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Protein

Protein crumbs homolog 1

Gene

Crb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. Isoform 3 could play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization.3 Publications

GO - Molecular functioni

GO - Biological processi

  • eye photoreceptor cell development Source: MGI
  • membrane organization Source: MGI
  • plasma membrane organization Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein crumbs homolog 1
Gene namesi
Name:Crb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2136343. Crb1.

Subcellular locationi

Isoform 1 :
  • Membrane; Single-pass type I membrane protein

  • Note: In the retina, localizes to the Mueller cell radial processes in the inner nuclear layer and in apical processes sclerad to the external limiting membrane. Localizes to the subapical region, adjacent to the adherens junction of photoreceptors. Isoform 3 which is secreted is found in the cytoplasmic area of undifferentiated keratinocytes and associates with the plasma membrane at the site of cell-cell contacts and focal adhesion upon keratinocytes differentiation.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 1339ExtracellularSequence analysisAdd BLAST1312
Transmembranei1340 – 1360HelicalSequence analysisAdd BLAST21
Topological domaini1361 – 1405CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • microvillus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000750128 – 1405Protein crumbs homolog 1Add BLAST1378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45By similarity
Disulfide bondi39 ↔ 54By similarity
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi55 ↔ 66By similarity
Disulfide bondi73 ↔ 84By similarity
Disulfide bondi78 ↔ 95By similarity
Disulfide bondi97 ↔ 106By similarity
Disulfide bondi113 ↔ 124By similarity
Disulfide bondi118 ↔ 133By similarity
Disulfide bondi135 ↔ 144By similarity
Disulfide bondi151 ↔ 162By similarity
Disulfide bondi156 ↔ 171By similarity
Disulfide bondi173 ↔ 182By similarity
Disulfide bondi189 ↔ 200By similarity
Disulfide bondi194 ↔ 209By similarity
Disulfide bondi211 ↔ 220By similarity
Disulfide bondi227 ↔ 238By similarity
Disulfide bondi232 ↔ 247By similarity
Disulfide bondi249 ↔ 258By similarity
Disulfide bondi265 ↔ 276By similarity
Disulfide bondi270 ↔ 285By similarity
Disulfide bondi287 ↔ 297By similarity
Disulfide bondi304 ↔ 315By similarity
Disulfide bondi309 ↔ 324By similarity
Disulfide bondi326 ↔ 335By similarity
Disulfide bondi342 ↔ 353By similarity
Disulfide bondi347 ↔ 382By similarity
Disulfide bondi384 ↔ 393By similarity
Disulfide bondi400 ↔ 411By similarity
Disulfide bondi405 ↔ 420By similarity
Disulfide bondi422 ↔ 437By similarity
Disulfide bondi444 ↔ 455By similarity
Disulfide bondi449 ↔ 468By similarity
Disulfide bondi470 ↔ 479By similarity
Glycosylationi560N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi641 ↔ 669By similarity
Glycosylationi656N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi675 ↔ 686By similarity
Disulfide bondi680 ↔ 695By similarity
Disulfide bondi697 ↔ 706By similarity
Glycosylationi756N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi850 ↔ 884By similarity
Glycosylationi879N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi890 ↔ 901By similarity
Disulfide bondi895 ↔ 910By similarity
Disulfide bondi912 ↔ 921By similarity
Disulfide bondi927 ↔ 938By similarity
Disulfide bondi932 ↔ 947By similarity
Glycosylationi967N-linked (GlcNAc...)Sequence analysis1
Glycosylationi974N-linked (GlcNAc...)Sequence analysis1
Glycosylationi999N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1095 ↔ 1136By similarity
Disulfide bondi1142 ↔ 1153By similarity
Disulfide bondi1147 ↔ 1162By similarity
Disulfide bondi1164 ↔ 1173By similarity
Disulfide bondi1180 ↔ 1190By similarity
Disulfide bondi1185 ↔ 1199By similarity
Glycosylationi1189N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1201 ↔ 1210By similarity
Disulfide bondi1217 ↔ 1228By similarity
Disulfide bondi1222 ↔ 1237By similarity
Disulfide bondi1239 ↔ 1248By similarity
Glycosylationi1242N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1258 ↔ 1273By similarity
Glycosylationi1264N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1267 ↔ 1282By similarity
Disulfide bondi1284 ↔ 1293By similarity
Disulfide bondi1300 ↔ 1311By similarity
Disulfide bondi1305 ↔ 1320By similarity
Disulfide bondi1322 ↔ 1331By similarity

