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Protein

Arsenite methyltransferase

Gene

As3mt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.

Catalytic activityi

S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.

GO - Molecular functioni

  • arsenite methyltransferase activity Source: UniProtKB
  • methylarsonite methyltransferase activity Source: UniProtKB
  • protein methyltransferase activity Source: RGD
  • S-adenosylmethionine-dependent methyltransferase activity Source: RGD

GO - Biological processi

  • arsonoacetate metabolic process Source: UniProtKB
  • response to arsenic-containing substance Source: MGI
  • toxin metabolic process Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.137 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenite methyltransferase (EC:2.1.1.137)
Alternative name(s):
Methylarsonite methyltransferase
S-adenosyl-L-methionine:arsenic(III) methyltransferase
Gene namesi
Name:As3mt
Synonyms:Cyt19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621325 As3mt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi156C → S: Complete loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002044491 – 369Arsenite methyltransferaseAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VHT6
PRIDEiQ8VHT6

PTM databases

iPTMnetiQ8VHT6
PhosphoSitePlusiQ8VHT6

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027223

Structurei

3D structure databases

ProteinModelPortaliQ8VHT6
SMRiQ8VHT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFW3 Eukaryota
ENOG410XSKB LUCA
HOGENOMiHOG000229966
HOVERGENiHBG050585
InParanoidiQ8VHT6
KOiK07755
PhylomeDBiQ8VHT6

Family and domain databases

InterProiView protein in InterPro
IPR025714 Methyltranfer_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF13847 Methyltransf_31, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits

Sequencei

Sequence statusi: Complete.

Q8VHT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRDAEIH KDVQNYYGNV LKTSADLQTN ACVTPAKGVP EYIRKSLQNV
60 70 80 90 100
HEEVISRYYG CGLVVPEHLE NCRILDLGSG SGRDCYVLSQ LVGQKGHITG
110 120 130 140 150
IDMTKVQVEV AKAYLEYHTE KFGFQTPNVT FLHGQIEMLA EAGIQKESYD
160 170 180 190 200
IVISNCVINL VPDKQKVLRE VYQVLKYGGE LYFSDVYASL EVSEDIKSHK
210 220 230 240 250
VLWGECLGGA LYWKDLAVIA KKIGFCPPRL VTANIITVGN KELERVLGDC
260 270 280 290 300
RFVSATFRLF KLPKTEPAGR CQVVYNGGIM GHEKELIFDA NFTFKEGEAV
310 320 330 340 350
EVDEETAAIL RNSRFAHDFL FTPVEASLLA PQTKVIIRDP FKLAEESDKM
360
KPRCAPEGTG GCCGKRKSC
Length:369
Mass (Da):41,056
Last modified:March 1, 2002 - v1
Checksum:iBD092F7317B138E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393243 mRNA Translation: AAL61609.1
RefSeqiNP_543166.1, NM_080890.1
UniGeneiRn.95453

Genome annotation databases

GeneIDi140925
KEGGirno:140925

Similar proteinsi

Entry informationi

Entry nameiAS3MT_RAT
AccessioniPrimary (citable) accession number: Q8VHT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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