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Protein

Transcription factor IIIA

Gene

Gtf3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 62C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri68 – 92C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri130 – 154C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri160 – 184C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 211C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 269C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri275 – 299C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processRibosome biogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Gene namesi
Name:Gtf3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913846. Gtf3a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198661 – 364Transcription factor IIIAAdd BLAST364

Proteomic databases

EPDiQ8VHT7.
MaxQBiQ8VHT7.
PaxDbiQ8VHT7.
PRIDEiQ8VHT7.

PTM databases

iPTMnetiQ8VHT7.
PhosphoSitePlusiQ8VHT7.

Expressioni

Gene expression databases

CleanExiMM_GTF3A.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119607.

Structurei

3D structure databases

ProteinModelPortaliQ8VHT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 62C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri68 – 92C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri130 – 154C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri160 – 184C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 211C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 269C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri275 – 299C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000207184.
HOVERGENiHBG017915.
InParanoidiQ8VHT7.
KOiK09191.
PhylomeDBiQ8VHT7.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.

Sequencei

Sequence statusi: Complete.

Q8VHT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRVSVAEA VSSLTIADAF VGACEGPAPP RPALPSRFIC SFPDCSASYN
60 70 80 90 100
KAWKLDAHLC KHTGERPFVC DYEGCGKAFI RDYHLSRHVL IHTGEKPFVC
110 120 130 140 150
ADDGCNQKFN TKSNLKKHIE RKHGNPQKQY VCSYEGCKKA FKKHQQLRTH
160 170 180 190 200
QCQHTSEPLF RCTHEGCGKH FASPSRLKRH GKVHEGYLCQ KGCSFMGKTW
210 220 230 240 250
TELLKHMREA HKEDITCNVC QRMFKRRDYL KQHMKTHAPE RDVYRCPRQG
260 270 280 290 300
CGRTYTTVFN LQSHILSFHE EKRPFVCEHA GCGKTFAMKQ SLMRHSVVHD
310 320 330 340 350
PDKKRMKLKV RAPRERRSLA SRLSGYFPPK RKQEPDYSLP NASAESSSSP
360
EAQLPPPAAL LTVC
Length:364
Mass (Da):41,571
Last modified:February 26, 2008 - v2
Checksum:iFEC01712C5C8D4DA
GO

Sequence cautioni

The sequence AAL69686 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB28476 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25209 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75 – 77CGK → HAS in AAH32292 (PubMed:15489334).Curated3
Sequence conflicti131V → L in AAL69686 (PubMed:11814676).Curated1
Sequence conflicti149 – 173THQCQ…KHFAS → PISASTPASRSSGVPTRDAG STLPR in BAC25209 (PubMed:16141072).CuratedAdd BLAST25
Sequence conflicti194S → P in BAC25209 (PubMed:16141072).Curated1
Sequence conflicti198K → I in BAC25209 (PubMed:16141072).Curated1
Sequence conflicti359A → T in AAH32292 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391799 mRNA. Translation: AAL69686.1. Different initiation.
AK008247 mRNA. Translation: BAC25209.1. Different initiation.
AK012797 mRNA. Translation: BAB28476.2. Different initiation.
BC032292 mRNA. Translation: AAH32292.1.
CCDSiCCDS19873.2.
RefSeqiNP_079928.2. NM_025652.3.
UniGeneiMm.196528.

Genome annotation databases

GeneIDi66596.
KEGGimmu:66596.
UCSCiuc009ano.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiTF3A_MOUSE
AccessioniPrimary (citable) accession number: Q8VHT7
Secondary accession number(s): Q8BJ79, Q8K270, Q9CSH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot