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Q8VHT7

- TF3A_MOUSE

UniProt

Q8VHT7 - TF3A_MOUSE

Protein

Transcription factor IIIA

Gene

Gtf3a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri38 – 6225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri68 – 9225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri98 – 12326C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri130 – 15425C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri160 – 18425C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri187 – 21125C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri215 – 23723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri244 – 26926C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri275 – 29925C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor IIIA
    Short name:
    TFIIIA
    Gene namesi
    Name:Gtf3a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1913846. Gtf3a.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Transcription factor IIIAPRO_0000319866Add
    BLAST

    Proteomic databases

    PRIDEiQ8VHT7.

    PTM databases

    PhosphoSiteiQ8VHT7.

    Expressioni

    Gene expression databases

    CleanExiMM_GTF3A.
    GenevestigatoriQ8VHT7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000119607.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHT7.
    SMRiQ8VHT7. Positions 37-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri38 – 6225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri68 – 9225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri98 – 12326C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri130 – 15425C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri160 – 18425C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri187 – 21125C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri215 – 23723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri244 – 26926C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri275 – 29925C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000207184.
    HOVERGENiHBG017915.
    InParanoidiQ8VHT7.
    KOiK09191.
    PhylomeDBiQ8VHT7.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 4 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VHT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPRVSVAEA VSSLTIADAF VGACEGPAPP RPALPSRFIC SFPDCSASYN    50
    KAWKLDAHLC KHTGERPFVC DYEGCGKAFI RDYHLSRHVL IHTGEKPFVC 100
    ADDGCNQKFN TKSNLKKHIE RKHGNPQKQY VCSYEGCKKA FKKHQQLRTH 150
    QCQHTSEPLF RCTHEGCGKH FASPSRLKRH GKVHEGYLCQ KGCSFMGKTW 200
    TELLKHMREA HKEDITCNVC QRMFKRRDYL KQHMKTHAPE RDVYRCPRQG 250
    CGRTYTTVFN LQSHILSFHE EKRPFVCEHA GCGKTFAMKQ SLMRHSVVHD 300
    PDKKRMKLKV RAPRERRSLA SRLSGYFPPK RKQEPDYSLP NASAESSSSP 350
    EAQLPPPAAL LTVC 364
    Length:364
    Mass (Da):41,571
    Last modified:February 26, 2008 - v2
    Checksum:iFEC01712C5C8D4DA
    GO

    Sequence cautioni

    The sequence AAL69686.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB28476.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC25209.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 773CGK → HAS in AAH32292. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311V → L in AAL69686. (PubMed:11814676)Curated
    Sequence conflicti149 – 17325THQCQ…KHFAS → PISASTPASRSSGVPTRDAG STLPR in BAC25209. (PubMed:16141072)CuratedAdd
    BLAST
    Sequence conflicti194 – 1941S → P in BAC25209. (PubMed:16141072)Curated
    Sequence conflicti198 – 1981K → I in BAC25209. (PubMed:16141072)Curated
    Sequence conflicti359 – 3591A → T in AAH32292. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF391799 mRNA. Translation: AAL69686.1. Different initiation.
    AK008247 mRNA. Translation: BAC25209.1. Different initiation.
    AK012797 mRNA. Translation: BAB28476.2. Different initiation.
    BC032292 mRNA. Translation: AAH32292.1.
    CCDSiCCDS19873.2.
    RefSeqiNP_079928.2. NM_025652.3.
    UniGeneiMm.196528.

    Genome annotation databases

    GeneIDi66596.
    KEGGimmu:66596.
    UCSCiuc009ano.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF391799 mRNA. Translation: AAL69686.1 . Different initiation.
    AK008247 mRNA. Translation: BAC25209.1 . Different initiation.
    AK012797 mRNA. Translation: BAB28476.2 . Different initiation.
    BC032292 mRNA. Translation: AAH32292.1 .
    CCDSi CCDS19873.2.
    RefSeqi NP_079928.2. NM_025652.3.
    UniGenei Mm.196528.

    3D structure databases

    ProteinModelPortali Q8VHT7.
    SMRi Q8VHT7. Positions 37-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000119607.

    PTM databases

    PhosphoSitei Q8VHT7.

    Proteomic databases

    PRIDEi Q8VHT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 66596.
    KEGGi mmu:66596.
    UCSCi uc009ano.2. mouse.

    Organism-specific databases

    CTDi 2971.
    MGIi MGI:1913846. Gtf3a.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000207184.
    HOVERGENi HBG017915.
    InParanoidi Q8VHT7.
    KOi K09191.
    PhylomeDBi Q8VHT7.

    Miscellaneous databases

    NextBioi 322116.
    PROi Q8VHT7.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GTF3A.
    Genevestigatori Q8VHT7.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 4 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA."
      Hanas J.S., Hocker J.R., Cheng Y.-G., Lerner M.R., Brackett D.J., Lightfoot S.A., Hanas R.J., Madhusudhan K.T., Moreland R.J.
      Gene 282:43-52(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Small intestine.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-364.
      Strain: FVB/N-3.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiTF3A_MOUSE
    AccessioniPrimary (citable) accession number: Q8VHT7
    Secondary accession number(s): Q8BJ79, Q8K270, Q9CSH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3