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Protein

Ankyrin repeat and SOCS box protein 16

Gene

Asb16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 16
Short name:
ASB-16
Gene namesi
Name:Asb16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2654437. Asb16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Ankyrin repeat and SOCS box protein 16PRO_0000066957Add
BLAST

Proteomic databases

PaxDbiQ8VHS5.
PRIDEiQ8VHS5.

Expressioni

Gene expression databases

BgeeiQ8VHS5.
CleanExiMM_ASB16.
GenevisibleiQ8VHS5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038450.

Structurei

3D structure databases

ProteinModelPortaliQ8VHS5.
SMRiQ8VHS5. Positions 40-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati56 – 8530ANK 1Add
BLAST
Repeati110 – 13930ANK 2Add
BLAST
Repeati142 – 17130ANK 3Add
BLAST
Repeati175 – 20430ANK 4Add
BLAST
Repeati209 – 23830ANK 5Add
BLAST
Repeati242 – 27938ANK 6Add
BLAST
Repeati283 – 31230ANK 7Add
BLAST
Domaini397 – 45357SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ8VHS5.
KOiK10338.
OMAiLHNACAN.
OrthoDBiEOG75B85F.
PhylomeDBiQ8VHS5.
TreeFamiTF333494.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGESFPFTS STLRALRLQR EWLDWEDRRR AAAQQCRRHR DLPCPQAQLL
60 70 80 90 100
RPRRSCRDPA VHNALFSGDL QQLQILFQDE DAANMIVETV SNQLAWSAEQ
110 120 130 140 150
GFWVLTPKTK QTAPLTIAVA RGYTDCARHL ILQGAELDAR IGGRAALHEA
160 170 180 190 200
CAQAHPDCVR LLLTFGAKAN VSSEEGMTPL HLCTSPESLQ CAKLLLEAGA
210 220 230 240 250
SVNVASQESE VTPLHVAAAR GLEQHVALYL QNGADVALRT SQGETALNAA
260 270 280 290 300
CAGAEGPGSS RQHEAAARQL LEAGADPQAA GRKRHTPLHN ACANGCGGLA
310 320 330 340 350
ELLLRHGASP GVTNGAGHTP MDCALQAVQD APNWEPEVLF AALLDYGAQP
360 370 380 390 400
VHPEMLKHCA NFPRALEVLL NAYPCVPSCD PWVEAVLPEL WQEHEAFYSS
410 420 430 440 450
ALSMENQPRQ LQHLARLAVR AQLGSHCRQA AAQLPLPPLL RDYLLLGVEG

RIQ
Length:453
Mass (Da):49,097
Last modified:March 1, 2002 - v1
Checksum:i6B8F4FB0165981F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403044 mRNA. Translation: AAL57363.1.
AK038411 mRNA. Translation: BAC29990.1.
CCDSiCCDS25493.1.
RefSeqiNP_683755.1. NM_148953.2.
UniGeneiMm.216432.

Genome annotation databases

EnsembliENSMUST00000036467; ENSMUSP00000038450; ENSMUSG00000034768.
GeneIDi217217.
KEGGimmu:217217.
UCSCiuc007lra.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403044 mRNA. Translation: AAL57363.1.
AK038411 mRNA. Translation: BAC29990.1.
CCDSiCCDS25493.1.
RefSeqiNP_683755.1. NM_148953.2.
UniGeneiMm.216432.

3D structure databases

ProteinModelPortaliQ8VHS5.
SMRiQ8VHS5. Positions 40-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038450.

Proteomic databases

PaxDbiQ8VHS5.
PRIDEiQ8VHS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036467; ENSMUSP00000038450; ENSMUSG00000034768.
GeneIDi217217.
KEGGimmu:217217.
UCSCiuc007lra.1. mouse.

Organism-specific databases

CTDi92591.
MGIiMGI:2654437. Asb16.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ8VHS5.
KOiK10338.
OMAiLHNACAN.
OrthoDBiEOG75B85F.
PhylomeDBiQ8VHS5.
TreeFamiTF333494.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi375659.
PROiQ8VHS5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHS5.
CleanExiMM_ASB16.
GenevisibleiQ8VHS5. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SOCS box proteins."
    Kile B.T., Nicola N.A.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 321-453.
    Strain: C57BL/6J.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiASB16_MOUSE
AccessioniPrimary (citable) accession number: Q8VHS5
Secondary accession number(s): Q8BYT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.