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Q8VHS2

- CRUM1_MOUSE

UniProt

Q8VHS2 - CRUM1_MOUSE

Protein

Protein crumbs homolog 1

Gene

Crb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. Isoform 3 could play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization.3 Publications

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. eye photoreceptor cell development Source: MGI
    2. membrane organization Source: MGI
    3. plasma membrane organization Source: MGI

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein crumbs homolog 1
    Gene namesi
    Name:Crb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2136343. Crb1.

    Subcellular locationi

    Isoform 1 : Membrane; Single-pass type I membrane protein
    Note: In the retina, localizes to the Mueller cell radial processes in the inner nuclear layer and in apical processes sclerad to the external limiting membrane. Localizes to the subapical region, adjacent to the adherens junction of photoreceptors. Isoform 3 which is secreted is found in the cytoplasmic area of undifferentiated keratinocytes and associates with the plasma membrane at the site of cell-cell contacts and focal adhesion upon keratinocytes differentiation.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. microvillus Source: MGI
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 14051378Protein crumbs homolog 1PRO_0000007501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 45By similarity
    Disulfide bondi39 ↔ 54By similarity
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi55 ↔ 66By similarity
    Disulfide bondi73 ↔ 84By similarity
    Disulfide bondi78 ↔ 95By similarity
    Disulfide bondi97 ↔ 106By similarity
    Disulfide bondi113 ↔ 124By similarity
    Disulfide bondi118 ↔ 133By similarity
    Disulfide bondi135 ↔ 144By similarity
    Disulfide bondi151 ↔ 162By similarity
    Disulfide bondi156 ↔ 171By similarity
    Disulfide bondi173 ↔ 182By similarity
    Disulfide bondi189 ↔ 200By similarity
    Disulfide bondi194 ↔ 209By similarity
    Disulfide bondi211 ↔ 220By similarity
    Disulfide bondi227 ↔ 238By similarity
    Disulfide bondi232 ↔ 247By similarity
    Disulfide bondi249 ↔ 258By similarity
    Disulfide bondi265 ↔ 276By similarity
    Disulfide bondi270 ↔ 285By similarity
    Disulfide bondi287 ↔ 297By similarity
    Disulfide bondi304 ↔ 315By similarity
    Disulfide bondi309 ↔ 324By similarity
    Disulfide bondi326 ↔ 335By similarity
    Disulfide bondi342 ↔ 353By similarity
    Disulfide bondi347 ↔ 382By similarity
    Disulfide bondi384 ↔ 393By similarity
    Disulfide bondi400 ↔ 411By similarity
    Disulfide bondi405 ↔ 420By similarity
    Disulfide bondi422 ↔ 437By similarity
    Disulfide bondi444 ↔ 455By similarity
    Disulfide bondi449 ↔ 468By similarity
    Disulfide bondi470 ↔ 479By similarity
    Glycosylationi560 – 5601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi641 ↔ 669By similarity
    Glycosylationi656 – 6561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi675 ↔ 686By similarity
    Disulfide bondi680 ↔ 695By similarity
    Disulfide bondi697 ↔ 706By similarity
    Glycosylationi756 – 7561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi850 ↔ 884By similarity
    Glycosylationi879 – 8791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi890 ↔ 901By similarity
    Disulfide bondi895 ↔ 910By similarity
    Disulfide bondi912 ↔ 921By similarity
    Disulfide bondi927 ↔ 938By similarity
    Disulfide bondi932 ↔ 947By similarity
    Glycosylationi967 – 9671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi974 – 9741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi999 – 9991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1095 ↔ 1136By similarity
    Disulfide bondi1142 ↔ 1153By similarity
    Disulfide bondi1147 ↔ 1162By similarity
    Disulfide bondi1164 ↔ 1173By similarity
    Disulfide bondi1180 ↔ 1190By similarity
    Disulfide bondi1185 ↔ 1199By similarity
    Glycosylationi1189 – 11891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1201 ↔ 1210By similarity
    Disulfide bondi1217 ↔ 1228By similarity
    Disulfide bondi1222 ↔ 1237By similarity
    Disulfide bondi1239 ↔ 1248By similarity
    Glycosylationi1242 – 12421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1258 ↔ 1273By similarity
    Glycosylationi1264 – 12641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1267 ↔ 1282By similarity
    Disulfide bondi1284 ↔ 1293By similarity
    Disulfide bondi1300 ↔ 1311By similarity
    Disulfide bondi1305 ↔ 1320By similarity
    Disulfide bondi1322 ↔ 1331By similarity

    Post-translational modificationi

    Glycosylated.Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8VHS2.