Post-translational modificationi

Glycosylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VHS2.
PRIDEiQ8VHS2.

PTM databases

iPTMnetiQ8VHS2.
PhosphoSitePlusiQ8VHS2.

Expressioni

Tissue specificityi

Expressed exclusively in brain and proliferative retinoblasts of the eye. In the brain, expressed in the granular layer of the cerebellum, the hippocampal dentate gyrus, the olfactory bulbs, the subventricular region lining the telencephalic ventricles and the rostral migratory stream. Isoform 3 is ubiquitously expressed.2 Publications

Developmental stagei

Primarily detected in the central nervous system at E10.5, in the ventral part of the neural tube including the ventral spinal cord, the ventral part of the mesencephalon, the mammillary and the hypothalamic regions, the optic area and the zona limitans intrathalamica. Expressed by the V3 interneurons placed between the floor plate and the motorneurons all along the spinal cord axis. In late embryogenesis, expressed mainly in ventral neural structures of the developing brain, including the mammillary, tuberalis regions of the hypothalamus and the preoptic area. Starting from E12.5, also strongly expressed in the neural area that gives rise to the dorsal thalamus. In the retina, expression starts at E11.5 and is enhanced at E12.5, E14.5 and E16.5. In postnatal stages and in the adult eye, it is strongly expressed in photoreceptors and also found in inner nuclear layer and iris. Isoform 3 expression starts at E14, is enhanced at E15 and E16 during active proliferation of epidermal cells, decreases after birth but is maintained in adult skin. Detected in the skin basal cells at E16, it was observed in upper layers after birth (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000063681.
CleanExiMM_CRB1.
ExpressionAtlasiQ8VHS2. baseline and differential.
GenevisibleiQ8VHS2. MM.

Interactioni

Subunit structurei

In photoreceptor cells, forms a complex with MPDZ, MPP4 and MPP5.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060769.

