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Q8VHS2

- CRUM1_MOUSE

UniProt

Q8VHS2 - CRUM1_MOUSE

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Protein

Protein crumbs homolog 1

Gene
Crb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. Isoform 3 could play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization.3 Publications

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: MGI

GO - Biological processi

  1. eye photoreceptor cell development Source: MGI
  2. membrane organization Source: MGI
  3. plasma membrane organization Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein crumbs homolog 1
Gene namesi
Name:Crb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2136343. Crb1.

Subcellular locationi

Isoform 1 : Membrane; Single-pass type I membrane protein
Note: In the retina, localizes to the Mueller cell radial processes in the inner nuclear layer and in apical processes sclerad to the external limiting membrane. Localizes to the subapical region, adjacent to the adherens junction of photoreceptors. Isoform 3 which is secreted is found in the cytoplasmic area of undifferentiated keratinocytes and associates with the plasma membrane at the site of cell-cell contacts and focal adhesion upon keratinocytes differentiation.4 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 13391312Extracellular Reviewed predictionAdd
BLAST
Transmembranei1340 – 136021Helical; Reviewed predictionAdd
BLAST
Topological domaini1361 – 140545Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. microvillus Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 14051378Protein crumbs homolog 1PRO_0000007501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 45 By similarity
Disulfide bondi39 ↔ 54 By similarity
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi55 ↔ 66 By similarity
Disulfide bondi73 ↔ 84 By similarity
Disulfide bondi78 ↔ 95 By similarity
Disulfide bondi97 ↔ 106 By similarity
Disulfide bondi113 ↔ 124 By similarity
Disulfide bondi118 ↔ 133 By similarity
Disulfide bondi135 ↔ 144 By similarity
Disulfide bondi151 ↔ 162 By similarity
Disulfide bondi156 ↔ 171 By similarity
Disulfide bondi173 ↔ 182 By similarity
Disulfide bondi189 ↔ 200 By similarity
Disulfide bondi194 ↔ 209 By similarity
Disulfide bondi211 ↔ 220 By similarity
Disulfide bondi227 ↔ 238 By similarity
Disulfide bondi232 ↔ 247 By similarity
Disulfide bondi249 ↔ 258 By similarity
Disulfide bondi265 ↔ 276 By similarity
Disulfide bondi270 ↔ 285 By similarity
Disulfide bondi287 ↔ 297 By similarity
Disulfide bondi304 ↔ 315 By similarity
Disulfide bondi309 ↔ 324 By similarity
Disulfide bondi326 ↔ 335 By similarity
Disulfide bondi342 ↔ 353 By similarity
Disulfide bondi347 ↔ 382 By similarity
Disulfide bondi384 ↔ 393 By similarity
Disulfide bondi400 ↔ 411 By similarity
Disulfide bondi405 ↔ 420 By similarity
Disulfide bondi422 ↔ 437 By similarity
Disulfide bondi444 ↔ 455 By similarity
Disulfide bondi449 ↔ 468 By similarity
Disulfide bondi470 ↔ 479 By similarity
Glycosylationi560 – 5601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi641 ↔ 669 By similarity
Glycosylationi656 – 6561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi675 ↔ 686 By similarity
Disulfide bondi680 ↔ 695 By similarity
Disulfide bondi697 ↔ 706 By similarity
Glycosylationi756 – 7561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi850 ↔ 884 By similarity
Glycosylationi879 – 8791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi890 ↔ 901 By similarity
Disulfide bondi895 ↔ 910 By similarity
Disulfide bondi912 ↔ 921 By similarity
Disulfide bondi927 ↔ 938 By similarity
Disulfide bondi932 ↔ 947 By similarity
Glycosylationi967 – 9671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi974 – 9741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi999 – 9991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1095 ↔ 1136 By similarity
Disulfide bondi1142 ↔ 1153 By similarity
Disulfide bondi1147 ↔ 1162 By similarity
Disulfide bondi1164 ↔ 1173 By similarity
Disulfide bondi1180 ↔ 1190 By similarity
Disulfide bondi1185 ↔ 1199 By similarity
Glycosylationi1189 – 11891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1201 ↔ 1210 By similarity
Disulfide bondi1217 ↔ 1228 By similarity
Disulfide bondi1222 ↔ 1237 By similarity
Disulfide bondi1239 ↔ 1248 By similarity
Glycosylationi1242 – 12421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1258 ↔ 1273 By similarity
Glycosylationi1264 – 12641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1267 ↔ 1282 By similarity
Disulfide bondi1284 ↔ 1293 By similarity
Disulfide bondi1300 ↔ 1311 By similarity
Disulfide bondi1305 ↔ 1320 By similarity
Disulfide bondi1322 ↔ 1331 By similarity

Post-translational modificationi

Glycosylated Inferred.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8VHS2.

