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Protein

Ankyrin repeat and SOCS box protein 16

Gene

Asb16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 16
Short name:
ASB-16
Gene namesi
Name:Asb16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2654437. Asb16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669571 – 453Ankyrin repeat and SOCS box protein 16Add BLAST453

Proteomic databases

PaxDbiQ8VHS5.
PRIDEiQ8VHS5.

PTM databases

PhosphoSitePlusiQ8VHS5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034768.
CleanExiMM_ASB16.
GenevisibleiQ8VHS5. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038450.

Structurei

3D structure databases

ProteinModelPortaliQ8VHS5.
SMRiQ8VHS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 85ANK 1Add BLAST30
Repeati110 – 139ANK 2Add BLAST30
Repeati142 – 171ANK 3Add BLAST30
Repeati175 – 204ANK 4Add BLAST30
Repeati209 – 238ANK 5Add BLAST30
Repeati242 – 279ANK 6Add BLAST38
Repeati283 – 312ANK 7Add BLAST30
Domaini397 – 453SOCS boxPROSITE-ProRule annotationAdd BLAST57

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ8VHS5.
KOiK10338.
OMAiLHNACAN.
OrthoDBiEOG091G08N2.
PhylomeDBiQ8VHS5.
TreeFamiTF333494.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGESFPFTS STLRALRLQR EWLDWEDRRR AAAQQCRRHR DLPCPQAQLL
60 70 80 90 100
RPRRSCRDPA VHNALFSGDL QQLQILFQDE DAANMIVETV SNQLAWSAEQ
110 120 130 140 150
GFWVLTPKTK QTAPLTIAVA RGYTDCARHL ILQGAELDAR IGGRAALHEA
160 170 180 190 200
CAQAHPDCVR LLLTFGAKAN VSSEEGMTPL HLCTSPESLQ CAKLLLEAGA
210 220 230 240 250
SVNVASQESE VTPLHVAAAR GLEQHVALYL QNGADVALRT SQGETALNAA
260 270 280 290 300
CAGAEGPGSS RQHEAAARQL LEAGADPQAA GRKRHTPLHN ACANGCGGLA
310 320 330 340 350
ELLLRHGASP GVTNGAGHTP MDCALQAVQD APNWEPEVLF AALLDYGAQP
360 370 380 390 400
VHPEMLKHCA NFPRALEVLL NAYPCVPSCD PWVEAVLPEL WQEHEAFYSS
410 420 430 440 450
ALSMENQPRQ LQHLARLAVR AQLGSHCRQA AAQLPLPPLL RDYLLLGVEG

RIQ
Length:453
Mass (Da):49,097
Last modified:March 1, 2002 - v1
Checksum:i6B8F4FB0165981F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403044 mRNA. Translation: AAL57363.1.
AK038411 mRNA. Translation: BAC29990.1.
CCDSiCCDS25493.1.
RefSeqiNP_683755.1. NM_148953.2.
UniGeneiMm.216432.

Genome annotation databases

EnsembliENSMUST00000036467; ENSMUSP00000038450; ENSMUSG00000034768.
GeneIDi217217.
KEGGimmu:217217.
UCSCiuc007lra.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403044 mRNA. Translation: AAL57363.1.
AK038411 mRNA. Translation: BAC29990.1.
CCDSiCCDS25493.1.
RefSeqiNP_683755.1. NM_148953.2.
UniGeneiMm.216432.

3D structure databases

ProteinModelPortaliQ8VHS5.
SMRiQ8VHS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038450.

PTM databases

PhosphoSitePlusiQ8VHS5.

Proteomic databases

PaxDbiQ8VHS5.
PRIDEiQ8VHS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036467; ENSMUSP00000038450; ENSMUSG00000034768.
GeneIDi217217.
KEGGimmu:217217.
UCSCiuc007lra.1. mouse.

Organism-specific databases

CTDi92591.
MGIiMGI:2654437. Asb16.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ8VHS5.
KOiK10338.
OMAiLHNACAN.
OrthoDBiEOG091G08N2.
PhylomeDBiQ8VHS5.
TreeFamiTF333494.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8VHS5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034768.
CleanExiMM_ASB16.
GenevisibleiQ8VHS5. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB16_MOUSE
AccessioniPrimary (citable) accession number: Q8VHS5
Secondary accession number(s): Q8BYT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.