Structurei

3D structure databases

ProteinModelPortaliQ8VHS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 67EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST38
Domaini69 – 107EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini109 – 145EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini147 – 183EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini185 – 221EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini223 – 259EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini261 – 298EGF-like 7PROSITE-ProRule annotationAdd BLAST38
Domaini300 – 336EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini338 – 394EGF-like 9PROSITE-ProRule annotationAdd BLAST57
Domaini396 – 438EGF-like 10PROSITE-ProRule annotationAdd BLAST43
Domaini440 – 480EGF-like 11PROSITE-ProRule annotationAdd BLAST41
Domaini482 – 669Laminin G-like 1PROSITE-ProRule annotationAdd BLAST188
Domaini671 – 707EGF-like 12PROSITE-ProRule annotationAdd BLAST37
Domaini713 – 884Laminin G-like 2PROSITE-ProRule annotationAdd BLAST172
Domaini886 – 922EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini923 – 959EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini950 – 1136Laminin G-like 3PROSITE-ProRule annotationAdd BLAST187
Domaini1138 – 1174EGF-like 15PROSITE-ProRule annotationAdd BLAST37
Domaini1176 – 1211EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1213 – 1249EGF-like 17PROSITE-ProRule annotationAdd BLAST37
Domaini1254 – 1294EGF-like 18PROSITE-ProRule annotationAdd BLAST41
Domaini1296 – 1332EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Belongs to the Crumbs protein family.Curated
Contains 19 EGF-like domains.PROSITE-ProRule annotation
Contains 3 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR70. Eukaryota.
ENOG411193Y. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000230899.
HOVERGENiHBG080001.
InParanoidiQ8VHS2.
KOiK16681.
OMAiCINLWQG.
OrthoDBiEOG091G00H8.
TreeFamiTF316224.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00008. EGF. 12 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 17 hits.
SM00179. EGF_CA. 16 hits.
SM00282. LamG. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 17 hits.
PS01187. EGF_CA. 6 hits.
PS50025. LAM_G_DOMAIN. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKRTAYLL FLYLSSSLLI CIKNSFCNKN NTRCLSGPCQ NNSTCKHFPQ
60 70 80 90 100
DNNCCLDTAN NLDKDCEDLK DPCFSSPCQG IATCVKIPGE GNFLCQCPPG
110 120 130 140 150
YSGLNCETAT NSCGGNLCQH GGTCRKDPEH PVCICPPGYA GRFCETDHNE
160 170 180 190 200
CASSPCHNGA MCQDGINGYS CFCVPGYQGR HCDLEVDECV SDPCKNEAVC
210 220 230 240 250
LNEIGRYTCV CPQEFSGVNC ELEIDECRSQ PCLHGATCQD APGGYSCDCA
260 270 280 290 300
PGFLGEHCEL SVNECESQPC LHGGLCVDGR NSYHCDCTGS GFTGMHCESL
310 320 330 340 350
IPLCWSKPCH NDATCEDTVD SYICHCRPGY TGALCETDIN ECSSNPCQFW
360 370 380 390 400
GECVELSSEG LYGNTAGLPS SFSYVGASGY VCICQPGFTG IHCEEDVDEC
410 420 430 440 450
LLHPCLNGGT CENLPGNYAC HCPFDDTSRT FYGGENCSEI LLGCTHHQCL
460 470 480 490 500
NNGKCIPHFQ NGQHGFTCQC LSGYAGPLCE TVTTLSFGSN GFLWVTSGSH
510 520 530 540 550
TGIGPECNIS LRFHTVQPNA LLLIRGNKDV SMKLELLNGC VHLSIEVWNQ
560 570 580 590 600
LKVLLSISHN TSDGEWHFVE VTIAETLTLA LVGGSCKEKC TTKSSVPVEN
610 620 630 640 650
HQSICALQDS FLGGLPMGTA NNSVSVLNIY NVPSTPSFVG CLQDIRFDLN
660 670 680 690 700
HITLENVSSG LSSNVKAGCL GKDWCESQPC QNRGRCINLW QGYQCECDRP
710 720 730 740 750
YTGSNCLKEY VAGRFGQDDS TGYAAFSVND NYGQNFSLSM FVRTRQPLGL
760 770 780 790 800
LLALENSTYQ YVSVWLEHGS LALQTPGSPK FMVNFFLSDG NVHLISLRIK
810 820 830 840 850
PNEIELYQSS QNLGFISVPT WTIRRGDVIF IGGLPDREKT EVYGGFFKGC
860 870 880 890 900
VQDVRLNSQT LEFFPNSTNN AYDDPILVNV TQGCPGDNTC KSNPCHNGGV
910 920 930 940 950
CHSLWDDFSC SCPTNTAGRA CEQVQWCQLS PCPPTAECQL LPQGFECIAN
960 970 980 990 1000
AVFSGLSREI LFRSNGNITR ELTNITFAFR THDTNVMILH AEKEPEFLNI
1010 1020 1030 1040 1050
SIQDARLFFQ LRSGNSFYTL HLMGSQLVND GTWHQVTFSM IDPVAQTSRW
1060 1070 1080 1090 1100
QMEVNDQTPF VISEVATGSL NFLKDNTDIY VGDQSVDNPK GLQGCLSTIE
1110 1120 1130 1140 1150
IGGIYLSYFE NLHGFPGKPQ EEQFLKVSTN MVLTGCLPSN ACHSSPCLHG
1160 1170 1180 1190 1200
GNCEDSYSSY RCACLSGWSG THCEINIDEC FSSPCIHGNC SDGVAAYHCR
1210 1220 1230 1240 1250
CEPGYTGVNC EVDVDNCKSH QCANGATCVP EAHGYSCLCF GNFTGRFCRH
1260 1270 1280 1290 1300
SRLPSTVCGN EKRNFTCYNG GSCSMFQEDW QCMCWPGFTG EWCEEDINEC
1310 1320 1330 1340 1350
ASDPCINGGL CRDLVNRFLC ICDVAFAGER CELDLADDRL LGIFTAVGSG
1360 1370 1380 1390 1400
TLALFFILLL AGVASLIASN KRATQGTYSP SGQEKAGPRV EMWIRMPPPA

