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Protein

Ankyrin repeat and SOCS box protein 15

Gene

Asb15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 15
Short name:
ASB-15
Gene namesi
Name:Asb15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1926160. Asb15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669551 – 583Ankyrin repeat and SOCS box protein 15Add BLAST583

Proteomic databases

PaxDbiQ8VHS6.
PRIDEiQ8VHS6.

PTM databases

iPTMnetiQ8VHS6.
PhosphoSitePlusiQ8VHS6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029685.
CleanExiMM_ASB15.
GenevisibleiQ8VHS6. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219698. 4 interactors.
STRINGi10090.ENSMUSP00000031696.

Structurei

3D structure databases

ProteinModelPortaliQ8VHS6.
SMRiQ8VHS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati75 – 104ANK 1Add BLAST30
Repeati110 – 139ANK 2Add BLAST30
Repeati143 – 172ANK 3Add BLAST30
Repeati176 – 205ANK 4Add BLAST30
Repeati209 – 238ANK 5Add BLAST30
Repeati242 – 271ANK 6Add BLAST30
Repeati275 – 304ANK 7Add BLAST30
Repeati307 – 336ANK 8Add BLAST30
Repeati349 – 378ANK 9Add BLAST30
Repeati379 – 408ANK 10Add BLAST30
Repeati416 – 444ANK 11Add BLAST29
Domaini524 – 579SOCS boxPROSITE-ProRule annotationAdd BLAST56

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
HOVERGENiHBG023406.
InParanoidiQ8VHS6.
KOiK10337.
OMAiGNPDCIS.
OrthoDBiEOG091G03QP.
TreeFamiTF315127.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 4 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINDDSNDD HLASYDIQLC IQESIEASQA IFHPKRLVQL SDQNRKLVEA
60 70 80 90 100
IRQGRIFELQ EYVQYKYALE EADEKGWFPL HEAVVQPIQQ ILETVLDASY
110 120 130 140 150
KTLWEFKTCD GETPLTLAVK AGLVENVKTL LDKGVWPNTK NDKGETPLLI
160 170 180 190 200
AIKRGSYDMV SALIKYNTSL DQPCVKRWSA MHEAAKQGRK DIITLLLNHR
210 220 230 240 250
GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVFALA DDGASVLFEA
260 270 280 290 300
AGGGNPDCIS LLLKYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
310 320 330 340 350
KHAIQKSGLT PIHSAAEGQN AQCLELLIEN GFDVNALLAD HISQSYDDER
360 370 380 390 400
KTALYFAVSN NDIHCTEVLL AAGADPNLDP LNCLLVAVRA NRHEIVRLLL
410 420 430 440 450
SYGANVNCYF MHVNDTRFPS AIQYALNDEI MLRLLLNNGY QVELCFDCMH
460 470 480 490 500
GNIFGNSFVW SETEEEGLPG WTSCIIKDNP FCEFITVPWM KHLVGGIVRI
510 520 530 540 550
LIDYMDYVPL CAKLKSVLEV QREWPEIRQI IENPCSLKHL CRLKIRRVMG
560 570 580
LQRLCQPASI QMLPLPAAMR RYLLFKEFDL YGQ
Length:583
Mass (Da):65,512
Last modified:October 3, 2012 - v2
Checksum:iD6115A548EC8CB3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335N → K in AAL57362 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403043 mRNA. Translation: AAL57362.1.
AK029759 mRNA. Translation: BAC26602.1.
AC153635 Genomic DNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13821.1.
BC050794 mRNA. Translation: AAH50794.1.
CCDSiCCDS19943.1.
RefSeqiNP_543123.2. NM_080847.3.
XP_011239391.1. XM_011241089.1.
UniGeneiMm.160150.

Genome annotation databases

EnsembliENSMUST00000031696; ENSMUSP00000031696; ENSMUSG00000029685.
ENSMUST00000117688; ENSMUSP00000112965; ENSMUSG00000029685.
GeneIDi78910.
KEGGimmu:78910.
UCSCiuc009bbt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403043 mRNA. Translation: AAL57362.1.
AK029759 mRNA. Translation: BAC26602.1.
AC153635 Genomic DNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13821.1.
BC050794 mRNA. Translation: AAH50794.1.
CCDSiCCDS19943.1.
RefSeqiNP_543123.2. NM_080847.3.
XP_011239391.1. XM_011241089.1.
UniGeneiMm.160150.

3D structure databases

ProteinModelPortaliQ8VHS6.
SMRiQ8VHS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219698. 4 interactors.
STRINGi10090.ENSMUSP00000031696.

PTM databases

iPTMnetiQ8VHS6.
PhosphoSitePlusiQ8VHS6.

Proteomic databases

PaxDbiQ8VHS6.
PRIDEiQ8VHS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031696; ENSMUSP00000031696; ENSMUSG00000029685.
ENSMUST00000117688; ENSMUSP00000112965; ENSMUSG00000029685.
GeneIDi78910.
KEGGimmu:78910.
UCSCiuc009bbt.2. mouse.

Organism-specific databases

CTDi142685.
MGIiMGI:1926160. Asb15.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
HOVERGENiHBG023406.
InParanoidiQ8VHS6.
KOiK10337.
OMAiGNPDCIS.
OrthoDBiEOG091G03QP.
TreeFamiTF315127.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8VHS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029685.
CleanExiMM_ASB15.
GenevisibleiQ8VHS6. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 4 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB15_MOUSE
AccessioniPrimary (citable) accession number: Q8VHS6
Secondary accession number(s): Q8CDP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.