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Protein

Voltage-dependent calcium channel gamma-8 subunit

Gene

Cacng8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-8 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-8 subunit
Transmembrane AMPAR regulatory protein gamma-8
Short name:
TARP gamma-8
Gene namesi
Name:Cacng8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1932376. Cacng8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Voltage-dependent calcium channel gamma-8 subunitPRO_0000164691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei251 – 2511PhosphoserineCombined sources
Modified residuei254 – 2541PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VHW2.
PaxDbiQ8VHW2.
PRIDEiQ8VHW2.

PTM databases

iPTMnetiQ8VHW2.
PhosphoSiteiQ8VHW2.
SwissPalmiQ8VHW2.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2.1 Publication

Protein-protein interaction databases

IntActiQ8VHW2. 1 interaction.
STRINGi10090.ENSMUSP00000090005.

Structurei

3D structure databases

ProteinModelPortaliQ8VHW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 360116Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVW. Eukaryota.
ENOG4110B1C. LUCA.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8VHW2.
PhylomeDBiQ8VHW2.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008372. VDCC_g8su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01796. VDCCGAMMA8.

Sequencei

Sequence statusi: Complete.

Q8VHW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLKRWNEE RGLWCEKGVQ VLLTTIGAFS AFGLMTIAIS TDYWLYTRAL
60 70 80 90 100
ICNTTNLTAG DDGPPHRGGS GSSEKKDPGG LTHSGLWRIC CLEGLKRGVC
110 120 130 140 150
VKINHFPEDT DYDHDSAEYL LRVVRASSIF PILSAILLLL GGVCVAASRV
160 170 180 190 200
YKSKRNIILG AGILFVAAGL SNIIGVIVYI SANAGEPGPK RDEEKKNHYS
210 220 230 240 250
YGWSFYFGGL SFILAEVIGV LAVNIYIERS REAHCQSRSD LLKAGGGAGG
260 270 280 290 300
SGGSGPSAIL RLPSYRFRYR RRSRSSSRGS SEASPSRDAS PGGPGGPGFA
310 320 330 340 350
STDISMYTLS RDPSKGSVAA GLASAGGGGS GAGVGAYGGA AGAAGGGGAG
360 370 380 390 400
SERDRGSSAG FLTLHNAFPK EAASGVTVTV TGPPAAPAPA PAPPAPAAPA
410 420
PGTLSKEAAA SNTNTLNRKT TPV
Length:423
Mass (Da):43,453
Last modified:March 1, 2002 - v1
Checksum:iD3AD13E18F9EB02D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361350 mRNA. Translation: AAL50045.1.
CCDSiCCDS57471.1.
UniGeneiMm.357990.

Genome annotation databases

UCSCiuc029wda.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361350 mRNA. Translation: AAL50045.1.
CCDSiCCDS57471.1.
UniGeneiMm.357990.

3D structure databases

ProteinModelPortaliQ8VHW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VHW2. 1 interaction.
STRINGi10090.ENSMUSP00000090005.

PTM databases

iPTMnetiQ8VHW2.
PhosphoSiteiQ8VHW2.
SwissPalmiQ8VHW2.

Proteomic databases

MaxQBiQ8VHW2.
PaxDbiQ8VHW2.
PRIDEiQ8VHW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc029wda.2. mouse.

Organism-specific databases

MGIiMGI:1932376. Cacng8.

Phylogenomic databases

eggNOGiENOG410IJVW. Eukaryota.
ENOG4110B1C. LUCA.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8VHW2.
PhylomeDBiQ8VHW2.

Miscellaneous databases

PROiQ8VHW2.
SOURCEiSearch...

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008372. VDCC_g8su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01796. VDCCGAMMA8.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-254, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
    Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
    Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CNIH2.

Entry informationi

Entry nameiCCG8_MOUSE
AccessioniPrimary (citable) accession number: Q8VHW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.