PTM databases

PhosphoSiteiQ8VHS2.

Expressioni

Tissue specificityi

Expressed exclusively in brain and proliferative retinoblasts of the eye. In the brain, expressed in the granular layer of the cerebellum, the hippocampal dentate gyrus, the olfactory bulbs, the subventricular region lining the telencephalic ventricles and the rostral migratory stream. Isoform 3 is ubiquitously expressed.2 Publications

Developmental stagei

Primarily detected in the central nervous system at E10.5, in the ventral part of the neural tube including the ventral spinal cord, the ventral part of the mesencephalon, the mammillary and the hypothalamic regions, the optic area and the zona limitans intrathalamica. Expressed by the V3 interneurons placed between the floor plate and the motorneurons all along the spinal cord axis. In late embryogenesis, expressed mainly in ventral neural structures of the developing brain, including the mammillary, tuberalis regions of the hypothalamus and the preoptic area. Starting from E12.5, also strongly expressed in the neural area that gives rise to the dorsal thalamus. In the retina, expression starts at E11.5 and is enhanced at E12.5, E14.5 and E16.5. In postnatal stages and in the adult eye, it is strongly expressed in photoreceptors and also found in inner nuclear layer and iris. Isoform 3 expression starts at E14, is enhanced at E15 and E16 during active proliferation of epidermal cells, decreases after birth but is maintained in adult skin. Detected in the skin basal cells at E16, it was observed in upper layers after birth (at protein level).2 Publications

Gene expression databases

BgeeiQ8VHS2.
CleanExiMM_CRB1.
GenevestigatoriQ8VHS2.

Interactioni

Subunit structurei

In photoreceptor cells, forms a complex with MPDZ, MPP4 and MPP5.

