1.
    RefSeqi NP_573446.1. NM_133183.1.
    UniGenei Mm.424047.
    Mm.463590.

    3D structure databases

    ProteinModelPortali Q8VHW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000104287.

    Proteomic databases

    PRIDEi Q8VHW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000182493 ; ENSMUSP00000138775 ; ENSMUSG00000097894 .
    ENSMUST00000183200 ; ENSMUSP00000138622 ; ENSMUSG00000078815 .
    GeneIDi 54378.
    KEGGi mmu:54378.
    UCSCi uc009euy.1. mouse.

    Organism-specific databases

    CTDi 59285.
    MGIi MGI:1859168. Cacng6.

    Phylogenomic databases

    eggNOGi NOG45843.
    GeneTreei ENSGT00390000007786.
    HOGENOMi HOG000293219.
    HOVERGENi HBG003868.
    InParanoidi Q8VHW3.
    KOi K04871.
    OMAi VCDAAHL.
    OrthoDBi EOG7WQ7TF.
    PhylomeDBi Q8VHW3.
    TreeFami TF331651.

    Miscellaneous databases

    NextBioi 311196.
    PROi Q8VHW3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VHW3.
    Genevestigatori Q8VHW3.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR008370. VDCC_g6su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF13903. Claudin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01794. VDCCGAMMA6.
    ProtoNeti Search...

    Publicationsi

    1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
      Chu P.-J., Robertson H.M., Best P.M.
      Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.

    Entry informationi

    Entry nameiCCG6_MOUSE
    AccessioniPrimary (citable) accession number: Q8VHW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3