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Protein

Voltage-dependent calcium channel gamma-like subunit

Gene

Tmem37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-like subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-like subunit
Transmembrane protein 37
Gene namesi
Name:Tmem37By similarity
Synonyms:Pr1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628689. Tmem37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Voltage-dependent calcium channel gamma-like subunitCuratedPRO_0000225602Add
BLAST

Proteomic databases

PaxDbiQ8VHW1.
PRIDEiQ8VHW1.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8N. Eukaryota.
ENOG4111WUN. LUCA.
HOVERGENiHBG028482.
InParanoidiQ8VHW1.
PhylomeDBiQ8VHW1.

Family and domain databases

InterProiIPR029372. Tmem37.
[Graphical view]
PANTHERiPTHR31767:SF0. PTHR31767:SF0. 1 hit.
PfamiPF15108. TMEM37. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIGAQAYK LLGPKRPHRS FFESFIRTLI IVCTALAVVL SSVSICDGHW
60 70 80 90 100
LLVEDRLFGL WYFCTISNHS EPHCLRDLSQ AQVPGVAVGM GLARSVAAMA
110 120 130 140 150
VVAAIFGLEL LIVSQVCEDV RSRSKWAIGS YLLLVAFILS SGGLLTFIIL
160 170 180 190 200
LKNQITLMGF TLMFWCEFTA SFLFFLNATS GLHINSLTRS PPAGTLAYRK

QGYDGTSLI
Length:209
Mass (Da):22,871
Last modified:March 1, 2002 - v1
Checksum:i8DAE9B111BC45297
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361355 mRNA. Translation: AAL50050.1.
RefSeqiNP_620795.1. NM_139095.1.
UniGeneiRn.92180.

Genome annotation databases

GeneIDi245953.
KEGGirno:245953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361355 mRNA. Translation: AAL50050.1.
RefSeqiNP_620795.1. NM_139095.1.
UniGeneiRn.92180.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ8VHW1.
PRIDEiQ8VHW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi245953.
KEGGirno:245953.

Organism-specific databases

CTDi140738.
RGDi628689. Tmem37.

Phylogenomic databases

eggNOGiENOG410IE8N. Eukaryota.
ENOG4111WUN. LUCA.
HOVERGENiHBG028482.
InParanoidiQ8VHW1.
PhylomeDBiQ8VHW1.

Miscellaneous databases

PROiQ8VHW1.

Family and domain databases

InterProiIPR029372. Tmem37.
[Graphical view]
PANTHERiPTHR31767:SF0. PTHR31767:SF0. 1 hit.
PfamiPF15108. TMEM37. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiCCGL_RAT
AccessioniPrimary (citable) accession number: Q8VHW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.