LERLI
Length:1,405
Mass (Da):153,350
Last modified:July 27, 2011 - v3
Checksum:iFE1ECCB17529797B
GO
Isoform 2 (identifier: Q8VHS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-389: Missing.
     1298-1376: NECASDPCIN...IASNKRATQG → EASVPPIPAS...VVEWGAQENY
     1377-1405: Missing.

Show »
Length:1,315
Mass (Da):144,240
Checksum:iA7BFB777507D5D50
GO
Isoform 3 (identifier: Q8VHS2-3) [UniParc]FASTAAdd to basket
Also known as: Crb1s

The sequence of this isoform differs from the canonical sequence as follows:
     709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
     762-1405: Missing.

Show »
Length:761
Mass (Da):82,539
Checksum:i237635C3735E06A8
GO
Isoform 4 (identifier: Q8VHS2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-372: Missing.
     373-389: SYVGASGYVCICQPGFT → MFGHKTQGFHILMAVLI
     709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
     762-1405: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):42,611
Checksum:i79E07040792E01A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46K → E in AAL65131 (PubMed:11744384).Curated1
Sequence conflicti46K → E in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti157H → L in AAL65131 (PubMed:11744384).Curated1
Sequence conflicti214E → K in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti261S → T in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti344S → N in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti371S → T in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti413N → S in AAL65131 (PubMed:11744384).Curated1
Sequence conflicti521Missing in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti536L → W in AAQ06606 (Ref. 3) Curated1
Sequence conflicti540C → G in AAQ06606 (Ref. 3) Curated1
Sequence conflicti545I → M in AAQ06606 (Ref. 3) Curated1
Sequence conflicti572T → P in AAQ06606 (Ref. 3) Curated1
Sequence conflicti591T → A in AAQ06606 (Ref. 3) Curated1
Sequence conflicti673D → DD in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti741F → L in AAQ06606 (Ref. 3) Curated1
Sequence conflicti745R → H in AAQ06606 (Ref. 3) Curated1
Sequence conflicti835P → L in AAQ06606 (Ref. 3) Curated1
Sequence conflicti886G → R in AAQ06606 (Ref. 3) Curated1
Sequence conflicti900 – 902VCH → ACR in AAQ06606 (Ref. 3) Curated3
Sequence conflicti942P → S in AAQ06606 (Ref. 3) Curated1
Sequence conflicti982H → Q in AAQ06606 (Ref. 3) Curated1
Sequence conflicti1062I → V in AAQ06606 (Ref. 3) Curated1
Sequence conflicti1275M → V in AAQ06606 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147301 – 372Missing in isoform 4. 1 PublicationAdd BLAST372
Alternative sequenceiVSP_014731329 – 389Missing in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014732373 – 389SYVGA…QPGFT → MFGHKTQGFHILMAVLI in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_014733709 – 761EYVAG…STYQY → GERSGVPQSAVPLSRAISNH PGCRPLLGNIRTPQDLCWYL FTNEIKWHSHDMY in isoform 3 and isoform 4. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_014734762 – 1405Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST644
Alternative sequenceiVSP_0147351298 – 1376NECAS…RATQG → EASVPPIPASMEDCAGTWST GSYASVMWPSLGERCELDVS GLSFYVSLLLWQNLFQLLSY LVLHMNDEPVVEWGAQENY in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_0147361377 – 1405Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406641 mRNA. Translation: AAL65131.1.
AY450552 mRNA. Translation: AAR20495.1.
AF492496 mRNA. Translation: AAQ06606.1.
AK044345 mRNA. Translation: BAC31879.1.
AK044704 mRNA. Translation: BAC32041.1.
AL606536, AC116810, AC138741 Genomic DNA. Translation: CAX16031.1.
CH466520 Genomic DNA. Translation: EDL39531.1.
CCDSiCCDS15336.1. [Q8VHS2-1]
RefSeqiNP_573502.2. NM_133239.2. [Q8VHS2-1]
UniGeneiMm.95700.

