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Protein

Transcription factor IIIA

Gene

Gtf3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 62C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri68 – 92C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri130 – 154C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri160 – 184C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 211C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 269C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri275 – 299C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • DNA binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processRibosome biogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Gene namesi
Name:Gtf3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619746. Gtf3a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198671 – 363Transcription factor IIIAAdd BLAST363

Proteomic databases

PaxDbiQ8VHT8.
PRIDEiQ8VHT8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065623.

Structurei

3D structure databases

ProteinModelPortaliQ8VHT8.
SMRiQ8VHT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 62C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri68 – 92C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri130 – 154C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri160 – 184C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 211C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 269C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri275 – 299C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG017915.
InParanoidiQ8VHT8.
KOiK09191.
PhylomeDBiQ8VHT8.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.

Sequencei

Sequence statusi: Complete.

Q8VHT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRVSVAEA VSSLTIADAF VRACVGPAPP RPALPSRFIC SFPDCSASYN
60 70 80 90 100
KAWKLDAHLC KHTGERPFVC DYEGCGKAFI RDYHLSRHIL IHTGEKPFVC
110 120 130 140 150
ADNGCNQKFS TKSNLKKHIE RKHENPQKQY VCNFEGCKKA FKKHQQLRTH
160 170 180 190 200
QCQHTNEPLF RCTHEGCGKH FASPSRLKRH GKVHEGYLCQ KGCSFVGKTW
210 220 230 240 250
TELLKHTREA HKEEVTCTVC QKMFKRKDHL KQHMKTHAPE RDVYRCPREG
260 270 280 290 300
CARTYTTVFN LQSHILSFHE EKRPFVCEHA GCGKTFAMKQ SLMRHSVVHD
310 320 330 340 350
PDKKRMKLKV RPPRERRSLA SRLSGYVPPK GKQEPDCSLP NSTESSSSPE
360
ATMLAPAALL TVH
Length:363
Mass (Da):41,387
Last modified:February 26, 2008 - v2
Checksum:iAACA8D5B80124563
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29 – 32PPRP → ARAG in AAL69685 (Ref. 1) Curated4
Sequence conflicti39I → T in AAL69685 (Ref. 1) Curated1
Sequence conflicti67P → S in AAL69685 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CB616240 mRNA. No translation available.
AF391798 mRNA. Translation: AAL69685.1.
RefSeqiNP_001107042.1. NM_001113570.1.
UniGeneiRn.195324.

Genome annotation databases

GeneIDi246299.
KEGGirno:246299.

Similar proteinsi

Entry informationi

Entry nameiTF3A_RAT
AccessioniPrimary (citable) accession number: Q8VHT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.Curated

Keywords - Technical termi

Complete proteome, Reference proteome