Q8VHT3 (Q8VHT3_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Calcium channel, voltage-dependent, L type, alpha 1C subunit, isoform CRA_c EMBL EDM02064.1

Submitted name:
L-type calcium channel alpha-1c subunit EMBL AAL47071.1

Gene names

Name:	Cacna1c EMBL EDM02064.1 RGD 2245
ORF Names:	rCG_29907 EMBL EDM02064.1

Organism

Rattus norvegicus (Rat) EMBL AAL47071.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2170 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ionic channel Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
Cellular component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8VHT3 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: FB5D7863100844E3	FASTA	2,170	243,375
	10 20 30 40 50 60 MIRAFAQPST PPYQPLSSCL SEDTERKFKG KVVHEAQLNC FYISPGGSNY GSPRPAHANM 70 80 90 100 110 120 NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK 130 140 150 160 170 180 KQGGTTATRP PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 190 200 210 220 230 240 DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA 250 260 270 280 290 300 ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH 310 320 330 340 350 360 IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET GHGRQCQNGT 370 380 390 400 410 420 VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI 430 440 450 460 470 480 FGSFFVLNLV LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 490 500 510 520 530 540 NEDEGMDEDK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN 550 560 570 580 590 600 RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPH WLTEVQDTAN KALLALFTAE 610 620 630 640 650 660 MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI LETILVETKI MSPLGISVLR CVRLLRIFKI 670 680 690 700 710 720 TRYWNSLSNL VASLLNSVRS IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD 730 740 750 760 770 780 NFPQSLLTVF QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA 790 800 810 820 830 840 IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEV MEKPAVEESK EEKIELKSIT 850 860 870 880 890 900 ADGESPPTTK INMDDLQPSE NEDKSPHSNP DTAGEEDEEE PEMPVGPRPR PLSELHLKEK 910 920 930 940 950 960 AVPMPEASAF FIFSPNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE DPVQHTSFRN 970 980 990 1000 1010 1020 HILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA 1030 1040 1050 1060 1070 1080 INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL 1090 1100 1110 1120 1130 1140 FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN VLAAMMALFT 1150 1160 1170 1180 1190 1200 VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ 1210 1220 1230 1240 1250 1260 EQGEQEYKNC ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL 1270 1280 1290 1300 1310 1320 LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI 1330 1340 1350 1360 1370 1380 VVGSIVDIAI TEVHPAEHTQ CSPSMSAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL 1390 1400 1410 1420 1430 1440 WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF 1450 1460 1470 1480 1490 1500 RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL 1510 1520 1530 1540 1550 1560 FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF 1570 1580 1590 1600 1610 1620 GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK 1630 1640 1650 1660 1670 1680 KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS 1690 1700 1710 1720 1730 1740 LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVSYY 1750 1760 1770 1780 1790 1800 QSDSRSNFPQ TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA 1810 1820 1830 1840 1850 1860 NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE SQGATVSQDM 1870 1880 1890 1900 1910 1920 FPDETRSSVR LSEEVEYCSE PSLLSTDILS YQDDENRQLT CLEEDKREIQ PSPKRSFLRS 1930 1940 1950 1960 1970 1980 ASLGRRASFH LECLKRQKDQ GGDISQKTAL PLHLVHHQAL AVAGLSPLLQ RSHSPSTFPR 1990 2000 2010 2020 2030 2040 PRPTPPVTPG SRGRPLQPIP TLRLEGAESS EKLNSSFPSI HCSSWSEETT ACSGGSSMAR 2050 2060 2070 2080 2090 2100 RARPVSLTVP SQAGAPGRQF HGSASSLVEA VLISEGLGQF AQDPKFIEVT TQELADACDM 2110 2120 2130 2140 2150 2160 TIEEMENAAD NILSGGAQQS PNGTLLPFVN CRDPGQDRAV VPEDESCVYA LGRGRSEEAL 2170 PDSRSYVSNL

References

[1]	"Cloning of a functional splice variant of L-type calcium channel beta2 subunit from rat heart." Yamada Y., Nagashima M., Tsutsuura M., Kobayashi T., Seki S., Makita N., Horio Y., Tohse N. J. Biol. Chem. 276:47163-47170(2001) [PubMed: 11604404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAL47071.1. Tissue: Heart EMBL AAL47071.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM02064.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM02064.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF394938 mRNA. Translation: AAL47071.1. CH473964 Genomic DNA. Translation: EDM02064.1.
IPI	IPI00476992.
PIR	JH0427.
UniGene	Rn.9827.
3D structure databases
HSSP	HSSP built from PDB template 1T0J based on UniProtKB Q13933.
ProteinModelPortal	Q8VHT3.
SMR	Q8VHT3. Positions 1642-1670.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VHT3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	AF394938. rat.
Organism-specific databases
RGD	2245. Cacna1c.
Phylogenomic databases
GeneTree	ENSGT00590000082785.
HOVERGEN	HBG050763.
InParanoid	Q8VHT3.
PhylomeDB	Q8VHT3.
Gene expression databases
ArrayExpress	Q8VHT3.
Genevestigator	Q8VHT3.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005451. VDCC_L_a1csu. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF47. LVDCCAlpha1C. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01635. LVDCCALPHA1C.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8VHT3_RAT

Accession

Primary (citable) accession number: Q8VHT3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)