Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Elongator complex protein 1

Gene

Ikbkap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).By similarity
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: RGD
  • phosphorylase kinase regulator activity Source: UniProtKB
  • protein kinase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 1
Short name:
ELP1
Alternative name(s):
IkappaB kinase complex-associated protein
Short name:
IKK complex-associated protein
Gene namesi
Name:Ikbkap
Synonyms:Elp1, Ikap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620072. Ikbkap.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002839971 – 1331Elongator complex protein 1Add BLAST1331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei803PhosphoserineBy similarity1
Modified residuei1170PhosphoserineBy similarity1
Modified residuei1173PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VHU4.
PRIDEiQ8VHU4.

PTM databases

iPTMnetiQ8VHU4.
PhosphoSitePlusiQ8VHU4.

Interactioni

Subunit structurei

Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022836.

Structurei

3D structure databases

ProteinModelPortaliQ8VHU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP1/IKA1 family.Curated

Phylogenomic databases

eggNOGiKOG1920. Eukaryota.
COG5290. LUCA.
HOGENOMiHOG000007712.
HOVERGENiHBG019038.
InParanoidiQ8VHU4.
KOiK11373.
PhylomeDBiQ8VHU4.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR006849. Iki3.
[Graphical view]
PANTHERiPTHR12747. PTHR12747. 1 hit.
PfamiPF04762. IKI3. 1 hit.
[Graphical view]
PIRSFiPIRSF017233. IKAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VHU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLKLHQTL EFRDIQAPGK PQCFCLRAEQ GTVLIGSERG LTEVDPVKKE
60 70 80 90 100
VKTEISLVAE GFLPEDGSGC IVGIQDLLDQ ESVCVATASG DVIVCNVSTQ
110 120 130 140 150
QLECVGNVAS GISVMSWSPD QELLLLATAQ QTLIMMTRDY EVITEQQIHQ
160 170 180 190 200
DDFGEGKFIT VGWGSKDTQF HGSEGRPITF PVQMHESALS WDDHRPQITW
210 220 230 240 250
RGDGQFFAVS VVCSQTGARK IRVWNREFAL QSTSESVPGL GPSLAWKPSG
260 270 280 290 300
SLIASTQDKP NQQDVVFFEK NGLLHGYFTL PFLKDEVKVN DLLWNADSSV
310 320 330 340 350
LAVWLEDLPK EGSSTLKSYV QLWTVGNYHW YLKQSLPFST TGKNQIVSLL
360 370 380 390 400
WDPVTPGRLH VLCQGWRYLC CDWHWTTDRS SGNSADDLAN VAVIDGNKVL
410 420 430 440 450
VTVFQRTVTP PPMCTYRLLI PHPVNQVMSS AHLGNDLAVL DASNQISVYK
460 470 480 490 500
CDDKPDMDST VKLGAVGGTG FKVPLRTPHL EKRYRIQFGN KEEEEDVSPL
510 520 530 540 550
QFRFLTWIEG DAFLAISHSH SSPQSIIHHL TMAGSEGDEE QGQLNVSSSV
560 570 580 590 600
TVDGVVIGLC CCSKTKSSAV QLADGQVLKY LWESPSSAVE PWKNSEGRPV
610 620 630 640 650
RFARPCTQME AAAIGGEECV LGLTDRCRFF INDTEVASNI TSFAVCDDFL
660 670 680 690 700
LVTTHSHTCQ CFSLSGASLK MLQAGLCGSQ VPSGEILRKV ERGSRIVTVV
710 720 730 740 750
PQDTKLILQM PRGNLEVVHH RALVLAQIRK WLDKLMFKEA FECMRKLRIN
760 770 780 790 800
LNLIHDHNPK VFLENVETFI KQIDSVNHLN LFFTELKEED VTKTMYPPPV
810 820 830 840 850
TKSVQVSTNP DGKKVDLICD AMRVAMETIN PRKFCLSILT SHVKKTTPEL
860 870 880 890 900
DIVLQKVHEL QGKIPFVPES VSAEEALKYL LLLVDVNELF NHSLGTYDFD
910 920 930 940 950
LVLMVAEKSQ KDPKEYLPFL NTLKKMETNY QRFTIDKYLK RYEKALGHLS
960 970 980 990 1000
KCGPEYFTEC LNLIKDKNLY KEALKLYRPD SPQYQAVSVA YGEHLVQELL
1010 1020 1030 1040 1050
YEPAGLVFAR CGAHEKALEA FLACGSWQQA LCMAAQLQMA KDKVAGLART
1060 1070 1080 1090 1100
LAGKLVEQRK HSEAATVLEQ YALDYEEAVL LLLEGSAWEE ALRLVYKYDR
1110 1120 1130 1140 1150
VDIIETSVKP SILEAQKNYM DFLDSQTATF IRHKNRLKVV RELKSQRPRV
1160 1170 1180 1190 1200
HVDHEVAHGR ETDLFSETSS IRSGSEMSGR YSHSNSRISA RSSKNRRKAE
1210 1220 1230 1240 1250
RKKHSLKEGS PLEGLALLEA LSEVVQSIEK LKDEVHAILK VLFLFEFEEQ
1260 1270 1280 1290 1300
ARELQRAFES TLQLMGTALP DIWTLTGQQS SSTPVLGPSS TVNSIMASYQ
1310 1320 1330
QQKTCVPVLD AWACLPPKID QRSQWKLSLL E
Length:1,331
Mass (Da):149,171
Last modified:March 1, 2002 - v1
Checksum:i6B33E22387495543
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388201 mRNA. Translation: AAL40926.1.
RefSeqiNP_543175.1. NM_080899.1.
UniGeneiRn.162816.

Genome annotation databases

GeneIDi140934.
KEGGirno:140934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388201 mRNA. Translation: AAL40926.1.
RefSeqiNP_543175.1. NM_080899.1.
UniGeneiRn.162816.

3D structure databases

ProteinModelPortaliQ8VHU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022836.

PTM databases

iPTMnetiQ8VHU4.
PhosphoSitePlusiQ8VHU4.

Proteomic databases

PaxDbiQ8VHU4.
PRIDEiQ8VHU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140934.
KEGGirno:140934.

Organism-specific databases

CTDi8518.
RGDi620072. Ikbkap.

Phylogenomic databases

eggNOGiKOG1920. Eukaryota.
COG5290. LUCA.
HOGENOMiHOG000007712.
HOVERGENiHBG019038.
InParanoidiQ8VHU4.
KOiK11373.
PhylomeDBiQ8VHU4.

Miscellaneous databases

PROiQ8VHU4.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR006849. Iki3.
[Graphical view]
PANTHERiPTHR12747. PTHR12747. 1 hit.
PfamiPF04762. IKI3. 1 hit.
[Graphical view]
PIRSFiPIRSF017233. IKAP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiELP1_RAT
AccessioniPrimary (citable) accession number: Q8VHU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.