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Q8VHT7

- TF3A_MOUSE

UniProt

Q8VHT7 - TF3A_MOUSE

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Protein

Transcription factor IIIA

Gene

Gtf3a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri38 – 6225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri68 – 9225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri98 – 12326C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 15425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 21125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26926C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Gene namesi
Name:Gtf3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1913846. Gtf3a.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Transcription factor IIIAPRO_0000319866Add
BLAST

Proteomic databases

MaxQBiQ8VHT7.
PRIDEiQ8VHT7.

PTM databases

PhosphoSiteiQ8VHT7.

Expressioni

Gene expression databases

CleanExiMM_GTF3A.
GenevestigatoriQ8VHT7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119607.

Structurei

3D structure databases

ProteinModelPortaliQ8VHT7.
SMRiQ8VHT7. Positions 37-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri38 – 6225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri68 – 9225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri98 – 12326C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 15425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 21125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26926C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000207184.
HOVERGENiHBG017915.
InParanoidiQ8VHT7.
KOiK09191.
PhylomeDBiQ8VHT7.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHT7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPRVSVAEA VSSLTIADAF VGACEGPAPP RPALPSRFIC SFPDCSASYN
60 70 80 90 100
KAWKLDAHLC KHTGERPFVC DYEGCGKAFI RDYHLSRHVL IHTGEKPFVC
110 120 130 140 150
ADDGCNQKFN TKSNLKKHIE RKHGNPQKQY VCSYEGCKKA FKKHQQLRTH
160 170 180 190 200
QCQHTSEPLF RCTHEGCGKH FASPSRLKRH GKVHEGYLCQ KGCSFMGKTW
210 220 230 240 250
TELLKHMREA HKEDITCNVC QRMFKRRDYL KQHMKTHAPE RDVYRCPRQG
260 270 280 290 300
CGRTYTTVFN LQSHILSFHE EKRPFVCEHA GCGKTFAMKQ SLMRHSVVHD
310 320 330 340 350
PDKKRMKLKV RAPRERRSLA SRLSGYFPPK RKQEPDYSLP NASAESSSSP
360
EAQLPPPAAL LTVC
Length:364
Mass (Da):41,571
Last modified:February 26, 2008 - v2
Checksum:iFEC01712C5C8D4DA
GO

Sequence cautioni

The sequence AAL69686.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB28476.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAC25209.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 773CGK → HAS in AAH32292. (PubMed:15489334)Curated
Sequence conflicti131 – 1311V → L in AAL69686. (PubMed:11814676)Curated
Sequence conflicti149 – 17325THQCQ…KHFAS → PISASTPASRSSGVPTRDAG STLPR in BAC25209. (PubMed:16141072)CuratedAdd
BLAST
Sequence conflicti194 – 1941S → P in BAC25209. (PubMed:16141072)Curated
Sequence conflicti198 – 1981K → I in BAC25209. (PubMed:16141072)Curated
Sequence conflicti359 – 3591A → T in AAH32292. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF391799 mRNA. Translation: AAL69686.1. Different initiation.
AK008247 mRNA. Translation: BAC25209.1. Different initiation.
AK012797 mRNA. Translation: BAB28476.2. Different initiation.
BC032292 mRNA. Translation: AAH32292.1.
CCDSiCCDS19873.2.
RefSeqiNP_079928.2. NM_025652.3.
UniGeneiMm.196528.

Genome annotation databases

GeneIDi66596.
KEGGimmu:66596.
UCSCiuc009ano.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF391799 mRNA. Translation: AAL69686.1 . Different initiation.
AK008247 mRNA. Translation: BAC25209.1 . Different initiation.
AK012797 mRNA. Translation: BAB28476.2 . Different initiation.
BC032292 mRNA. Translation: AAH32292.1 .
CCDSi CCDS19873.2.
RefSeqi NP_079928.2. NM_025652.3.
UniGenei Mm.196528.

3D structure databases

ProteinModelPortali Q8VHT7.
SMRi Q8VHT7. Positions 37-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000119607.

PTM databases

PhosphoSitei Q8VHT7.

Proteomic databases

MaxQBi Q8VHT7.
PRIDEi Q8VHT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 66596.
KEGGi mmu:66596.
UCSCi uc009ano.2. mouse.

Organism-specific databases

CTDi 2971.
MGIi MGI:1913846. Gtf3a.

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000207184.
HOVERGENi HBG017915.
InParanoidi Q8VHT7.
KOi K09191.
PhylomeDBi Q8VHT7.

Miscellaneous databases

NextBioi 322116.
PROi Q8VHT7.
SOURCEi Search...

Gene expression databases

CleanExi MM_GTF3A.
Genevestigatori Q8VHT7.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 4 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA."
    Hanas J.S., Hocker J.R., Cheng Y.-G., Lerner M.R., Brackett D.J., Lightfoot S.A., Hanas R.J., Madhusudhan K.T., Moreland R.J.
    Gene 282:43-52(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-364.
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTF3A_MOUSE
AccessioniPrimary (citable) accession number: Q8VHT7
Secondary accession number(s): Q8BJ79, Q8K270, Q9CSH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3