Genome annotation databases

EnsembliENSMUST00000059825; ENSMUSP00000060769; ENSMUSG00000063681. [Q8VHS2-1]
ENSMUST00000196402; ENSMUSP00000142702; ENSMUSG00000063681. [Q8VHS2-3]
GeneIDi170788.
KEGGimmu:170788.
UCSCiuc007cwc.1. mouse. [Q8VHS2-1]
uc007cwe.1. mouse. [Q8VHS2-4]
uc007cwf.1. mouse. [Q8VHS2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406641 mRNA. Translation: AAL65131.1.
AY450552 mRNA. Translation: AAR20495.1.
AF492496 mRNA. Translation: AAQ06606.1.
AK044345 mRNA. Translation: BAC31879.1.
AK044704 mRNA. Translation: BAC32041.1.
AL606536, AC116810, AC138741 Genomic DNA. Translation: CAX16031.1.
CH466520 Genomic DNA. Translation: EDL39531.1.
CCDSiCCDS15336.1. [Q8VHS2-1]
RefSeqiNP_573502.2. NM_133239.2. [Q8VHS2-1]
UniGeneiMm.95700.

3D structure databases

ProteinModelPortaliQ8VHS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060769.

PTM databases

iPTMnetiQ8VHS2.
PhosphoSitePlusiQ8VHS2.

Proteomic databases

PaxDbiQ8VHS2.
PRIDEiQ8VHS2.

Protocols and materials databases

DNASUi170788.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059825; ENSMUSP00000060769; ENSMUSG00000063681. [Q8VHS2-1]
ENSMUST00000196402; ENSMUSP00000142702; ENSMUSG00000063681. [Q8VHS2-3]
GeneIDi170788.
KEGGimmu:170788.
UCSCiuc007cwc.1. mouse. [Q8VHS2-1]
uc007cwe.1. mouse. [Q8VHS2-4]
uc007cwf.1. mouse. [Q8VHS2-3]

Organism-specific databases

CTDi23418.
MGIiMGI:2136343. Crb1.

Phylogenomic databases

eggNOGiENOG410IR70. Eukaryota.
ENOG411193Y. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000230899.
HOVERGENiHBG080001.
InParanoidiQ8VHS2.
KOiK16681.
OMAiCINLWQG.
OrthoDBiEOG091G00H8.
TreeFamiTF316224.

Miscellaneous databases

PROiQ8VHS2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063681.
CleanExiMM_CRB1.
ExpressionAtlasiQ8VHS2. baseline and differential.
GenevisibleiQ8VHS2. MM.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00008. EGF. 12 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 17 hits.
SM00179. EGF_CA. 16 hits.
SM00282. LamG. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 17 hits.
PS01187. EGF_CA. 6 hits.
PS50025. LAM_G_DOMAIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRUM1_MOUSE
AccessioniPrimary (citable) accession number: Q8VHS2
Secondary accession number(s): B7ZC63
, Q6ST50, Q71JF2, Q8BGR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.