    PTM databases

    PhosphoSiteiQ8VHS2.

    Expressioni

    Tissue specificityi

    Expressed exclusively in brain and proliferative retinoblasts of the eye. In the brain, expressed in the granular layer of the cerebellum, the hippocampal dentate gyrus, the olfactory bulbs, the subventricular region lining the telencephalic ventricles and the rostral migratory stream. Isoform 3 is ubiquitously expressed.2 Publications

    Developmental stagei

    Primarily detected in the central nervous system at E10.5, in the ventral part of the neural tube including the ventral spinal cord, the ventral part of the mesencephalon, the mammillary and the hypothalamic regions, the optic area and the zona limitans intrathalamica. Expressed by the V3 interneurons placed between the floor plate and the motorneurons all along the spinal cord axis. In late embryogenesis, expressed mainly in ventral neural structures of the developing brain, including the mammillary, tuberalis regions of the hypothalamus and the preoptic area. Starting from E12.5, also strongly expressed in the neural area that gives rise to the dorsal thalamus. In the retina, expression starts at E11.5 and is enhanced at E12.5, E14.5 and E16.5. In postnatal stages and in the adult eye, it is strongly expressed in photoreceptors and also found in inner nuclear layer and iris. Isoform 3 expression starts at E14, is enhanced at E15 and E16 during active proliferation of epidermal cells, decreases after birth but is maintained in adult skin. Detected in the skin basal cells at E16, it was observed in upper layers after birth (at protein level).2 Publications

    Gene expression databases

    BgeeiQ8VHS2.
    CleanExiMM_CRB1.
    GenevestigatoriQ8VHS2.

    Interactioni

    Subunit structurei

    In photoreceptor cells, forms a complex with MPDZ, MPP4 and MPP5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHS2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 13391312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1361 – 140545CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1340 – 136021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 6738EGF-like 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini69 – 10739EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini109 – 14537EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini147 – 18337EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini185 – 22137EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini223 – 25937EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini261 – 29838EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini300 – 33637EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini338 – 39457EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini396 – 43843EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini440 – 48041EGF-like 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 669188Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini671 – 70737EGF-like 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini713 – 884172Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini886 – 92237EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini923 – 95937EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini950 – 1136187Laminin G-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1138 – 117437EGF-like 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1176 – 121136EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1213 – 124937EGF-like 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1254 – 129441EGF-like 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini1296 – 133237EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Crumbs protein family.Curated
    Contains 19 EGF-like domains.PROSITE-ProRule annotation
    Contains 3 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00750000117426.
    HOGENOMiHOG000230899.
    HOVERGENiHBG080001.
    InParanoidiQ8VHS2.
    KOiK16681.
    OMAiATFLNDS.
    OrthoDBiEOG7KH9HX.
    TreeFamiTF316224.