Structurei

3D structure databases

ProteinModelPortaliQ8VHS2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 6738EGF-like 1; atypicalAdd
BLAST
Domaini69 – 10739EGF-like 2Add
BLAST
Domaini109 – 14537EGF-like 3Add
BLAST
Domaini147 – 18337EGF-like 4; calcium-binding Reviewed predictionAdd
BLAST
Domaini185 – 22137EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini223 – 25937EGF-like 6; calcium-binding Reviewed predictionAdd
BLAST
Domaini261 – 29838EGF-like 7Add
BLAST
Domaini300 – 33637EGF-like 8Add
BLAST
Domaini338 – 39457EGF-like 9Add
BLAST
Domaini396 – 43843EGF-like 10Add
BLAST
Domaini440 – 48041EGF-like 11Add
BLAST
Domaini482 – 669188Laminin G-like 1Add
BLAST
Domaini671 – 70737EGF-like 12Add
BLAST
Domaini713 – 884172Laminin G-like 2Add
BLAST
Domaini886 – 92237EGF-like 13Add
BLAST
Domaini923 – 95937EGF-like 14Add
BLAST
Domaini950 – 1136187Laminin G-like 3Add
BLAST
Domaini1138 – 117437EGF-like 15Add
BLAST
Domaini1176 – 121136EGF-like 16; calcium-binding Reviewed predictionAdd
BLAST
Domaini1213 – 124937EGF-like 17Add
BLAST
Domaini1254 – 129441EGF-like 18Add
BLAST
Domaini1296 – 133237EGF-like 19; calcium-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the Crumbs protein family.
Contains 19 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00750000117426.
HOGENOMiHOG000230899.
HOVERGENiHBG080001.
InParanoidiQ8VHS2.
KOiK16681.
OMAiATFLNDS.
OrthoDBiEOG7KH9HX.
TreeFamiTF316224.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00008. EGF. 11 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00179. EGF_CA. 7 hits.
SM00282. LamG. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 17 hits.
PS01187. EGF_CA. 6 hits.
PS50025. LAM_G_DOMAIN. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VHS2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKLKRTAYLL FLYLSSSLLI CIKNSFCNKN NTRCLSGPCQ NNSTCKHFPQ     50
DNNCCLDTAN NLDKDCEDLK DPCFSSPCQG IATCVKIPGE GNFLCQCPPG 100
YSGLNCETAT NSCGGNLCQH GGTCRKDPEH PVCICPPGYA GRFCETDHNE 150
CASSPCHNGA MCQDGINGYS CFCVPGYQGR HCDLEVDECV SDPCKNEAVC 200
LNEIGRYTCV CPQEFSGVNC ELEIDECRSQ PCLHGATCQD APGGYSCDCA 250
PGFLGEHCEL SVNECESQPC LHGGLCVDGR NSYHCDCTGS GFTGMHCESL 300
IPLCWSKPCH NDATCEDTVD SYICHCRPGY TGALCETDIN ECSSNPCQFW 350
GECVELSSEG LYGNTAGLPS SFSYVGASGY VCICQPGFTG IHCEEDVDEC 400
LLHPCLNGGT CENLPGNYAC HCPFDDTSRT FYGGENCSEI LLGCTHHQCL 450
NNGKCIPHFQ NGQHGFTCQC LSGYAGPLCE TVTTLSFGSN GFLWVTSGSH 500
TGIGPECNIS LRFHTVQPNA LLLIRGNKDV SMKLELLNGC VHLSIEVWNQ 550
LKVLLSISHN TSDGEWHFVE VTIAETLTLA LVGGSCKEKC TTKSSVPVEN 600
HQSICALQDS FLGGLPMGTA NNSVSVLNIY NVPSTPSFVG CLQDIRFDLN 650
HITLENVSSG LSSNVKAGCL GKDWCESQPC QNRGRCINLW QGYQCECDRP 700
YTGSNCLKEY VAGRFGQDDS TGYAAFSVND NYGQNFSLSM FVRTRQPLGL 750
LLALENSTYQ YVSVWLEHGS LALQTPGSPK FMVNFFLSDG NVHLISLRIK 800
PNEIELYQSS QNLGFISVPT WTIRRGDVIF IGGLPDREKT EVYGGFFKGC 850
VQDVRLNSQT LEFFPNSTNN AYDDPILVNV TQGCPGDNTC KSNPCHNGGV 900
CHSLWDDFSC SCPTNTAGRA CEQVQWCQLS PCPPTAECQL LPQGFECIAN 950
AVFSGLSREI LFRSNGNITR ELTNITFAFR THDTNVMILH AEKEPEFLNI 1000
SIQDARLFFQ LRSGNSFYTL HLMGSQLVND GTWHQVTFSM IDPVAQTSRW 1050
QMEVNDQTPF VISEVATGSL NFLKDNTDIY VGDQSVDNPK GLQGCLSTIE 1100
IGGIYLSYFE NLHGFPGKPQ EEQFLKVSTN MVLTGCLPSN ACHSSPCLHG 1150
GNCEDSYSSY RCACLSGWSG THCEINIDEC FSSPCIHGNC SDGVAAYHCR 1200
CEPGYTGVNC EVDVDNCKSH QCANGATCVP EAHGYSCLCF GNFTGRFCRH 1250
SRLPSTVCGN EKRNFTCYNG GSCSMFQEDW QCMCWPGFTG EWCEEDINEC 1300
ASDPCINGGL CRDLVNRFLC ICDVAFAGER CELDLADDRL LGIFTAVGSG 1350
TLALFFILLL AGVASLIASN KRATQGTYSP SGQEKAGPRV EMWIRMPPPA 1400
LERLI 1405
Length:1,405
Mass (Da):153,350
Last modified:July 27, 2011 - v3
Checksum:iFE1ECCB17529797B
GO
Isoform 2 (identifier: Q8VHS2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-389: Missing.
     1298-1376: NECASDPCIN...IASNKRATQG → EASVPPIPAS...VVEWGAQENY
     1377-1405: Missing.

Show »
Length:1,315
Mass (Da):144,240
Checksum:iA7BFB777507D5D50
GO
Isoform 3 (identifier: Q8VHS2-3) [UniParc]FASTAAdd to Basket

Also known as: Crb1s

The sequence of this isoform differs from the canonical sequence as follows:
     709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
     762-1405: Missing.

