L-type calcium channel alpha-1c subunit

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Unreviewed, UniProtKB/TrEMBL Q8VHT3 (Q8VHT3_RAT)

Last modified January 19, 2010. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
L-type calcium channel alpha-1c subunit EMBL AAL47071.1
Submitted name:
Calcium channel, voltage-dependent, L type, alpha 1C subunit, isoform CRA_c EMBL EDM02064.1

Gene names

Name:	Cacna1c RGD 2245
ORF Names:	rCG_29907 EMBL EDM02064.1

Organism

Rattus norvegicus (Rat) EMBL AAL47071.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	2170 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	adult walking behavior Inferred from electronic annotation. Source: Compara calcium ion transport Inferred from mutant phenotype. Source: RGD calcium ion-dependent exocytosis Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara growth hormone secretion Inferred from electronic annotation. Source: Compara insulin secretion Inferred from electronic annotation. Source: Compara regulation of blood pressure Inferred from electronic annotation. Source: Compara regulation of organ growth Inferred from electronic annotation. Source: Compara regulation of vasoconstriction Inferred from electronic annotation. Source: Compara smooth muscle contraction involved in micturition Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from electronic annotation. Source: Compara transmembrane transport Inferred from electronic annotation. Source: InterPro visual learning Inferred from electronic annotation. Source: Compara
Cellular component	T-tubule Inferred from direct assay. Source: RGD caveolar macromolecular signaling complex Inferred from electronic annotation. Source: Compara cell soma Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara dendritic shaft Inferred from electronic annotation. Source: Compara membrane fraction Inferred from direct assay. Source: RGD postsynaptic density Inferred from electronic annotation. Source: Compara voltage-gated calcium channel complex Ref.1 Inferred from direct assay. Source: RGD
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: Compara dihydropyridine-sensitive calcium channel activity Inferred from electronic annotation. Source: Compara protein domain specific binding Inferred from physical interaction. Source: RGD protein phosphatase 2A binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q8VHT3-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: FB5D7863100844E3
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FASTA

2,170

243,375

        10         20         30         40         50         60 
MIRAFAQPST PPYQPLSSCL SEDTERKFKG KVVHEAQLNC FYISPGGSNY GSPRPAHANM 

        70         80         90        100        110        120 
NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK 

       130        140        150        160        170        180 
KQGGTTATRP PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 

       190        200        210        220        230        240 
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA 

       250        260        270        280        290        300 
ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH 

       310        320        330        340        350        360 
IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET GHGRQCQNGT 

       370        380        390        400        410        420 
VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI 

       430        440        450        460        470        480 
FGSFFVLNLV LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 

       490        500        510        520        530        540 
NEDEGMDEDK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN 

       550        560        570        580        590        600 
RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPH WLTEVQDTAN KALLALFTAE 

       610        620        630        640        650        660 
MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI LETILVETKI MSPLGISVLR CVRLLRIFKI 

       670        680        690        700        710        720 
TRYWNSLSNL VASLLNSVRS IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD 

       730        740        750        760        770        780 
NFPQSLLTVF QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA 

       790        800        810        820        830        840 
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEV MEKPAVEESK EEKIELKSIT 

       850        860        870        880        890        900 
ADGESPPTTK INMDDLQPSE NEDKSPHSNP DTAGEEDEEE PEMPVGPRPR PLSELHLKEK 

       910        920        930        940        950        960 
AVPMPEASAF FIFSPNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE DPVQHTSFRN 

       970        980        990       1000       1010       1020 
HILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA 

      1030       1040       1050       1060       1070       1080 
INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL 

      1090       1100       1110       1120       1130       1140 
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN VLAAMMALFT 

      1150       1160       1170       1180       1190       1200 
VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ 

      1210       1220       1230       1240       1250       1260 
EQGEQEYKNC ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL 

      1270       1280       1290       1300       1310       1320 
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI 

      1330       1340       1350       1360       1370       1380 
VVGSIVDIAI TEVHPAEHTQ CSPSMSAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL 

      1390       1400       1410       1420       1430       1440 
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF 

      1450       1460       1470       1480       1490       1500 
RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL 

      1510       1520       1530       1540       1550       1560 
FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF 

      1570       1580       1590       1600       1610       1620 
GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK 

      1630       1640       1650       1660       1670       1680 
KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS 

      1690       1700       1710       1720       1730       1740 
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVSYY 

      1750       1760       1770       1780       1790       1800 
QSDSRSNFPQ TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA 

      1810       1820       1830       1840       1850       1860 
NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE SQGATVSQDM 

      1870       1880       1890       1900       1910       1920 
FPDETRSSVR LSEEVEYCSE PSLLSTDILS YQDDENRQLT CLEEDKREIQ PSPKRSFLRS 

      1930       1940       1950       1960       1970       1980 
ASLGRRASFH LECLKRQKDQ GGDISQKTAL PLHLVHHQAL AVAGLSPLLQ RSHSPSTFPR 

      1990       2000       2010       2020       2030       2040 
PRPTPPVTPG SRGRPLQPIP TLRLEGAESS EKLNSSFPSI HCSSWSEETT ACSGGSSMAR 

      2050       2060       2070       2080       2090       2100 
RARPVSLTVP SQAGAPGRQF HGSASSLVEA VLISEGLGQF AQDPKFIEVT TQELADACDM 

      2110       2120       2130       2140       2150       2160 
TIEEMENAAD NILSGGAQQS PNGTLLPFVN CRDPGQDRAV VPEDESCVYA LGRGRSEEAL 

      2170 
PDSRSYVSNL

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References

[1]	"Cloning of a functional splice variant of L-type calcium channel beta2 subunit from rat heart." Yamada Y., Nagashima M., Tsutsuura M., Kobayashi T., Seki S., Makita N., Horio Y., Tohse N. J. Biol. Chem. 276:47163-47170(2001) [PubMed: 11604404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAL47071.1. Tissue: Heart EMBL AAL47071.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM02064.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM02064.1.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AF394938 mRNA. Translation: AAL47071.1. CH473964 Genomic DNA. Translation: EDM02064.1.
IPI	IPI00476992.
PIR	JH0427.
UniGene	Rn.9827
3D structure databases
HSSP	HSSP built from PDB template 1T0J based on UniProtKB Q13933.
SMR	Q8VHT3. Positions 150-234, 1642-1670.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VHT3.
Genome annotation databases
Ensembl	ENSRNOT00000052017; ENSRNOP00000048790; ENSRNOG00000007090; Rattus norvegicus. [Genome view]
UCSC	AF394938. rat.
Phylogenomic databases
HOVERGEN	Q8VHT3.
InParanoid	Q8VHT3.
PhylomeDB	Q8VHT3.
Gene expression databases
ArrayExpress	Q8VHT3.
Genevestigator	Q8VHT3.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005451. VDCC_L_a1csu. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF47. LVDCCAlpha1C. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01635. LVDCCALPHA1C.
ProtoNet	Search...

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Entry information

Entry name

Q8VHT3_RAT

Accession

Primary (citable) accession number: Q8VHT3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 19, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information