    Family and domain databases

    Gene3Di2.60.120.200. 3 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF00008. EGF. 11 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 3 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 10 hits.
    SM00179. EGF_CA. 7 hits.
    SM00282. LamG. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 3 hits.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
    PS00022. EGF_1. 15 hits.
    PS01186. EGF_2. 11 hits.
    PS50026. EGF_3. 17 hits.
    PS01187. EGF_CA. 6 hits.
    PS50025. LAM_G_DOMAIN. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VHS2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLKRTAYLL FLYLSSSLLI CIKNSFCNKN NTRCLSGPCQ NNSTCKHFPQ     50
    DNNCCLDTAN NLDKDCEDLK DPCFSSPCQG IATCVKIPGE GNFLCQCPPG 100
    YSGLNCETAT NSCGGNLCQH GGTCRKDPEH PVCICPPGYA GRFCETDHNE 150
    CASSPCHNGA MCQDGINGYS CFCVPGYQGR HCDLEVDECV SDPCKNEAVC 200
    LNEIGRYTCV CPQEFSGVNC ELEIDECRSQ PCLHGATCQD APGGYSCDCA 250
    PGFLGEHCEL SVNECESQPC LHGGLCVDGR NSYHCDCTGS GFTGMHCESL 300
    IPLCWSKPCH NDATCEDTVD SYICHCRPGY TGALCETDIN ECSSNPCQFW 350
    GECVELSSEG LYGNTAGLPS SFSYVGASGY VCICQPGFTG IHCEEDVDEC 400
    LLHPCLNGGT CENLPGNYAC HCPFDDTSRT FYGGENCSEI LLGCTHHQCL 450
    NNGKCIPHFQ NGQHGFTCQC LSGYAGPLCE TVTTLSFGSN GFLWVTSGSH 500
    TGIGPECNIS LRFHTVQPNA LLLIRGNKDV SMKLELLNGC VHLSIEVWNQ 550
    LKVLLSISHN TSDGEWHFVE VTIAETLTLA LVGGSCKEKC TTKSSVPVEN 600
    HQSICALQDS FLGGLPMGTA NNSVSVLNIY NVPSTPSFVG CLQDIRFDLN 650
    HITLENVSSG LSSNVKAGCL GKDWCESQPC QNRGRCINLW QGYQCECDRP 700
    YTGSNCLKEY VAGRFGQDDS TGYAAFSVND NYGQNFSLSM FVRTRQPLGL 750
    LLALENSTYQ YVSVWLEHGS LALQTPGSPK FMVNFFLSDG NVHLISLRIK 800
    PNEIELYQSS QNLGFISVPT WTIRRGDVIF IGGLPDREKT EVYGGFFKGC 850
    VQDVRLNSQT LEFFPNSTNN AYDDPILVNV TQGCPGDNTC KSNPCHNGGV 900
    CHSLWDDFSC SCPTNTAGRA CEQVQWCQLS PCPPTAECQL LPQGFECIAN 950
    AVFSGLSREI LFRSNGNITR ELTNITFAFR THDTNVMILH AEKEPEFLNI 1000
    SIQDARLFFQ LRSGNSFYTL HLMGSQLVND GTWHQVTFSM IDPVAQTSRW 1050
    QMEVNDQTPF VISEVATGSL NFLKDNTDIY VGDQSVDNPK GLQGCLSTIE 1100
    IGGIYLSYFE NLHGFPGKPQ EEQFLKVSTN MVLTGCLPSN ACHSSPCLHG 1150
    GNCEDSYSSY RCACLSGWSG THCEINIDEC FSSPCIHGNC SDGVAAYHCR 1200
    CEPGYTGVNC EVDVDNCKSH QCANGATCVP EAHGYSCLCF GNFTGRFCRH 1250
    SRLPSTVCGN EKRNFTCYNG GSCSMFQEDW QCMCWPGFTG EWCEEDINEC 1300
    ASDPCINGGL CRDLVNRFLC ICDVAFAGER CELDLADDRL LGIFTAVGSG 1350
    TLALFFILLL AGVASLIASN KRATQGTYSP SGQEKAGPRV EMWIRMPPPA 1400
    LERLI 1405
    Length:1,405
    Mass (Da):153,350
    Last modified:July 27, 2011 - v3
    Checksum:iFE1ECCB17529797B
    GO
    Isoform 2 (identifier: Q8VHS2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         329-389: Missing.
         1298-1376: NECASDPCIN...IASNKRATQG → EASVPPIPAS...VVEWGAQENY
         1377-1405: Missing.

    Show »
    Length:1,315
    Mass (Da):144,240
    Checksum:iA7BFB777507D5D50
    GO
    Isoform 3 (identifier: Q8VHS2-3) [UniParc]FASTAAdd to Basket

    Also known as: Crb1s

    The sequence of this isoform differs from the canonical sequence as follows:
         709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
         762-1405: Missing.

    Show »
    Length:761
    Mass (Da):82,539
    Checksum:i237635C3735E06A8
    GO
    Isoform 4 (identifier: Q8VHS2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-372: Missing.
         373-389: SYVGASGYVCICQPGFT → MFGHKTQGFHILMAVLI
         709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
         762-1405: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:389
    Mass (Da):42,611
    Checksum:i79E07040792E01A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461K → E in AAL65131. (PubMed:11744384)Curated
    Sequence conflicti46 – 461K → E in AAR20495. (PubMed:14684155)Curated
    Sequence conflicti157 – 1571H → L in AAL65131. (PubMed:11744384)Curated
    Sequence conflicti214 – 2141E → K in AAR20495. (PubMed:14684155)Curated
    Sequence conflicti261 – 2611S → T in AAR20495. (PubMed:14684155)Curated
    Sequence conflicti344 – 3441S → N in AAR20495. (PubMed:14684155)Curated
    Sequence conflicti371 – 3711S → T in AAR20495. (PubMed:14684155)Curated
    Sequence conflicti413 – 4131N → S in AAL65131. (PubMed:11744384)Curated
    Sequence conflicti521 – 5211Missing in AAR20495. (PubMed:14684155)Curated
    Sequence conflicti536 – 5361L → W in AAQ06606. 1 PublicationCurated
    Sequence conflicti540 – 5401C → G in AAQ06606. 1 PublicationCurated
    Sequence conflicti545 – 5451I → M in AAQ06606. 1 PublicationCurated
    Sequence conflicti572 – 5721T → P in AAQ06606. 1 PublicationCurated
    Sequence conflicti591 – 5911T → A in AAQ06606. 1 PublicationCurated
    Sequence conflicti673 – 6731D → DD in AAR20495. (PubMed:14684155)Curated
    Sequence conflicti741 – 7411F → L in AAQ06606. 1 PublicationCurated
    Sequence conflicti745 – 7451R → H in AAQ06606. 1 PublicationCurated
    Sequence conflicti835 – 8351P → L in AAQ06606. 1 PublicationCurated
    Sequence conflicti886 – 8861G → R in AAQ06606. 1 PublicationCurated
    Sequence conflicti900 – 9023VCH → ACR in AAQ06606. 1 PublicationCurated
    Sequence conflicti942 – 9421P → S in AAQ06606. 1 PublicationCurated
    Sequence conflicti982 – 9821H → Q in AAQ06606. 1 PublicationCurated
    Sequence conflicti1062 – 10621I → V in AAQ06606. 1 PublicationCurated
    Sequence conflicti1275 – 12751M → V in AAQ06606. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 372372Missing in isoform 4. 1 PublicationVSP_014730Add
    BLAST
    Alternative sequencei329 – 38961Missing in isoform 2. 1 PublicationVSP_014731Add
    BLAST
    Alternative sequencei373 – 38917SYVGA…QPGFT → MFGHKTQGFHILMAVLI in isoform 4. 1 PublicationVSP_014732Add
    BLAST
    Alternative sequencei709 – 76153EYVAG…STYQY → GERSGVPQSAVPLSRAISNH PGCRPLLGNIRTPQDLCWYL FTNEIKWHSHDMY in isoform 3 and isoform 4. 2 PublicationsVSP_014733Add
    BLAST
    Alternative sequencei762 – 1405644Missing in isoform 3 and isoform 4. 2 PublicationsVSP_014734Add
    BLAST
    Alternative sequencei1298 – 137679NECAS…RATQG → EASVPPIPASMEDCAGTWST GSYASVMWPSLGERCELDVS GLSFYVSLLLWQNLFQLLSY LVLHMNDEPVVEWGAQENY in isoform 2. 1 PublicationVSP_014735Add
    BLAST
    Alternative sequencei1377 – 140529Missing in isoform 2. 1 PublicationVSP_014736Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF406641 mRNA. Translation: AAL65131.1.
    AY450552 mRNA. Translation: AAR20495.1.
    AF492496 mRNA. Translation: AAQ06606.1.
    AK044345 mRNA. Translation: BAC31879.1.
    AK044704 mRNA. Translation: BAC32041.1.
    AL606536, AC116810, AC138741 Genomic DNA. Translation: CAX16031.1.
    CH466520 Genomic DNA. Translation: EDL39531.1.
    CCDSiCCDS15336.1. [Q8VHS2-1]
    RefSeqiNP_573502.2. NM_133239.2. [Q8VHS2-1]
    UniGeneiMm.95700.

    Genome annotation databases

    EnsembliENSMUST00000059825; ENSMUSP00000060769; ENSMUSG00000063681. [Q8VHS2-1]
    GeneIDi170788.
    KEGGimmu:170788.
    UCSCiuc007cwc.1. mouse. [Q8VHS2-1]
    uc007cwe.1. mouse. [Q8VHS2-4]
    uc007cwf.1. mouse. [Q8VHS2-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF406641 mRNA. Translation: AAL65131.1 .
    AY450552 mRNA. Translation: AAR20495.1 .
    AF492496 mRNA. Translation: AAQ06606.1 .
    AK044345 mRNA. Translation: BAC31879.1 .
    AK044704 mRNA. Translation: BAC32041.1 .
    AL606536 , AC116810 , AC138741 Genomic DNA. Translation: CAX16031.1 .
    CH466520 Genomic DNA. Translation: EDL39531.1 .
    CCDSi CCDS15336.1. [Q8VHS2-1 ]
    RefSeqi NP_573502.2. NM_133239.2. [Q8VHS2-1 ]
    UniGenei Mm.95700.

    3D structure databases

    ProteinModelPortali Q8VHS2.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8VHS2.

    Proteomic databases

    PRIDEi Q8VHS2.

    Protocols and materials databases

    DNASUi 170788.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059825 ; ENSMUSP00000060769 ; ENSMUSG00000063681 . [Q8VHS2-1 ]
    GeneIDi 170788.
    KEGGi mmu:170788.
    UCSCi uc007cwc.1. mouse. [Q8VHS2-1 ]
    uc007cwe.1. mouse. [Q8VHS2-4 ]
    uc007cwf.1. mouse. [Q8VHS2-3 ]

    Organism-specific databases

    CTDi 23418.
    MGIi MGI:2136343. Crb1.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00750000117426.
    HOGENOMi HOG000230899.
    HOVERGENi HBG080001.
    InParanoidi Q8VHS2.
    KOi K16681.
    OMAi ATFLNDS.
    OrthoDBi EOG7KH9HX.
    TreeFami TF316224.

    Miscellaneous databases

    NextBioi 370423.
    PROi Q8VHS2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VHS2.
    CleanExi MM_CRB1.
    Genevestigatori Q8VHS2.

    Family and domain databases

    Gene3Di 2.60.120.200. 3 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF00008. EGF. 11 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 3 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 10 hits.
    SM00179. EGF_CA. 7 hits.
    SM00282. LamG. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 3 hits.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
    PS00022. EGF_1. 15 hits.
    PS01186. EGF_2. 11 hits.
    PS50026. EGF_3. 17 hits.
    PS01187. EGF_CA. 6 hits.
    PS50025. LAM_G_DOMAIN. 3 hits.
    [Graphical view ]
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    Publicationsi

    1. "Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain."
      den Hollander A.I., Ghiani M., de Kok Y.J.M., Wijnholds J., Ballabio A., Cremers F.P.M., Broccoli V.
      Mech. Dev. 110:203-207(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
      Tissue: Eye.
    2. "Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin development."
      Watanabe T., Miyatani S., Katoh I., Kobayashi S., Ikawa Y.
      Biochem. Biophys. Res. Commun. 313:263-270(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
      Strain: ICR.
      Tissue: Skin.
    3. "Mouse Crumbs-2 in developing nervous system."
      Chang C.-H., Fan S.-S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: ICR.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: C57BL/6J.
      Tissue: Retina.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis."
      Pellikka M., Tanentzapf G., Pinto M., Smith C., McGlade C.J., Ready D.F., Tepass U.
      Nature 416:143-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina."
      Mehalow A.K., Kameya S., Smith R.S., Hawes N.L., Denegre J.M., Young J.A., Bechtold L., Haider N.B., Tepass U., Heckenlively J.R., Chang B., Naggert J.K., Nishina P.M.
      Hum. Mol. Genet. 12:2179-2189(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DISEASE, FUNCTION.
    9. "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."
      van de Pavert S.A., Kantardzhieva A., Malysheva A., Meuleman J., Versteeg I., Levelt C., Klooster J., Geiger S., Seeliger M.W., Rashbass P., Le Bivic A., Wijnholds J.
      J. Cell Sci. 117:4169-4177(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, COMPLEX FORMATION WITH MPDZ; MPP4 AND MPP5, FUNCTION.

    Entry informationi

    Entry nameiCRUM1_MOUSE
    AccessioniPrimary (citable) accession number: Q8VHS2
    Secondary accession number(s): B7ZC63
    , Q6ST50, Q71JF2, Q8BGR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3