Show »
Length:761
Mass (Da):82,539
Checksum:i237635C3735E06A8
GO
Isoform 4 (identifier: Q8VHS2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-372: Missing.
     373-389: SYVGASGYVCICQPGFT → MFGHKTQGFHILMAVLI
     709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
     762-1405: Missing.

Note: No experimental confirmation available.

Show »
Length:389
Mass (Da):42,611
Checksum:i79E07040792E01A8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 372372Missing in isoform 4. VSP_014730Add
BLAST
Alternative sequencei329 – 38961Missing in isoform 2. VSP_014731Add
BLAST
Alternative sequencei373 – 38917SYVGA…QPGFT → MFGHKTQGFHILMAVLI in isoform 4. VSP_014732Add
BLAST
Alternative sequencei709 – 76153EYVAG…STYQY → GERSGVPQSAVPLSRAISNH PGCRPLLGNIRTPQDLCWYL FTNEIKWHSHDMY in isoform 3 and isoform 4. VSP_014733Add
BLAST
Alternative sequencei762 – 1405644Missing in isoform 3 and isoform 4. VSP_014734Add
BLAST
Alternative sequencei1298 – 137679NECAS…RATQG → EASVPPIPASMEDCAGTWST GSYASVMWPSLGERCELDVS GLSFYVSLLLWQNLFQLLSY LVLHMNDEPVVEWGAQENY in isoform 2. VSP_014735Add
BLAST
Alternative sequencei1377 – 140529Missing in isoform 2. VSP_014736Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461K → E in AAL65131. 1 Publication
Sequence conflicti46 – 461K → E in AAR20495. 1 Publication
Sequence conflicti157 – 1571H → L in AAL65131. 1 Publication
Sequence conflicti214 – 2141E → K in AAR20495. 1 Publication
Sequence conflicti261 – 2611S → T in AAR20495. 1 Publication
Sequence conflicti344 – 3441S → N in AAR20495. 1 Publication
Sequence conflicti371 – 3711S → T in AAR20495. 1 Publication
Sequence conflicti413 – 4131N → S in AAL65131. 1 Publication
Sequence conflicti521 – 5211Missing in AAR20495. 1 Publication
Sequence conflicti536 – 5361L → W in AAQ06606. 1 Publication
Sequence conflicti540 – 5401C → G in AAQ06606. 1 Publication
Sequence conflicti545 – 5451I → M in AAQ06606. 1 Publication
Sequence conflicti572 – 5721T → P in AAQ06606. 1 Publication
Sequence conflicti591 – 5911T → A in AAQ06606. 1 Publication
Sequence conflicti673 – 6731D → DD in AAR20495. 1 Publication
Sequence conflicti741 – 7411F → L in AAQ06606. 1 Publication
Sequence conflicti745 – 7451R → H in AAQ06606. 1 Publication
Sequence conflicti835 – 8351P → L in AAQ06606. 1 Publication
Sequence conflicti886 – 8861G → R in AAQ06606. 1 Publication
Sequence conflicti900 – 9023VCH → ACR in AAQ06606. 1 Publication
Sequence conflicti942 – 9421P → S in AAQ06606. 1 Publication
Sequence conflicti982 – 9821H → Q in AAQ06606. 1 Publication
Sequence conflicti1062 – 10621I → V in AAQ06606. 1 Publication
Sequence conflicti1275 – 12751M → V in AAQ06606. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF406641 mRNA. Translation: AAL65131.1.
AY450552 mRNA. Translation: AAR20495.1.
AF492496 mRNA. Translation: AAQ06606.1.
AK044345 mRNA. Translation: BAC31879.1.
AK044704 mRNA. Translation: BAC32041.1.
AL606536, AC116810, AC138741 Genomic DNA. Translation: CAX16031.1.
CH466520 Genomic DNA. Translation: EDL39531.1.
CCDSiCCDS15336.1. [Q8VHS2-1]
RefSeqiNP_573502.2. NM_133239.2. [Q8VHS2-1]
UniGeneiMm.95700.

Genome annotation databases

EnsembliENSMUST00000059825; ENSMUSP00000060769; ENSMUSG00000063681. [Q8VHS2-1]
GeneIDi170788.
KEGGimmu:170788.
UCSCiuc007cwc.1. mouse. [Q8VHS2-1]
uc007cwe.1. mouse. [Q8VHS2-4]
uc007cwf.1. mouse. [Q8VHS2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF406641 mRNA. Translation: AAL65131.1 .
AY450552 mRNA. Translation: AAR20495.1 .
AF492496 mRNA. Translation: AAQ06606.1 .
AK044345 mRNA. Translation: BAC31879.1 .
AK044704 mRNA. Translation: BAC32041.1 .
AL606536 , AC116810 , AC138741 Genomic DNA. Translation: CAX16031.1 .
CH466520 Genomic DNA. Translation: EDL39531.1 .
CCDSi CCDS15336.1. [Q8VHS2-1 ]
RefSeqi NP_573502.2. NM_133239.2. [Q8VHS2-1 ]
UniGenei Mm.95700.

3D structure databases

ProteinModelPortali Q8VHS2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VHS2.

Proteomic databases

PRIDEi Q8VHS2.

Protocols and materials databases

DNASUi 170788.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059825 ; ENSMUSP00000060769 ; ENSMUSG00000063681 . [Q8VHS2-1 ]
GeneIDi 170788.
KEGGi mmu:170788.
UCSCi uc007cwc.1. mouse. [Q8VHS2-1 ]
uc007cwe.1. mouse. [Q8VHS2-4 ]
uc007cwf.1. mouse. [Q8VHS2-3 ]

Organism-specific databases

CTDi 23418.
MGIi MGI:2136343. Crb1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00750000117426.
HOGENOMi HOG000230899.
HOVERGENi HBG080001.
InParanoidi Q8VHS2.
KOi K16681.
OMAi ATFLNDS.
OrthoDBi EOG7KH9HX.
TreeFami TF316224.

Miscellaneous databases

NextBioi 370423.
PROi Q8VHS2.
SOURCEi Search...

Gene expression databases

Bgeei Q8VHS2.
CleanExi MM_CRB1.
Genevestigatori Q8VHS2.

Family and domain databases

Gene3Di 2.60.120.200. 3 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00008. EGF. 11 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 3 hits.
[Graphical view ]
SMARTi SM00181. EGF. 10 hits.
SM00179. EGF_CA. 7 hits.
SM00282. LamG. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 3 hits.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 17 hits.
PS01187. EGF_CA. 6 hits.
PS50025. LAM_G_DOMAIN. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain."
    den Hollander A.I., Ghiani M., de Kok Y.J.M., Wijnholds J., Ballabio A., Cremers F.P.M., Broccoli V.
    Mech. Dev. 110:203-207(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    Tissue: Eye.
  2. "Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin development."
    Watanabe T., Miyatani S., Katoh I., Kobayashi S., Ikawa Y.
    Biochem. Biophys. Res. Commun. 313:263-270(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
    Strain: ICR.
    Tissue: Skin.
  3. "Mouse Crumbs-2 in developing nervous system."
    Chang C.-H., Fan S.-S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ICR.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Retina.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis."
    Pellikka M., Tanentzapf G., Pinto M., Smith C., McGlade C.J., Ready D.F., Tepass U.
    Nature 416:143-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina."
    Mehalow A.K., Kameya S., Smith R.S., Hawes N.L., Denegre J.M., Young J.A., Bechtold L., Haider N.B., Tepass U., Heckenlively J.R., Chang B., Naggert J.K., Nishina P.M.
    Hum. Mol. Genet. 12:2179-2189(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DISEASE, FUNCTION.
  9. "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."
    van de Pavert S.A., Kantardzhieva A., Malysheva A., Meuleman J., Versteeg I., Levelt C., Klooster J., Geiger S., Seeliger M.W., Rashbass P., Le Bivic A., Wijnholds J.
    J. Cell Sci. 117:4169-4177(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, COMPLEX FORMATION WITH MPDZ; MPP4 AND MPP5, FUNCTION.

Entry informationi

Entry nameiCRUM1_MOUSE
AccessioniPrimary (citable) accession number: Q8VHS2
Secondary accession number(s): B7ZC63
, Q6ST50, Q71JF2, Q8BGR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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