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Q8VHT7 (TF3A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor IIIA

Short name=TFIIIA
Gene names
Name:Gtf3a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 9 C2H2-type zinc fingers.

Caution

It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.

Sequence caution

The sequence AAL69686.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB28476.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAC25209.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Transcription factor IIIA
PRO_0000319866

Regions

Zinc finger38 – 6225C2H2-type 1
Zinc finger68 – 9225C2H2-type 2
Zinc finger98 – 12326C2H2-type 3
Zinc finger130 – 15425C2H2-type 4
Zinc finger160 – 18425C2H2-type 5
Zinc finger187 – 21125C2H2-type 6
Zinc finger215 – 23723C2H2-type 7
Zinc finger244 – 26926C2H2-type 8
Zinc finger275 – 29925C2H2-type 9

Experimental info

Sequence conflict75 – 773CGK → HAS in AAH32292. Ref.3
Sequence conflict1311V → L in AAL69686. Ref.1
Sequence conflict149 – 17325THQCQ…KHFAS → PISASTPASRSSGVPTRDAG STLPR in BAC25209. Ref.2
Sequence conflict1941S → P in BAC25209. Ref.2
Sequence conflict1981K → I in BAC25209. Ref.2
Sequence conflict3591A → T in AAH32292. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8VHT7 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: FEC01712C5C8D4DA

FASTA36441,571
        10         20         30         40         50         60 
MEPRVSVAEA VSSLTIADAF VGACEGPAPP RPALPSRFIC SFPDCSASYN KAWKLDAHLC 

        70         80         90        100        110        120 
KHTGERPFVC DYEGCGKAFI RDYHLSRHVL IHTGEKPFVC ADDGCNQKFN TKSNLKKHIE 

       130        140        150        160        170        180 
RKHGNPQKQY VCSYEGCKKA FKKHQQLRTH QCQHTSEPLF RCTHEGCGKH FASPSRLKRH 

       190        200        210        220        230        240 
GKVHEGYLCQ KGCSFMGKTW TELLKHMREA HKEDITCNVC QRMFKRRDYL KQHMKTHAPE 

       250        260        270        280        290        300 
RDVYRCPRQG CGRTYTTVFN LQSHILSFHE EKRPFVCEHA GCGKTFAMKQ SLMRHSVVHD 

       310        320        330        340        350        360 
PDKKRMKLKV RAPRERRSLA SRLSGYFPPK RKQEPDYSLP NASAESSSSP EAQLPPPAAL 


LTVC 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA."
Hanas J.S., Hocker J.R., Cheng Y.-G., Lerner M.R., Brackett D.J., Lightfoot S.A., Hanas R.J., Madhusudhan K.T., Moreland R.J.
Gene 282:43-52(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Small intestine.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-364.
Strain: FVB/N-3.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF391799 mRNA. Translation: AAL69686.1. Different initiation.
AK008247 mRNA. Translation: BAC25209.1. Different initiation.
AK012797 mRNA. Translation: BAB28476.2. Different initiation.
BC032292 mRNA. Translation: AAH32292.1.
CCDSCCDS19873.2.
RefSeqNP_079928.2. NM_025652.3.
UniGeneMm.196528.

3D structure databases

ProteinModelPortalQ8VHT7.
SMRQ8VHT7. Positions 37-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000119607.

PTM databases

PhosphoSiteQ8VHT7.

Proteomic databases

PRIDEQ8VHT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID66596.
KEGGmmu:66596.
UCSCuc009ano.2. mouse.

Organism-specific databases

CTD2971.
MGIMGI:1913846. Gtf3a.

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000207184.
HOVERGENHBG017915.
InParanoidQ8VHT7.
KOK09191.
PhylomeDBQ8VHT7.

Gene expression databases

CleanExMM_GTF3A.
GenevestigatorQ8VHT7.

Family and domain databases

Gene3D3.30.160.60. 8 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio322116.
PROQ8VHT7.
SOURCESearch...

Entry information

Entry nameTF3A_MOUSE
AccessionPrimary (citable) accession number: Q8VHT7
Secondary accession number(s): Q8BJ79, Q8K270, Q9CSH8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot